The norm of uric acid in men after 50. Urinary acid in the blood is increased

The date: 08.04.2019

Urolic acid (MK) is one of the most important markers of the metabolism of purines in the body. In healthy people, in the norm, its indicator may increase when increased consumption Products containing purine nucleotides (oily meat, offal, beer, etc.).

The pathological increase can be associated with the decay of cell deoxyribonucleic acid after taking cytostatic drugs, a common malignant damage to tissues, heavy atherosclerosis, cardiovascular pathologies, etc.

If urine acid in the blood is increased, the risk of a common pathology is significantly increasing, which is also called the "disease of the kings" (due to the consumption of expensive fatty products) is a gap. That same bump on the leg in the area thumb.

Reference. The level of uric acid is one of the most important markers in primary diagnosis: gout and subsequent control of the course of the disease.

Due to the utilization of MK from the body, excess nitrogen is removed. W. healthy man Purines are formed due to the natural process of the death and regeneration of cells, also in small quantities they come with food.

Normally, when they are decaying, urinary acid is formed, which, after interaction with the enzyme xanthine oxidase in the liver, is transferred to the blood flow into the kidneys. After filtration, about seventy percent of the MK is excreted with urine, and the remaining 30% are transported to the gastrointestinal tract and is disposed of.

Attention. In case of massive destruction of cells, genetic predisposition to the enhanced synthesis of uric acid, kidney diseases, accompanied by a violation of the removal of MK, etc., there is an increase in its blood level.

Uric acid in blood, what it is

The increase in the level of uric acid in the blood is called hyperuricemia. Due to the fact that uric acid is disposed of mainly with urine, an increase in its level can be associated with the defeat of the kidneys.

With a decrease in its disposal from the body, it begins to accumulate in the blood of sodium salt. The development of hyperuricemia contributes to the crystallization of urates Na. This leads to the development of urolithiasis.

A long-grained uric acid in the blood can become a trigger factor in the development of gout - pathology, in which the crystallized MK is deposited in the articular fluid, causing inflammation and damage to the joints. In the future, under the progression of the disease, urinary acid urates accumulate in organs (gouganic damage to the renal structures) and soft tissues.

The crystallization of urates Na in hyperuricemia is caused by the extremely low solubility of the salt of uric acid. It should be noted that the in itself the hyperuricemia is not separate disease. It should be considered as a risk factor of metabolic disorders, as well as as a symptom of certain diseases.

It is important to remember that the level of uric acid in the blood is a fairly labile indicator and depends on the age, gender, cholesterol level, alcoholic drinks, etc.

Important. In case of interpretation of analyzes, it is necessary to take into account that in children the level of uric acid will be lower than in adults. Also, the norm of uric acid in the blood in women will be lower than in men. MK values \u200b\u200bare completely equal only after sixty years.

Urinary acid in the urine

A pronounced hyperuricemia, respectively, is accompanied by increased indicators of MK in the urine. However, kidney diseases accompanied by a decrease in their filtration capacity are accompanied by reduced level MK in the urine during its high blood content (due to reduced recycling).

Important. It should also be noted that for a comprehensive assessment of the function of the kidney function and protein metabolism in the body, the MK must be assessed in a complex with other non-protein nitrogen substances: and urea.

Urinary

To determine the content of uric acid in the blood, the colorimetric (photometric) method is used. The test material serves blood from Vienna. Analysis answers are recorded in micromoles per liter (μmol / l).

Increased (or reduced) uric acid content in the urine is detected using an enzymatic (uricaznaya) method. Daily urine is used as the material under study. The results of the analysis are recorded in millyol (mmol / day).

For a reliable estimate of the level of uric acid in the blood, the following rules must be followed:

blood fence must be carried out exclusively on an empty stomach;
consumption of tea, coffee, compotes, juices, carbonated drinks, and smoking is excluded for twelve hours;
the use of alcoholic beverages can significantly affect the results of the analysis, so their reception must be excluded in the week;
on the eve of the diagnosis, a diet with a low content of purines and proteins should be followed;
before the blood fence, a half-hour vacation is required;
per day exclude psycho-emotional and physical exertion;
the doctor and laboratory technicians must be informed about the drugs taken by the patient;
children under five years old must be half an analysis to the analysis of the analysis of boiled water (up to 150-200 milliliters).

Study of the values \u200b\u200bof uric acid in the blood in obligatory It is carried out when: - diagnosis and monitoring of the treatment of gout,

control of therapy drugs of cytostatics,
diagnosis of gestosis in pregnant women
lymphoproliferative diseases
evaluating the filtering ability of the kidneys
ICD ( urolithiasis disease),
blood diseases.

MK in blood is necessarily investigated in patients with gout symptoms. For the disease, indicative:

inflammation of the joints on the one hand (that is, the defeat is asymmetrically),
sharp, burning pains,
swelling,
hyperemia skin Pokrov Above the inflamed joint.

Especially characteristic of the defeat of the thumb, less often there is inflammation of the knee, ankle other joints. Also, highly specific appearance of tofuses - gouty nodules (deposits of MK salts).

Attention! The level of MK in the urine is also explored for lead intoxication and diagnosis of folic-deficient states.

In case of interpretation of analyzes, the factors under which the increase in uric acid in the blood will be false positive. These include:

stress
heavy exercise,
excessive consumption of purines with food,
use:
- steroid cp,
- nicotinic acid
- tiazid diuretics
- furosemide
- adrenoblockers
- caffeine
- ascorbic acid,
- cyclosporine
- small doses of acetylsalicylic k-you,
- calcitriola
- clopidogrel
- diclofenaca
- ibuprofen
- indomethacin,
- pyroxicam.

The false reduction of uric acid indicators in the blood is observed at:

compliance with a low-level diet,
eating tea or coffee analysis,
treatment:
- allopurinol,
- glucocorticosteroids,
- warfarin,
- anti-parkinsonic drugs
- amlodipine,
- verapamil
- vinblastine,
- methotrexat,
- spirolactone.

Also, it should be noted that the level of MK can fluctuate during the day. In the morning the level of MK is higher than in the evening.

When evaluating the MK in the urine, the basic rules for the fence of daily urine should be followed. Therefore, the day before the study exclude products that paint urine and diuretic drugs. Urine, allocated with the first morning portion, is not taken into account.

All the rest of the material obtained during the day, (including the morning portion the next day) must be collected in one container. The resulting material should be stored in the refrigerator at a temperature of four to eight degrees.

After the fence of the daily urine, it is necessary to clearly determine its volume, shake and merge into a sterile container of about five milliliters. This amount should be attributed to the laboratory for analysis.

On the letterhead with the direction should be indicated by the floor, age, weight, volume of daily diurea, as well as the drug substances.

Attention! It is important to remember that in women during menstruation, the fence of urine does not produce.

Normal values \u200b\u200bof MK in the blood

for children, fourteen is in the range of 120 to 320 μmol / l;
from fourteen years in analyzes, sexual differences are observed. Blood uric acid: the norm in women is from 150 to 350. The norm of uric acid in men - from 210 to 420.

It should also be borne in mind that the uric acid rate in the blood can be somewhat varied in different laboratories.

Uric acid. Norm in daily urine

In kids, up to the year, the results of the analysis must be in the range from 0.35 to 2.0 mmol / l.

From year to four years - from 0.5 to 2.5.

From four to eight years - from 0.6 to three.

With eight to fourteen - from 1.2 to six.

In children over fourteen, the MK in the urine is in the range from 1.48 to 4.43.

Blood uric acid increased. Causes

The increase in the MK in the blood is observed at:

gout;
abuse of alcohol drinks;
myeloproliferative pathologies;
diabetic ketoacidosis;
OPN and CPN (acute and chronic kidney failure);
pregnant women;
exhaustion after long starvation;
increased consumption of products in which Purines are contained;
hereditary hyperuricemia;
lymphomas;
abdominal typhoid;
malignant neoplasms;
treatment with cytostatic drugs;
leukemia;
acute heart failure;
hypoparatyase and hypoteriosis;
tuberculosis;
genetically determined, pathologically enlarged synthesis of MK (Lesha Nihana syndrome);
severe pneumonia;
face inflammation;
down syndrome;
blood diseases (hemolytic and sickle-cell anemia);
exacerbation of psoriasis;
lead intoxication.

Important. Also, uric acid in the blood is increased in patients with obesity, hyperlipidemia and hypercholyterine.

Uric acid lowered at:

liver diseases (including alcoholic cirrhosis);
fanconi syndrome (defect for the development of renal channels, accompanied by a decrease in the reabsorption of MK);
hepatocerebral dystrophy (Wilson Konovalova);
disadvantage of xanthinoxidase (xanthinuria);
lymphogranulomatosis;
pathological production of ADG (antidiuretic hormone);
compliance with a low-fingered diet.

Changes in the urine

gout
oncological blood diseases
syndrome Lesha Nihana,
cystinosis
hepatitis viral etiology,
sick-shaped cell anemia
heavy pneumonia
after epileptic seizures,
hepatocerabral dystrophy.

Reducing the MK in the daily urine is detected in patients with:

xanthinuria
folic-deficient states
lead poisoning,
heavy muscle tissue atrophy.

How to lower urinary acid

When goug medical therapy It is selected individually and depends on the severity of gouty arthritis and the availability of complications. For relief acute attack Used non-steroidal anti-inflammatory agents and colchicine.

In order to prevent the recurrences of gogress arthritis, anti-aigipermic therapy (allopurinol) is selected. As an alternative to Allopurinol, urricauric drugs can be assigned (probe, sulfinpyrazon).

In patients with hyperuricemia caused by the treatment of thiazide diuretics, it is advisable to use losartan (angiotensin receptor antagonist).

It is also possible to use potassium citrate (urocyte-k). The drug contributes to the active disposal of MK crystals.

Non-drug treatment is:

normalization of weight;
increased fluid intake;
observance of a small-calorie and low-carbid diet, with an increased content of polyunsaturated fatty acids (diet with increased uric acid - mandatory);
refusal to receive alcoholic beverages.

Diet with hyperuricemia provides for the maximum limitation of products containing many purines (oily meat and fish, mushrooms, sorrel, chocolate, cocoa, nuts, spinach, asparagus, legumes, eggs, offal, beer). In the period of exacerbation of gout arthritis, these products are completely excluded.

Also, when goug is harmful to use any oily, fried, acute food, carbonated sweet drinks, alcohol and strong tea.

Important. If possible, it is advisable to completely eliminate alcohol. In the period of resistant remission, the use of dry wine glasses is allowed, no more than three times a week.

Also, it is important to maximize the technique of food containing fructose. Restricted by the use of sweets, berries, fruits, syrups, ketchup.

Sdobu and puff pastry, it is necessary to replace on products from solid grain. Also should increase vegetables.

It is better to give preference to dairy products having a reduced fat content. Undorcetic cottage cheese, kefir, cereal, cooked on diluted milk.

Increased fluid consumption (in the absence of cardiovascular diseases And kidney pathologies) also contributes to the reduction of MK and the achievement of the rescue.

The by-product of purine base metabolism, located in the blood plasma in the form of a sodium base, is a urinary acid or a stone, the content of which in the blood, the urine is one of the diagnostic markers, symptom inflammatory processes, deposits of crystals, violations of the metabolism of purines. Both high and low indicator indicates pathological mechanisms in the body.

What is uric acid

The organic substance, sampled as a by-product of the exchange of purines during metabolism, is called urinary (stone) acid. Its normal content does not harm the tissues of the body, but at elevated concentration in the blood, it begins to accumulate in cartilage, joints, causing their active inflammation. Salt crystals contribute to the risk of development acute inflammation. Increased level of substance occurs when the urinary system is poorly functioning (with kidney stones). Increased uric acid in the blood is called hyperuricemia.

Formula

The organic substance belongs to the class of dioxide acids, has the form of white crystals. In metabolism in the human body, it forms acidic and medium salts called urates. Exists in two forms - Lactam and Lottimna. For the first time was discovered by the Swedish pharmacist chemist of Shelele in 1776, synthesized artificial method Gorbachevsky in 1882

Blood urinary acid analysis

Measuring the content of this metabolite is not a standard analysis, is prescribed by a doctor in case of suspected diseases that violate the metabolism or the normal functioning of the kidneys. For research on the content of acid in plasma, blood is taken from veins in the morning on an empty stomach, in an amount of 5-10 ml. Biochemical analysis in the laboratory is about a day with special serums, enzymes.

What shows urinary acid in blood analysis

The content of metabolite shows, in what condition are all the main systems of the body, type and quality of food, the degree of functioning of metabolism. Increased uric acid level means disruption of the kidney, liver, or metabolism. Sub-quality nutrition, an increase or decrease in the content of fructose in the diet is immediately reflected on the amount of acid in the blood plasma. Excess synthesis of the substance leads to extraction of extra salts, violation of normal nucleic acid metabolism.

Deciphering blood test

Purine base metabolites in biochemical analysis The blood of the old sample is indicated by the reduction of "urine Acid ", in new electronic, clinical computer programs - the Latin abbreviation" UA ". The content of the substance is expressed by kilodes per liter of blood plasma, which denotes the number of molecules contained in the blood.

Norm

If the analysis shows that the metabolite content is on the border of the upper or lower rate, the doctor must be prescribed additional laboratory, instrumental research, in more detail to collect anamnesis of the patient. The extreme indicator may indicate a developing pathological mechanism, early diagnosis which will avoid many symptoms and complications (kidney diseases). The physiological norm of uric acid in the blood is:

in children under 14 years old - 120 - 320 μmol / l;
in adult women - 150 - 350 μmol / l;
in adult men - 210 - 420 μmol / l.

Blood uric acid increased

In therapy distinguish two types of hyperuricemia: primary and secondary. Idiopathic or primary called the disease resulting from the inheritance of a mutated gene that is responsible for the normal process of cleavage of purines. Diagnosed in children in the first year of life, it is rare. Secondary hyperuricemia arises for a number of reasons: pathology of organs (liver disease), improper nutrition. It is often found in the elderly, in aggregate with arthritis, patients with gout.

Symptoms of excess

With a minor increase in the level of metabolite, the patient's well-being does not change. Significant health damage causes constantly high or repeating hyperuricemia. Clinical picture, its intensity depends on the age of the patient:

In children until 14-15 years old appear permanent signs Skin problems: rash, peeling, itching, the development of psoriasis. Affects physical development Children under three years old.
Men older than 50-55 years suffer from pain in the joints when moving and alone, the edema of the limbs, the bouts of the gout.
Men and middle-aged women suffer from strong itching, wet rash on the body, pain.
In women suffers from the microflora of the vagina, the attacks of the aggravation of the candidiasis are rapidly. Hyperuricemia leads to long-term disorders of the menstrual cycle.

Causes

Hyperuricemia can cause two main reasons for an increase in the concentration of urinary grounds: a violation of their rejection of the kidneys and an elevated decay of Purinov. In addition, some drugs can cause increased concentration Metabolites when exchanging Purines, for example, diuretics. High content may be caused by the formation of their depot - the accumulation of crystalline salt.

The causes of deposit can be:

Diseases of the urinary system. When the kidneys do not cope with the filtering function, metabolites are settled, deposited in the tissues of the joints, the gout develop.
Endocrine diseases. DiabetesThe incidence of acidosis causes intense cleavage of purines, and, as a result, a high concentration of end metabolites that do not have time to be excreted by the kidneys.
Wrong food, starvation, overabundance of meat in food, dairy products.

Uric acid lowland

Reducing the concentration of metabolite is diagnosed by a doctor when two and more biochemical blood plasma analysis showed an acid concentration below the bottom limit. The state is due to a decrease in the production of metabolite, an increase in the separation from the body along with the urine, bile, the decay of the acid under the influence of a uricase enzyme, which is a component of some drugs to combat the gout.

Causes

Among the reasons causing a decrease in the number of metabolites of purines, the following are allocated:

the hereditary deficiency of xanthinoxidase is a disease at which no conversion of xanthine to the final metabolite, due to the lack of enzymes;
acquired deficiency of xanthine oxidase;
low-level or low-facility diet;
increased selection of substance with urine;
fanconi syndrome - the reverse absorption of acid in the kidney channels is maximally reduced;
family renal hypover hyperthy - healthy diseasecaused by the mutation of genes responsible for the reverse absorption of Pyrin metabolites;
an increase in extracellular volume of fluid.

Treatment

The therapy of the condition of hyperrixia is to diagnose the disease that caused a decrease in the content of the metabolite. If the disease is hereditary, incurable in nature, the doctor prescribes medicines that bind symptoms of the disease. The mandatory basis of therapy is a diet, a change in lifestyle. Patient, to monitor the state, assigned analysis every week, then every month.

How to downgrade the level of uric acid in the blood

Drug therapy is used to reduce the concentration of metabolite: diuretics, enzyme preparations, drugs that reduce the absorption of matter kidney tubules. For background treatment to reduce the content by-mattersThe nutritional adjustment is required - reduced food consideration a large number of Purines, their grounds. Diet with increased uric acid in women must necessarily include fats for animal origin - it warns the imbalance of sex hormones.

Medical therapy

For the treatment of a reduced or elevated acid level, the following drugs are used:

Allopurinol. Medicine, produced in the form of tablets, 30 or 50 pcs. packaged. Hypurrummic, anti-dagic agent. Prevents Xantinoxidase enzyme synthesizing, which enhances the production of purine bases to final metabolites, exchange products. Of positive characteristics You can highlight the accumulative effect, soft gradual effects. The disadvantage of the drug is an aggressive effect on the cardiovascular system.
Etmaid. It is used to reduce the concentration of acid by reducing its reabsorption by renal tubules. It has a tableted form of release, contraindicated for children under 14, patients with renal failure helps to remove surplus salts. A positive feature of the drug is the effect of reducing the synthesis of purines, reduces the content of sodium salts, negative - strong impact on the kidneys, which can provoke the failure of the organ.
Sulfinpirazon. Increases the removal of acid by the kidneys with a reinforced diurea. Release form - drops or pills. Drops are prescribed mainly to children. Pros of medication use is a soft but strong action. Cons - removes potassium and sodium from the body.
Benzbromanon. Prevents metabolite reabsorption back into the bloodstream. Produced in the form of capsules, tablets. Contraindicated for people with kidney disease. Pros of the use of medication is the accumulative effect of therapy, minuses - contributes to the delay of salts, water in the intercellular fluid.

Diet

When diagnosing a patient change normal level Acids assigned to him special diet. Power adjustment will not cure the disease, but will help bring the level of metabolite to the limits of the norm. The list of prohibited and allowed products depends on whether the content of the substance or lowered is increased. At high level it is forbidden to use protein food, fructose. If the content of the substance is lowered, then these foods, on the contrary, are required.

Treatment with folk remedies

To reduce the level of acid, to increase its kidney excavation, it is recommended to use infusions, bark leaves birch, lingonberries, degilla root, lavra leaf. Herbs contribute to the excitation kidney, reducing its content. Prepare a drink from infusion follows as follows:

on a glass of boiling water should add two tablespoons of dry herbs;
cover with a lid for 2-3 hours;
use on a tablespoon 2 times a day before meals.

Herbs, roots are considered potent means To remove salts. To combat the inflammation of the joints, the removal of the blade, the treatment of gout can be prepared self-made ointment from the root of the burdock. The burdock has an excellent anti-inflammatory effect, enhances the elimination harmful substances, there is a decrease in uric acid in the blood, urine acidity. If the acid is elevated, with regular use, patients note a decrease owl syndrome, Sustav swelling. So, to do ointment from the root of the reurenik follows:

take 4-5 units of ground root root, vaseline, tablespoon of alcohol;
mix up to consistency thick sour cream;
apply to the sick joint;
wrap in a towel or diaper;
leave for night.

How to increase urinary acid

After the detection of low concentration of the substance, the doctor must assign additional research To identify a disease or condition that caused a decrease in the number of finite metabolite of purines. Prescribed drugs, a special diet with an increased protein content, vitamins, a decrease in salt intake. In order to eliminate the decrease in the acid content in the blood, it is necessary to eliminate the cause of its appearance. Helps reduce the risk of hyporinum the correct mode of the use of pure water.

Video

To diagnose diseases, doctors are prescribed to patients to pass different studies, including to pass the blood to the volume of uric acid contained in it. Urolic acid (foodstuffs) in men determines the state of proteins - an important building material.

Uric acid indicators do not meet the requirements if such diseases are diagnosed:

stone formation;
there is a kidney dysfunction;
there is a suspicion of gout;
worried diseases affecting the lymphatic system.

For food substances in men, the men were shown in real meanings, it is important to pass the analysis correctly. Take into account such rules:

An analysis is given on an empty stomach, it is impossible for 7-8 hours, you can drink water.
Two days before the designated analysis, it is impossible to consume greasy, fried food, alcoholic beverages.
For one day before the blood fence, limit the volume of drinking tea, coffee and eaten fish products. Refuse from meat dishes, offal, legume dishes because of the high composition of Purines.
Perform an analysis before the therapeutic course and after it, after a couple of weeks.
It is not allowed to donate blood immediately after passing fluorography, ultrasound, the passage of physiotherapeutic procedures. Indicators may be incorrect and not appropriate.

Blood uric acid regulations in men aged 60

Deviations are called low indicators and elevated, both require a detailed study of the specific history of the disease and the appointment of therapy.

Why appear deviations from the norm

If the volume of foods in the blood serum of men after 60 years exceeds the stated standards, the doctor makes a diagnosis of "Hyperuricemia". If the disease is primary, the cause is a congenital disruption of the splitting of purines enzymes, which causes the active formation of an increased uric acid content. Causes of the appearance of the disease:

gout;
syndrome Lesha Nihana or Kelly Sigmiller;
genetic FRF synthesis failure.

Secondary hyperuricemia can be caused by ailments acquired, for example, improper metabolism, excessive consumption of dishes saturated with purines. Provoke diseases:

psoriasis;
anemia of a hemolytic format;
renal failure flowing in acute or chronic form;
poisoning lead components;
oncology diagnosed in blood and bone marrow;
the consequence of chemotherapy;
alcohol abuse;
malnutrition;
eating a large number of protein products.

The reduced value of food substances happens with such a littleness:

congenital within xanthinuria;
side effect after receiving allopurinol, which is inhibited by the formation of purines;
diabetes;
burns;
the presence of cancer neoplasm;
AIDS.

Careful need to be when taking estrogen, warfarin, mannitol, clofibrate - these active substances Significantly reduce uric acid indicators in serum.

How to bring urinary acid to normal

If the urinary acid is beyond the generally accepted standard, a man after 60 years is prescribed one of the treatment:

Reception of drugs that increase renal secretion. As a result, the nutrients leave the patient's body, and their concentration becomes normal.
Taking allopurinol - contributes to the braking of uric acid formation.

In the complex you need to stick diet nutrition. Dietary does not mean starving, on the contrary, it reasonable approach To prepare a daily balanced menu. The goal is to achieve the right metabolism.

How can I do this? Take note of the recommendations of the doctors:

The formation of uric acid contributes fatty meat dishes, broths, offal, canned food.
Refuse the pickles and alcohol.
For dessert, you can eat everything except chocolate. Minimize the volume of the eaten sweet, confectionery.
Instead of tea, coffee and carbonated drinks clean water.

What should be included in the diet?

Non-fat bird meat.
Dairy dishes.
Eggs (1-2 pieces per day).
Vegetable oil.
Fruits vegetables.
Vitamin Natural Juices and Compote, Mors, Kissel.

A large amount of liquid helps the rapid outflow of food substances. The daily dose should be from 2 to 3 liters. If the diet is ineffective and the uric acid indicators in a man after 60 years fail to normalize, the doctor discharges the medicine:

Allopurinol;
Colchicine saving from complications;
means designed to quickly eliminate urine.

How much time to take each of the drugs, solves the attending physician. The pharmacy medications will not prevent add chasters made of currant leaves, lingonberries, kidneys of birch, nettle, hill grass.

If a man has revealed an increased or lowered urine acid, it is desirable to hand over blood to study every six months in a planned order.

Blood uric acid level and urine is one of the most important indicators normal work Human organism.

Therefore, the decrease or increase in uric acid should not be ignored, since it practically indicate a violation of such vital organs such as liver and kidneys.

Given the importance of this indicator, we propose to figure out what uric acid is why it rises in blood and urine, and how to deal with it.

Uric acid is crystals consisting of nitrogen, carbon, hydrogen and oxygen, which are formed in the liver during the decay of purines.

The removal of uric acid from the human body is carried out by the kidneys.

Urates are potassium salts and urinary acid sodium, which form in the urine of the sediment. Urates are synthesized from uric acid. Urinary acid in the urine is measured by examining urine analysis, and in the blood - with the help of a biochemical blood test.

increases the effect of the effects of catecholamines on the cells of the body, activating the work of the brain and other departments nervous system;
protects the body from the negative effects of free radicals;
controls the qualitative composition of organism cells.

At the same time, increased uric acid in the blood is a serious signal of some diseases and requires a number of studies that will allow determine the causes and eliminate them. After all, excess of uric acid is a poison that poists the body from the inside.

Blood uric acid: norm

The norm of this indicator directly depends on the floor and age of a person.

Uric acid rate in children

In children, the norm of this indicator is 120-330 μmol / l.

Blood uric acid rate

In men under 60 years old, the uric acid indicator should be in the range from 250 to 400 μmol / l, and in men over 60 years old - from 250-480 μmol / l.

Blood uric acid rate

The norm in women has slightly smaller meanings than in men. In people under 60 years old should not go beyond from 200 to 300 μmol / l, and people over 60 persons from 210 to 430 μmol / l.

Analysis on urinary acid is carried out both to healthy persons for the purpose of dispensarization, and patients with diseases that lead to a delay in the removal of uric acid from the body. This can include sugar diabetes mellitus. of cardio-vascular system, Gout and others.

So that the results of the analysis are objective, should be properly prepared for blood. For this 24 hours before the blood taking procedure from day diet It is necessary to remove fruit and vegetable juices, caffeint and alcoholic beverages, chewing gum, as well as reduce physical and mental loads.

Blood fence is carried out in the morning on an empty stomach, so the last meal must be no later than 12 hours before the procedure. Also you can not smoke 1 hour before the analysis.

For analysis, venous blood is taken from vessels that pass in the elbow yam.

The analyzes are processed during the day and are issued the next day. But in emergency cases, the biochemical study of blood can be carried out in an emergency (in CITO) within 2-3 hours.

Uric acid elevated: causes

Increased uric acid level can be caused the following diseases:

hypertonic disease. With a constant increase in blood pressure, the kidneys are damaged, as a result of which hyperuricemia appears. In this case, a cardiologist or doctor therapist gives a sick recommendation how to reduce the level of uric acid in the body, which are in the reception of drugs reduced arterial pressure and diet;
gout. Cause this disease is a reinforced synthesis of purines. The target organ for gout are kidneys, as a result of which their insufficiency is developing. Also, the joints are affected by gout, so called, gouty arthritis. In addition, with this pathology, blasting crystals are debugged under the skin. Such deposits are called tofuces. All patients necessarily assign a diet with increased uric acid in the blood and drug therapy that contributes to the removal of the urate from the body. For more information about the treatment of gouts and preparations with urinary acid from the body, we will talk further;
diseases endocrine system. Hyperfunction parachitovoid glands It leads to an increase in the concentration of calcium level in the blood, and this in turn to hyperuricemia. Sugar diabetes is accompanied by a violation of practical all types of metabolism in the body, including purine;
overweight and obesity. These states do not directly affect purified metabolism, but increase the risk of gaining hypertensive disease, gout and diabetes;
increase cholesterol in the body and atherosclerosis. Hyperuricemia often appears against the background of high cholesterol and atherosclerosis;
pathology of the urinary system. In this case, we can talk about a vicious circle, since urinary acid is a component of the council. In turn, urolithiasis contributes to nephropathy, polycystic, renal failure, that is, the states that cause hyperuricemia;
pathology of blood. Hyperuricemia can lead polycithimera, anemia, erythrocyte hemolysis, leukemia and others. Hyperuricemia for blood diseases is explained by the fact that fabrics and purine bases are actively disintegrated, from which urinary acid is synthesized, it goes into the blood.

Also, an increased amount of uric acid in the body can be formed in massive burns, Down syndrome, unbalanced nutrition, abuse of alcoholic beverages, long protein diets, excessive physical exertion, admission of furosemide, aspirin, teofiline and other drugs.

Reducing the level of uric acid in the blood: what does this mean?

If the urinary acid in the blood is lowered, they are talking about hyperroom. The causes of hyperrixia can be the following pathological conditions:

the disadvantage of such enzymes such as xanthine oxidase, and phosphorylase, which participate in purine exchange. Such states can be both congenital and acquired;
mutations of the genes of URAT1 and GLUT9, since they are responsible for the regulation of reverse absorption of uric acid in the proximal kidney channels;
polydipsy;
big introduction of fluid into the body with infusion therapy;
hyponatremia;
intravenous meals;
HIV infection and AIDS;
cancer of various location, which leads to the depletion of the body;
diseases of fine and colonists in which proteins and others are disturbed.

Higiperhemia can be observed in the first trimester of pregnancy, compliance with a low-facility diet, use large quantities Caffeing beverages, taking such drugs such as losartan, aspirin and trimethoprim, as well as with estrogen therapy.

In most cases, low hyperuricemia is found randomly with a biochemical blood test, since it does not give any clinical manifestations.

But enough high level Hyperuricemia will manifest such symptoms like:

arthralgia (joint pain);
the appearance of spots, tofuses and ulcers on the skin;
oligurauria (reduction of daily urine volume);
skin hyperemia over elbow and knee joints;
an increase in blood pressure;
arrhythmia;
increased fatigue;
general weakness;
stone raid on the teeth and others.

Also, patients will present the manifestations of the underlying disease, which led to hyperuricemia.

Higherover: symptoms

In hyperrixias can be observed the following symptoms:

decline in all types of skin sensitivity;
reduction of vision, up to blindness;
hearing loss;
violation of the psycho-emotional sphere in the form of asthenia;
worsening memory;
paralysis, including respiratory muscles;
demelinization of nerve fibers.

First of all, it is necessary to eliminate the cause of hyperroom.

Also this indicator can be improved using balanced nutrition. In the day diet, the products must be present are rich in purines, namely: meat, fish, bean, liver, kidneys, mushrooms, spinach, cocoa, chocolate and others.

To calculate the daily amount of protein used next formula:

for women: 1 g * 1kg;
for men: 1.7-2.5 g * 1 kg;
for a child: 1.5 g * 1kg.

How to bring urinary acid from the body?

Before proceeding with a decrease in the level of uric acid in the blood, it is necessary to find out the reason for its increase. After the reason is determined begin the treatment of the main disease and in parallel the following ways:

diet;
weight normalization;
consumption of sufficient liquid;
medication therapy;
folk remedies.

Consider every method in more detail.

Diet with gout and increased uric acid should be a small-calorie. Patients with normal weight are prescribed table No. 5 according to Pevznera, and overweight - Table number 8.

During the exacerbation of the gout, remove products from day diet, which contain Purines, namely:

sub-products: brains, liver, kidneys, tongue, thyroid gland;
veal;
chick;
fatty varieties of meat, fish and birds;
smoked meat and fish products;
canned fish products;
concentrated bird brows, fish and meat;
legumes;
mushrooms;
greens (sorrel, spinach);
caffeint-containing drinks;
alcoholic drinks;
chocolate and cocoa.

The food is better to prepare gentle methods of heat treatment, that is, a couple, boil or stew. It should also be preferred with liquid dishes and products.

In addition, you need to consume a large amount of liquid - 2-3 liters. It is better to drink clean water without gas and sugar or weathered alkaline water.

How to reduce urinary acid in the blood using medicines?

Medicase treatment with hyperuricemia is to use next preparations:

diuretic, such as furosemide, hypothiazide, Veroshpirirov, Indapamide and others;
Allopurinol, apurin, uridoside, uripherim and others, which reduce the severity of hyperuricemia by binding xanthinoxidase;
Benzobromaron, Uritorm, Desurric, Normurat. These drugs associate enzymes that participate in purine exchange;
Sulfinpyrazone, sulfone and pyrocardia activate the removal of uric acid by the kidneys;
Etamide - blocks the inverse absorption of uric acid in the kidneys.

Any of the above preparations can be taken exclusively for the purpose of the attending physician under the control of the level of uric acid in the blood.

How to reduce urinary acid by simple folk remedies?

Folk remedies under hyperuricemia are used exclusively as prevention or addition to basic drug treatment.

For your attention the most effective folk remedies against Hyperuricemia:

Infusion of leaf lingry: 1 tablespoon of crushed fresh or dried leaves lingers poured with one glass of boiling water, covered with a lid and breeds 35 minutes. One glass of infusion is used inside before eating three times a day.
The juice of dwarm net: 5 ml of freshly squeezed cluster juice is used daily before each meal intake.
Brigade leaf decoction: 20 grams of crushed fresh or dried birch leaves are poured 250 ml of boiling water, put on a weak fire and boil 20 minutes, after which they are given under the lid of 30 minutes and flicker through fine sieve or gauze. 50 ml of medication is taken inward 3-4 times a day before meals.
Baths with Infusion medicinal herbal: Carefully mix 100 grams pharmacy chamomile, Calendula and Sage. After that, it takes 1 cup of obtained collection, poured it with 2 liters of boiling water, covered with a lid and insist 2-3 hours. When the infusion is cooled to the body temperature, it is transferred to a wide pelvis and lowered his legs or arms into it, that is, those limbs where the joints are amazed with gout. Such a bath is carried out within 15-20 minutes once a day before bedtime. The course of treatment consists of 20 procedures.

To avoid re-increasing uric acid in the blood, it is necessary to comply with the above-described diet for life, lead, control the weight, etc., since diseases that lead to hyperuricemia are mainly chronic and incurable.

Uric acid is a chemical compound that is the result of the exchange of purine substances, and of them consists of part of our DNA. Blood uric acid analysis shows the position of the kidneys, liver and metabolism in general.

Functions of uric acid

In substances in uric acid there are two appointments:

Enhances adrenaline and norepinephrine, ensuring the activation of the functioning of the brain;
It is an antioxidant, it does not allow the rebirth of cells.

Blood uric acid norms are individual, as they are transmitted at the genetic level.

However, there are general boundaries. They have a difference in the age of age. Blood uric acid rate:

Man - 130 - 310 MKMOLL / liter
Woman - 160 - 330 μmoll / liter
Child - 190 - 410 μmoll / liter

Surplus of uric acid human body removes natural way: 70% goes through the kidneys, and 30% - with feces.

You can get urinary acid in three ways:

Eating purines from food
When decaying cells in the body (this is done or in the process of natural aging of the body or during any disease)
A huge number of cells of our body form blades

Why do you need analysis?

The level of uric acid can be determined only by analyzing blood. And it is necessary to make it necessary to immediately identify hypericemia and begin treatment.

Hyperuricemia - Raising upper borders Uric acid norms. Often, hyperuricemia is a temporary increase in the content of uric acid, it can be associated with the time conditions:

A large number of physical Loads (sharp increase in their);
Seating girls on diets, hunger exhaust;
Overbinding products of protein origin.

However, an increase in the amount of uric acid can be constant. This already requires treatment, otherwise the disease may begin development, called Gout.

What does the reduced level say

The reduced uric acid content is a rather rare phenomenon. But neglected treatment in this case. There are a number of reasons affecting the decrease of substance:

Increased removal of uric acid from the body through the kidneys;
Consumption of protein products in small quantities, or their absolute non-consumption;
Urinary acid development disorder in the liver;
Increased use alcoholic beverages, worsening the activities of the kidneys and liver;
Deviation from the norm of the liver, which reduces the content of enzymes producing this substance;
Reduced uric acid level associated with genetics.
Toxicosis, developing during the first three months of pregnancy.

Violations in the liver - the cause of a decrease in uric acid

The reduced content of this substance can lead to such pathology as dispelled sclerosis (damage to nerve endings around the perimeter of the entire body).

The level of uric acid can be false. It is connected with food consumed by you (or rather with its composition) or with the use of medicines. When normalizing the diet and discontinuation of drug use, the content of uric acid is normalized within 4 days.

What is the high level

Incorrect meals, overabundance of fatty, salt, sweet, sharp food. Obesity;
Reduced content group of vitamins B;
Problems with thyroid and parathyroid gland;
Toxicosis during the first three months of pregnancy;
Strong alcohol poisoning (not for the first time, and repeated);
Diseases of the kidneys or liver;
Diabetes;
Long use of some medicinal preparations or antibiotics.

The higher the uric acid content in the blood, the higher the probability (and / or frequency) of gouty attacks.

Causes of exceeding

The uric acid rate can be exceeded, to which, as a rule, irregular nutrition affects (oversupply of meat in the diet). Therefore, the first thing to be done is to reduce the level of uric acid - a decrease in the use of products of protein origin.

What symptoms are characteristic of hyperuricemia

Hyperuricemia has quite a lot of symptoms for which it is possible to determine. If at least two symptoms are detected, it is necessary to immediately take the analysis of urinary acid. However, it does not always work like this.

Attention! With hyperrowema, there may be no absent various symptomsAnd it is possible to determine it only with the help of the analysis.

In this case, they are diagnosed with "Uslimmatous Hyperuricemia". Therefore, it is regularly recommended to undergo a general survey on identifying diseases associated with an increased or reduced uric acid level.

Symptoms of hyperuricemia:

Immediately increased urinary acid content;
In young children - manifestation of hyperuricemia on the skin (that is, large pink spots on the skin, which are strongly squeaked);
Representatives of strong sex at pre-subsidizing age - frequent pain In the joints (strengthening pain at night). Often - defeat big fingers on foot, knee joints. Tumor, tumor swelling, loss (deterioration) ability to move;
Pain in the lower back, in groin, belly sides;
When examining a dentist, a dent stone is possible, the inflammation of the gums, an increase in the sensitivity of the teeth (it becomes very difficult to chew food);
The defeat of the nerves and the nervous system often leads to rapid fatigue.

Lowering uric acid level - what to do

In order to reduce the uric acid coefficient, it is necessary to observe a sufficiently strict diet. Approximate list of what needs to be excluded from its diet for the period of recovery of uric acid levels:

Fatty meat, kidneys, liver, brains (replaced recommended by boiled or parenchy chicken breast);
Smoked food (fat);
Marinated vegetables (salted cucumbers, tomatoes, mushrooms);
Carbonated drinks, or drinks containing gas more than 0.5
Alcoholic beverages (as alcohol harms the liver work, which contributes to an increase in the level of uric acid, and the opposite effect is necessary);
Black tea, or coffee;
Butter;
Many sweet food and sugar in pure form.

Boiled or cooked for a pair of chicken meat and / or chicken;
A small amount of vegetable oil;
Green tea;
Dairy products (kefir, milk, yogurt, cottage cheese, cheese);
Eggs (but not more than one per day);
Vegetables (in unlimited quantity);
Fruit (in unlimited quantity);
Fresh juices and / or self-preparation compotes (not purchased).

When this diet is observed, the level of uric acid will be reduced. Once a week recommended unloading Days. There is a special popularity - a kefir unloading day, it can replace watermelon, vegetables or fruits.

In case the diet is observed, the level of uric acid is not reduced, medications are used.

Uric acid - an indicator that affects the work of the whole body. Therefore, in order to avoid failure or infarction (possibly when increased level) It is possible to periodically take the analysis to the level of blood uric acid.