Caproic acid application in medicine. Aminocaproic acid - official instructions for use

A solution of aminocaproic acid is classified as a hemostatic and antihemorrhagic agent.

On this page you will find all the information about Aminocaproic Acid: complete instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Aminocaproic acid. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

hemostatic drug. Fibrinolysis inhibitor - an inhibitor of the transition of plasminogen to plasmin.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does aminocaproic acid cost? average price in pharmacies is at the level of 190 rubles.

Release form and composition

Aminocaproic acid is a hemostatic drug that inhibits the conversion of profibrinolysin to fibrinolysin.

Released:

• Powder for solution for intravenous use;
• Granules (Aminocaproic acid for children);
• 5% solution of the agent in isotonic solution sodium chloride.

Aminocaproic acid can be used:

• For intravenous injections. This method is most in demand for acute bleeding, as well as during surgical treatment.
• For oral administration. Such use of the drug is indicated not only for bleeding, but also for rotovirus.
• For instillation into the nose. Both a ready-made solution and powdered or granular aminocaproic acid mixed with unsweetened water are used (a 5% solution is also prepared from this form of the drug).
• For inhalation. The procedures are carried out with a nebulizer for adenoids, for coughing, as well as for a long runny nose or sinusitis.
• For washing the nose. This manipulation is sometimes prescribed to remove yellow or green thick nasal discharge. In this case, the washing must be carried out by a doctor, since an incorrect procedure can cause increased swelling and irritation of the mucosa.

Pharmacological effect

Aminocaproic acid is an antihemorrhagic and hemostatic drug that has a specific hemostatic effect on bleeding related to increased fibrinolysis (the process of dissolving blood clots).

This drug helps to reduce capillary permeability, as well as the inhibition of fibrinolysis in general. Aminocaproic acid increases the antitoxic ability of the liver, exhibits moderate anti-shock and anti-allergic activity. The drug is able to improve some indicators of specific and nonspecific protection in acute respiratory viral infections.

After application, the maximum concentration of aminocaproic acid in the blood is observed after 2-3 hours. Plasma protein binding is practically absent. The main part of the drug is excreted by the kidneys unchanged, and 10-15% is biotransformed in the liver. The accumulation of aminocaproic acid occurs only if there is a violation of the urinary function.

Indications for use

According to the instructions, aminocaproic acid is prescribed to prevent and stop bleeding, which is associated with increased fibrinolytic activity, or a state of hypofibrinogenemia and afibrinogenemia.

Indications for the use of the drug are:

• Complicated abortion and uterine bleeding;
• Premature placental abruption;
• Operations in the field of ENT organs and nosebleeds;
• Surgical operations on organs that are rich in fibrinolysis activators (brain, lungs, adrenal glands, uterus, pancreas, thyroid and prostate);
• extracorporeal circulation;
• Period postoperative recovery(at surgical operations on vessels and heart);
• burn disease;
• Diseases internal organs, complicated hemorrhagic syndrome(bleeding from Bladder, gastrointestinal bleeding).

Doctors of the old school are often prescribed for ENT pathologies. In such cases, it is used to:

• elimination of swelling of the mucous membrane and a feeling of nasal congestion;
• reducing the amount of mucus produced;
• decrease in severity inflammatory process, in particular, with rhinitis of allergic origin;
• stop nosebleeds.

Since ACC is a compound close to the human body, in many cases it is even prescribed to prevent the development of complications in mild forms of rhinitis. But such a preventive measure is indicated only if the child has a tendency to nosebleeds or diseases accompanied by increased capillary fragility.

Thus, the medicine is indicated for:

• any etiology, including allergic;
• all kinds;
• nosebleeds;
• influenza and acute respiratory infections.

Also, aminocaproic acid is often instilled into the child's nose during the so-called cold season.

Contraindications

The drug is contraindicated in:

1. Individual intolerance;
2. Tendencies to thrombosis and thromboembolic diseases;
3. Kidney diseases with impaired function;
4. Coagulopathy based on diffuse intravascular coagulation;
5. DIC;
6. Pregnancy and lactation;
7. Violations cerebral circulation;
8. Bleeding from the upper respiratory tract of unknown origin.

Use during pregnancy and lactation

The drug is not prescribed to pregnant and lactating women. This remedy is inappropriate in cases where there is a possibility of increased blood loss during childbirth, because in postpartum period thromboembolic complications may develop.

Instructions for use

The instructions for use indicate that Aminocaproic acid is used intravenously, drip.

If necessary, achieve quick effect(acute hypofibrinogenemia) inject up to 100 ml of a 50 mg/ml solution at a rate of 50-60 drops per minute for 15-30 minutes. During the first hour, a dose of 4-5 g (80-100 ml) is administered, and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until the bleeding stops completely.

In case of continued or repeated bleeding, infusions of 50 mg/ml aminocaproic acid solution are repeated every 4 hours.

Children, at the rate of 100 mg / kg - in 1 hour, then 33 mg / kg / h; maximum daily dose-18 g/sq.m. Daily dose for adults - 5-30 g. Daily dose for children under 1 year old - 3 g; 2-6 years - 3-6 g; 7-10 years - 6-9 g, from 10 years - as for adults. At acute blood loss: children under 1 year old - 6 g, 2-4 years old - 6-9 g, 5-8 years old - 9-12 g, 9-10 years old - 18 g. Duration of treatment - 3-14 days.

Aminocaproic acid in the nose: instructions

It is also recommended to use the drug Aminocaproic acid in the nose (child or adult), locally. Laying for 10 minutes in the nasal passage cotton turunda every three hours, pre-moistened with a solution of 5% Aminocaproic acid or following the indicated frequency, instill 4-5 drops of the solution into the nasal passages. The drug can be used for inhalation in children and adults. In such cases, a nebulizer can be used for inhalation to the child.

• In severe hypertoxic types of influenza or SARS, it is allowed to increase the dosage of the drug to the maximum recommended in given age with a moderate increase in fibrinolytic activity.
• Aminocaproic acid, if necessary, can be used in combination with other antiviral drugs, interferon-containing agents and interferon inducers.
• Intranasal instillation of aminocaproic acid up to four times a day is advisable to carry out during the epidemic period for prevention.

The duration of therapy depends on the severity of the disease and is determined individually by the doctor.

Side effects

Aminocaproic acid is generally well tolerated, but the following adverse reactions may occur.

1. From the side nervous system: headache, dizziness, tinnitus, convulsions.
2. From the side of cardio-vascular system: orthostatic hypotension, subendocardial hemorrhage, bradycardia, arrhythmia.
3. From the side digestive tract: nausea, vomiting, diarrhea.
4. From the blood coagulation system: violation of blood coagulation.
5. Other: possible reactions hypersensitivity (including catarrhal phenomena of the upper respiratory tract), skin rash, myoglobinuria, rhabdomyolysis, acute kidney failure.

Side effects are rare and dose-dependent; when the dose is reduced, they usually disappear.

At topical application ACC is quite safe and rarely causes the development of undesirable consequences and side effects.

Overdose

Symptoms of an overdose of aminocaproic acid: gain side effects, thrombus formation, embolism. With prolonged use (more than 6 days) high doses(for adults - more than 24 g per day) - hemorrhages.

Treatment: drug withdrawal, symptomatic therapy.

special instructions

Before using the drug, you must carefully study the instructions for its use. It is worth paying attention to the features of its use:

1. Long-term use of aminocaproic acid or its intravenous administration in the form of a solution must be accompanied by laboratory control functional state blood coagulation system.
2. During the period of use of the drug, it is necessary to refuse to take fatty foods, which can provoke thrombus formation in the vessels, followed by thromboembolism.
3. Do not take Aminocaproic Acid with oral contraceptives as it can increase blood clotting.
4. During the period of treatment, you can not perform work related to the need increased concentration attention and speed of psychomotor reactions.

drug interaction

It can be combined with the introduction of hydrolysates, glucose solutions (dextrose solutions), anti-shock solutions. In acute fibrinolysis, the introduction of aminocaproic acid with a fibrinogen content of 2-4 g (maximum - 8 g) must be supplemented with a subsequent infusion.

No drugs should be added to the aminocaproic acid solution.

Antiaggregatory decrease while taking anticoagulants of direct and indirect action.

Aminocaproic acid refers to hemostatic and antihemorrhagic drugs. By inhibiting fibrinolysis, it helps to stop bleeding.

Release form and composition

Active active ingredient The drug is a substance with the same name - aminocaproic acid.

The drug is available as a 5% solution for infusion in 100, 250 or 500 ml vials. 1 ml of this solution contains 50 mg of aminocaproic acid.

For hospitals, the drug is packaged in special laminated aluminum foil bags.

Indications for use Aminocaproic acid

According to the instructions, aminocaproic acid is prescribed to prevent and stop bleeding, which is associated with increased fibrinolytic activity, or a state of hypofibrinogenemia and afibrinogenemia.

Indications for the use of the drug are:

• Surgical operations on organs that are rich in fibrinolysis activators (brain, lungs, adrenal glands, uterus, pancreas, thyroid and prostate);
• extracorporeal circulation;
• The period of postoperative recovery (during surgical operations on the vessels and the heart);
• burn disease;
• Complicated abortion and uterine bleeding;
• Premature placental abruption;
• Operations in the field of ENT organs and nosebleeds;
• Diseases of internal organs complicated by hemorrhagic syndrome (bleeding from the bladder, gastrointestinal bleeding).

Effective use of aminocaproic acid in extensive blood transfusions to prevent secondary hypofibrinogenemia.

Contraindications

The drug should not be used in case of hypersensitivity, a tendency to thromboembolic diseases and thrombosis, with cerebrovascular accidents, DIC (disseminated intravascular coagulation), hypercoagulability and during pregnancy.

With caution, the drug is prescribed for chronic renal failure, arterial hypotension and valvular heart disease.

Method of application and dosage of Aminocaproic acid

According to the instructions, Aminocaproic acid is administered intravenously by drip.

In acute hypofibrinogenemia, up to 100 ml of a 5% solution is prescribed at a rate of 60 drops / min for 15-30 minutes. In the first hour, the dosage is 80-100 ml, in the following hours (if necessary), the dose is reduced to 20 ml per hour and continued to drip for 8 hours, or until the bleeding has completely stopped. With repeated bleeding or in the case when the bleeding has not stopped, the infusion of a 5% solution of the drug is continued every four hours.

When using aminocaproic acid in children, the dosage medicinal product calculated based on the weight of the child: in the first hour - 100 mg / kg of weight, in the following hours - 33 mg / kg.

For adults, the maximum daily dose is 5-30 g, and for children, depending on age, from 3 to 15 g:

• Babies up to a year - 3 g;
• 2-6 years - from 3 to 6 g;
• 7-10 years - from 6 to 9 g;
• Over 10 years old - from 10 to 15 years.

Side effects of aminocaproic acid

When using Aminocaproic acid, the following negative reactions are possible:

• Bradycardia and arrhythmia;
• orthostatic hypotension;
• subendocardial hemorrhage;
• Rash on the skin;
• Inflammation of the mucous membrane of the upper respiratory tract;
• Headaches and dizziness, accompanied by tinnitus;
• Diarrhea.

reduce side effects The drug is helped by anticoagulants and antiplatelet agents. Anticoagulants prevent the formation of blood clots by preventing the formation of fibrin, and antiplatelet agents inhibit platelet aggregation, thereby reducing the rate of blood clots.

special instructions

When treating with the use of aminocaproic acid, constant monitoring of the content of fibrinogen and fibrinolytic activity of the blood is required.

The use of the drug in women in order to prevent severe blood loss during childbirth, according to some reports, is not advisable, since thromboembolic complications are possible in the postpartum period.

Aminocaproic acid analogues

The analogue of the drug is the drug Polycapran.

Terms and conditions of storage

Aminocaproic acid should be stored at room temperature not exceeding 25 ° C, protected from sunlight and out of the reach of children. The shelf life of the drug is 2 years from the date of manufacture.

rr d / inf. 50 mg/ml: 100 ml cont.
Reg. No: 17/09/1002 dated 09/05/2017 - Validity of reg. beats not limited

Solution for infusion transparent, colorless.

Excipients: sodium chloride - 0.9 g, water for injection - up to 100 ml.

Theoretical osmolality: 708 mOsmol/kg.

100 ml - polymer containers (1) - plastic bags.
100 ml - polymer containers (1) for hospitals - plastic bags (80) - cardboard boxes (for hospitals).
100 ml - polymer containers (1) for hospitals - plastic bags (100) - cardboard boxes (for hospitals).

Description of the medicinal product AMINOCAPRONIC ACID was created in 2012 on the basis of instructions posted on the official website of the Ministry of Health of the Republic of Belarus. Date of update: 04/24/2013

pharmachologic effect

Aminocaproic acid inhibits blood fibrinolysis. By blocking plasminogen activators and partially inhibiting the action of plasmin, aminocaproic acid has a specific hemostatic effect in bleeding associated with increased fibrinolysis. In addition, aminocaproic acid inhibits the activating effect of streptokinase, urokinase and tissue kinases on fibrinolysis, neutralizes the effects of kallikrein, trypsin and hyaluronidase, and reduces capillary permeability.

Pharmacokinetics

When administered intravenously, the effect manifests itself after 15-20 minutes. It has been established that with prolonged administration, aminocaproic acid is distributed in all extravasal and intravasal compartments of the body, including erythrocytes. 65% of the administered dose is excreted in the urine unchanged and 11% is excreted as adipic acid metabolites. T 1/2 for the drug is about 2 hours.

In violation of the excretory function of the kidneys, there is a delay in the excretion of aminocaproic acid, as a result of which its concentration in the blood increases sharply. Aminocaproic acid does not bind to plasma proteins.

Indications for use

• to stop bleeding surgical interventions and various pathological conditions in which fibrinolytic activity of blood and tissues is increased after operations on the lungs, prostate, pancreas and thyroid glands;
• with premature detachment of a normally located placenta, long delay in the uterus of a dead fetus;
• liver diseases;
• acute pancreatitis;
• hypoplastic anemia;
• with massive transfusions of canned blood, if there is a possibility of developing secondary hypofibrinogenemia.

Dosing regimen

Before administration, visually inspect the polymer container with the drug, check the tightness of the package and the presence of the label. The solution should be transparent, not contain suspended particles or sediment. Aminocaproic acid is injected into / in.

Daily dose for adults is 5-30 g. If it is necessary to achieve a quick effect (acute hypofibrinogenemia), up to 100 ml of aminocaproic acid solution in isotonic sodium chloride solution is injected intravenously at a rate of 50-60 drops / min. During the 1st hour, it is administered at a dose of 4-5 g, in case of ongoing bleeding, 1 g every hour for no more than 8 hours or until it stops completely. With the resumption of bleeding, the infusion is repeated every 4 hours.

children- at the rate of 100 mg/kg of body weight in the first hour, then 33 mg/kg/h, the maximum daily dose is 18 g/m 2 of body surface. Duration of treatment - 3-14 days.

Side effects

General: swelling, headache, weakness.

Allergic reactions: allergic and anaphylactoid reactions, anaphylactic shock.

Local reactions: reactions at the injection site, pain and necrosis.

From the side of the cardiovascular system: bradycardia, arterial hypotension, peripheral ischemia, thrombosis.

From the gastrointestinal tract: abdominal pain, diarrhea, nausea, vomiting.

Hematological: agranulocytosis, coagulation disorders, leukopenia, thrombocytopenia.

From the side musculoskeletal system: increased creatine phosphokinase, muscle weakness, myalgia, myopathy, myositis, rhabdomyolysis.

From the nervous system: confusion, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.

From the side respiratory system: shortness of breath, nasal congestion, pulmonary embolism.

From the side skin: itching, rash.

From the sense organs: tinnitus, decreased vision, lacrimation.

From the side genitourinary system: increase in the level of urea in the blood serum, renal failure.

Contraindications for use

• hypersensitivity;
• hypercoagulability (thrombosis, thromboembolism), a tendency to thrombosis and thromboembolic diseases;
• coagulopathy due to diffuse intravascular coagulation;
• acute disorders of the coronary circulation;
• DIC;
• kidney disease with impaired excretory function;
• hematuria;
• disorders of cerebral circulation;
• pregnancy, lactation.

Carefully: arterial hypotension, valvular heart disease, liver failure, chronic renal failure, children and adolescents under 18 years of age (due to the lack of clinical data on safety and efficacy).

Use in children

Carefully:

• children and adolescents up to 18 years of age.

The drug is used in children at the rate of 100 mg / kg of body weight in the first hour, then 33 mg / kg / h, the maximum daily dose is 18 g / m 2 of body surface. Duration of treatment - 3-14 days.

special instructions

Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, plasmin. The drug should not be prescribed without a definite diagnosis and / or laboratory confirmation of hyperfibrinolysis. When using a solution of aminocaproic acid, the doctor must control the content of fibrinogen, fibrinolytic activity and blood clotting time.

With intravenous administration, it is necessary to control the coagulogram, especially with coronary artery disease, after myocardial infarction, and with pathological processes in the liver.

Use with caution in diseases of the heart and kidneys (due to the risk of developing acute renal failure). Cannot be used for bleeding upper divisions urinary system due to the risk of intrarenal obstruction in the form of glomerular capillary thrombosis.

Rarely, skeletal muscle weakness with necrosis of muscle fibers has been reported after prolonged use. Clinical picture may range from mild myalgia with weakness and fatigue to severe proximal myopathy with rhabdomyolysis, myoglobinuria, and acute renal failure. At the same time, there is an increase in muscle enzymes in the blood serum, primarily creatine phosphokinase (CPK). Therefore, during long-term therapy, serum CPK levels should be monitored. If an increase in the concentration of CPK is detected, treatment with the drug should be interrupted. The possibility of damage to the heart muscle in skeletal myopathy should also be considered. Rapid intravenous administration of the drug should be avoided as this may cause hypotension, bradycardia, and/or arrhythmias.

Epsilon-aminocaproic acid should not be administered with drugs containing factor IX or other factors that affect the coagulation system, due to an increased risk of thrombosis.

Overdose

With severe overdose, hypotension, cardiac and renal failure develops. Treatment is symptomatic.

In some rare cases, hypercoagulation is possible with the risk of thrombosis and embolism. To correct increased blood clotting, it is recommended to use streptokinase, urokinase, fibrinolysin and heparin.

There is evidence that aminocaproic acid can be removed by hemodialysis and peritoneal dialysis.

drug interaction

The use of aminocaproic acid solution can be combined with the introduction of glucose solutions, hydrolysates and anti-shock solutions.

With the simultaneous appointment of a solution of aminocaproic acid with anticoagulants and antiplatelet agents, the hemostatic effect is weakened.

Unfortunately, all children get sick from time to time. With the onset of autumn, pediatricians are increasingly diagnosing influenza and SARS in young patients. For effective treatment a runny nose of an infectious and allergic nature, and in some other cases, the doctor may prescribe a solution of aminocaproic acid for instillation into the child's nose.

Action, release form, composition of the drug

Aminocaproic acid solution is medicinal product group of hemostatics used in various fields of medicine. Traditionally, it is used in surgery, as it helps to stop bleeding. This happens due to a decrease in capillary permeability and strengthening of blood vessels.

In addition, the drug has antiallergic properties (relieves swelling of the mucous membranes and sinuses), and also enhances the antitoxic function of the liver.

For the treatment and prevention of acute respiratory viral infections, the ability of aminocaproic acid to weaken the interaction of the mucosa with viral infection. It also strengthens local immunity by enhancing the action of its own interferon protein in the human body. To top it all, the drug successfully fights adenovirus infection.

The tool is available in the following forms:

• solution for infusions of various volumes (from 100 to 1 thousand ml);
• powder for solution preparation;
• granules.

The active ingredient of the drug is ε(epsilon)-aminocaproic acid. The composition of the solution additionally includes water and sodium chloride.

Indications for use

A pediatrician may prescribe aminocaproic acid in the following cases:

It is worth noting that in the treatment of such serious diseases as tonsillitis, bronchitis, etc., aminocaproic acid is prescribed in complex therapy with other drugs.

Contraindications and overdose

There are few contraindications to the use of the drug, but they are:

• chronic kidney disease;
• violation of the blood circulation of the brain;
• blood clotting disorder;
• thrombosis or thromboembolism in history.

An overdose of aminocaproic acid solution is possible and manifests itself as follows:

• nausea;
• vomit;
• diarrhea;
• lowering blood pressure;
• arrhythmia and bradycardia;
• skin rashes;
• dizziness.

Safety for children, drug interactions

The official instructions do not contain any restrictions on the age of patients. However, the drug cannot be called unconditionally safe. For example, during pregnancy it is prescribed extremely rarely, because international classification FDA (determining the possible negative effect on the fetus) aminocaproic acid received category C. This means that animal studies have revealed a certain negative effect on the unborn baby, but the use is still possible if the expected benefit of the drug exceeds the potential harm.

The drug should be used only after consulting a doctor, especially for newborn patients and infants.

When introducing aminocaproic acid into a solution, no other drugs should be added.

Instructions for use for the common cold, allergies and other diseases

Aminocaproic acid can be used in several ways, depending on the indication and the age of the child.

Methods of using aminocaproic acid: instillation, nasal lavage, inhalation - table

Mode of application	Indications	Features of treatment
Instillation into the nose	prevention and treatment of influenza and other viral infections; cupping allergic reactions in the form of rhinitis; prevention of nosebleeds.	For kids under one year old the drug is recommended to be diluted with saline in equal parts. The duration of treatment is up to 7 days. If the remedy is used for prevention, then the duration of the course can be increased to 2 weeks.
Washing the sinuses	sinusitis; prolonged runny nose; adenoid treatment.	The procedure is carried out only by a qualified nurse as prescribed by a doctor.
Inhalations	treatment of diseases of the upper respiratory tract; adenoid treatment.	For inhalation, a nebulizer is used. Children under one year are recommended to carry out inhalations in a hospital.
Outwardly	nosebleeds	Cotton turundas are formed, which must be moistened with a solution and placed in each nostril.

What can replace aminocaproic acid

The drug has no absolute analogues, but if necessary, you can pick up drugs with a similar spectrum of action.

Substitutes for aminocaproic acid - table

Name	Release form	Active substance	Indications	Contraindications	From what age is it applied?	Price
Tranexam	tablets; solution.	tranexamic acid	stop bleeding; allergic reactions; inflammatory diseases: pharyngitis, laryngitis, stomatitis, etc.	hypersensitivity to the components of the drug; subarachnoid hemorrhage.	from 12 years old	250–600 rubles
Aqua Maris	spray; drops.	isotonic solution of Adriatic Sea water	inflammatory diseases of the nasal cavity, paranasal sinuses and nasopharynx; adenoiditis; allergic rhinitis; prevention and treatment of influenza and SARS.	individual intolerance	drops - no restrictions; spray - from 1 year.	200–400 rubles
Grippferon		interferon	prevention and treatment of influenza and SARS	hypersensitivity to the components of the drug; severe allergic reactions.	drops - no restrictions; spray - from 3 years.	300-350 r.
Nazivin		oxymetazoline hydrochloride	treatment of rhinitis caused by viral infections; allergic rhinitis.	hypersensitivity to the components of the drug; atrophic rhinitis; closed-angle glaucoma.	drops - no restrictions; spray - from 6 years.	150–200 rubles

Aminocaproic Acid Powder - antihemorrhagic (hemostatic), hemostatic agent used for bleeding caused by increased fibrinolysis.
Mechanism specific action due to competitive inhibition of plasminogen activators and partial inhibition of plasmin activity (in high doses), as well as inhibition of biogenic polypeptides - kinins.
It inhibits the activating effect of streptokinase, urokinase and tissue kinases on the processes of fibrinolysis, neutralizes the effects of kallikrein, trypsin and hyaluronidase, and reduces capillary permeability.
Shows moderate anti-allergic and anti-shock activity; increases the antitoxic function of the liver. It inhibits the proteolytic activity associated with the influenza virus, inhibits the proteolytic activity of hemagglutinin. Improves some cellular and humoral indicators of specific and non-specific protection in respiratory viral infections.
Pharmacokinetics. After oral administration, it is rapidly absorbed in the upper sections. gastrointestinal tract. The maximum concentration in the blood in adults and adolescents is reached after 2 to 3 hours. It practically does not bind to blood proteins. Partially (10 - 15%) biotransformed in the liver; the rest is excreted by the kidneys mainly unchanged. During the day, about 60% of the administered dose is excreted from the body (with normal function kidneys).
In case of violation of the urinary function, cumulation of the drug is possible.

Indications for use

Indications for the use of the powder Aminocaproic acid are: prevention and treatment parenchymal bleeding, hemorrhages from the mucous membranes, menorrhagia, bleeding from erosions and ulcers of the stomach and intestines. Prevention of bleeding during operations on the liver, lungs, pancreas. Different kinds hyperfibrinolysis, including those associated with the use of thrombolytic drugs and massive transfusion of canned blood. As a symptomatic remedy - bleeding due to thrombocytopenia and qualitative inferiority of platelets (dysfunctional thrombocytopenia).

Mode of application

Powder Aminocaproic acid appoint inside, during or after a meal, dissolving the powder in sweet water or drinking it. The daily dose for adults is divided into 3-6 doses, for children - 3-5 doses.
Moderately pronounced increase in fibrinolytic activity. Adults are usually prescribed in a daily dose of 5-24 g (5-24 packets).
For children under 1 year of age, a single dose is 0.05 g / kg of body weight (but not more than 1 g). The daily dose for children is: under the age of 1 year - 3 g (3 packages), 2 - 6 years - 3 - 6 g (3 - 6 packages), 7 - 10 years - 6 - 9 g (6 - 9 packages) . For adolescents, the maximum daily dose is 10 - 15 g (10 - 15 packets).
Acute bleeding (including gastrointestinal). Adults are prescribed 5 g (5 packets), then 1 g (1 packet) every hour (for no more than 8 hours) until the bleeding stops completely. Daily dose for children with acute blood loss: under the age of 1 year - 6 g (6 packages), 2 - 4 years - 6 - 9 g (6 - 9 packages), 5 - 8 years - 9 - 12 g (9 - 12 packages), 9 - 10 years -
18 g (18 packets).
Subarachnoid hemorrhage. Adults appoint a daily dose of 6 - 9 g (6 - 9 packets).
Traumatic hyphema. Assign at a dose of 0.1 g / kg of body weight every 4 hours (but not more
24 g/day) for 5 days.
Metrorrhagia associated with intrauterine devices. Assign 3 g (3 packets) every 6 hours.
Prevention and control of bleeding during dental interventions. Adults appoint 2 - 3 g (2 - 3 packages) 3 - 5 times a day.
For adults, the average daily dose is 10 - 18 g (10 - 18 packets), the maximum daily dose is 24 g (24 packets).
The course of treatment is 3 - 14 days.
The duration of treatment is determined individually and depends on the severity of the disease. According to the indications, repeated courses of treatment are possible.

Side effects

From the side of the cardiovascular system: orthostatic hypotension, subendocardial hemorrhage, bradycardia, arrhythmias. From the digestive system: nausea, diarrhea. From the blood coagulation system: with prolonged use (more than 6 days) of high doses (for adults - more than 24 g per day) - hemorrhages. From the side of the central nervous system: headache, dizziness, tinnitus, convulsions. Other: catarrhal phenomena of the upper respiratory tract, skin rash, myoglobinuria, rhabdomyolysis, acute renal failure.
Side effects are rare and dose dependent; when the dose is reduced, they usually disappear.

Contraindications

:
Powder contraindications Aminocaproic acid are: increased individual sensitivity to aminocaproic acid, a tendency to thrombosis and embolism, all hereditary and secondary thrombophilias, disseminated intravascular coagulation syndrome, macrohematuria, severe violations kidney function, pregnancy, lactation.

Pregnancy

:
Powder Aminocaproic acid contraindicated in pregnancy. It is inappropriate to use in women in order to prevent increased blood loss during childbirth, since thromboembolic complications may occur. If necessary, use during lactation, breastfeeding should be discontinued.

Interaction with other drugs

When taking the powder Aminocaproic acid inside well combined with thrombin. The effect of the drug is weakened by antiplatelet agents and anticoagulants of direct and indirect action. Combined use with estrogen-containing contraceptives, blood coagulation factor IX increases the risk of thromboembolism.

Overdose

:
Powder overdose symptoms Aminocaproic acid: increased side effects, the formation of blood clots, embolism. With prolonged use, it is possible to develop the opposite effect - hemorrhage.
Treatment: drug withdrawal, symptomatic therapy.

Storage conditions

Store in a dry place at temperatures between 8°C and 25°C. Keep out of the reach of children.
Shelf life 2 years.

Release form

Aminocaproic acid - powder for oral administration.
1 g of powder in bags No. 1 or in coupled bags No. 2, or in coupled bags No. 4 (No. 2x2), No. 10 (2x5) in a cardboard box.

Compound

:
1 packet of powder Aminocaproic acid contains aminocaproic acid 1 g.

Additionally

:
Precautions are prescribed for heart disease, liver and / or kidney failure.
It is not recommended to use the drug for hematuria (due to the risk of developing acute renal failure).
With prolonged use (more than 6 days) of high doses (more than 24 g per day for adults), hemorrhages may occur due to inhibition of platelet aggregation and adhesion.
With menorrhagia, effective reception from the first to last day monthly.
During drug therapy, it is recommended to check the fibrinolytic activity of the blood and the level of fibrinogen.

main parameters

Name:

AMINOCAPRONIC ACID POWDER