Utrezhastan instructions for use. Uremines in pregnancy - side effects

Uremines is hormonal medicinal preparation from the Gestagenne Group.

Composition, form of release

The preparation of the Uropozhantan includes natural micronized progesterone. The medicine is produced in the form of soft capsules of 100 or 200 mg. As auxiliary components Speakers: peanut butter, lecithin, glycerol, gelatin, titanium dioxide.

The pharmacological effect of the drug was due to the presence of a substance of the substance progesterone, which is hormone yellow Body. Active Component It has the ability to communicate with receptors that are on the surface of target organs, penetrate the kernel and activate DNA, as well as stimulate RNA synthesis.

The use of the drug contributes to the provision of the following positive impacts:

The use of the drug in Utrezhastan contributes to the activation of the growth of the secretory departments of the oscincions of the mammary glands. This medicine is used in complex therapy Fibrozno-cystic mastopathy.

Indications for use

The uremines is designed for disease therapy that is provoked by the deficit of progesterone in women. Oral reception is shown in the treatment of the following states:

• Complex therapy of infertility, which is caused by the lack of lutein phase.
• For premenstrual voltage syndrome therapy.
• In the treatment of violations menstrual cycle.
• IN complex treatment Fibrozno-cystic mastopathy.
• The drug is used to facilitate the main symptoms of pre-menopause.
• With replacement hormone therapy, menopause. In this case, the drug can be used in conjunction with other hormonal medicines Based on estrogen.

Intravagial application is intended for:

• Substitution hormone therapy in case of progesterone deficiency.
• To support the lutein phase during the preparation for extracorporeal fertilization.
• In order to support the lutein phase.
• With premature menopause.
• With infertility, which is due to lutein deficiency.
• In order to prevent the miscarriage, which may be due to progressive failure.
• In order to prevent the uterine and endometriosis.

Ureminest in pregnancy, application

Urozhenan during pregnancy can be used in 1 and 2 trimester of pregnancy. During the period of tooling the child and lactation, the drug should be taken with extreme caution due to the risk of developing violations of the normal functioning of the liver.

Contraindications

Uroprustan during pregnancy is contraindicated to use in the case of individual intolerance to the main or auxiliary components of the drug. In addition, the following states are opposed to contraindications:

• Next to the development of thrombosis.
• Development of acute phlebitis or thromboembolism.
• In the uterine bleeding of unclear origin.
• In case of incomplete abortion and porphyry.
• With suspected or diagnosing malignant neoplasms of the dairy glands or genital organs.
• P. acute violations normal functioning of the tract (for oral administration).

Preparation with caution is used in violations of the normal functioning of the cardiovascular system, elevated arterial pressure, with the development of diabetes, bronchial asthma, depression, migraine, epileptic seizures.

Adverse reactions

The use of the drug can contribute to the development of the following adverse reactions:

Dreaming and dizziness, which develop for 2-4 hours after taking the drug and pass on their own for a short period of time.

• Reducing the menstrual cycle and intermented bleeding.
• Development of allergic reactions.

Described adverse reactions develop only during oral use of the drug.

Uremines can not be used to provide contraceptive effects.

The use of the drug in the urozhastan may influence the management transport mechanismsSince the medicine can reduce the concentration of attention.

In case of violations of the normal functioning of the kidneys, the drug can be used with extreme caution and only under the supervision of the doctor.

In case of violations of the normal functioning of the liver, oral intake of ureversary when planning pregnancy is contraindicated.

Mode of application

The preparation can be used for oral or intravaginal use. The duration of the use of the drug was determined individually, depending on the testimony to use and associated disease manifestations.

Oral reception

When orally use, uremines, when planning pregnancy, should be taken twice a day, drinking sufficient water. With a lack of progesterone, the maximum daily dosage should not exceed 400 mg.

For syndrome PMS.As well as in the treatment of fibrous-cystic mastopathy, the maximum daily dosage should not exceed 400 mg, the duration of therapy is 10 days. The drug must be taken from 17 to 26 day of the menstrual cycle.

In the event that the drug is used during the period or postmenopause, then the duration of reception should not exceed 12 days.

Intravaginal application

With the complete absence of progesterone, women uremines use at least 3 months. The dosage is selected individually.

In the threat of abortion, the drug is used in 1 and 2 trimester of pregnancy twice a day. The capsule should be introduced deep into the vagina.

Medicinal interaction

With simultaneous use, the ureasia can enhance the pharmacological effect of the following groups of medicines:

• Anticoagulants.
• Diuretics.
• Hypotensive preparations.
• Immununopressants.

With simultaneous use with oxytocin, the ureasically helps to reduce its lactogenic effect.

Cost, analogs

Uremines, the price of this drug for the period January-February 2015 was formed as follows:

• Capsules 100 mg, 30 pcs. - 402-450 rubles.
• Capsules 200 mg, 14 pcs. - 410-460 rubles.

The counterparts are the following drugs: Hyprogin, Krowstone, Prajisan, progesterone, viselel.

It is assigned as substitution therapy when the hormone deficit leads to non-dishevement of pregnancy. Wastep capsules can be taken orally or intravaginal. The drug is not suitable for self-medication, as it affects the entire hormonal background women. Accurate dosage And the necessary course of treatment is appointed only by a doctor.

Dosage form

Capsules for receiving inside and administration to the vagina at 100 and 200 mg.
Description and composition

Soft capsules, the surface is brilliant, yellowish color. Capsules of 100 mg round, 200 mg - oval. Inside them contain an oil whitish homogeneous suspension without a noticeable visual border of the phases.

The active substance of the drug is natural micronized. In 100 mg capsules, 100 mg of the active substance, 200 mg - 200 mg, is contained.

As additional components, they contain E476 and sunflower oil.

The composition of the shell capsules includes:

• gelatin;
• titanium Belil;
• glycerol.

Pharmacological group

The active substance of urezhestan - a hormone of a yellow body. It binds to receptors localized on the surface of the cells of target organs. It penetrates their kernel, activates DNA, stimulates the production of RNA.

Helps to move endometrial from the proliferation stage, which is caused by a follitropine, to the secretory phase. After the combination of the egg cell with sperm contributes to the endometrium transition to a state that allows the germin to develop. Reduces the excitability and reduction of the myometrium and muscles of ovidodes, activates the development of the terminal elements of the breast, the growth of the secretory department of its acinuses, activates the lactation.

It acts on proteinlipase, the resulting of lipids increases, the absorption of glucose increases, glycogen accumulates in the liver. Increases the production of pituitary gonadotropins, reduces nitrogen levels in the blood and increases its removal and urine.

When taking inside active substance absorbed from the gastrointestinal tract. Its content in the blood plasma slowly increases during the first hour and reaches a maximum after 1-3 hours after reception.

When intravaginal introduction quickly absorbs and deposited in the uterus. High content active substance Observed 1 hour after administration. The maximum level of blood plasma is observed in 2-6 hours after administration.

With the introduction of a medication in a daily dosage at least 200 mg, the level corresponds to the I trimester of pregnancy.

In the body, the drug is subjected to metabolism.

Exchanged through the kidneys.

Indications

Uremines are prescribed with a shortage of women.

Insolent the ureasically prescribe if diagnosed:

• infertility, developed against the background of lutein insufficiency;
• disorders of the menstrual cycle caused by a disorder of ovulation or its absence;
• fibrozno-cystic disease;
• potlimax;
• replacement hormone therapy (UGT) in pre- and menopause (In a complex with estrogen-containing medicines).

Intravaginally discharged it if observed:

• early menopause;
• support for the second phase when preparing for ECO, in a spontaneous or conveyed monthly cycle;
• UGT (in combination with estrogen-containing drugs);
• infertility caused by a shortage.

Indications for use during pregnancy

Intravaginally during the tooling of the child the drug is prescribed:

• UGT with a deficiency provoked by the absence of ovaries (donation of oocytes);
• if there is a threat of miscarriage or in order to prevent the usual miscarriage due to the deficit;
• to prevent early childbirth in pregnant women from a risk group (with a shortened cervical canal, non-leaving pregnancy in history).

Contraindications

Capsules Utrezhastan can not be prescribed if the patient is:

• the intolerance of the composition of the medication;
• bleeding from vagina unclear etiology;
• breast cancer I. reproductive organs or suspicion of it;
• hemorrhage into the brain, including history;
• thrombosis and veins embolism, thrombophlebitis;
• porphyry.

The medicine cannot be prescribed inside with severe liver pathologies.

Orally need to be taken with caution, if the patient suffers from such pathologies as:

• cSS diseases;
• high pressure;
• chronic renal failure;
• bronchial asthma;
• epilepsy;
• migraine pains;
• depressive condition;
• elevated cholesterol level in blood;
• violation of the liver function of light and moderate severity;
• photosensabilization.

Contraindications during pregnancy

During pregnancy, the urozhestan is allowed to be used only vaginally. It is forbidden to appoint when an incomplete abortion is observed.

Method of application and dose

The duration of therapy depends on clinical picture pathology.

When taking inside the capsule, you need to drink water.

As a rule, in case of insufficiency, the daily dosage of the medication varies from 200 to 300 mg, which is needed 2 times (in the morning and in the evening).

In case of lack of lutein phase (PMS, painful monthly, prelimax), the daily dose of the drug is 200 or 400 mg within 10 days (usually from the 17th to the 26th day of the cycle).

With the UGT in the preclimacteric period, simultaneously with estrogen, the ureasia must be used in the daily dosage of 200 mg for 12 days.

With UGT during postmenopause in continuous mode, it must be used in a dosage of 100-200 mg from the 1st day of estrogen. The dosage is selected individually.

Schemes Treatment during pregnancy

The drug is used intarvaginally.

At the same time, the capsules are introduced deep into the vagina.

For prophylaxis premature birth Pregnant women from the risk group (with a shortened cervix, previous pregnancies, which ended in unbearable) the drug is usually prescribed in the 200 mg dosage per night, from the 22nd to the 34th week of pregnancy.

The uremines can provoke a decrease in glucose tolerance, resulting in increasing the need for insulin or other sugar-anti-medicaments in patients suffering.

In case of intravaginal use, the interaction of urozheptan with other medicines was not estimated. You should not at the same time insert other medicines in the vagina, in order to avoid discrofing and suction.

special instructions

Uremines can not be taken simultaneously with food, as in this case increases bioavailability.

It is necessary to observe patients with depression in history, and with the development of severe form on the background of treatment, it is necessary to cancel therapy.

Patients suffering from cardiovascular pathologies should be regularly observed by the doctor.

With prolonged therapy you need to pass medical inspections and in case of detection of deviations from normal indicators Or cholestatic jaundice treatment must be interrupted.

According to statistics, more than 50% of cases of miscarriage on early timing connected with genetic violations, infections I. mechanical damage. Application in these cases can only delay the rejection and evacuation of non-visual fetus.

When appointing the UGT with estrogens during the perimenopause, you need to take a minimum of the menstrual cycle at least 12 days.

With continuous UGT in postmenopausal, it is worthwhile from the 1st day of taking estrogen.

Against the background of the UGT, the likelihood of development increases venous thromboembolia, ischemic stroke and IBS.

Due to the risk of the appearance of thromboembolic complications, it is worth interrupting therapy if observed:

• visual disorders (weakening of vision, pooregility, bias in the eyes), vascular damage retina;
• migraine pains;
• thrombosis and embolia veins.

Patients with thrombophlebitis in history should be under constant supervision.

Ugt in patients over 65 years old risk the risk of dementia.

Before the start of the UGT and during her, the patient regularly needs a survey in order to detect contraindications to its conduct.

Treatment of ureversible can change the results of some laboratory tests:

• label function indicators, thyroid;
• blood clotting;
• concentration of pregnandiol.

When taking the drug inside, care must be taken when driving a car.

Overdose

• drowsiness;
• menstrual cycle disorder (its shortening, pain during periods);
• dizziness;
• euphoria.

In some women, even the average therapeutic dosage may be excessive due to non-permanent production in the body, hypersensitivity to the medicine or very low levels of estradiol.

• when drill or dizziness appears, it is necessary to reduce the daily dosage or assign a medication reception for the night for 10 days of the menstrual cycle;
• in shortening monthly cycle or the appearance of "cargo" bloody discharges should be transferred to the beginning of therapy on a later day of the cycle (for example, on the 19th day instead of the 17th);
• during the perimenopause and with substitution hormone therapy in postmenopausal, it is necessary to make sure that the level of estradiol is optimal.

If necessary, with overdose, symptomatic therapy is prescribed.

Storage conditions

Capsules in the morning need to be stored in place inaccessible for children at t no higher than 25 degrees. The shelf life of the drug is 3 years.

Analogs

Instead of ureversible, you can take the following medicines:

1. Vanal is a Spanish drug, which is a complete analogue of ureversive. It is produced in capsules for oral reception and vaginal administration. Drug can be used during pregnancy. Vanal can not be faces under the age of 18 and with breastfeeding.
2. Hyprozhin is an Italian medicine that contains the active substance. It is produced in capsules taken inside and inserted into the vagina. They are allowed to use during the extension of the fetus. The drug can not children and mothers, nursing breasts.
3. - Domestic medicine that is produced in the form of oil injection solution. Pricks of the drug need to be done in the muscle. They are contraindicated to children, in the II and III trimester, during breastfeeding.
4. - Indian medicine, which is a complete analogue of the preparation of the ureasian. It is sold in the form of a gel and capsules, which can be pregnant and nursing with caution.

Price of drug

The cost of ureminus is an average of 412 rubles. Prices fluctuate from 356 to 489 rubles.

Uremines for pregnancy are prescribed with progesterone shortage. Progesterone contributes to the development of pregnancy and is normal in a sufficient number of adrenal glands and the placenta.

With pronounced varicose expansion veins and liver diseases drug do not prescribe. He prepares the body to conceive, not harming him. Available in the form of candles and in the form of capsules. Capsules are taken in the evening in the dosage of 200-300 mg, which you need to split twice.

How does the uremines affect the pregnancy?

Uroprustan during pregnancy helps fruit egg It is normal to implanted to the wall of the uterus and further supports its normal development in the embryo. Uremines - synthetic analogue of progesterone. He does not affect the child. Caution is prescribed with varicose veins, sugar diabetes and CNS diseases. The drug is gradually canceled during the month, reducing the dosage. The lack of progesterone often ends in infertility, but we have joyful news for you - now this problem can be completely solved! Just do not, please, by self-medication, dear women, because pregnancy is a very thin process, the slightest shift of the hormonal background can cause miscarriage. Before receiving, hand over blood to progesterone.

Uremines in early pregnancy

Urozhenan during early pregnancy, in the first trimester, is prescribed mainly in the form of candles, which are introduced at the same time in the evening every day. This form of the drug is preferable to tablets, as it is less unwanted for pregnant and baby side effects, especially from the side of the liver.

Many of the problems with hatching medicine can decide by appointing women an adequate dose of progesterone. The drug reduces the tone of the uterus and puts in order nervous system. The side effects of the urozhastan during pregnancy in the early stages: dizziness and absentment, so be extremely attentive when driving the machine and in production. Thrombophlebitis, varicose veins and liver problems can also cause the doctor to refuse you in the therapy in urozhastan. In most cases, uremines have good tolerability. Additional attentiveness is needed when taking the drug with pregnant, suffering diabetes and having problems in cardiovascular system. There are no uniform recommendations for all pregnant women - a possible daily dosage - 300-600 mg. Since the drug plant baseYou will not be able to gain weight at its reception. It does not take part in carbohydrate and lipid metabolism. Utrezhastan does not cause swelling and does not harm the baby, does not lead to hormonal violations In a child after birth. This is evidenced by the fact that hundreds of thousands of children around the world were born due to the fact that the doctor recommended urozhastan in the threat of abortion. The drug has no analogues.

Utzenadan at 5 week of pregnancy

Pregnancy is special condition The body is a reason for joy and new hopes. But often during pregnancy, already on a small period, it is necessary to assign drugs that help to save it. Uroprustan during pregnancy in 5 weeks you can assign if there is a small blood blood or uterus in a tone. The ureasia is designed for long-term use. It is made on the basis of vegetable raw materials. So lowering the hormonal background should not cause you panic, it can be completely eliminated without consequences for your health during pregnancy. But self-treatment should not be engaged in any case - everything is under the control of the gynecologist!

The drug has a minimum of side effects, if you receive it, you will not suffer from edema or gain weight. It normalizes the endometrium structure on the early period of pregnancy, so that the child is good in your stomach.

It is impossible to abruptly cancel the drug. The doctor will tell you at the reception, how to better reduce the dosage. Usually weekly it decreases by 50 mg.

Utzenastan at week 13 pregnancy

Uremines at week 13 pregnancy are prescribed if there is a threat of abortion due to a lack of progesterone. This problem is very common today. Often also prescribe antispasmodics. They are fully compatible with the urestylene. Uroprustan during pregnancy in most cases is prescribed in a dosage of 200 mg. The uremines did not suppress the production of pregnancy hormones by your body, and complements them and therefore cannot harm. The only thing to consider is to be taken into account that the uremines can not be prescribed to women with liver problems, thrombosis and varicose veins.

Welding in late pregnancy

Uroprustan during pregnancy in late terms can be used if there is a lapidness of the placenta. If there is a chronic habitual imperfection of pregnancy, the doctor can be reinforced and assign it to you after 20 weeks and almost to the birth. Also, the urozhastan in the later dates is shown by those mommies who spent Eco. It is preferable to use candles - they do not act on the liver. You can not worry - the drug does not harm the fetus.

Uremines after 20 weeks of pregnancy

Uroprustan during pregnancy after the period of 20 weeks is rarely assigned, since hormonal support after this period actually loses its importance. But it happens that, according to the results of analyzes in the blood, there is still not enough progesterone, even taking into account the one who starts to develop a placenta at 20 weeks. In this case, it may be necessary to drink urozhastan to childbirth. The problem may also be relevant if pregnancy has come as a result artificial fertilization And in women with Eastic-cervical insufficiency.

Uremines at the 22nd week of pregnancy

Uroprustan during pregnancy for 22 weeks is prescribed in shortening the cervix, as it can cause premature birth due to the threat of its early disclosure. If the history was miscarriage, frozen pregnancy or premature childbirth, the doctor can also assign a ureasically to progress. There is nothing terrible in this. Strictly follow its recommendations and when the time comes, on the designated scheme, cancel the drug. He will definitely help you give birth on time. healthy baby, without bringing him any harm, as in its composition a vegetable analogue of progesterone.

Uremines for 30 weeks of pregnancy

In the 30th week of pregnancy, the ureasia is prescribed with a short soft cervix and if the child is located low in the uterus cavity. If the doctor prescribes you in the morning on this term, it means that he has reasonable, so it should not refuse - it can be dangerous for the baby. Of course, mostly the drug is applied in early terms, but each clinical case perfectly individual. Trust the specialists.

Duphaston or urozhastan during pregnancy: what is better?

Progesterone - a hormone of pregnancy, which is made by the placenta and adrenal glands. Both drugs are designed to compensate for the lack of progesterone in the body of a woman. Placental insufficiency is one of the most common causes of miscarriage.

The difference is that the uremines is a natural analogue of progesterone, and Duphaston is synthetic progesterone. But the experience of using Duphaston is longer, which can be attributed to the pros.

And Duphaston, and the urozhastan during pregnancy removes elevated uterine tone.

The uremines has a slight sedative effect.

Duphaston is much stronger than the drug. As a rule, it is prescribed in the dosage of 1-4 tab to 18 weeks. Contraindications: asthma, diabetes mellitus.

Instructions for the use of ureminus during pregnancy

Uroprustan in pregnancy is taken inside or intrusing. Usually the dosage of tablets is 200 mg. The drug is taken in two receptions.

200 mg of the drug in two receptions is introduced into the vagina, better at night, since it has a property to flow.

Utrezhastan is carefully used in diabetes, epilepsy, depression, varicose veins, thrombosis, when problems with the liver are not at the compensation stage, malignant neoplasms Female genital sphere and mammary glands at the time of reception, or in history.

When taking the drug, drowsiness and scattered. Be careful, sitting behind the wheel.

Uroprustan during pregnancy is appointed today with gynecologists quite often. However, caution must be taken when using progesterone during pregnancy, unacceptably self-medication. In some European countries, the ureasia is not used. This is due to the fact that its effect on the fruit is still little studied. The drug is new. When receiving the drug is justified:

1. If a lack of progesterone was revealed in the laboratory in the blood test during pregnancy.
2. If you have a habitual imperfection of pregnancy associated with the disadvantage of progesterone.
3. If you can not get pregnant because of the lack of progesterone.

Be sure to take into account that the dosage and the duration of treatment of the ureasiastin is installed only by a doctor! Usually a dose of 200-300 mg is entered twice. The abolition of the drug is gradually carried out. Cancellation scheme appoints a doctor. Usually every week is administered by 100 mg less than in the previous until complete cancellation. A sharp cancellation can provoke miscarriage!

How much to take ureminic during pregnancy?

Uroprustan during pregnancy future mom Effective hormonal support. He is prescribed if there is a threat of miscarriage to 24 weeks of pregnancy. In women with problems with the cookie, it is preferable to use candles in the urban.

Cancel of urezheptan during pregnancy

Uroprustan during pregnancy is canceled, reducing the dose by 100 mg per week, or 50 mg every three days. At the same time, it is followed that there are no bleeding from the genital tract. In any case, the urbal is gradually canceled to not harm the child.

Allocations after ureversive during pregnancy

Allocations After the introduction of candles, uremines in pregnancy should not disturb you, as they melt into the vagina and flow out. White selection is the norm in this case.

Blood selection require dose correction of the drug. If you discovered a kettle on underwear, go to an extraordinary reception to the akuster-gynecologist!

Pregnancy after taking upringness

The desired pregnancy sometimes does not occur due to the deficit of progesterone. Uroprustan during pregnancy and at the planning stage in the form of capsules and candles copes with this problem. Thousands of women he helped get pregnant and give birth healthy child. To be reinforced, at the planning stage, the doctor may appoint a wiping to women with acne or masculine type. It is impossible to assign a drug yourself. Reception of urban in some women causes dizziness and drowsiness.

Reception of urezheptan when measured pregnancy

Uroprustan during pregnancy can be assigned after frozen pregnancy, especially if there are alarming symptoms, for example, brown discharge. Progesterone contained in the preparation will help you to convey pregnancy. The tablet of urban or candles drink or administered in the morning and in the evening. Usually a dosage of 200-300 mg per day, but if the threat is very strong and the analysis of the hormonal sphere is expressed according to analyzes, the dose can increase to 600 mg per day.

Dose of urezheptan during pregnancy

Uropozhantan during pregnancy, if there is insufficiency of progesterone, prescribe 200-300 mg in the morning and in the evening inside or intravaginal. The method of application chooses a doctor, given your individual features.

When eco and the familiar non-obscure pregnancy, a gynecologist can increase the dosage of up to 800 mg (also in two receptions). In this case, therapy continues until 24-26 weeks of pregnancy.

Uremines 100 during pregnancy

Utrezhantan during pregnancy is used in the form of capsules of 100 and 200 mg. Different dosage Allows you to individually approach the appointment of the drug to each patient. It has been proven that intravaginal introduction of a capsule in the threat of pregnancy interruption is more efficient and safe than the reception of the tablets inward. This minimizes side effects And does not harm liver.

Urozhenan is carefully used in problems with the functioning of the kidneys and liver, varicose diabetes and epilepsy.

Uremines 200 during pregnancy

Progesterone still during the menstrual cycle, when there is no pregnancy, it prepares the body for the possible attachment of the fertilized egg. It produces a yellow body. The yellow body arises on the site of the bunting follicle with an egg cell and is a temporary iron of the internal secretion.

Basically, the drug urozhestan 200, containing the vegetable analog of progesterone, is prescribed in the first 24 weeks of pregnancy, and then the reception is stopped, as it begins to accumulate in the liver and adversely reflect on its functions.

Contraindications for reception of the drug Uropozhastan during pregnancy: diabetes, epilepsy, depression, varicose veins, heavy violations Liver functions, tumors of female genital organs and mammary glands.

You during the reception of the drug may have some unwanted sideflines, for example, drowsiness and abutment. Individual sensitivity is possible, allergic.

Candles of uremines in pregnancy

Progesterone helps a fertilized egg tools to fully develop. But sometimes it happens that a woman in the body is missing. And then pregnancy either can not come at all, or comes, but interrupts, ending with miscarriage. In this case, during the next pregnancy, the doctor insists at the reception of progesterone. Considering the fact that pregnancy and taking drugs are compatible, which you need to minimize everything side effects And the liver working for two, the gynecologist can assign you not pills, but vaginal candles, for example, uremines.

Industry produces candles of 100 mg and 200 mg. Preparation in the form vaginal candles Very quickly absorbed into the blood, bypassing the liver. Welding is wonderfully combined with vitamin complexes For pregnant women and sedatives. Cancellation of the drug is carried out in the II trimester, gradually reducing the dose. It is not allowed a sharp abolition of the drug in the urozhastan during pregnancy.

Tablets Uroprustan during pregnancy

Nowadays, the problem of miscarriage is very relevant. Only 80% of pregnancies end in childbirth. On female Health Most of all the stress and STDs. Gynecologist can prescribe a pregnant tablet in the morning, if these negative factors influenced her hormonal background, and she dropped the level of progesterone. The uremines in pregnancy also applies in the form of candles, but the doctor can solve in some cases that the concrete pregnant woman is more suitable for the form of tablets. This drug reduces the reduction of the uterus and uterine pipes. The drug complements hormones that produce female organism. The oversight of progesterone is impossible when applied. And yet, there are a number of contraindications: thrombosis, malignant tumors female genital organs heavy Diseases liver leading to strong violation Its functions.

Uremines, often used in gynecology, belongs to hormonal drugs. The main component of this drug is a hormone progesterone. In order to understand when assigned this drugIt is necessary to determine what role progesterone is performed in the female body. It is necessary to determine the side effects of urezheptan, and, therefore, when it is strictly forbidden to apply it.

How does Progesterone affect the female organism?

Progesterone, as is known, correlates to the Gestagen group. It is produced by a yellow body, which is formed at the end of the menstrual cycle. This hormone contributes to the transition of the mucous membrane from the proliferation phase, which is controlled by follicular hormone, in secretory.

Also progesterone helps to reduce the excitability and reduction of the mother-in-law muscles. That is why it is called a hormone of pregnancy.

When is uremines appointed?

This drug has pretty wide spectrum Applications. So, it is prescribed at:

• premenstrual syndrome;
• mastopathy various origin;
• premenopause;
• as a hormone planer during menopause.

When is the use of urezheptan forbidden?

Women who are prescribed candles of uremines are increasingly interested in side effects and contraindications to the use of the drug. So, this drug can be contraindicated in the following cases:

• hypersensitivity to the drug;
• the presence of a tendency to the formation of thrombosis ( increased clotting blood);
• bleeding from sex tract, not related to monthly.

In addition, the ureas should be used with caution at:

• chronic renal failure;
• diabetes;
• bronchial asthma;
• epilepsy;
• migraine;
• depression.

What are the main side effects of urezheptan?

Having understood with the action of urozheptan on a female organism, it is necessary to say about what the main side effects of this drug are.

Most often, after taking uremines, the following side effects are noted:

• allergic reactions;
• drowsiness;
• dizziness development almost immediately (after 1-3 hours) after taking the drug;
• reduction of the menstrual cycle;
• the appearance of bleeding between monthly.

Most often, after the ureversive appear bloody issueswho are not related to menstruation, which gives a woman certain inconvenience.

Also, the side effects of urezhestan can be treated and weight gain, for which many women complain. This is due to the fact that progesterone contributes to the formation of adipose tissue. As a rule, after the end of the drug intake, the hormonal background is normalized, and the weight gradually begins to decline.

Is the drug appointed during pregnancy?

The uremines is quite often prescribed during the baby tooling, especially in the early stages. It is due to the fact that it is at this time that the likelihood of the development of spontaneous abortion is great.

However, it is possible to occur and side effects from the adoption of ureminus during pregnancy. Most often it is:

Pharmacodynamics. Pharmacological properties The drug is due to progesterone - one of the hormones of the yellow body, which contributes to the formation of normal secretory endometrium in women. Causes the transition of the uterine mucosa from the proliferation phase to the secretory phase, and after fertilization contributes to its transition to the state required for the development of a fertilized egg. Reduces the excitability and reduction of the muscles of the uterus and uterine pipes. Does not have androgenic activity. Shows a blocking effect on the secretion of hypothalamic factors for the release of LG and FSH, inhibits ovulation and secretion of gonadotropic hormones by hypophysome.
Pharmacokinetics. Oral application. Increasing the level of progesterone in blood plasma is observed from the first hour after the intake. The maximum concentration of progesterone in the blood plasma is observed in 1-3 hours after taking (after 1 hour it is an average of 4.25 ng / ml, after 2 h - 11.75 ng / ml, after 4 hours - 8.37 ng / ml After 6 h - 2 ng / ml, after 8 hours - 1.64 ng / ml). The main metabolites of progesterone, determined in the blood plasma, are 20α-hydroxy, D4α-presenolon and 5α-dihydroprogesterone. The drug with urine in the form of glucuronic metabolites is derived, the main of which is 3α, 5β-pre-puntediol (pregnantiol). These metabolites are identical to metabolites that are formed during the physiological secretion of the yellow body.
Intravaginal. When intravaginal use, progesterone is quickly resubped by the mucous membrane. The maximum concentration in the blood plasma is observed in 2-6 hours after intravaginal administration and is maintained for 24 hours on average at 9.7 ng / ml after use of 100 mg in the morning and in the evening. This indicator is identical to the concentration of progesterone, which is noted during the lutein phase. When applied in doses over 200 mg / day, the concentration of progesterone is similar to its concentration in I trimester of pregnancy. The drug is excreted with urine, mainly in the form of Pregnandiol. Metabolites, which are determined in the urine and plasma of blood, are similar to metabolites that appear in the physiological secretion of the yellow body.

Indications for the use of the drug Utrezhastan

Violations caused by progesterone deficit.
Oral reception: Premenstrual syndrome, menstrual disorders (dysisulation, annotulation), fibrous-cystic mastopathy, prelimacteric period, climax (in combination with estrogenic therapy), infertility with lutein deficiency, preventing the usual miscarriage or threat of miscarriage against the background of lutein insufficiency, the threat of premature birth.
Intravaginal application: Reducing the possibility of fertilization during primary or secondary infertility at partial or complete luteane failure (dysisulation, support for the lutein phase during the preparation of extracorporeal fertilization, the donation program of egg cells); Prevention of the usual miscarriage or threat of miscarriage against the background of lutein insufficiency.

Application of the drug in Utrezhastan

The duration of use depends on the nature of the disease.
Reception inside
In most cases, the average daily dose is 200-300 mg in 2 receptions (200 mg in the evening, before bedtime and 100 mg in the morning, in case of need).
In case of lack of lutein phase (Premenstrual syndrome, fibrous-cystic mastopathy, disorders of the menstrual cycle, premenopause) take over 10 days (from the 17th to the 26th day of the cycle).
With replacement hormone therapy in the period of menopause Due to the fact that separately estrogen therapy is not recommended, progesterone is used as an addition to the last 2 weeks of each course of therapy, which occur after the one-week replacement therapy during which possible bleeding Cancels.
In the threat of premature birth 400 mg of utrazhenda are prescribed every 6-8 hours before the disappearance of symptoms. Effective dose and multiplicity of application are established individually depending on clinical manifestations Threats of premature labor. After the disappearance of symptoms, the dose of urezheptan is gradually reduced to supporting - 200 mg 3 times a day. In this dose, the drug can be used up to 36 weeks.
Intravaginal administration
Capsules enter deep into the vagina.
On average, the dose is 200 mg of progesterone per day (1 capsule of 200 mg or 2 capsules of 100 mg, in 2 receptions, in the morning and in the evening, which are introduced deep into the vagina, if necessary using an aplikator). The dose can be enlarged depending on the patient's reaction.
With partial lack of lutein phase (Dysisulation, impairment of the menstrual cycle) The daily dose is 200 mg for 10 days (from the 17th to 26th day of the cycle).
With the complete deficiency of lute enterprise:
Full absence of progesterone in women with non-functioning (absent) ovaries (donation of egg cells): the dose of progesterone is 100 mg in the morning and in the evening from the 15th to the 25th day of the cycle. Starting from the 26th day, in the case of early diagnosis Pregnancy, the dose increases by 100 mg of progesterone per day, reaching a maximum - 600 mg per day, in 3 reception. Such a dosing must be respected until the 60th day.
Support for Luteinovo Phase during the cycle of the Eccorporal fertilization: 600 mg 3 times a day (200 mg once every 8 h).
In the event of a threat of miscarriage or for the prevention of familiar miscarriage against the background of progesterone deficit: Assigns to 200-400 mg / day (100-200 mg every 12 hours) to 12 weeks of pregnancy.

Contraindications for the use of the drug Utrezhastan

Severe liver diseases; Increased sensitivity to the drug.

Side Effects of the Preparation of Uroprustan

When oral administration, such side effects are observed:

Sleepiness and / or dizziness are observed in the case of concomitant hypoestrogenation. Reducing the dose of the drug or an increase in the dose of estrogen pulls out these phenomena without reducing the therapeutic effect.
If the course of treatment begins at the beginning of the monthly cycle, until the 15th day, there is a reduction in cycle or random bleeding. In general, when taking progestins, changes in menstruation, amenorrhea or bleeding in the middle of the cycle are observed.
When intravaginal use: no side effect.

Special guidelines for the use of the drug in Utrezhastan

Treatment in recommended doses has no contraceptive effect.
If the course of treatment begins very early at the beginning of the monthly cycle, especially until the 15th day of the cycle, cycle reductions or bleeding can be observed.
When uterine bleeding The drug should not be prescribed without clarifying their causes, in particular during the endometrium examination.
Due to the risk of developing thromboembolic complications and metabolic disorders It is necessary to cancel the reception of the drug when:

• visual disorders (loss of vision, diplopia, vascular retinal lesions);
• thromboembolic venous or thrombotic complications, regardless of the area of \u200b\u200bthe defeat;
• strong headache.

In the case of a history of thrombophlebitis, the patient must be under the strict observation of the doctor.
In case of amenorrhea, pregnancy should be eliminated during the treatment.
Application during pregnancy or breastfeeding.
IN clinical studies During the period of use of the drug, there was no adverse effect on the fruit. In the II and III trimesters of pregnancy, the liver function is needed.
Penetration of Progesterone B. breast milk It was not studied in detail, so it is necessary to avoid its appointment during breastfeeding period.
The ability to influence the reaction rate when managing vehicles or working with other mechanisms.
Sleepiness and dizziness associated with the reception of the drug inside are possible.

The interactions of the drug in Utzenodan

In the treatment of the threat of premature labor, the uremines is combined with β-adreminimetics, the dosing of the latter can be reduced. With simultaneous use with hepatic enzyme inductors (barbiturates, phenytoin, rifampicin, phenylbutone, spironolactone, griseofulvin) or antibiotics (ampicilines, tetracyclines), it is possible to increase or decrease the concentration of progesterone in the blood plasma.
Progestins reduce glucose tolerance, and it may be necessary to increase daily dose Insulin and other antidiabetic drugs in patients with diabetes mellitus.

Overdose of the preparation of uremines, symptoms and treatment

The symptoms described above, as a rule, appear as a result of an overdose. They will be afraid spontaneously with a decrease in the dose.
In some people, the usual dose may be overwhelmed due to the existing or secondary appearance of unstable endogenous secretion of progesterone, increased sensitivity to the drug or a very low associated level of estradiol in the blood; In such cases, it is enough: to reduce the dose of progesterone or assign a reception of progesterone in the evening before bedtime for 10 days of the cycle in the event of druminess or dizziness;
transfer the start of treatment for more late time cycle (for example, the 19th day instead of the 17th) in case of its reduction or blood discharge;
need to check if the estradiol level is sufficient in a patient who receives replacement hormonal therapy in premopause.

Conditions for the storage of the drug Ureminest

At temperatures up to 25 ° C.

List of pharmacies where you can buy uremines:

• St. Petersburg