Infertility of unclear genes: what is it and how to treat? Infertility of unclear genesis - how to get to the truth and find the cause.

The date: 05.04.2019

The diagnosis of "infertility" sounds like a sentence. Although the medicine over the past decade stepped far forward, such a news would significantly complicate the task of a man and a woman to become parents. First, there is a survey among specialists of a different profile to clarify the reasons that caused the inability of patients to have children.

If, in the presence of innovative diagnostic methods, it was not possible to understand why pregnancy does not occur, the doctors can diagnose idiopathic infertility. It is worth noting that a few decades ago, the so-called inexplicable infertility was diagnosed about half of the marital couple accepted into the clinic.

Now the statistics are much more encouraging - only 10 percent of patients failed to find out why they had problems with conception. Such a significant improvement in the infertility diagnosis indicator has become possible due to improved medical devices and examination methods. An output for married couples, who failed to reveal the cause of unsuccessful attempts to become pregnant, was the procedure for extracorporeal fertilization (ECO).

The conditions under the diagnosis

If we are talking about women, diagnose infertility unclear origin You can, when:

the ovulation phase comes on time and regularly, which is confirmed by the results of the survey passed;
the results of the analyzes showed the presence of a normal hormonal background;
there is no endometriosis;
according to the results of the survey, the uterine pipes have normal permeability;
there are no pathologies during the examination of the uterus;
according to the results of the postcoital test in the blood, antispermal bodies were found.

Inexplicable infertility becomes diagnosed exclusively for women after passing diagnostic laparoscopyallowing to ensure the lack of problems that interfere with pregnancy, such as endometriosis.

According to experts, the number of patients suspecting infertility of unclear genes was significantly reduced after the diagnostic laparoscopy. One overseas medical Institute A study was conducted in which more than two hundred women with a diagnosis of infertility took part. Laparoscopy was carried out for the final decision, whether auxiliary technologies use or not. After it, ovulation stimulation was continued during the year. Then the patients who were diagnosed with infertility of unclear genesis, was proposed for extracorporeal fertilization (ECO) procedure.

What made the result of this study? It turned out that among 200 women suffering from infertility for unclear reasons, after laparoscopy, only a quarter of them heard the diagnosis of idiopathic infertility. The rest were revealed various stages Endometriosis, which caused problems with conception in their case.

Unlike women, men to diagnose infertility of unclear genesis, it is enough to pass a spermogram analysis, which detects the amount and quality of sperm in seminal fluid and perform a postcoital test for the detection of antispermal bodies in a woman.

With normal indicators in the above areas and regular sexual intercourse without the use of contraceptive means, specialists can already diagnose infertility of unclear genes. In this case, some pairs can decide on the ECO procedure.

Probable reasons for inexplicable infertility

Patients who have been delivered so disappointing diagnosis can be divided into 2 categories. The first group is pairs that do not have absolutely no fertility problems. The absence of pregnancy in their case is explained by the usual bad luck. Another group consists of people who have certain problems that interfere with conception, but it has not been possible to identify them yet. Reception of infertility without accurate definition The reasons that caused it is impossible.

Although the process of conceiving a child is natural for a man and a woman, his complexity is simply amazing. Even with modern diagnostic tools, it is difficult to determine why the pair can not conceive a child. After a long and unsuccessful attempts to identify the causes of infertility, many pairs are solved on the ECO procedure, which allows to defeat the shocking diagnosis.

The correct sequence of certain processes is very important. With the destruction of one of the "links" of the chain of conception, the attempts of the pair will be pregnant can not lead to anything. Consider only some errors that can manifest themselves at any stage of conception or the development of the embryo.

Lack of hormones developing an egg cell.
The appearance of defects in its formation.
Not finally matched eggs.
Error in the seizure of the eggs with a fallopye tube.
Spermochozoid could not maintain viability or activity.
The necessary biochemical reactions did not occur inside the sperm.
The embryo stopped sharing.
The embryo did not get into the uterus.
The unpretentiousness of the endometrium layer take the embryo.
Blastocysta could not attach to the endometry of the uterus.

Only some problems that are capable of emerging before and after the fertilization of the egg are named this list. Anyone, even the slightest, violation in the circuit of a set of complex events of conception may not allow pairs to become parents.

To determine which of these processes "gave failure," it would be necessary to be examined too often. And for standard Procedure Professionals take into account more obvious pathologies affecting the conception. Over time, it is possible to determine more and more violations, which increases the chances of many men and women to have children without resorting to the ECO procedure.

Eco in diagnosing infertility unclear genesis

The method of extracorporeal fertilization is already practiced enough for a long time ago and for many married couples who have heard the diagnosis of infertility, he became a "saving boat" in the ocean not justified by the expectations of the birth of a child.

What makes it possible to achieve Eco method?

get a few egg cell due to the stimulation of ovarian injections of gonadotropins;
observe the process of fertilization and the further development of the embryo in the laboratory;
make a choice of embryo having best indicators For his transfer to the uterus;
if no pregnancy has come, that is, it is possible to use frozen embryos that do not lose their properties to re-conduct an operation to transfer the embryo in the uterus.

The ECO method is pleased with the advantages of the evaluated by couples who received their kids in this way. These include the possibility at the right time to change the course of treatment or use the necessary technologies if the pregnancy has not come during past attempts. Among them is to note the technologies of auxiliary hatching and Ixi. The eco method for pregnancy in the diagnosis of infertility of unclear genesis is especially relevant for women older than 35 years, the probability of conception in which it decreases with each cycle.

What features is conception using Eco methods? Before his holding, a woman begins with the reception of hormonal drugs that stimulate the ripening of several follicles, which is not typical of the usual cycle. This is required to obtain several embryos in case of a failed conception. Such treatment continues approximately within 10-14 days, after which the follicle puncture is made.

In some cases, some procedures are performed by specialists to receive sperm. If the formation of a seed fluid occurs normally, and its extraction is impossible - it is impossible, the puncture carried out under general anesthesia is assigned.

The process of conception is made by embryologic doctors in special solutions. Further, the process of pre-impulant diagnostics follows, after which the embryo is transferred to the uterus. The latter procedure is the simplest. It does not require anesthesia and adherence to a special regime.

The disadvantage of extracorporeal fertilization methods can be called their high cost, not allowing the procedure to many people. Eco is available only to patients well-equipped clinics, which are usually in big cities. This fact also limits the availability of funds.

How to deal with infertility unclear genesis?

Experts insist on the existence of 5 ways to combat the diagnosis of inexplicable infertility. One of them we have already considered - the ECO method.

What else to do?

Waiting for pregnancy. Such an image of the action involves the refusal of a girl from all kinds of treatment and the hope of becoming pregnant in a natural way. This strategy to combat infertility of unclear genes will suit young women. If age does not allow you to wait, that is, a universal output - conception by the method of extracorporeal fertilization (ECO).
Procedure of VMI. Intrauterine insemination is made to increase the probability of conception. This indicator is achieved due to the introduction of seed fluid into the uterine cavity. The number of active spermatozoa becomes significantly higher than with natural conception. The effectiveness of the VMI procedure increases ovulation stimulation.
Using Citrate Clomiphene for Ovulation Stimulation. Such an approach helps to increase the number of eggs ready to fertilize, which increases the chances of conception.
The use of gonadotropins for stimulation in parallel with the procedure of VMI. The method is very similar to the previous one, but it is distinguished by great efficiency. Specialists insist on a 30 percent increase in the likelihood of becoming pregnant using gonadotropin ovulation stimulation. The trend of the emergence of multiple pregnancy is seen.

The output is almost from any position. Even in the formulation of the diagnosis of idiopathic infertility, a couple have every chance of becoming happy parents.

The terms idiopathic, or inexplicable infertility, infertility of unclear genes relate to a state at which, despite the conduct of a comprehensive and complete examination of a woman and a man, the reasons for such a state were still not identified.

Diagnostic conditions of idiopathic infertility

It may arise as a result of failures during natural processes such as:

Move into the vagina or in the cervical mucus of the sperm.
Maturation of the female genital cell, for example, with insufficient synthesis of hormones.
The process of the formation of the zygote, during which genetic defects may occur.
Division, or crushing, fertilized egg, which is absent for incomprehensible reasons.
The division of germinal blastomers and the implantation of the embryo.

Thus, infertility of unclear genes can be established only by eliminating various all kinds of reasons after all necessary surveys, the results of which were without deviations from the norm. The eligibility of such a diagnosis is recognition limited opportunities Reproductive medicine on modern stage its development.

Certificate of this is the statistics of different years, on the basis of which it can be argued about the improvement, but still insufficient perfection. So, for example, the number of diagnoses "idiopathic infertility" for about 30 years ago was installed almost 50% of married couples who were about infertility. All subsequent years, this figure is constantly reduced and is currently about 10-20%.

This state can be primary and secondary. Under the first one refers to the lack of conception in history for unknown reasons. Secondary infertility of unclear genesis is a diagnosis that is established by a woman in the event that she has already had at least one pregnancy. Such women have more often to identify the cause and choose the medical program.

The diagnosis is based on the presence of relevant criteria, that is, on the obvious absence of all current reasons. These criteria in women are:

The presence of a regular (monthly) in the middle of the menstrual cycle, which is confirmed by functional diagnostic tests.
The absence of any visible disorders of phallopy pipes.
Normal results of the hormonal status studies corresponding to certain days of the menstrual cycle.
When conducting an ultrasound study, the endometrium thickness is normal, and its structure corresponds to the periods of the menstrual cycle.
No disorders of the anatomical structure of internal genital organs, including the absence of myomatous nodes, polyps, etc.
The absence of infectious pathology, especially diseases that are transmitted in sexual means.
Positive results .
No antisperm anti-sphermal antibodies in serum.

In addition, a physician cannot be installed such a diagnosis, if a woman was not conducted laparoscopic diagnostics, since some pathological conditions can be detected only by this method. Diagnostic laparacopy with infertility of unclear genesis allows diagnosing deformation and obstruction uterine pipes, safety process In the small pelvis, the presence of tumor-like formations and, especially, the presence of endometriosis. Often, measure involuntarily becomes therapeutic, because even if the reason does not find out, approximately six months after a woman's procedure, conception is possible.

Criteria related to men is the absence:

Pathological changes and processes in reproductive bodies.
Any deviations from the norm in, for example, from normal quantities and / or morphological structure, mobility, etc.
Sex tract infections, including sexually transmitted diseases.

General conditions for the married couple:

The absence of chronic somatic diseases.
Lack of narcotic and alcohol addiction.
The frequency of sexual intercourse is sufficient for conception for at least 1 year.

If not detected, in fact, no pathological deviations, then what, after all, maybe the reason for the impossibility of pregnancy and what to do next?

Possible causes of state

The more thoroughly the family pair is being examined, the greater the probabilities of detecting the cause. Most frequent reasons The following factors may be.

Minor not determined existing methods, Change structural structure Uterine pipes

The consequence of this may be the insufficient activity of Fambry and the absence of the process of the seizure of ochetics after the ovulation process, is not enough active or the absence of moving an egg cell fallopyeye tuber In the uterine cavity due to the violation of the function or the destruction of the tube-sized epithelium.

Infliction of lutein phase

The yellow body forming on the site of the follicle after the exit of the egg () produces progesterone, which is involved in the preparation of endometrials to the implantation of the fertilized egg. The absence of this or to other reasons for the synthesis of the yellow body of a sufficient amount of progesterone leads to the absence of adequate preparation of endometrial and implantation process.

Processes of premature luteinization

At the same time, the transformation of the follicle in the lutein body occurs before ovulation, as a result of which the egg cell is not freed from the follicle, that is, the ovulatory phase is absent.

Inferiority of egg cell

The factor of the quality of the genital cell is one of the main factors of fertilization and successful. Despite the fact that the ripening of eggs occurs in the norm, almost every month, but not every one comes to perform fertilization and embryonic development. The inferiority of the female genital cell may be due to incorrect form Or sizes, incomplete chromosome and other (often unknown) causes.

The presence in the body of infections, especially vaginal and sexually transmitted

Their particles can exist in the body in such minor quantities, which are very often impossible to immediately detect the currently existing methods.

Immunological factors infertility

Among the listed and rarely detected causes, the leading place is currently allocated to immunological factors, which includes such basic components as:

antiphospollipid antibodies that cause damage to cell membranes;
the presence of antibodies to the receptors of thyroid hormones or to hormones themselves;
the presence of anti-spermal (sperm of the husband) antibodies that reduce the ability of sperm to merge with an egg or / and the degree of their activity;
violation of the hormonal regulation of the menstrual cycle due to the presence of antibodies to the ovarian tissues;
excessive activity of large granular lymphocytes (natural killers), which are special cells of the immune system;
the presence of antibodies to the gonadotropic pituitary hormones involved in the regulation of the synthesis of sex hormones;
excessive immune reaction on chorionic gonadotropin, which is an ovulation stimulator and participates in the normalization of implantation of a fertilized egg;
the relativeness of the structure of the structure of the GKGS (in cases of the presence of a significant number of identical fragments process immune protection The embryo is broken, resulting in its damage to the maternal immune system, the embryo dies on the most early stages development).

Also for reasons should include:

various anomalies of male sex cells that can not always be detected as a result of a laboratory study, and the sperm seems normal;
change of the genetic material of spermatozoa or / and egg cells;
incompatibility for immune factors at one of the steps of fertilization and implantation processes;
premature aging of a woman's body, accompanied by early (long before the start of menopause) exhaustion of ovaries, in which the genetically determined content of the amount of oocytes in them is significantly reduced, that is, a decrease;
the negative effect of stress factors on the central nervous system, which can lead to a violation of the regulation by the function of reproductive organs.

Treatment of infertility unclear genesis

Most families of family planning centers believe that if it is impossible to establish the reason for their infertility, then medicine is not able to help them. However, such a judgment is incorrect. Patients are offered to choose from various options.

Expectant strategy

One of these options. He involves the continuation of attempts independent conception without any special treatment. According to various sources for 5 years, pregnancy is still occurring in 30-60% of married couples. However, when making such a decision, the spouses should take into account the duration of the absence of pregnancy. The more this period, the less hope for the development of independent conception. After a 5-year period, it is possible no more than 10%.

The campaign strategy is suitable mainly to persons. young ageSince the number of oocytes in women on average at the age (after 30-35 years) begin to quickly decline. There is also a constant deterioration in the quality of egg cells, since the number of defects increases in their genetic material. Therefore, women over 30 years old from such an option is better abandoned.

Intrauterine insemination with stimulation of ovarian function

The method of intrauterine insemination is applied for a very long time. Its essence is in the introduction of sperm into the cervical channel or in the uterine cavity, which allows you to pre-select the most suitable spermatozoa (). However, effectiveness in cases of inexplicable infertility is very low. It increases significantly (on average by 30%) when combined with ovulation stimulation nonteroid drug Clomiphene citrate (clostilbegit, clomide) or with follicle-sustamulating hormone.

Intrauterine insemination

The technique is empirical. It is based on the assumption that stimulation of the ovarian function contributes to an increase in the number of genital cells, of which at least one is mature and ready for fertilization. Thus, it is possible that stimulation with insemination is somehow accidentally able to correct non-discovered disorders of ovulation or poor quality eggs. At the same time, one of the disadvantages of the method is a high degree of probability of development of multiple pregnancy.

Eco (extracorporeal fertilization)

Analysis of world scientific literature suggests that Eco with infertility of unclear genesis provides significant opportunities to achieve pregnancy, which make up 20-70%. Such statistical oscillations are due primarily to the age of women.

Eco technology is highly effective due to the fact that it gives sex cells the opportunity to avoid a significant number of obstacles that are quite a few in the body of a woman and men, even in cases where existing methods identify these obstacles and correctly determined the diagnosis is not possible.

Infertility is a common problem among both men and women. In the treatment of infertility, it is important to eliminate its cause. That is why infertility of unclear genes, called idiopathic infertility, due to the lack of certain reasons is difficult in treatment.

What is idiopathic infertility

At the beginning of the 20th century, cases of diagnosis of rapid infertility were much more than today. This is due to the fact that there are currently many diagnostic methods have been developed, therefore, much more infertility is amenable to explain and subsequent treatment. Moreover, more and more of his new reasons will be opened, which made the diagnosis of "infertility of unclear genes" rarity.

This diagnosis is made in the event that two healthy partners with regular sexual contacts for a long time Can't conceive a child. Doctors do not exclude elemental badness as the cause. In most cases, infertility of unclear genes explain the genetic incompatibility of partners, but this problem has been little studied on this moment.

Causes of infertility of unclear genesis

It is impossible to speak definitely about the causes of idiopathic infertility, since his name speaks for itself: there is no clear causes of such infertility. If infertility is unreasonable, make it possible to understand information about the state of the health of partners and the time interval, during which attempts to conceive the child were performed. If no barriers to conception are observed and it does not occur for such a long time, it is impossible to explain the failure of the failure or coincidence, it remains to talk about infertility of unclear origin.

Track the reasons for which the conception does not happen is difficult. This is due to the fact that to conceive the well-coordinated work of physiological and hormonal processes, and if at least one of them is accompanied, pregnancy may not come. Diagnose such cases is quite difficult, and in this situation, doctors are diagnosed with idiopathic infertility.

The main difficulty of treating idiopathic infertility is related to the fact that the reasons that need to be eliminated are unknown. But medicine is in a state of permanent development, so there are fewer cases of unfortunate infertility. It is hope for women who cannot become pregnant for obscure reasons.

At the moment, the following potential causes of idiopathic infertility are distinguished:

not previously identified pathology in one of the potential parents;
rejection of embryo endometrial due to immunological disorders;
genetic disorders that prevent fertilization or development of the fetus;
genetic incompatibility of partners.

Medical statistics have the facts when absolutely healthy partners who failed to conceive a child in the future successfully do it with other partners. One of the indirect evidence of genetic incompatibility becomes unsuccessful ECO procedures.

Symptoms and signs

To judge the reasons for infertility of unclear genes is partly impossible due to the fact that there are no certain symptoms and signs. Results of research, analyzes and other diagnostic events Do not detect pathologies. And the symptom of infertility of unclear genes is only one - the absence of pregnancy.

It is possible only to understand that there are some deviations, according to the available statistical data. If after two years of constant attempts of conception and stable sexual life of pregnancy, it is safe to talk about unfortunate infertility. If it is impossible to conceive a child throughout the year, thinking about this diagnosis early: this is just a reason to be examined in detail at the gynecologist and the reproductologist.

Diagnostics

The diagnosis of infertility of unclear genesis is reduced to the exclusion of well-known causes that are eliminated by targeted treatment. For infertility diagnosis, the following surveys are needed:

Full medical examination of the pair

Problems with conception most often are provoked by the poor health of health, and they must be excluded first.

Postcoital test

It is carried out to assess the mobility of sperm in the cervix.

Analysis on antispermal antibodies

Antispermal antibodies contained in the blood of a woman interfere with the conception of the child.

Analysis on ovulation

If there is no ovulation, the conception cannot happen.

Infection analysis

If they are detected, it will be enough to just cure.

Analysis on hormones

If irreversible work endocrine Systemshormonal processes needed for conception do not occur.

Resects possible mechanical obstacles to conceive - for example, an anomalies of the structure of reproductive organs.

Colposcopy.

It is assigned to eliminate endometriosis and other endometrial pathologies that interfere with successful conception.

Test on genetic diseases and similarity of antigens

In some cases, conception may not occur due to the presence of genetic diseases and the genetic incompatibility of spouses.

Infertility is recognized as unprecedented if the above studies have not revealed any deviations and pathologies.

Treatment of infertility unclear genesis

Treatment with a given diagnosis is difficult, but perhaps, and even with a positive result. In case of infertility of unclear genesis, the doctor seeks to exclude even the most minor pathologies, which normally do not interfere with the conception. With rapid infertility, the following treatment methods are used:

Surgical

When infertility of unclear genes, surgical dissection of adhesions and pipe cleaning are carried out even if there are no direct readings. The slightest spikes or insignificant obstruction, as well as other deviations are eliminated by laser and other methods of surgery.

Partly surgical procedure You can call Eco (extracorporeal fertilization). In this case, the seed fluid is delivered to the uterus using a medical instrument. If eco helps become pregnant, you can judge the imperimental of spermatozoa to the egg during the natural process.

Medicate

For infertility of unclear genesis, drug treatment is carried out according to the usual infertility scheme. It is impossible to use all types of drug treatment at once, therefore, it is fully responsible for the doctor.

For example, the absence of pathogenic flora and other signs of genital infections does not yet mean that they are not. Therefore, appropriate therapy may be appointed, aimed at the treatment of hidden diseases.

But most often held hormonal therapywhich is most effectively able to increase the possibility successful conception. Hormone therapy has a beneficial effect on the endometrium state, which contributes to the successful attachment to the embryo it.

Also K. medical therapy Believe the stimulation of supervision, which is prescribed before conducting Eco for a successful conception. In this case, hormonal therapy creates a larger load on the body of the woman, therefore it is considered to be extremely measure. Actually, the elecorporal fertilization itself - the last chance to conceive a child for those who cannot do it natural way.

Combined

This is the most common treatment method, which involves the use of a complex of drugs containing hormones, vitamins and promoting immunity to strengthen. Comprehensive therapy It has an impact on all system systems and significantly increases the chances of conception.

During combination therapy, it is strongly recommended to track ovulation and continue attempts to conceive a child.

Narodi

Like anyone traditional medicine, popular treatment Not the most effective way. In itself, such treatment is not able to bring positive results, but can increase the efficiency of other methods with accurate follows of the recommendations of the doctor. Should be discussed such therapy with his doctor also for the reason that folk Methods They have their own contraindications - for example, with individual intolerance of the components, they are even harmful.

IN folk medicine The salary and sea buckthorn, plantain beams are used. They can be used in a complex with the above treatment methods in the absence of contraindications.

The results of the treatment of infertility of unclear genes largely depend on the qualifications of the doctor, so the question of choosing a clinic or reproduction center is especially important.

It is known that a befriended marriage for most families is a tragedy. After unsuccessful attempts to conceive a child, the couple usually appeals for medical help. But it happens that even thorough examinations cannot explain the causes of failures ...

What is infertility?

Infertility is usually determined as a lack of pregnancy in the family within 1 year after the start of regular sex life without protection.

Term - 1 year - it is determined statistically: it has been proven that 30% of healthy marital couples pregnancy occurs in the first three months of living together, still in 60% - for subsequent seven, the remaining 10% - in 11-12 months after the start of sex life . Thus, a year is a sufficient period in order to evaluate the ability of a pair to conceive and in the absence of pregnancy to talk about infertility.

Infertility does not apply to one person, but to a couple of spouses, and it is more correct to call this condition a fruitless marriage. In about a third of cases, the childbody function (fertility) is reduced by her husband, and the wife. And, on the contrary, in 20 cases out of 100, both spouses may have perfect indicators reproductive function, and pregnancy still does not occur.

Speaking of infertility, it is necessary to designate the "primary" and "secondary" infertility. Primary - if a woman has never had pregnancies. Secondary - if a woman had at least one pregnancy.

If the cause of fruitless marriage is certain violations in the body of a woman, they talk about female infertion. The male factor is the cause of a fruitless marriage if a woman is healthy, and a man has a sharp decrease in the fertilizing sperm ability. With a combination of female and there is a combined form of infertility. In the case when both spouses are found normal indicators Reproductive function, however, special samples indicate their incompatibility, the latter is considered as a special form of a fruitless marriage, requiring a special approach in determining the tactics of treatment. Finally, infertility can meet both completely healthy and well-compatible married couples. In such cases, even a complete and in-depth examination does not allow to determine its cause. Then the diagnosis of infertility of unclear origin, or idiopathic infertility is made.

Mechanism of conception

"The stock" of eggs is determined already at the birth of the girl, it is about 400 thousand. During one menstrual cycle (from the first day of one menstruation until the first day of the next day) in one of the ovaries, as a rule, one egg-cell ripens. After the exit of the egg from the ovary (ovulation), which occurs in about the 14th day of the menstrual cycle, a yellow body is formed in the ovary. It highlights hormones (gestagen), preparing the uterus for the introduction of the embryo, and in the case of a successful conception - preserve pregnancy. The role of Gestagennes in the first trimester of pregnancy is especially great.

From the ovary, the egg cell falls into abdominal cavity. Next to each ovary there is an ovage - Fallopiev (uterine) pipe, in the funnel of which should get the egg thanks to the movements of the uterine tube ciliary, which "capture" an egg cell (she does not have the ability to move). For 6-7 days, the egg cell due to the cuts of the fallopian tube should overcome the distance from the funnel to the uterus at 30-35 cm. In ideal conditions Fertilization occurs while the egg is in the upper third of the egg. After ovulation, the eggs retains vitality about 24 hours.

Required research during infertility

Traditionally, this diagnosis is made only after all methods of examination and in the absence of any pathology. Surveys should include a number of methods.

Evaluation of the quality of ovulation (exit of eggs from the ovary). This study requires:

hormonal examination - At certain days of the menstrual cycle, a woman gives blood to various groups of hormones reproductive systemThe doctor assesses the levels of these hormones and the ratio of them between themselves (in the group);
at certain days, the cycle conducts ultrasound of the small pelvis organs, ultrasound monitoring of follicles (bubbles in which eggs ripen) and endometrial (inner layer of the uterus) - tracking the growth of follicles and their gap (ovulation) with the help of an ultrasonic apparatus. This study allows you to establish whether ovulation occurs and when it occurs (for the occurrence of pregnancy, it is necessary that it was in the middle of the menstrual cycle).

Study of the readiness of the endometrial to the adoption of a fertilized egg. This is a combination of ultrasonic studies of the state of the uterine mucosa in the second (secretory) cycle phase with a histological (under a special microscope) by studying the endometrium cells obtained using a papel biopsy (a small piece of the inner layer of the uterus in the outpatient conditions, without anesthesia). Normally, certain changes should occur in endometrials in the middle of the cycle in order for a fruit egg to be embedded there.

Evaluation of the patency of the uterine pipes. The study includes:

sonogisterography — ultrasound procedure With preliminary administration to the uterus in the catheter of the saline. In addition to the patency of the uterine pipes, this study allows you to see various pathology uterus (abnormalities of the structure, tumors, etc.);
Methods for solving the problem of infertility

Without finding any deviations in reproductive Health Couples with a full traditional examination, it is offered a scheme attempts to achieve fertilization. This scheme includes ovulation stimulation, intrauterine, extracorporeal fertilization. These technologies can be applied in different combinations.

Stimulation of ovulation. So called use medicinal preparations To obtain several mature eggs at once during one menstrual cycle, which increases the chances of fertilization. Ovulation stimulation can be repeated for 3-6 menstrual cycles. Intrauterine insemination (VMI). In the natural cycle or on the background hormonal stimulation Ovulation during the period of ovulation, a pre-prepared sperm of her husband is introduced. Artificial insemination is carried out 2-3 times during one menstrual cycle. Extracorporal fertilization (ECO). This method includes the fertilization of the egg, obtained by a woman, a sperm of her husband in laboratory conditions, and the subset in the subsequent fertilized egg in the uterus.

In the conditions of compulsory medical examination inspection necessary to determine the cause of infertility are free. However, not all health care facilities have the equipment required for the survey, and then the woman is sent to larger centers or is being examined in commercial medical centers, ovulation stimulation and intrauterine insemination is also possible in compulsory insurance. The procedure of extracorporeal fertilization only in some regions of the country may be free for a sufficiently limited number of patients.

Tatyana Kubjev, doctor obstetrician gynecologist,
gynecologist-Endocrinologist, Moscow

Discussion

From reading an article there is a feeling of squeamishness.
11/22/2008 11:41:43, Kira
Comment Article "Without visible reasons. Infertility of unclear genesis"

To whom, for what and why it is time to make an appointment with a doctor, you will learn from an interview with a reproductologist, a gynecologist-an endocrinologist, an andrologist of the medical center Natalia Sergeyevna Melnikova. If a woman does not have health problems, is there a need to visit the reproductologist? Infertility is such a disease when nothing hurts, but it is very painful. Unfortunately, the woman herself does not know that she has this problem. She does not bother her, and she thinks that if ...

Discussion

When you hear the word-infertility, it's scary, you realize that you can't give life to a small little man and become a mother. Thank you to someone who came up with Eco !!! And thank you to those people who give the Eco method to life. And I survived it! And I want to say More to women who are already desperate and tired of fighting, try everything to the last !!! After all, being a mother is the most important thing in the life of every woman.
And helped me here

The press conference dedicated to the tragic cases of the death of babies selected from mothers was held on November 19 in IA REGNUM. Olga Nikolaevna and Taisia \u200b\u200bKhargchenko from Chelyabinsk - Grandma and Mom Girls, who, at the end of October, were taken by deception from the family in the hall. Olga Nikolaevna (in the photo) told (from 01:09:49) that what happened in their family is very similar in cases of the families of thin and Nazarov. Let me remind you - a 3-month-old Rodion of subtle and 5-month-old Nazarov died ...

Discussion

Hello. I understand you perfectly. I can advise you as the Ascension Julia. This is a doctor gynecologist reproductist. Very sensible man. Works in the clinic can safely handle. Health to you and your family.

Yeah, your story is something like our, it is very important not to break and believe and hope, then everything will be easier or late and you will come to this moment when you kiss your happiness in the top! Doctors from the clinic "Alliance Frances" who supported not only morally and helped get pregnant and endure a child

Lymphadenopathy is an increase in sizes, as well as a change in the shape of one or a whole group of lymph nodes. various origin, without signs of inflammation. A person has about 600 lymph nodes. Normal dimensions Up to 1 cm. More often the cervical, axillary, inguinal, as well as intra-abdominal lymph nodes increase. Performing a protective role the lymph nodes One of the first to rise in way of the spread of infections and other alien antigens (allergens, tumor cells, etc.). Before reaching ...

Dry coughing in adult, its treatment and prevention require special attention. The reason for this symptom is not a sputum, but irritation of cough receptors located in various sections. Dry cough begins to disturb on the background inflammatory processnegative impacts. Therefore, if a dry cough in an adult is detected, the treatment is selected comprehensive taking into account the causes of the occurrence. At the same time, medications are used that can influence the cough reflex. Such treatment ...

Discussion

I think everything depends on the case. When light shames - then the chamber can be drunk or soul, and if it is serious - it is necessary normal drugs. If the cough is dry and even attacks - get together above the child, give him a real medicine!

I also believe that it is better to take syrup with a well-known composition and a well-known action. The grass is generally incomprehensible as the body can affect, I, for example, the anaphylactic shock has been, in Pete fell. I usually pay attention to how old you can give the drug - if it is allowed for use in very small, then it seems to me that it is safe. Kids than having to be treated will not.

And then the diagnosis - you have infertility of unclear genes. But at the very case, not everything is surveyed. When she was infertility, the reasons were: one (total) impassable tube and there are no necessary hormones. Apparently, they sought.

Discussion

sometimes it happens. Are you sure that everything is normal in the medical unit? And how is the husband? We, too, we all wondered, the gynecologist said that yes, there were problems, but you can get pregnant. And then they decided to take advice in the eco-clinic, it turned out that her husband had practically no mobile spermatozoa. They relied the spermogram in different clinics, the verdict was confirmed. We did Eco as a result of the Nova-Clinic and thank God, which went on time, a little more, and after all, the gods could not stay at all. And so, we are going to cryo, for the second

Maybe you can relax and for one thing to ventilate in the good sense of the word) on vacation will often be pregnant)

1. "Alphabet" - 4 hours. 2. "Working with a dictionary" - 4 hours. 3. "Thoughtful and conscious reading under paragraphs" - 7 hours. four. " Oral speech" - 7 o'clock. 5. "Written speech" - 12 hours. Total - 34 hours. The program "Alphabet", the main events. 1. Acquaintance with the goals and objectives of the program. Alphabet from A to Ya. (1 level) Game "Alphabet" - 1 hour. 2. Publications and consonants in alphabetical order (2 levels) The game "Alphabet" - 1 hour. 3. Compliance with the letter (3 level) game "Alphabet" - 1 hour. 4. Alphabet from me ...

Do you think you need a child to listen to you? Communicate, everyone can scream and punish. But find an approach to the baby, and to achieve obedience to peaceful ways, not everyone is given. But I have good news for you! The problem of child disobedience is solved! Elena Pyatnitskaya, in his free online training "Little" disobedient "or 5 simple steps to the good behavior of your child" reveals all the secrets of the impact on the naughty in harder [link-1] after passing the course ...

Without visible reasons. Infertility of unclear origin. Infertility does not apply to one person, but to a couple of spouses, and it is more correct to call this state today in Russia without the help of doctors can not have children 10-15 ...

Discussion

Look in the internet reviews on Shaharatova Irina Aleksandrovna. She works in Zhulebino in the clinic and plus somewhere in the center of reception leads. According to reviews a good adequate doctor. Just engaged in infertility. Och nice woman and competent doctor. :)

I observe at Sukharevskaya in Evromeda, Arlashina Olga Anatolyevna, this is a borrowing. I know that they specialize in misunderstanding and froze. I know that in infertility they will examine, but I can't say anything about infertility, it was not interested on this issue. I want to congratulate you very much, you need to find a good doctor, let you all be fine

One of my favorite books is the Roman Bulgakov "Master and Margarita". There are several reasons for it. First, I was attracted by an unusual, mystical plot. On the one hand, the action takes place in perfectly real life. They have any fictional worlds who love scribe writers, but who personally do not cause interest. Mysticism in Bulgakov's novel, I would say folklore: demons, witches, speaking cats - all this is like that from pages of Russian fairy tales. With the other side ...

Actress Marcia Cross, who played the red-haired "desperate housewife" of Brie, dreamed of becoming a mother for almost 10 years. The desire of the actress was so great that she even tried to conceive with the help of donor sperm. But in 2005, Marcia Cross met the exchange broker Tom Mahoney, almost immediately married him - and for the next year, passing the procedure of extracorporeal fertilization, twin girls gave birth to girls. Despite the fact that the pregnancy proceeds hard, the chart of filming the third season ...

Causes of infertility in women and men

Without visible reasons. Infertility of unclear origin. With a combination of female and male infertility, a combined form of infertility takes place. Osteopathy and infertility treatment. Male "infertility": causes and forms.

Hello everybody! I have long wanted to register here and now I am with you! But I can't understand how the forum is arranged? Something I got lost :(

Infertility - lack of pregnancy for 2 years and more in a woman of childbearing age, regularly living sexual life without use contraceptives. Infertility can be primary if the woman had no pregnancy, and secondary, if earlier pregnancy was. There are also absolute infertility, in which in the body of a woman there are irreversible pathological changes that impede conception, and relative infertility, when the reasons for infertility can be ...

Infertility does not always have an obvious medical cause. If these surveys show that everything seems to be normal, and pregnancy does not occur, then it is possible functional disorders. In this case, it is worth contacting osteopath. Under the course of treatment is necessary not only future mom, but also to the future dad. As a result of treatment, blood circulation in a small pelvis, the functions of nervous and endocrine systems, and the likelihood of pregnancy will increase by an order of magnitude. And of course...

Discussion

The competent doctor knows that the occurrence of pregnancy and the prosperous tooling is possible in the case of a general balance in the body: this concerns not only endocrine and nervous system. Each person has the reason for infertility individually and, indeed, is caused by completely unusual problems (unusual from the point of view of doctors - gynecologists). But, real osteopaths are rarely rare :))

Osteopathy has proven itself in the treatment of various diseases. Every year, millions of patients around the world turn to osteopaths, because traditional medicine could not solve their problems. How can Osteopath help? Consider the most common cases: painful monthly. Often women celebrate pain at the bottom of the abdomen or back in the first days of menstruation. Usually use painkillers and suffer. But actually pain is alarm signaltalking about problems in the body and ...

Nowadays, infertility is not a sentence. The most important thing is to find have a good specialistwho can help.

Sometimes even full examination Both spouses do not give objective reasons for infertility. This situation is called - infertility of unclear genes. In this case, specialists, even with the help of the most modern methods, Can not reveal the reasons for the impossibility of having children.

According to modern scientific research Infertility of unclear genes bind with with pathologies of egg cells or sperm, which can not be recognized. But medicine does not stand still and today a similar diagnosis is made only in a 10% case.And 40 years ago - it was almost half of those who applied for the help of married couples.

There are also such cases as secondary infertility of unclear genesis. They are stated when the woman was already pregnant, at least once. The final diagnosis is made only after the entire research complex for both spouses.

There are a number of criteria in the presence of the diagnosis of:

the woman does not work get pregnant during the year, with regular sex certificates;
the man has indicators normally, there are no other pathology;
the woman is regular menstrual cycle (25-35 days), timely ovulation;
hormonal background indicators within the normal range;
on the ultrasound showed the absence of endometriosis, pathologies of the uterus and ovaries;
the absence of antispermal antibodies;
the absence of antibodies to chlamydia.

In this video, the doctor will tell that such infertility is unclear origin:

In some cases are assigned additional examinations Both spouses, or resort to artificial fertilization. In this case, a specialist with the help of a microscope will be able to observe the behavior of the egg and spermatozoa, and the further development of the embryo.

Not always in the ECO process, it is possible to determine the reasons for infertility of unclear genesis, but extracorporeal fertilization will help solve the problem, overcoming infertility.

What to do with this form of infertility?

The diagnosis of unclear genesis is placed in the case when in the absence of obvious causes a woman cannot become pregnant for a long time. Often, in this case, the spouses have no visible violations in the functioning of the reproductive system. AND existing problems It is extremely difficult to diagnose.

Infertility is unclear itezes because it is unclear that it is very difficult to determine the cause or impossible.

At the initial stage, all the forces should be aimed at obtaining their own sex cells, and only as a last resort are used alternative options. When infertility unclear genes are recommended:

Refrain from alcohol consumption, cigarettes. Really exclude coffee from the diet.
In the presence of excess weight It is worth losing a little, or to gain weight when it is shortage ( minimum weight 44 kg., And the maximum 89 kg.).
Course of reception special preparationsprescribed by the doctor.
Conduct artificial insemination.
Procedure artificial fertilization — .
Using donor: sperm, eggs, embryo.

Types of treatment

Treatment primarily begins with comprehensive examination Family couple. This is necessary to determine the optimal method of treatment. Then there is a table with a list of necessary surveys that need to pass a man and a woman.

A complete list of surveys that need to pass.

Infertility treatment with unclear genesis

Often, the treatment of infertility with an unclear genesis is appointed for women older than thirty years. This is due to the fact that women under when conducting regular sex life, pregnancy may occur naturally. Experts give the likelihood of such an outcome about 10%.

But in the case when a woman is over 35 years old, the chances of a pregnancy naturally falling every day. Therefore, it is often assigned to the reception of hormonal drugs, to stimulate the body. In parallel with the reception of hormones is carried out artificial insemination. It is believed that the chances of the pregnancy of pregnancy rises.

Extracorporal fertilization

The ECO procedure often contributes to successful overcoming infertility with an unclear genesis. It is considered the most effective way to treat or overcoming infertility (including infertility of unclear genesis). With an extracorporeal fertilization (ECO) on the spermatozoa path to the egg, barriers do not occur.

Conception and subsequent pregnancy in Eco will be successful in 50% of cases.

Unclear genes is detected by prolonged and thoroughly examining both spouses. And often is the main reason for the impossibility of conceiving a child. But comprehensive treatment Or the procedure of artificial fertilization can help solve this problem.

Do not give your hands, the main thing to believe that everything will work out. If you get pregnant in a natural way, it will not work - you will definitely help Eco.