Hypokinesia entails various diseases. Hypokinesia - the particular condition of the body due to the insufficiency of motor activity

Date: 03.03.2020

Black acanthosis refers to the category of heavy and rare species of dermatosis. A distinctive feature of this dermatological disease is that it is localized in the field of natural skin folds. As the ailment is developed, the epithelial surface begins to become coarse to the touch, excessive pigmentation of the affected area appears, and in complicated cases it is possible to form warts and extensive papillomatosis. The disease preferably covers the largest sections of epidermal tissues, which almost never come across the sun's rays and completely absent air movement. In the risk group there are people with overweight and plenty of skin folds.

What is this disease and what are the reasons for its development?

Black acanthosis is a disease that is characterized by changing the skin structure due to the fact that it is tightly closed in a natural fold. In fact, the physiological process is occurring, resembling with something atrophy of the epithelium, conjugate with the pathological processes of its destruction.

This disease is extremely rare in modern dermatology, therefore scientists fail through laboratory research to establish the exact cause of the occurrence of this disease. The following causal factors are distinguished, which indirectly or directly affect the appearance of black acanthose in a previously healthy person.

Hereditary predisposition

There are a number of genetic diseases, the presence of which contributes to the development of black acanthose on one or another stage of the patient's life. These are pathologies called ore syndrome, or Misher. They are characterized by a violation of metabolic processes in epithelium cells, which ultimately leads to a change in their structure. Natural folds suffer primarily, since in most cases local immunity is always reduced in this part of the body.

Malignant neoplasm

If there is a rapidly developing body in the body, the appearance of black acuthesis on the body, as a skin reaction to the presence of cancer cells. Most often, when passing the diagnosis of the body, women detect a malignant tumor of ovaries or mammary glands, men reveal prostate or pancreas cancer. Such an oncological pattern is due to the fact that the glands of the internal secretion and the bodies of the reproductive system take part in the exchange processes occurring in the cells of the skin. They produce hormones, without which there is no stable operation and the development of epidermal tissues.

Violation of the functioning of the endocrine system

If there are pathologies from the sides of the internal secretion glands that produce hormonal secrets develop metabolic disorders in the skin, which can manifest itself in the form of black acanthose. This kind of signs are most common in patients with dependence on insulin suffering from Cushusha's disease, obesity of the last stages, hypogonadism, Addison's disease. The stabilization of the hormonal balance provides rarely cure and dermatological disease.

Eating some drugs

Reception of medicines containing synthetic hormones in its composition entails violations by the work of the internal secretion glands, which produce natural hormones of the organism, as well as the suspension of the epithelium by the spree of a large number of hormonal substances.

Most often, the pathological condition of the skin occurs in the case of use in orally oral contraceptives, glucocorticosteroids, large doses of nicotine acid, as well as anabolic steroids to accelerate metabolism.

Black acanthosis is a disease that can occur in the skin of a person, regardless of its age and the social layer, to which he belongs. In people of young people, the dermatological disease is developing under the influence of a factor of negative heredity, hormonal disorders, diseases of the endocrine system. Middle and older patients face black acanthosis, as with one of the indirect symptoms of the presence in the body of a malignant tumor.

What do the first signs of black acanthose in humans look like?

The first signs of the development of black acanthose include three main symptoms that are almost simultaneously manifested on the surface of the skin. They are in the following pathological processes:

(the formation of a coarse epithelium layer, which peels and peel);
(the affected area of \u200b\u200bthe epithelial layer changes the color on dark brown or repainted into black tone at all);
papillomatosis (on the skin of the folds, papillomas, fibromes and other benign tumors begin to grow).

In most cases, the first signs of black acanthose make themselves known, manifesting in the skin of large folds in the area of \u200b\u200bsuch parts of the body, like:

groin and the inner side of the hips;
axillary depressions;
obba area of \u200b\u200belbows and knees;
space between buttocks;
skin covering, located under the lactic glands in women;
folds on the skin area between the population and the lower segment of the neck.

Depending on the configuration of a person, the other localization of black acanthose is also possible. The nature of this dermatological disease remains to the end not studied, therefore it is possible that the pathological change in the cellular structure of the epithelium will manifest itself in another part of the human body. In some cases, the disease applies not only to the folds of the skin, but also affects the mucous membrane of the oral cavity, esophagus, vagina, and even the rectum. Such a disease behavior is a manifestation of a complicated form of black acanthose.

In the first stages of its development, the affected areas of the epidermis have a little yellowish tint, which gradually acquires dark tones and eventually filled with brown pigment. Visually creates the impression that skin cover on the folds is simply dirty and the patients are trying to get rid of black spots and strips by bathing, but all sorts of efforts do not bring the desired effect.

In the future, the epithelium becomes coarse, the surface layer of the skin is compacted, peel and peeling in the form of a plurality of small particles. In this case, there are no signs of itching or pain syndrome. In 10% of cases, multiple benign tumors in the form, fibrom, warts are formed in the folds.

Development speed depends on the form of a dermatological disease, as well as the individual characteristics of the human body that has encountered this skin pathology. Some patients with a strong immune system live with black acanthose dozens of years and their disease is manifested only in the form of dense formations on the sides of the folds.

There is also a group of patients whom the disease is exhausting in just one calendar year is striking not only the epithelial layer of the skin, but also applies to the mucous membranes of vital organs. A benign type of black acanthose develops more slowly, and the oncological form of illness always behaves aggressively and is characterized by an acute clinical picture.

What to treat ackantozis nigricks?

Black acanthosis is a specific disease, so its therapy is individual. At first, the attending physician must establish the cause that caused pathological changes in the cells of the skin. After that, measures are being taken to eliminate the pathogenic factor. In parallel with the process of treating the main disease, the patient is assigned the therapy of the affected skin cover in the folds, which is to take the following drugs:

vitamin and mineral complexes containing an increased concentration of zinc, potassium, magnesium, calcium, vitamin A and group B;
application on damaged epithelium disease of moisturizing creams, in order to minimize the process of peeling the skin and its peeling;
anti-inflammatory and antibacterial agents (the type of medication is selected by a dermatologist in each individual case under a specific patient);
medicines Bificol, Bifidumbactrine, Lactobacillin;
synthetic hormones in the form of tablets and intramuscular injections, if the cause of black acuthesis is the hormonal imbalance;
cyticostatics in the case of a patient a severe clinical picture of black acanthose.

The simultaneous use of these therapeutic agents is much more efficient if the patient regularly takes baths from a weak solution of potassium permanganate.

Also, patients with black acanthosis must be observed a diet that limits the use of a large amount of animal fats. At all stages of treatment it is very important to observe the hygiene of the skin and regularly purify the skin of the folds.

If the skin appears on the skin of benign neoplasms in the form of papillom, fibrom, warts and other epithelial growths, their surgical removal is made. For this apply, or. What to apply a method of treatment in a particular case, determines the treating doctor a dermatologist, which has a patient. Each of the listed methods of surgical therapy is effective only if the main reason provoking dermatological pathology has been eliminated. Otherwise, the recurrence of the disease is not excluded.

Black acanthosis is a fairly rare dermatological disease, characterized by the appearance of coarse, papillomal expansions and hyperpigmentation in the area of \u200b\u200bthe skin folds. Most often, parts of the darkening and hyperkeratosis are localized in inguinal and cervical folds, poning and elbow bends, armpits.

Symptomatics of the disease

The disease has several clinical forms:

benign;
not caused by hormonal changes, hereditary diseases and neoplasms;
associated with hereditary pathologies and endocrine disorders;
malignant shape that happens in patients with identified neoplasms;
pseudoacanthosis arising against the background of hormonal disorders in obese people.

The clinical picture of the disease includes such symptoms:

hyperpigmentation (darkening, spots of dark brown color);
lubration and peeling of skin sections;
papillomatosis.

Occasionally, the symptoms triad is observed on the face or in the umbilical area. Skin changes sometimes affect the mucous membranes of the esophagus, mouth, vagina and intestines. But in most cases, the most typical locations of pathology are:

groin area;
axillary depressions;
folding on the neck;
region between the buttocks;
pioneered zone;
cobwebs;
region near the chest glands.

The skin in these places is dark and dry, drawing is strengthened, relief due to thickening stupid, papillomas and folds occur. The patient may have keratosis of brushes and stop, pigment stains and fibromes. Hair rods and nail plates are thinned. Man complains of skin depth and itching.

Juvenile form

This form of the disease exhibits itself in children or youthful and is observed mainly in the hereditary pathologies in the child. It differs from paraneoplastic in that it is poorly expressed, and there are no tumors and characteristic symptoms. In the overwhelming number of cases, symptoms begins to fade after the end of the puberty period, and sometimes it passes without a trace.

Pareenoplastic form

This form is found in mature people and is characterized by pronounced pathological changes in skin coverings, which are to cut the relief, brown-black pigmentation and a significant number of papillomal growths. The process of vagina and gastrointestinal shells are involved. There may be a change in the opposite side of the stop and brushes by the type of acrokerage.

This form of pathology gives early signs of oncology:

fast fatigue;
general weakness;
apathy in relation to what is happening;
drowsiness with sufficient sleep;
deterioration of appetite;
significant and inexplicable weight drop.

Symptoms of the disease under paranoplastic acanthosis occur sharply, strongly progressed and very quickly progress. The process is often involved in the shells of vagina and gastrointestinal tract. On the reverse side of the brushes and stops may occur papillomal growths. The surface has areas of flaprge, but sometimes it can be smooth, and the color of warts and papules is often different from normal skin, it is closer to reddish brown or black. Sometimes thickening, merging, form plaque.

Pseudoacantoz.

Such a form of pathology is diagnosed in women's overweight and is caused by hormonal disorders, more often due to the dideline dysfunction. The hot climate can also contribute to the appearance of pseudo-adantoma. The patient has hyperpigmentation and thickening in the area of \u200b\u200blarge skin folds. There may be single papillomas or fibromes. The patient is recommended to reduce weight. After its normalization, the symptoms of pseudo-adantomes quickly regress.

Causes of occurrence

Associate the appearance of the disease can various factors. It is certainly unknown why there are persistent changes in pigmentation and oil flaws. In the course of patient observations and clinical research, they managed to establish the connection of the Akutoza with the following factors:

Hereditary predisposition. The emergence of the disease is associated with some congenital pathologies characterized by mental disabilities and exchange failures. Also, the disease is often accompanied by the Misher or Ore syndrome.
Hormonal disorders. Black acanthosis often occurs as a result of failures in the work of the hormonal system in obesity, Cushing syndrome, Addison, insulin resistance, and hypogonadism.
Oncological neoplasms. The disease develops as a consequence of biochemical reactions occurring in the body, but the mechanism of its occurrence is unclear. With this pathology, individuals of prostate, stomach or pancreas are most often diagnosed, while women - breast cancer and appendages are diagnosed. Equally, both sexes find lung cancer. Also, the disease is often diagnosed with some other onco-formations of gastrointestinal and genital organs.
Uncontrolled reception of pharmaceuticals, for example, nicotine acid in elevated doses. Long use of glucocorticosteroid and estrogen-containing hormonal means. In this case, black acanthosis develops rarely.

The disease is equally common in people of different ages. But the factors of occurrence are specific to each of these groups. According to observations, the appearance of black acanthose in the elderly people often testifies to the presence of oncological neoplasms in the body. Young patients acantosis arises mainly due to hereditary diseases, hormonal failures, obesity or hypogonadism. Unfortunately, the disease is very often becoming the first sign of oncology.

Treatment

Patients with black acanthosis should constantly be under the supervision in the dispensary. This will help to conduct a qualitative examination and timely detect some changes in the patient's state. The treatment of black acanthose should be directed to the cause that caused skin pathology, and effectively stop symptoms.

With benign acanthosis, the following drugs are prescribed:

hormonal agents;
antiseptics and anti-inflammatory drugs;
vitamins, adaptogens, soiling drugs;
softening agents;
preparations containing zinc;
a solution of potassium permanganage for baths.

Also, the testimony includes additional drugs:

prebiotics and probiotics;
neurotropic agents;
aromatic retinoids;
cytostatics;
antibiotics.

Recommended therapeutic diet. Patients with black acanthosis is especially important to observe the hygiene of the skin folds. When the disease occurs during treatment with some drugs, it is usually enough to cancel a means that caused skin pathology, and the appointment of another, more secure, preparation. Sometimes it helps a simple dosage reduction.

If the expansion of papillomas is strongly pronounced, surgical treatment methods are applied. Most often, removal is carried out using cryodestruction or electrocoagulation. In each case, its method is selected.

Malignant acanthosis can be treated only by the removal method of cancellation or by passing radio or chemotherapy, which is shown in cases where the formation is inoperable. Conventional therapy used for a benign form of acanthose in this case is inexpedient. If the operation was carried out in a timely manner, the patient recovers very quickly, while the symptoms of skin pathology completely disappear. A course of chemothy or radiation therapy gives a temporary relief of the patient's condition, but the progression of the tumor causes the return of the symptoms of black acanthose.

To which doctor to turn

In the presence of characteristic flaws of the skin with hyperpigmentation, it is necessary to urgently consult a doctor-dermatologist. It examines the patient and after establishing a diagnosis will send it to consult the therapist. If oncology is suspected, it can assign a corresponding examination. After determining the causes of the disease, the patient is sent to a reception to a profile doctor (endocrinologist, gastroenterologist, oncologist, gynecologist, urologist, mammologist or pulmonary).
Usually, difficulties with the diagnosis of the disease does not occur. Differentiate pathology most often accounted for by Addison's disease and Darius, as well as ichthyosis.

The diagnosis is made according to the histology of the bioptata taken. The sample of tissues shows the accumulation of pigment and keratose cells. If the concomitant symptoms causes a suspicion for the presence of an onducation, then a full examination of the patient should be carried out. The patient is directed to the analysis of blood to oncomarkers, MRI, CT and ultrasound diagnostics. Pseudoacanthosis and juvenile form require consultation of the endocrinologist to identify and therapy of hormonal disorders.

Complications

The malignant form of the disease has an unfavorable forecast. The tumor very quickly metastasizes to other organs. Comprehensive treatment prolongs the patient's life at most up to two years. When revealed on the body of coarse pigmented stains, it is important to seek medical care as soon as possible to identify the causes of pathology and timely treatment.

Prevention

Preventive activities are in the right way of life. It is necessary to eat correctly, follow weight, control the level of glucose in the blood and regularly visit the doctor. It is unacceptable to carry out independent treatment with folk remedies, especially to take the pharmaceuticals in large quantities. The prescription of drugs and the dosage correction should be carried out by a doctor.

Black acanthosis is a rather rare disease. Its appearance can be revealed in the folds of the skin if the root has occurred. In this place there are small warts. They can settle armpits, in Pahu, on the neck. Acantosis has other names. It can be called nobular melanomodermy, skin dystrophy, gendermanmatosis. The disease has certain causes of development, characteristic symptoms and flow form. Why does acanthosis occur in a person? Do you have a child's disease?

Why does the disease appear?

The favorite place of appearance is the folds of the skin, which usually appear in the presence of excess weight.

What is the reason for this:

the tendency transmitted by inheritance. It is usually its development provoke a violation of metabolism, changing psycho-emotional background, epilepsy;
oncological diseases. In this case, complex chemical reactions occur in the body. In women, it may be breast cancer or ovaries, and men have an oncological disease of the pancreas. But other cancer diseases are not excluded;
failure in the work of the endocrine system. These may be hormonal disorders, elevated weight, metabolic disorders;
the use of hormonal drugs;
nicotine Acid in large quantities.

This is subject to people at different ages. But depending on the number of years, characteristic causes appear.

It can be:

In young patients, genetic inclinations become reasons, high weight, failure in the work of the endocrine system.
Older patients typically discover cancer diseases.

Individual causes of black acanthose development can be also. To identify them can examine and consult a doctor.

Forms of the disease and symptoms

What are the symptoms of occurrence? Specialists define three main forms of acanthose.

These will be:

a benign form that can develop in endocrine or genetic failures;
malignant, it will develop in the formation of a cancer tumor;
false acanthosis, it provokes obesity, when restoring normal weight, the problem may disappear.

The patient will have symptoms in the form of:

The appearance of the coarse and peeling skin.
The appearance of black or dark brown spots.
The formation of warts or papillom in large quantities.

Where these symptoms usually appear:

on cervical folds in the field of the head;
on the inside of the hips in the area of \u200b\u200bthe groin;
between the buttocks;
on the elbows in the places of folds;
kneeling;
under the milk glands.

Infrequently, but the acanthosis can manifest itself on her face. But several zones on the patient's body can be amazed at the same time. These are usually places near the mucous membranes.

How does the disease develop? Black acantosis manifests itself gradually. What happens to the skin?

What are the mechanisms of development:

A skin section appears with a dirty yellow tint.
Then in this place the skin becomes very thick.
Next, he begins to peel and will be dry.
All lines on the skin will be pronounced and will be quite deep.
In this place, the skin can be almost black.
In completion, warts and papillomas will be shown on it.

Malignant or benign

Malignant acanthosis is more often developing in adult patients. It provokes an oncological disease that can affect not only the skin, but also internal organs.

What is the probability of cancer development:

about 20% of such patients are registered with the oncologist about 5 years after the development of black acanthose;
in almost 60-65% of patients, acanthosis and oncological disease are revealed at the same time;
in 20% of manifestations on the skin become noticeable when the disease is already progressing.

As cancer is manifested at an early stage of development:

There is a loss of forces, weakness.
A person has apathy.
He quickly gets tired and constantly wants to sleep.
The weight is quickly reduced.
There is a loss of appetite.

When several symptoms appear at the same time, you need to contact a medical institution.

There is a benign form of the disease. It can be congenital and usually becomes noticeable in children and adolescents. At the same time, the skin will not be strongly noticeable changes and characteristic symptoms.

Papillomas or warts appear one way and in small quantities. When the transition to the reproductive age will be carried out, all signs of the disease will be held, or small and low-charts will remain.

In women with a lot of weight, there may be a violation of the work of the endocrine system and because of this skin folds will begin to become dark color. But it will not be a manifestation of black acanthose. His specialists call pseudoacanthosis. When restoring normal weight indicators, all signs pass.

Diagnosis and treatment

The correct diagnosis can be installed a dermatologist. Acantosis is quite similar to ichthyosis. Therefore, it is necessary to make a histological study to establish an accurate diagnosis.

When suspected the development of malignant diseases, they are carried out:

magnetic resonance tomography;
ultrasound procedure;
analyzes are held on monackers;
x-ray.

If a benign form of the disease proceeds, there is also a survey. It is necessary to investigate the flow of metabolic processes, the work of the digestive organs.

For the treatment of acanthose, it is not placed in the hospital, it is treated outpatient under the supervision of the doctor.

For this use:

Preparations that will strengthen the general health condition. These will be vitamins and various complexes.
Well acts with echinacea, vitamin C, A, V.
Antiseptics in the form of ointments, sprinkle, softening creams.
Means with zinc and biopreparations.
Antitumor drugs.
Hormonal agents.
Package preparations.
Compliance with diet.

At the same time, it is necessary to comply with personal hygiene of all skin cover.

Medicinal preparations pick up the doctor individually. It is impossible to make an appointment yourself. It is important to comply with personal hygiene. In the process of treatment, it can be shown to remove papilloma and warts.

How to remove? When forming black acanthose on large areas, it is proposed to remove the neoplasm. To do this, use standard methods for removing moles.

But if the disease has become malignant, use special therapies to combat cancer cells. The possibility of complete cure depends on many factors. The main is the type of illness. A benign form of the disease often passes independently, pseudoacanthosis disappears when the weight is normalized, and malignant disease should be treated for a long time.

Black acanthosis (code on the ICD-10 - L 83) is a type of dermatosis, which is extremely rare. The disease is observed among the ceiling of people with a frequency of 1%, 13.5% are found among the dark-skinned people. Female body the disease amazes more often than men's.

Black acanthosis has a lot of varied synonyms, such as papillary-pigment skin dystrophy, papillary melanomy, black keratosis and gender modelmatosis. The first fixed case of such a disease was described by the doctors of the Union and Politzer in 1889. And by 1909, pathology was described in 50 cases. Scientists concluded that the disease may be associated with malignant processes.

The disease is characterized by the appearance (root) in the areas of natural skin folds. Papillomas are localized in such places, as well as noticeable. Mortarist folds, inguinal and cervical are most often affected. Consider diseases need to be comprehensively.

Etiology

Various factors affect the development of gendermanmatosis. To date, researchers failed to find the exact cause of the development of the disease, however, a reliable relationship was established with the following factors:

hereditary factor;
malignant processes and neoplasms;
changes in the work of the endocrine system;
consumption of estrogen and glucocorticosteroid hormones;
receiving certain medicines.

As for the hereditary factor, the disease may progress if the patient has accompanied by disruption of exchange functions or mental disabilities congenital syndromes.

The tumor process provokes black acanthosis with a list of biochemical reactions and immune interactions. Male gender preferably suffers from, female - from and. Papillary-pigment dystrophy of the skin is also observed in the presence of other malignant tumors.

Pathology can provoke a hormonal violation (, cellulite). During the use of nicotine acid in large dosages, the development of the disease is also noted.

Classification

The following forms of black acanthose distinguish:

benign (juvenile);
malignant;
pseudoacanthosis.

The disease in the child usually appears due to hereditary factor in a benign form. The first signs of black acanthose can be noticed in childhood, less often in publity. The hereditary form is pronounced in childhood, and partially fades in adult.

Also, the disease can be classified depending on the cause of its appearance:

hereditary (youthful form) - occurs in childhood during puberty, often appears with various development defects -, dementia, idiocy, infantilism;
a benign species - it is often noted in pathology of the domestic secretion glands, which is accompanied by diabetes mellitus using insulin, in the blood is a high amount of insulin, accompanied by polycystic ovaries;
false form - develops against the background of excess weight or in people living in a hot wet climate, while eliminating the cause of the disease is possible self-appeal;
dumptosis dosage form - develops because of the insulin in large quantities, or nicotine acid preparations;
malignant - more often observed in people after 40 years, provokes the development of malignant neoplasms of internal organs;
aklen - It is quite rare, located in places uncharacteristic.

The form of pathology is determined by diagnostic measures.

Symptomatics

The clinical picture of a rare disease is characterized by the following symptomatics:

slab
leather exfoliation;
the presence of black or brown tint of spots on the skin;
skin lesion by papillomas or fibromes.

The emergence of such skin defects is noted in natural skin folds:

axillary folds;
the fold between the neck and the back;
patch-femoral fold;
inter-fodded fold;
elbow fold;
area under the knee;
folding under the milk glands (in female).

There are cases when the deformation of the skin is observed in other places on the human body (face, navel area).

Initially, black acanthosis in humans is manifested by the appearance of a plot with a yellowish tint of the skin, which over time becomes darker. Due to the development of the disease, the affected skin becomes dry and rough, acquiring dark brown or black. Defects on the skin are increasing in size, they appear on them or small, tightly contact with each other.

The development time of the disease directly depends on the form of pathology. The malignant shape of black acanthose will be more pronounced and develop much faster than benign.

Diagnostics

In order to correctly determine the diagnosis, the specialist should:

conduct a thorough examination of the patient;
examine the clinical picture of the patient.

Additionally, the following tests can be assigned to confirm the diagnosis:

biopsy;
blood test;
x-ray study.

It is also necessary to carry out differential diagnosis in order to be able to distinguish black acanthosis from diseases such as:

black pseudoacanthosis;
senile keratosis;
darius disease.

The clinician should not confuse the disease with exogenous keratosis, in which papillomas appear in places of contact with the stimulus.

Treatment

If there are black keratosis, treatment should be developed comprehensively, and tactics are aimed at eliminating the root cause. Also, all patients must be constantly observed in the dispensary.

If a benign form of black keratosis is diagnosed, then assigned:

vitamin complexes (complex of vitamins A, B and C, medication with ginseng and echinacea);
mazi with anti-inflammatory and antiseptic effects;
creams for softening and calm skin;
medicines with zinc content;
biopreparations;
in case of disorders in the work of the thyroid gland - hormonal drugs;
neurotropic drugs (depending on the course of the disease);
antibacterial drugs (depending on the course of the disease).

Black acanthosis treatment provides in the form of diet compliance in cases where the factor in the development of the disease was overweight.

In the presence of complications, cyticostatics or aromatic retinoids may be prescribed. The malignant form involves treatment with radiolochy therapy, chemotherapy or surgery, which is the best solution to solve the problem. After surgical intervention and removal of the seal, a complete recovery of the patient is observed.

Prevention

Black acanthosis provides the following preventive measures:

regular examination at the dermatologist;
compliance with proper nutrition;
it is necessary to regularly monitor blood sugar;
eliminate self-proof.

The forecast of pathology primarily depends on its form. If, with benign black acanthosis and pseudoacanthosis, forecasts are predominantly favorable, up to the complete disappearance of characteristic symptoms, the malignant form is characterized by negative consequences, since the neoplasms are rapidly metastasized.

Timely appeal to a qualified specialist will help to rapidly diagnose the disease and proceed to treatment without allowing adverse effects.

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