Amosin from what these pills. Amosin: what helps, method of application and dose, contraindications

Registration number 000748/01-081007

Trade name of the drug: Amosin

International non-proprietary name:

amoxicillin

Dosage form:

capsules

Compound:

Active substance: amoxicillin trihydrate (in terms of amoxicillin) - 0.250 g.
Excipient: potato starch.
The composition of the gelatin capsule: titanium dioxide, methylhydroxybenzoate, propylhydroxybenzoate, acetic acid, gelatin.

Description: Capsules white color No. 0. The contents of the capsules are white granules.

Pharmacotherapeutic group:

antibiotic - semi-synthetic penicillin.

ATX Code: .

Pharmacological properties
Pharmacodynamics: Semi-synthetic penicillin bactericidal action, has a wide spectrum of action. Violates the synthesis of peptidoglycan (the reference polymer cell wall) during division and growth, causes lysis of bacteria.
Active against aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Penicillinase-producing strains are resistant to the action of amoxicillin.

Pharmacokinetics: Absorption - fast, high (93%), food intake does not affect absorption, is not destroyed in acidic environment stomach. When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 mcg / ml, respectively. The time to reach maximum concentration after oral administration is 1-2 hours. It has a large volume of distribution: in high concentrations found in plasma, sputum, bronchial secretions(weak distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate, middle ear fluid (with inflammation), bone, adipose tissue, gallbladder(at normal function liver), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. Poorly penetrates the blood-brain barrier, with inflammation meninges concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins -17%. Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted by 50-70% by the kidneys unchanged (by tubular secretion - 80% and glomerular filtration - 20%), by the liver -10-20%. It is excreted in a small amount from breast milk. Amoxicillin is removed by hemodialysis.

Indications for use
Bacterial infections caused by susceptible pathogens: infections of the lower respiratory tract(bronchitis, pneumonia) and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media), genitourinary system(pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), gastrointestinal tract(cholangitis, cholecystitis, dysentery, salmonellosis, salmonella carriage), infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), endocarditis (prevention).

Contraindications
Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), childhood up to 3 years (for this dosage form).

Carefully
allergic diseases(including a history), a history of gastrointestinal disease in history (especially colitis associated with the use of antibiotics), renal failure, severe violations liver function, pregnancy, lactation, Infectious mononucleosis, lymphocytic leukemia.

Pregnancy and lactation
The use of the drug during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Dosage and administration
Inside, before or after a meal.
Adults and children over 10 years old (weighing more than 40 kg) are prescribed 0.5 g 3 times a day; at severe course infections - 0.75-1 g 3 times a day. Children aged 5-10 years are prescribed 0.25 g 3 times a day; younger than 5 years - prescribed in the form of a suspension. The course of treatment is 5-12 days, depending on the form and severity of the disease. In acute uncomplicated gonorrhea, 3 g is prescribed once; in the treatment of women, repeated administration of the indicated dose is recommended.
For acute infectious diseases gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases for adults - 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.
With leptospirosis for adults - 0.5-0.75 g 4 times a day for 6-12 days.
With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.
For the prevention of endocarditis in small surgical interventions adults - 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is reduced by 2 times.
In patients with impaired renal function with a creatinine clearance (CC) of 15-40 ml / min, the interval between doses is increased to 12 hours; with CC below 10 ml / min, the dose is reduced by 15-50%; with anuria - maximum dose 2 g/day

Side effects
Allergic reactions: possible urticaria, skin hyperemia, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, multiforme exudative erythema(including Stevens-Johnson syndrome); reactions similar to serum sickness; in isolated cases - anaphylactic shock.
From the gastrointestinal tract: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, moderate increase in the activity of "liver" transaminases, rarely - pseudomembranous enterocolitis.
From the side nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavioral changes, depression, peripheral neuropathy, headache, dizziness, epileptic reactions.
Laboratory indicators: leukopenia, neutropenia, thrombocytopenic purpura, anemia.
Others: shortness of breath, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Overdose
Symptoms: nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea). Treatment: gastric lavage, Activated carbon, saline laxatives, drugs to maintain water and electrolyte balance; hemodialysis.

Interaction with other drugs
Antacids, glucosamine, laxative drugs, food, aminoglycosides slow down and reduce absorption; vitamin C enhances absorption.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.
Increases efficiency indirect anticoagulants(suppressing intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing breakthrough bleeding. Amoxicillin reduces clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs, and other drugs that block tubular secretion increase the concentration of amoxicillin in the blood.
Allopurinol increases the risk of skin rashes.

special instructions
During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires an appropriate change. antibiotic therapy.
When administered to patients with sepsis, it is possible to develop a bacteriolysis reaction (Jarish-Herxheimer reaction) (rarely).
In patients with hypersensitivity to penicillins, cross-over allergic reactions with other beta-lactam antibiotics.
At treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.
Treatment necessarily continues for another 48-72 hours after the disappearance clinical signs diseases. With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods contraception.

Release form
Capsules 250 mg, 10 pieces in a blister pack.
1 or 2 blisters with instructions for use are placed in a cardboard box.

Storage conditions
List B.
In a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Best before date
2 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
On prescription.

Claims from buyers are accepted by the manufacturer:
Open Joint Stock Company "Joint Stock Kurgan Company medical preparations and products "Sintez" (JSC "Sintez"). 640008, Russia, Kurgan, pr. Constitution, 7.

Registration number Р N000748/02-060812
Trade name of the drug: Amosin®
international generic name: amoxicillin
Dosage form: tablets

Composition per 1 tablet:
Active substance:
Amoxicillin trihydrate (in terms of amoxicillin) - 250 mg 500 mg
Excipients:
*Potato starch 102.8 mg 170.53 mg
Magnesium stearate 1.85 mg 3.5 mg
Talc 9.0 mg 14.0 mg
Povidone (collidone 90F) 4.5 mg 8.47 mg
Calcium stearate 1.85 mg 3.5 mg
*The amount of potato starch may vary depending on the content of the active substance in the amoxicillin trihydrate substance.
Description: tablets of white or almost white color, ploskotsilindrichesky with a facet and risk.
Pharmacotherapeutic group: antibiotic - semi-synthetic penicillin.

ATX code: .

Pharmacological properties

Pharmacodynamics: bactericidal antibiotic a wide range actions from the group of semi-synthetic penicillins. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.
Active against aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic Gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Penicillinase-producing strains are resistant to the action of amoxicillin.
Pharmacokinetics: Absorption - fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach. When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 mcg / ml, respectively. The time to reach maximum concentration after oral administration is 1-2 hours.
It has a large volume of distribution: it is found in high concentrations in plasma, sputum, bronchial secretions (in purulent bronchial secretions, the distribution is weak), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid (with inflammation), bone, adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times.
The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. Poorly penetrates the blood-brain barrier, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins - 17%. Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted by 50-70% by the kidneys unchanged (by tubular secretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. A small amount is excreted in breast milk. In case of impaired renal function (creatinine clearance (CC) less than or equal to 15 ml / min), the half-life increases to 8.5 hours.
Amoxicillin is removed by hemodialysis.

Indications for use

Bacterial infections caused by susceptible pathogens: infections of the lower respiratory tract (bronchitis, pneumonia) and upper respiratory tract (sinusitis, pharyngitis, tonsillitis, acute otitis media), urinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), gastrointestinal tract (cholangitis, cholecystitis, dysentery, salmonellosis, salmonella carriage), skin and soft tissue infections (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), endocarditis (prevention).

Contraindications

Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), children under 3 years of age (for this dosage form).
With caution - allergic diseases (including history), diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics), renal failure, severe liver dysfunction, pregnancy, lactation, infectious mononucleosis, lymphocytic leukemia.

Pregnancy and lactation

The use of the drug during pregnancy is possible when the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Dosage and administration

Inside, take regardless of the meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water.
Adults and children over 10 years old (weighing more than 40 kg) are prescribed 0.5 g 3 times a day; in severe infections - 0.75-1 g 3 times a day.
Children aged 3-5 years are prescribed 0.125 g 3 times a day, 5-10 years - 0.25 g 3 times a day; in severe infections - 60 mg / kg / day 3 times a day. The course of treatment is 5-12 days.
In acute uncomplicated gonorrhea, 3 g is prescribed once; in the treatment of women, repeated administration of the indicated dose is recommended.
In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, in gynecological infectious diseases for adults - 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.
With leptospirosis for adults - 0.5-0.75 g 4 times a day for 6-12 days.
With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.
For the prevention of endocarditis in minor surgical interventions for adults - 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is reduced by 2 times.
In patients with impaired renal function with CC 15-40 ml / min, the interval between doses is increased to 12 hours; with CC below 10 ml / min, the dose is reduced by 15-50%; with anuria - the maximum dose is 2 g / day.

Side effects

Allergic reactions: possible urticaria, skin hyperemia, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome); reactions similar to serum sickness; in isolated cases - anaphylactic shock.
From the side digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, moderate increase in the activity of "liver" transaminases, rarely - pseudomembranous enterocolitis.
From the nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic reactions.
Laboratory indicators: leukopenia, neutropenia, thrombocytopenic purpura, anemia.
Others: shortness of breath, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Overdose

Symptoms: nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea).
Treatment: gastric lavage, activated charcoal, saline laxatives, drugs to maintain water and electrolyte balance; hemodialysis.

Interaction with other drugs

Antacids, glucosamine, laxative drugs, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.
Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing breakthrough bleeding.
Amoxicillin reduces clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs, and other drugs that block tubular secretion increase the concentration of amoxicillin in the blood.
Allopurinol increases the risk of skin rashes.

special instructions

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.
When administered to patients with sepsis, it is possible to develop a bacteriolysis reaction (Jarish-Herxheimer reaction) (rarely).
In patients with hypersensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.
In the treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.
Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease.
With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used whenever possible.

Release form
Tablets 250 mg, 500 mg.
10 tablets in a blister pack. 1 or 2 blisters with instructions for use are placed in a cardboard box.
240 blister packs are placed in a cardboard box with 1-5 instructions for use for delivery to hospitals.

Best before date
3 years. Do not use after the expiration date.

Storage conditions
In a dry, dark place at a temperature not exceeding 25°C.
Keep out of the reach of children.

Terms of dispensing from pharmacies
On prescription.

Amosin - modern, popular antibiotic. He fights with bacterial infections and effective against streptococcus, salmonella, listeria, anthrax, Helicobacter pylori. The drug belongs to the group of semi-synthetic penicillins. His can be given to children from birth.

Amosin is a broad-spectrum antibiotic.

Action

The main active ingredient of the drug is amoxicillin.

It prevents the synthesis of substances that make up the cell membranes of pathogenic microorganisms. This leads to the death of bacteria. The active components of Amosin penetrate the body and begin to act already 15 minutes after ingestion.

Release form, prices and manufacturers

The medication is available in different forms, so it can be used to treat children of any age.

• Capsules- white gelatin (250 mg, 20 pieces per pack) - 60 rubles.
• Tablets- semi-cylindrical + 5 white color with an active ingredient content of 250 mg or 500 mg. Price 250 mg (blister 10 pieces) - 25 rubles; 500 mg (blister 10 pieces) - 60 rubles.

Tablets are used only for the treatment of children older than 5 years.

• Powder for suspension preparation- yellowish with a specific smell is available in dosages: 125 mg, 250 mg, 500 mg (10 sachets each) - 40, 55, 85 rubles. respectively.

Amosin is a domestically produced drug produced by the pharmaceutical company Sintez AKO OJSC. The medicine is sold without a prescription.

Indications for use

The drug is prescribed for infections caused by pathogenic microorganisms if they are sensitive to the antibiotic. Amosin is used for:

• pathologies of the respiratory system;
• diseases of ENT organs;
• diseases of the urinary organs;

Urinary tract infection is one of the most common diseases in children.

• skin infections;
• endocarditis;
• endometritis;
• enterocolitis, peritonitis;
• meningitis;
• listeriosis;
• dysentery and other diseases.

The drug is absorbed from the digestive organs, spreads with blood throughout the body.

The medicine is effective for eight hours after ingestion.

Method of application and dosage

It is most convenient for children to give Amosin in the form of a suspension. To prepare it, you need to pour the contents of the sachet into a glass of boiled chilled water (if the content of the active substance is 125 mg, then the powder is diluted in 2.5 ml of liquid, 250 mg - 5 ml and 500 mg - 10 ml, respectively), stir.

The dosage is determined by the attending physician and depends on the severity and nature of the disease.

The dosage of the drug is set individually in each case. The instruction recommends the following scheme for taking Amosin suspension:

• Children over 10 years old- Three times a day, 500 mg.
• Patients aged 5 to 10 years - three times a day, 250 mg.
• 2 to 5 years- 125 mg three times a day.
• Dose for babies under 2 years old calculated as follows: 20 mg per kilogram of the child's weight. This dose is divided into three doses per day.

Children over 5 years of age can be given the drug in the form of tablets, capsules or suspensions.

Capsules must be swallowed without chewing, before or after meals.

A newborn and a child under 5 years old - only in the form of a liquid.

Accurate adherence to the dosage will avoid unpleasant side effects.

Side effects

Amosin - strong antibiotic and sometimes causes side effects. In such cases, it is replaced by softer analogues.

The drug can cause the development of side effects from:

• gastrointestinal tract - indigestion, nausea;

The drug may cause abdominal pain and nausea.

• CNS - overexcitation, sleep disturbance, anxiety, tearfulness;
• respiratory organs - shortness of breath;
• allergies - itching, rash, nasal congestion,.

In some cases, in children, as a result of taking the drug, the liver slightly increased in size. Rarely, but still, side effects may occur. of cardio-vascular system(tachycardia).

If after taking Amosin the baby has any reactions, inform your doctor.

Usually, during and after antibiotic therapy, parents give their children drugs that help restore normal intestinal microflora. We will talk about how to restore a child's body after taking antibiotics.

Contraindications

The use of Amosin for the treatment of children is not always possible. The drug has a number of contraindications. Read the instructions beforehand or consult your doctor. The medicine should not be given to children with:

• diseases of the digestive tract;
• problems in the liver, kidneys;
• mononucleosis of infectious origin;
• bronchial asthma.

Sick bronchial asthma medicine is contraindicated.

The drug in the form of tablets and capsules is contraindicated in children under the age of five years. in such cases, only Amosin suspension can be given.

Overdose

Cases of overdose are known, but there is no specific antidote (an agent that binds and removes the components of a drug from the body) to Amosin. Patients may experience symptoms such as nausea, diarrhea,.

In such cases, you should immediately call an ambulance. In case of an overdose of an antibiotic, the child's stomach is washed, laxatives and enterosorbent drugs are prescribed.

Amosin's analogs

On sale there are analogues of the drug Amosin, they are also prescribed for babies with infectious diseases. Below is a brief overview of the most popular of these medicines. The active substance of these drugs is also amoxicillin:

• (manufacturer Astellas Pharma, Netherlands), - release form - tablets ( average price- 300 rubles for 20 tablets of 250 mg); prescribed for respiratory tract infections, urinary organs, skin. For children under one year old, the drug is given in doses not exceeding 60 mg per kilogram of body weight per day.

Amosin's analogue is Flemoxin Solutab.

• (manufacturer Lek, Slovenia) - sold in the form of tablets (230 rubles for 14 pieces) and powder for suspension (120 rubles). Give the drug to children from birth. Patients under the age of three months appoint 30 mg per kilogram of body weight per day.
• (manufacturer GlaxoSmithKline Export, UK) - available in the form of a powder for suspension (average price - 145 rubles per bottle) and tablets (260 rubles for 20 pcs.); a modern antibiotic, often prescribed to children by doctors of various profiles.

Among other well-known analogues in composition and mechanism of action, Danemox, Amoxon.

Content

According to medical classification, Amosin refers to antibiotics from the group of penicillins. The active substance amoxicillin is destroyed by penicillinase. The tool is produced by the Russian pharmacological company Sintez. Check out its instructions for use.

Composition and form of release

Antibiotic Amosin (Amosin) is presented in several formats:

Characteristics		Tablets	Powder and granules for suspension	Solution for injections
Description	Capsules, white granules inside	White flat pills	White-yellow powder, ready-made suspension of yellowish color with vanilla flavor	clear liquid
The concentration of amoxicillin in the form of trihydrate, mg		250 or 500 per piece	125, 250 or 500 per sachet
Additional components	Gelatin, potato starch, acetic acid, titanium dioxide, propyl hydroxybenzoate, methyl hydroxybenzoate	Povidone, starch, talc, magnesium stearate, calcium stearate	Sugar, povidone, vanillin, glucose, sodium alpha-glutamate monohydrate, sodium edetate, sodium phosphate	Oil filler
Package	Packs of 20 pcs.	Packs of 10 pcs.	Packets of 1.5, 3 or 6 g, 10 pcs. in a pack	Ampoules of 10 ml or vials of 100 ml

Pharmacological properties

Amosin refers to antibiotics with bactericidal action. It destroys bacteria. The drug is acid-resistant, is active against staphylococci, streptococci, neisseria, bacilli, listeria, klebsiella, Helicobacter pylori.

Microbes producing penicillinase are resistant to the action of amoxicillin. When taken orally, the active ingredient is almost completely absorbed in the stomach, food does not affect its absorption. After 1-2 hours active substance reaches its maximum concentration.

Amoxicillin is found in sputum, plasma, bronchial secretions, urine, pleural, peritoneal fluid, lung tissues, contents of skin blisters, intestinal mucosa, prostate, adipose tissue, bones, gallbladder, and crosses the placenta. The agent weakly penetrates the membranes of the brain. Active substance has an hour and a half elimination half-life. It is excreted 60% in urine, 20% in bile.

What helps Amosin

The instruction indicates the following indications for the use of Amosin:

• bronchitis, pneumonia;
• pharyngitis, sinusitis;
• cervicitis, endometritis;
• pyelitis, pyelonephritis, cystitis, gonorrhea, urethritis;
• enterocolitis, peritonitis, cholangitis, typhoid fever, cholecystitis;
• impetigo, erysipelas, leptospirosis;
• borreliosis, meningitis;
• listeriosis;
• dysentery, salmonellosis.

Method of application and dosage

Doctors often prescribe Amosin for angina. When treating any disease with a drug, it is important to follow the point of special instructions:

1. During therapy, it is necessary to control the state of the hematopoietic organs.
2. At hypersensitivity cross-allergic reactions with cephalosporins can develop to penicillins.
3. If mild diarrhea develops while taking the medicine, it is forbidden to treat it with antidiarrheal drugs that reduce intestinal motility. It is allowed to use products based on kaolin or attapulgite. In severe diarrhea, differential diagnosis is carried out.
4. When using oral contraceptives based on estrogen, you need to additionally protect yourself.

Amosin capsules and tablets are taken orally. The standard dose for adults is 500 mg three times a day, with serious illnesses- 750 mg three times a day. Dosages depend on diseases:

		Reception frequency, once a day	Course of treatment, days	Notes
				For women, repeat the reception
			Before normalization	Or 1-1.5 g 4 times a day
Leptospirosis
Salmonella carrier
Prevention of endocarditis		One hour before surgery		You can repeat after 8-9 hours, in children the dose is half as much

Powder and granules for suspension preparation

Dosages for suspension do not differ from tablets and capsules. Preparation of medicine from powder or granules:

1. Pour boiled chilled water into a clean glass (for 125 mg of powder 2.5 ml, for 250 mg - 5 ml, for 500 mg - 10 ml).
2. Empty the contents of the package.
3. Mix.
4. After taking the glass, rinse with water and dry.

Solution for intravenous and intramuscular administration

Amosin injections are administered subcutaneously or intramuscularly, rarely - intravenously. For injection, the contents of the ampoule are mixed with 5-10 ml of saline (0.9% sodium chloride). Dosages for adults: intramuscularly - up to 1 g per day in 2 doses, intravenously - 2-13 g each, depending on the severity of the condition. In severe diseases, Amosin can be administered three times.

Amosin during pregnancy

You can use the drug during pregnancy if the doctor evaluates the benefit to the mother above the risk to the fetus. During lactation, the use of Amosin is prohibited by the instructions.

Amosin for children

Amosin can be used for children in the form of tablets and capsules (over 3 years old), suspensions (up to 5 years old) and injections (from newborn age). Dosage:

drug interaction

Instructions for use Amosin advises to study drug interactions:

1. Glucosamine, antacids, laxatives, aminoglycosides can slow down and reduce the absorption of the drug, ascorbic acid can increase it.
2. Synergists with amoxicillin are cephalosporins, aminoglycosides, Cycloserine, Rifampicin, Vancomycin, antagonists are macrolides, lincosamides, Chloramphenicol, sulfonamides, tetracyclines.
3. The agent suppresses the intestinal microflora, reduces the effect of ethinylestradiol, estrogen-containing oral contraceptives.
4. Diuretics, Oxyphenbutazone, Allopurinol, Metronidazole are able to increase the concentration of the drug.
5. During therapy, you should refrain from drinking alcohol, otherwise there is a risk of developing tachycardia, myocardial infarction, lowering pressure, allergies, fever, vomiting, loss of consciousness, nausea.

Side effects

In the treatment of Amosin, the development of side effects is possible:

• urticaria, erythema, skin hyperemia, angioedema, dermatitis, erythema, anaphylactic shock;
• conjunctivitis, rhinitis, fever, joint pain;
• eosinophilia;
• anxiety, agitation, insomnia, confusion, ataxia, depression, behavior change, neuropathy, dizziness, convulsions;
• interstitial nephritis;
• tachycardia;
• glossitis, stomatitis;
• anorexia, hepatitis, jaundice;
• difficulty breathing;
• candidiasis, superinfection.

Overdose

Overdose symptoms include nausea, diarrhea, and vomiting. It is necessary to wash the stomach, give the patient sorbents, and carry out hemodialysis.

Contraindications

The drug is prescribed with caution in case of renal failure, pregnancy, history of bleeding. Contraindications, according to the instructions, are:

• allergic diathesis;
• Infectious mononucleosis;
• hay fever, bronchial asthma;
• lymphocytic leukemia;
• colitis against the background of taking antibiotics in history;
• liver failure;
• lactation;
• intolerance to the components of the composition;
• hypersensitivity to cephalosporins, penicillins, carbapenems.

Terms of sale and storage

Amosin refers to prescription drugs, stored at a temperature of 15-25 degrees for no longer than 2 years.

Analogues

Antibiotics with the same or different composition can replace the drug. Analogues of Amosin based on amoxicillin:

• Ecobol - tablets;
• Hikoncil, Danemox - capsules;
• Ospamox - granules for suspension.

Amosin and Amoxicillin - what is the difference

The drugs Amosin and Amoxicillin have the same side effects, contraindications, duration of action, course of treatment, dosage. Amoxicillin is an analogue of Amosin according to active ingredient so they are interchangeable. The differences are in the price (Amosin is cheaper) and the taste of the suspension (Amoxicillin has a fruity one).

Amosin price

The cost of the drug in pharmacies in Moscow:

Type of medicine	Pharmacy name	Price, rubles
Tablets 250 mg 10 pcs.	City Health
Tablets 500 mg 10 pcs.	City Health
	pills.ru
Granules for suspension 10 sachets 125 mg	City Health
Granules for suspension 250 mg 10 pcs.
	City Health
Capsules 250 mg 20 pcs.
Powder for suspension 250 mg 10 pcs.	pills.ru
Solution 1 ampoule 10 ml	Ver.ru

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Amosin is an antibacterial medicine from the group of semi-synthetic penicillins.

Release form and composition

The active substance of the drug is amoxicillin.

Amosin is available in the following dosage forms:

• Capsules - 10 pieces in a cell pack;
• Powder in sachets for suspension for oral administration. One sachet contains 125, 250 or 500 mg of amoxicillin;
• Powder in vials or jars made of polymeric materials for the preparation of oral suspension containing 5 g of the active ingredient;
• Tablets containing 250 or 500 mg of amoxicillin. Packed in blisters of 10 pieces.

Indications for use Amosin

According to the instructions for Amosin, it is effective in a number of infectious and inflammatory diseases:

• Infections of ENT organs - pharyngitis, tonsillitis, sinusitis, otitis media;
• Respiratory infections - pneumonia, bronchitis;
• Gynecological infections - cervicitis, endometritis;
• Infections of the genitourinary system - urethritis, cystitis, pyelitis, pyelonephritis, gonorrhea;
• Infections of soft tissues and skin - secondarily infected dermatoses, erysipelas and impetigo;
• Infections of the gastrointestinal tract - typhoid fever, peritonitis, cholangitis, enterocolitis, cholecystitis;
• Borreliosis (Lyme disease);
• Dysentery;
• Listeriosis;
• Leptospirosis;
• Meningitis;
• salmonellosis;
• Sepsis;
• Prevention of endocarditis.

Contraindications

Contraindications to the use of Amosin are:

• Liver failure;
• Bronchial asthma and hay fever;
• Allergic diathesis;
• lymphocytic leukemia;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
• The period of breastfeeding;
• Children's age up to 3 years (for the dosage form in the form of capsules and tablets).

With caution, Amosin is prescribed to pregnant women and patients with kidney failure and a history of bleeding.

Method of application and dosage of Amosin

Amosin tablets and capsules are intended for oral use (orally). Capsules must be swallowed without chewing, before or after meals. Tablets can be crushed or divided.

Amosin, according to the instructions, is recommended to be taken at regular intervals. The dosage and duration of treatment is determined by the doctor. Children over 10 years of age and adults are prescribed 500 mg of the drug three times a day. For children aged 5-10 years, the dose is halved (250 mg three times a day). On average, the duration of the course of treatment is 5-12 days. After the disappearance of all symptoms of the disease, therapy should be continued for another 2-3 days.

Amosin powder for suspension is also intended for oral use. To prepare the suspension, measure the required amount of chilled boiled water (depending on the dose of amoxicillin), pour the contents of the sachet and stir until a suspension is obtained. The suspension thus prepared is taken before or after meals. The dosage of Amosin and the duration of treatment are similar to the instructions indicated above for capsules and tablets.

In case of impaired renal function, the interval between doses of the drug is recommended to be increased to 12 hours.

Side effects of Amosin

When using Amosin, such unwanted effects, caused by amoxicillin, as:

• From the gastrointestinal tract and hepatobiliary system - a violation of taste sensations, nausea, vomiting, dysbacteriosis, diarrhea, stomatitis, glossitis, pseudomembranous colitis;
• From the hemopoietic system - leukopenia, neutropenia, anemia, eosinophilia, thrombocytopenic purpura;
• From the side of the peripheral and central nervous system - a change in behavior, confusion, ataxia, agitation, anxiety, disruptions in sleep and wakefulness, depressive states, rarely headaches, convulsions, dizziness and peripheral neuropathy;
• Allergic reactions - conjunctivitis and rhinitis, erythema, itching, urticaria, hyperemia, hyperthermia, Quincke's edema, exfoliative dermatitis, rarely anaphylactic shock.

From others adverse reactions Amosin, according to the instructions, tachycardia, shortness of breath, superinfection, candidal vaginitis and interstitial nephritis are possible.

special instructions

When using Amosin, it is necessary to monitor the state of the function of the kidneys, liver and hematopoietic organs.

During treatment with the drug, superinfection may develop, which requires a change in antibiotic therapy.

In patients with bacteremia, the Jarisch-Herxheimer reaction (bacteriolysis reaction) may occur, manifested by fever, chills, nausea, headache, tachycardia, decreased blood pressure and exacerbation of symptoms of the underlying disease.

With increased sensitivity to penicillins, the use of Amosin can cause cross-allergic reactions with cephalosporin antibiotics.

If mild diarrhea occurs during treatment with Amosin, drugs that reduce intestinal motility should be avoided. For this, attapulgite- or koalin-containing antidiarrheals can be used. Severe diarrhea requires differential diagnosis and prescribing appropriate treatment.

With the simultaneous use of amoxicillin and oral contraceptives containing estrogen, it is recommended to use additional methods of protection against unwanted pregnancy.

Amosin's analogs

Amosin has quite a few analogues. Below are some of them:

• Amoxicar;
• Amine;
• Amoxilate;
• Amoxicillin;
• Amoxon;
• Atoxylin;
• Gonoform;
• Ospamox;
• Taysil;
• Flemoxin Solutab;
• E-mox.

Terms and conditions of storage

According to the instructions, Amosin belongs to the drugs of list B. It should be stored in a dry place, protected from light, out of the reach of children. Powder for suspension preparation is stored at a temperature of 15-25°C, tablets and capsules - at a temperature not exceeding 25°C. Amosin is good for two years.