Phenilin instructions for use analogs. Features of the use of the indirect anticoagulant phenylin

Few facts about the product:

Instructions for use

Online pharmacy price website: from 35

Composition and release form of the drug

Phenilin is available in standard tablet form. Original tablets are light or creamy. The average price of Phenilin is 100 rubles. You can buy Phenilin at any pharmacy without a prescription. The main components in the composition of the drug: Fenindion; Lemon acid; Milk sugar; Talc; Starch

pharmachologic effect

Doctors classify this drug as a coagulant with an indirect effect on the patient's body. It also improves the blood clotting rate. After using this remedy, patients feel positive changes in blood circulation. The first therapeutic effect appears 9 hours after the use of this remedy. The full effect appears after about 26 hours. The medicine is absorbed immediately after use, and, moreover, almost in full. The main components tend to gradually accumulate in the tissues. The drug releases a metabolite in the liver. Both the original components and the metabolite are excreted by the kidneys.

Indications

The presence of the following ailments and circumstances is an indication for the use of the drug: Thrombosis at any stage. This agent is also prescribed as an effective preventive measure with an increased likelihood of thrombosis in a patient; The period after surgery (if there is a risk of thrombosis); Thrombophlebitis; Embolic trauma; Complications after myocardial infarction; Strokes (except for hemorrhagic).

Contraindications

According to the official instructions for use, the original drug and the main analogs of Fenilin are contraindicated when: The patient's prothrombin level is below 70%; Not prescribed for menstruation; The patient has diseases that accelerate the process of blood clotting; Pericarditis; Serious problems in the functioning of the kidneys and liver; Malignant pathology; Stomach ulcer.

Dosage

It is recommended that you read the official description before using the medicine. Violation of the recommended dose can harm the patient's health. The standard dose on the first day is from 0.12 to 0.18 grams. It is necessary to stretch it for three to four steps. Further, the dose is reduced to 0.9-0.15 grams. Next, it is necessary to adjust the course of treatment depending on changes in laboratory parameters. Joint use of the drug with heparin may be prescribed. The entire course of treatment must be carried out under full medical supervision. The course should be stopped gradually.

Side effects

In case of intolerance to one of the components in the composition, various allergic reactions may appear. Also, patients note the appearance of discomfort in the abdomen and fever (in rare cases).

The heart is the motor of the human body. Modern life, environmental disaster, unhealthy diet, as well as a high level of stress on a daily basis lead to disruption of the work of a vital organ.

For the most part, heart disease leads to a sharp deterioration in the standard of living of a person, less often to disability, and in a difficult situation - to his death.

To treat them, a cardiologist may prescribe a drug, for example, the drug Fenilin.

Phenylin is a drug that prevents blood from clotting. How should it be taken correctly so that the remedy has only benefit?

There is a wide range of reviews on the internet. They can be found in this article.

Instructions for the use of this tool

In this article, you can find data on exactly when the drug can be prescribed, what composition it has, how the agent should be taken, what contraindications it has, what side effects can be isolated, how the agent should be stored, and with what agents in no case the drug is not recommended to be taken, what actions should be taken in case of an overdose, and in what form can it be produced?

In addition, here you can also find data such as the price, as well as possible analogs.

Pharmacology

To start functioning in the human body, Phenilin must accumulate in the required concentration, therefore its effect does not appear immediately - it begins after 10 hours, and the maximum effect is reached in a day or two.

The drug Phenilin is quite well absorbed from the gastrointestinal tract. Its further transformation occurs in the liver. It is excreted from the body through the kidneys.

Under what conditions is the remedy prescribed?

This tool can be assigned:

1. For the treatment of thrombophlebitis or thrombosis;
2. For the prevention of myocardial infarction;
3. With embolic strokes.

In addition, the agent can be prescribed for thrombus formation after surgery.

How to take the remedy correctly?

Elderly patients should adjust the dosage.

Finilin is prescribed to patients over 14 years of age (whose body weight is more than 45 kg) inside. The drug should be taken after meals. The optimal dosage is selected individually in each case. The dosage is influenced by the severity of the disease, the individual characteristics of the patient's body, the characteristics of the diet and the treatment that the patient is already receiving.

Adults on the first day are prescribed 4-6 tablets. Reception of funds is divided by 3-4 times. On the second day, the dosage is reduced to 3-5 days, then it should not exceed two tablets. The duration of the receptions a day is several times.

In the first few days, adolescents should take 3-5 tablets in three to four doses, then the dosage is reduced to one or two tablets in one or two doses.

For the prevention of thromboembolic complications, the drug is prescribed in a dosage of one tablet, which must be taken once or twice a day.

The highest dosage for an adult: single - 50 mg, daily - 200 mg.

Composition

This tool can be found in the form of tablets, white with a creamy shade.

The product contains phenindione. Auxiliary components are components such as talc, milk sugar, starch, citric acid.

Combination of funds

When combined with ACTH, the anticoagulant effect of the drug Fenilin is enhanced.

With simultaneous combination with dopyridamole, cases of increased bleeding were observed. This is due to a decrease in adhesiveness, as well as platelet aggregation under the influence of dopyridamole.

When combined with clofibrate, the anticoagulant effect of the drug is enhanced. When combined with liothyronine, the anticoagulant effect of phenindione is enhanced.

When combined with cimetidine, the anticoagulant effect of phenindione increases due to the slowdown of its metabolism in the liver under the influence of cimetidine, which is an inhibitor of liver enzymes.

When taken with ethylestrenol, the anticoagulant effect increases, the risk of bleeding increases.

Adverse Reactions

Sometimes the patient's body can malfunction. As a result, the patient may experience symptoms such as:

1. Vomiting, nausea, diarrhea, constipation, toxic form of hepatitis. Sometimes a person may experience flatulence, bloating, abnormal liver function.
2. Arganulocytosis, leukopenia.
3. Violation of the kidneys.
4. Sleep disturbance, headache.
5. Discoloration of urine, fever.
6. Eosinophilia, skin rash, a sharp increase in body temperature, dermatitis, urticaria, peeling of the skin, itching.

If during the course of treatment these conditions began to appear in you, then in this case, you should refuse to take this remedy, because this drug may harm your health.

Overdose

If a person has taken the medicine in a large dosage, then the person may have an overdose.

This condition is evidenced by such manifestations as depression, pain in the abdomen / back / chest, excitability of the condition, nausea, vomiting, constipation, diarrhea, bloating, flatulence, sleep disturbance, eosinophilia, hepatitis, abnormal liver function, abnormal kidney function , headache, as well as any other manifestations of an overdose.

For treatment, the stomach should be flushed, and all measures should be taken to eliminate those symptoms that manifest in humans.

Contraindications

1. Disorders in the work of the kidneys, as well as the liver (if the disease is serious). If the defeat is mild, then you should not stop taking the drug.
2. Ulcerative lesion of the gastrointestinal tract, gastritis.
3. Malignant neoplasms.
4. Increased vascular permeability.

With increased caution, the agent can be prescribed for gynecological diseases, as well as erosion in the gastrointestinal tract.

Taking medication during pregnancy

If you still need to take this drug, then the doctor may prescribe a remedy in late pregnancy, but at the same time he must carefully monitor the patient.

It is also best to refrain from taking this drug when breastfeeding. this is due to the fact that the drug has a negative effect on a small organism.

Moreover, if it is required to take the drug during this period of time, then it can be carried out only on condition of refusal from natural feeding.

Storage

The medicine should be placed in a room where the temperature does not exceed 25 degrees. In this case, it should be borne in mind that in the chosen place it should be dark enough, cool, and also dry.

If you do not comply with these requirements, then the life of the drug will be sharply reduced. The drug must be removed to a place where children, as well as beloved pets, will in no case have access.

Price

In different countries, the cost can vary significantly. For example, we will consider two states - Ukraine and Russia.

The article presents the average price data.

Price in Russia is 120 rubles.

In Ukraine for the packaging of this drug will have to pay 65.49 hryvnia.

Analogs

Drugs similar in effect are such drugs as Plestazol, Sinkumar, Atrombone, Aterocard, Warfarin, Gedulin, Atrogrel, Acecardin, Diofindal, Agrelid, Pindion, Tromazal, Trombozol, Fenindion, Thrombantin, Phenylindandione and other drugs.

It should be borne in mind that all these drugs can have different effects on the body, as well as cost. That is why only a specialist should deal with the selection of an analogue.

HEALTH Health Pharm. company, LLC TALLINSKY HFZ JSC

Country of origin

Russia Ukraine

Product group

Blood and circulation

Indirect anticoagulant

Forms of issue

• 20 - cans (1) - packs of cardboard 20 - contour cell packs (1) - packs of cardboard 50 - cans (1) - packs of cardboard.

Description of the dosage form

• pills

pharmachologic effect

Indirect anticoagulant. It causes hypoprothrombinemia associated with a violation of the formation of prothrombin in the liver, it also causes a decrease in the formation of coagulation factors VII, IX, X, a decrease in plasma tolerance to heparin, blood lipids and an increase in vascular permeability. The effect occurs within 8-10 hours and reaches a maximum 24-30 hours after taking phenindione.

Pharmacokinetics

Clinical data on the pharmacokinetics of phenindione are limited. Cumulation is less pronounced than that of neodycoumarin.

Special conditions

The drug should be used with caution in elderly patients, with hepatic and / or renal failure, pulmonary embolism (including in oncology), erosive and ulcerative lesions of the gastrointestinal tract, with pericarditis, in the postpartum period. Treatment should be carried out under close medical supervision with a mandatory systematic study of the content of prothrombin and other coagulation factors in the blood. General urine tests are systematically performed for the early detection of hematuria. In some patients, palms are stained orange and urine pink, which is associated with the metabolism of phenindione.

Phenylin indications for use

• Prevention of thromboembolism (including with myocardial infarction, after surgery); coronary thrombosis, thrombophlebitis and deep vein thrombosis of the lower extremities; prevention of thrombosis after surgery for prosthetic heart valves (continuous use).

Phenylin contraindications

• Hemophilia, hypocoagulation, I trimester of pregnancy, hypersensitivity to phenindione.

Phenylin dosage

• 30 mg

Phenylin side effects

• From the digestive system: nausea, diarrhea, abnormal liver function, toxic hepatitis. From the hematopoietic system: oppression of bone marrow hematopoiesis. From the urinary system: renal dysfunction. On the part of the cardiovascular system: myocarditis. From the side of the blood coagulation system: with prolonged use - micro- and macrohematuria, bleeding from the oral cavity and nasopharynx, from the gastrointestinal tract, hemorrhage into the muscles. From the side of the central nervous system: headache. Allergic reactions: skin rash, dermatitis, eosinophilia, fever

Drug interactions

With simultaneous use with ACTH, the anticoagulant effect is enhanced. With simultaneous use with dipyridamole, cases of increased bleeding have been described, apparently due to a decrease in adhesiveness and platelet aggregation under the influence of dipyridamole. With simultaneous use with clofibrate, the anticoagulant effect is enhanced. It is believed that fibrates can increase the affinity of oral anticoagulants for the corresponding receptors or, possibly, disrupt the metabolism of anticoagulants. With simultaneous use with liothyronine, the anticoagulant effect of phenindione is enhanced. It is believed that thyroid hormones can increase the affinity of oral anticoagulants for the corresponding receptors. When used simultaneously with miconazole, the anticoagulant effect of phenindione is enhanced. The risk of bleeding increases.

Storage conditions

• keep away from children

Information provided

Phenindione

Composition and release form of the drug

20 pcs. - cans (1) - packs of cardboard
20 pcs. - contour cell packaging (1) - cardboard packs
50 pcs. - cans (1) - cardboard packs.

pharmachologic effect

Allergic reactions: skin rash, dermatitis, eosinophilia, fever.

Drug interactions

With simultaneous use with ACTH, the anticoagulant effect is enhanced.

With simultaneous use with described cases of increased bleeding, apparently due to a decrease in adhesiveness and platelet aggregation under the influence of dipyridamole.

With simultaneous use with clofibrate, the anticoagulant effect is enhanced. It is believed that fibrates can increase the affinity of oral anticoagulants for the corresponding receptors or, possibly, disrupt the metabolism of anticoagulants.

With simultaneous use with liothyronine, the anticoagulant effect of phenindione is enhanced. It is believed that thyroid hormones can increase the affinity of oral anticoagulants for the corresponding receptors.

When used simultaneously with miconazole, the anticoagulant effect of phenindione is enhanced. The risk of bleeding increases.

With simultaneous use with, the anticoagulant effect of phenindione is enhanced due to the slowdown of its metabolism in the liver under the influence of cimetidine, which is an inhibitor of liver microsomal enzymes.

With simultaneous use with ethylestrenol, the anticoagulant effect increases, there is a risk of bleeding.

special instructions

The drug should be used with caution in elderly patients, with hepatic and / or pulmonary embolism (including in oncology), erosive and ulcerative lesions of the gastrointestinal tract, with pericarditis, in the postpartum period.

Treatment should be carried out under close medical supervision with a mandatory systematic study of the content of prothrombin and other coagulation factors in the blood. General urine tests are systematically performed for the early detection of hematuria.

In some patients, palms are stained orange and urine pink, which is associated with the metabolism of phenindione.

Pregnancy and lactation

Contraindicated in pregnancy. Avoid using in the first days after childbirth.

Fenindione should not be used during lactation (breastfeeding).

Phenindione should be discontinued 2 days prior to initiation and should not be used during menstruation.

With impaired renal function

The drug should be used with caution in case of renal failure.

For violations of liver function

The drug should be used with caution in liver failure.

Use in the elderly

The drug should be used with caution in elderly patients.

What do they say about a drug like "Fenilin"? Feedback from doctors and patients will be considered at the very end of the article. We will also tell you about the purposes for which this remedy is prescribed, how to take it correctly, whether it has side effects, analogs and contraindications.

Composition and form

In what form is the medicine "Fenilin" produced? The instructions for use inform that this drug is available in tablets, the active substance of which is phenindione. Milk sugar, starch, citric acid and talc are used as auxiliary components.

Pharmacodynamics

What are the pharmacological features of the drug "Fenilin"? The instructions for use state that this drug has a direct effect on It is an action.

Taking the medication contributes to the occurrence of hypoprothrombinemia, which is caused by a violation of the formation of prothrombin in the liver. Also, this agent significantly reduces the formation of factors 7, 9 and 10. At the same time, it has a greater cumulative effect in comparison with neodycoumarin.

After oral administration of tablets, the concentration of blood clotting factors decreases within 8-10 hours. The maximum effect of the drug is observed after 25-30 hours.

Pharmacokinetics

Is the drug "Fenilin" absorbed into the systemic circulation? Experts say that this medication is characterized by full and fairly fast absorption. Its active ingredient penetrates the histo-hematological barriers and accumulates in tissues.

The drug is metabolized in the liver, and excreted by the kidneys (in the form of metabolites and unchanged).

Indications for use

For what purpose are Phenilin tablets prescribed? Experts say that this drug is used for both treatment and prevention. The main indications for admission are thrombosis, thrombophlebitis, thromboembolic complications caused by embolic stroke and myocardial infarction, as well as similar disorders.

In addition, the medication in question is often prescribed to prevent blood clots after surgery.

Contraindications for use

Under what conditions of the patient is it forbidden to take the drug "Fenilin"? Instructions for use inform about the following contraindications:

• disturbances in the work of the kidneys and liver;
• the initial level of prothrombin is up to 70%;
• increased vascular permeability;
• and other diseases associated with a decrease in blood clotting;
• ulcerative diseases of the gastrointestinal tract;
• malignant neoplasms;
• pericarditis.

It should also be said that the drug in question is not recommended for use at the very beginning of pregnancy, within a few days after childbirth and during menstruation.

The drug "Fenilin": instructions for use

The medication in question is used only for oral administration. Its therapeutic scheme has certain features, in this regard, this medicine should be used only as directed by a doctor.

The initial daily dose of the drug is usually 0.11-0.17 g (4 times a day). The next day, the amount of the drug is reduced to 0.08-0.14 g, and later to 0.02-0.05 g. After that, the dosage of the tablets depends on the level of prothrombin in the blood.

The maximum amount of the drug at a time should be 0.05 g, and the daily amount should be about 0.2 g.

For the prevention of thromboembolic complications, it is necessary to take 0.03 g of the drug per day, dividing this dose in half.

Therapy of acute thrombosis requires additional intake of heparin. In this case, strict control by a doctor is required, as well as a mandatory systematic study of the amount of prothrombin in the blood and other factors of its coagulability.

Treatment with the drug "Fenilin", the analogs of which we will definitely list below, is gradually stopped.

Side effects

Does Phenilin cause side effects? The route of administration and dosage of this medication must be strictly observed. This is primarily due to the fact that during therapy, the patient may experience various allergic reactions in the form of diarrhea, nausea and hepatitis. Also, according to the reviews of doctors and patients, in rare cases, headaches, fever, skin changes, and problems with hematopoiesis are observed.

Signs of overdose

In case of an overdose, patients may aggravate symptoms that are related to side effects. As a treatment for such conditions, it is necessary to cancel the drug, as well as the immediate intramuscular administration of "Vikasol", the appointment of rutin, or vitamin P, calcium chloride, ascorbic acid and general symptomatic therapy.

Drug interaction of the drug "Fenilin"

From what this remedy is prescribed, we have described above. Let's move on to additional information.

When the drug in question is combined with "Heparin", salicylates, "Cymetidine" and sulfonamides, their anticoagulant effect may increase. At the same time, anabolic steroids, Allopurinol, Azathioprine, narcotic analgesics, Amiodarone, tricyclic antidepressants, antibiotics, glucocorticosteroids, androgens, Diazoxide, Disopyramide, Isoniazid, “ Butadion "," Metronidazole "," Clofibrate "," Alpha-tocopherol "," Reserpine "," Quinidine "," Paracetamol "," Disulfiram "," Cyclophosphamide "and thyroid hormones.

Vitamin K, Propranolol, ascorbic acid, urine alkalizing agents, Rifampicin, antacids, Fenazone, Haloperidol, barbiturates, oral contraceptives, diuretics, Meprotan, ibamazepine can significantly weaken the effect of phenindione. Kolestyramine ".

With extreme caution, this drug is prescribed to elderly patients, as well as to people with pulmonary embolism, hepatic and renal failure, erosive and ulcerative diseases of the gastrointestinal tract, in the postpartum period and with pericarditis.

Treatment with "Fenilin" must be carried out under the special supervision of a doctor with a mandatory systematic blood test for the amount of prothrombin and other coagulation factors. General urine tests are also performed for the early detection of hematuria.

In some patients, while taking the drug, urine may turn pink and palms orange. This is due to the metabolism of phenindione.

The drug "Fenilin": analogues and cost

The main analogues of the agent under consideration are such drugs as "Warfapex", "Marevan", "Neodikumarin", etc.

You can buy the medicine "Fenilin" in the amount of 20 tablets for 120-140 rubles.