The antiviral agent isoprinosine. Isoprinosine tablets: instructions for use

Date of: 05.03.2020

Latin name: Isoprinosine
ATX code: J05AX05
Active substance: Inosine pranobex
Manufacturer: Teva, Israel
Pharmacy leave condition: On prescription
Price: from 284 to 1920 rubles.

"Isoprinosine" (500 mg) is an immunostimulant drug that has a complex effect, has antiviral characteristics, is used with therapeutic purpose and for the prevention of ailments provoked by the herpes virus.

Indications for use

Therapeutic therapy, as well as prevention using the drug "Isoprinosine" is indicated for a number of ailments and pathological conditions:

Viral infections, as well as the flu
Diseases of infectious genesis, provoked by herpesvirus type 1-5 (treatment of herpesvirus types 6, 7 and 8 is possible), as well as herpetic keratitis
Chickenpox, shingles
Exacerbation of measles symptoms
For mononucleosis caused by specific viruses
Cytomegalovirus infection caused by herpesvirus type 5
Papillomavirus or the so-called HPV, which manifests itself as fibrous papillomas of the larynx
Polyps of the cervical canal
HPV of external and internal genital organs in both women and men, therapeutic therapy to get rid of warts.

Compound

Each tablet of the drug "Isoprinosine" from "Teva" contains 500 mg of the main active ingredient- inosine pranobex. The preparation contains a number of auxiliary components.

Medicinal properties

The drug "Isoprinosine" (500 mg) is considered an artificial derivative of purine, stimulates the immune system, has non-specific antiviral properties.

Thanks to the use of this drug, it is possible to restore lymphocytic function during the course of an immunosuppressive state, increase blastogenesis in a population of monocyte cells, as a result of which the process of expression of membrane receptors that are outside of T-helpers is activated. In addition, the main component of "Isoprinosine" (500 mg) prevents a decrease in the reaction of lymphocyte cells in the case of the action of drugs from the group of glucocorticoids, and contributes to the normalization of intracellular thymidine.

"Isoprinosine" from "Teva" is active against such a virus as herpes simplex, pathogens of measles, cytomegavirus A and B, poliovirus, ECHO virus, human T-cell lymphoma virus (type 3), equine encephalitis, as well as encephalomyocarditis and other types of viral infection.

The antiviral effect of the drug is due to the inhibitory effect on the RNA of the virus itself, as well as the enzyme dihydropteroate synthetase, which is involved in the synthesis of a number of microorganisms. Along with the detrimental effect on RNA pathogenic virus, increases the production of interferons (α and γ), which have a pronounced antiviral effect.

The main active ingredient of the drug is quickly absorbed by the mucous membranes of the gastrointestinal tract.

The highest concentration of the main active substance - inosine pranobex in plasma is observed 1-2 hours after oral administration.

Metabolism proceeds with excretion uric acid, the process of excretion of metabolites is carried out by the kidneys for 48 hours after the administration.

The average price is from 300 to 1900 rubles.

Release form

Tablets "Isoprinosine" whitish-cream shade, convex, have a barely perceptible amine flavor, packed in blisters of 10 pieces.

The carton may contain 2, 3 or 5 such blisters of "Isoprinosine" (500 mg).

Mode of application

Isoprinosine by Teva is taken orally with a small amount of water (better after a meal).

Usually, the daily dosage of "Isoprinosine" for adults, as well as children from 3 years old, is calculated taking into account body weight (with a weight of 20 kg, the dose of the drug is calculated as 50 mg - 1 kg). Children and adults are often prescribed to drink Isoprinosine tablets immediately after meals three or four times a day.

Adults for treatment and prevention are recommended to take the drug at a dose of six or eight tablets throughout the day, for children preschool age(from 3 years): it is recommended to drink ½ tablet per 5 kg of the child's weight - daily dose"Isoprinosine" - 0.25.

In case of urgent need and with a complicated course of ailments of an infectious nature, it is possible to increase the daily dosage of "Isoprinosine" for both a child and an adult with the calculation of 1 kg - 100 mg of the drug, should be given in equal portions from 4 to 6 times. The course of treatment recommended for children and its duration is determined by the attending physician.

For elderly patients, the highest daily dose of Isoprinosine in (g) is 3-4 g.

With SARS, influenza

During treatment, as well as the prevention of acute ailments (with SARS, colds, flu), the course of therapy for patients of all ages is 5-14 days. After the complete disappearance of signs of SARS and influenza, it is recommended to continue therapy for adults and children for about a couple of days. The course of treatment for SARS and influenza (swine) for children and adults can be extended if the patient's condition is monitored by the attending physician. During therapy, an antibiotic may be prescribed.

For chronic ailments, including tonsillitis

In the case of the prevention of chronic ailments (in particular tonsillitis) with frequent relapses prescribe several courses of treatment lasting from 5 to 10 days, each subsequent course is best done with an interval of at least 8 days.

Supportive medical therapy chronic diseases, including tonsillitis, can be carried out using a reduced daily dosage (500 mg or 1000 mg, which corresponds to 1 or 2 tablets). The course of treatment is 30 days.

With herpes

The drug "Isoprinosine" from "Teva" quite effectively treats herpes infections. When a herpes virus is detected (including chickenpox), adults and children are prescribed therapeutic therapy, which lasts 5-10 days, until all the symptoms of the disease completely disappear. Prevention of recurrence of the herpes virus during remission should last 30 days with the use of a daily dose of Isoprinosine (1 g), which is divided into 2 doses.

For human papillomavirus (HPV)

With the human papillomavirus (HPV), the daily dosage for adults is 6 tablets. Usually prescribed to drink 2 tablets. three times during the day. Calculating the dose to a child in the treatment of human papillomavirus (HPV) is simple: ½ tab. - 5 kg of weight for a child (from 3 years old), the received dose of "Isoprinosine" for children of the fourth year of life is recommended to be given 3-4 times during the day. The course of monotherapy aimed at curing the human papillomavirus is 14-28 days.

With genital warts and polyps

For the treatment of genital warts and polyps of the internal genital organs, the dosage of Isoprinosine is often prescribed the same as for HPV. It is possible to undergo monotherapy, as well as a combination with surgery. The total duration is 14-28 days. After that, a three-time course of treatment for polyps is recommended at intervals of 1 month.

With polyps of the cervical canal and cervical dysplasia

It should be noted that this medicine effectively treats gynecological diseases. During treatment with pathological changes in the cervix, as well as with polyps of the cervical canal caused by HPV, a daily dosage of 6 tablets is prescribed, drunk three times (single dose - 2 tablets). Duration medical therapy with polyps is 10 days. After that, 2 or 3 of the same treatment courses are prescribed for prevention, each course with a break of 10 to 14 days. After treatment, pregnancy planning is possible.

For warts

Usually, in the presence of single warts, there is no need for treatment if the neoplasms do not cause discomfort, since the drug treats multiple manifestations of the pathology. With reduced immunity, a significant number of warts are observed throughout the body, which requires complex treatment. The use of the drug "Isoprinosine" significantly reduces the possibility of relapse after therapy. You can drink the drug both before the procedure for excising warts, and immediately after surgical intervention. With papillomavirus infection, treatment with this drug will increase the chance of the warts disappearing on their own without surgical interventions. The daily dosage of "Isoprinosine" and how much to take the drug is determined individually after consultation with a specialist.

When menstruation is delayed

It is worth noting that the delay in menstruation during the use of "Isoprinosine" is in no way connected with medicinal effect this medication for reproductive system women. If a woman has a delay in menstruation throughout the entire course of treatment, it is better to consult a gynecologist, it is possible to diagnose diseases of the internal genital organs that provoke this pathology.

Contraindications

The drug "Isoprinosine" is not prescribed in the following cases:

The period of pregnancy and lactation
In the presence of urolithiasis
Kidney pathologies (chronic course)
Change in heart rate
Increased susceptibility to the main component of "Isoprinosine"
Children's age (up to 3 years)
Gout.

There are no other contraindications to the use of the described drug.

During pregnancy and breastfeeding

To date, there is no information about how the medicine acts on the body of a woman and the embryo during pregnancy, as well as on the baby during breastfeeding. In order to avoid complications during pregnancy, it is better to exclude treatment with Isoprinosine.

Precautionary measures

After a two-week course of drug treatment has been carried out, there is a need for laboratory research urine and blood to determine the level of uric acid.

In the case of a long course of treatment (over 4 weeks), it is recommended to monthly monitor the functioning of the kidneys, as well as the liver according to the main laboratory criteria.

Cross-drug interactions

The simultaneous use of uricosuric drugs, as well as diuretics and xanthine oxidase inhibitors, increases the likelihood of changes in the volume of uric acid directly in the blood serum. During therapeutic therapy with Isoprinosine, it is better not to start taking this series of medications together with Isoprinosine, so as not to harm the body.

Against the background of Isoprinosine therapy, you can take an antibiotic (there is compatibility with antibacterial drugs).

"Isoprinosine" and alcohol: compatibility

It is worth noting that you should not take Isoprinosine and alcohol together. The effect of alcoholic beverages is detrimental to immune system, therefore, using "Isoprinosine" and alcohol together, therapeutic effect from treatment will not be observed.

Side effects

When taking the drug, the manifestation of multiple negative manifestations is possible, quite often they are diagnosed:

CNS: fatigue, lethargy, headaches, overexcitation, dizziness, worsening sleep
GIT: loss of interest in food, pain in the epigastric region, nausea, urge to vomit, disruption of the intestines
Hepatobiliary system: increased activity of liver enzymes
Urogenital system: polyuria
Allergy: urticaria, maculopapular rash, edema
Musculoskeletal system: pain in the periarticular region, exacerbated gout.

Along with the symptoms listed above, it is possible to increase the level of urea nitrogen in the blood. Body temperature may also rise, which is explained by the reaction of the immune system to viruses. After a few days, the body temperature drops and returns to normal. If the child has a temperature above 38 C, the use of antipyretic drugs is indicated.

Overdose

On this moment there are no cases of overdose with Isoprinosine.

Terms and conditions of storage

It is best to store the drug in tablet form "Izprinosin" at a temperature of less than 25 ° C. The medicine can be used within 5 years from the date of production.

Analogues

« »

Gedeon Richter, Poland
Price from 483 to 1634 rubles.

"Groprinosin" is a complete analogue of the drug "Isoprinosine" both in the form of release and in the main characteristics and therapeutic effect only the manufacturer differs. Each tablet of "Groprinosin" contains 500 mg of inosine pranobex.

pros

An effective drug for the treatment of human papillomavirus infection (warts, herpes virus, warts), SARS, including tonsillitis
Can be given to a child over 3 years old
Minimal chance of adverse reactions

Minuses

High price
The drug is not prescribed during the entire period of pregnancy
After oral administration of the drug "Groprinosin", there may be a loss of appetite.

BioMedInvest, Russia
Price from 1195 to 2776 rubles.

"Indinol" - dietary supplement, which includes food indinol. The drug is active against human papillomavirus infection (HPV), normalizes the level of sex hormones in the blood, and contributes to the normalization of the immune system. "Indinol" is available in capsules.

pros

Highly effective drug in the treatment gynecological diseases, human papillomavirus, with polyps, SARS and tonsillitis
Rarely occur adverse reactions

Minuses

Against the background of taking the drug "Indinol", body temperature may slightly increase.
Treatment with the drug "Indinol" is not prescribed during pregnancy and lactation
It is better to exclude the simultaneous use of drugs that reduce the acidity of gastric juice.

« »

POLYSAN, Russia
Price from 124 to 870 rubles.

"Cycloferon" is an antiviral agent (highly effective in the treatment of acute respiratory viral infections, including chronic tonsillitis). The manufacturer offers various dosage forms of the drug: a solution for intramuscular injections, liniment, tablets. The basis of the drug "Cycloferon" is meglumine acridone acetate, which stimulates the synthesis of endogenous interferon.

pros

"Cycloferon" does not provoke adverse reactions in the treatment of papillomavirus infection
Acceptable price
"Cycloferon" can be given to a child from 4 years old.

Minuses

"Cycloferon" can be purchased only if there is a prescription
Prohibited for use in cirrhosis of the liver
"Cycloferon" is recommended to be taken with caution if you are allergic to medicines.

Feron, Russia
Price from 153 to 958 rubles.

"Viferon" has antiviral and immunomodulatory effects. The main active ingredient of the drug "Viferon" is human recombinant interferon, which allows you to effectively treat viral infections, including human papillomavirus (HPV). "Viferon" is available in the following dosage forms: ointment, suppositories and gel.

pros

It is possible to use in the complex "Viferon" + antibiotic
Used for the treatment and prevention of warts, papillomas, effective for polyps, herpes, SARS, tonsillitis
Candles and ointment "Viferon" can be used during pregnancy, for the treatment of children up to a year

Minuses

Allergy to the components of the drug is not excluded
Before taking the drug "Viferon" it is recommended to consult a doctor.

Isoprinosine is a complex medicinal antiviral and immunostimulating agent. Instructions for use indicate that syrup and 500 mg tablets are prescribed for the treatment of diseases caused by herpes viruses. Patient reviews and doctors' recommendations report that this medication helps in the treatment of influenza, herpes, HPV (human papillomavirus), as well as other colds.

Release form and composition

The drug Isoprinosine is available in dosage form tablets for oral (oral) intake. They have an oblong shape, a biconvex surface, white color and a slight amine smell. On one side of the tablet, a separating line is applied. Main active substance The drug is inosine pranobex, its content in the 1st tablet is 500 mg.

Isoprinosine tablets are packaged in a blister of 10 pieces. A cardboard pack contains 2, 3 or 5 blisters and instructions for using the drug.

Isoprinosine can be found in the form of an almost colorless clear syrup with a slight plum odor. The liquid is supplied to pharmacies in 150 ml glass bottles. The bottle is placed in cardboard box Comes with a measuring spoon for easy dosing.

pharmachologic effect

The active component of Isoprinosine (inosine pranobex) has an immunostimulating and antiviral effect on the body. This substance blocks the reproduction of various viruses, and also reduces symptoms. viral infections.

Isoprinosine helps speed up recovery. This drug increases the body's resistance to mumps, measles and various herpes viruses (Varicella-Zoster, Epstein-Barr).

Indications for use

What is Isoprinosine good for? Tablets 500 mg and syrup are prescribed:

with HPV of the genitals in women and men and in therapy for getting rid of warts;
human papillomavirus infection (HPV), including papillomas of the vocal cords and larynx, fibrous type;
therapy of the influenza virus and other acute respiratory viral infections;
infectious mononucleosis due to herpes virus type 4 (Epstein-Barr virus);
molluscum contagiosum;
infectious diseases that were caused by the herpes virus type 1, 2, 3, 4 and 5 (in Lately there was evidence of effectiveness in the treatment of herpes types 6, as well as types 7 and 8), labial herpes, genital herpes and herpetic keratitis;
cytomegalovirus infection caused by the herpes virus type 5;
measles (with severe course diseases);
chickenpox, shingles.

Instructions for use

Isoprinosine tablets are taken after meals with a small amount of water. The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses, which averages for adults - 6-8 tablets per day, for children - 1/2 tablet per 5 kg of body weight per day.

At severe forms infectious diseases the dose may be increased individually up to 100 mg/kg of body weight per day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g per day, for children aged 3 years and older - 50 mg / kg per day.

The duration of treatment for acute diseases in adults and children aged 3 years and older, it usually ranges from 5 to 14 days. Treatment must be continued until the disappearance clinical symptoms and for another 2 days already in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic recurrent diseases in adults and children aged 3 years and older, treatment should be continued in several courses of 5-10 days with a break in admission of 8 days. For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

For recurrent genital warts, adults are prescribed 2 tablets 3 per day, children aged 3 years and older - 1/2 tablet per 5 kg / body weight per day in 3-4 doses, either as monotherapy or in combination with surgical treatment within 14-28 days, then with a threefold repetition of the specified course at intervals of 1 month.

At herpetic infection adults and children aged 3 years and older, the drug is prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

In case of papillomavirus infection, adults are prescribed 2 tablets 3 times a day, children aged 3 years and older - 1/2 tablet per 5 kg / body weight per day in 3-4 doses for 14-28 days as monotherapy.

For babies aged 1 to 3 years, it is more convenient to take the drug in the form of a syrup. The recommended dose in this case is 1 ml per 1 kg of the weight of a small patient. The attending physician adjusts the amount of medication depending on individual characteristics baby's body.

Contraindications

Isoprinosine according to the instructions is contraindicated in:

Arrhythmias.
Gout.
Urolithiasis.
Hypersensitivity to the components of Isoprinosine.
Chronic renal failure.
Tablets are not prescribed for children under 3 years of age (or with a body weight of less than 15 kg).

Side effects

After taking Isoprinosine tablets, negative reactions from various bodies and systems, which include:

Musculoskeletal system - pain in the joints, exacerbation of the course of gout.
Nervous system - headache, dizziness, sometimes general weakness, drowsiness or insomnia may develop.
Urinary system - polyuria (increased volume of urine excreted during the day).
Skin - severe itching.
Digestive system - nausea, vomiting, pain in the stomach (epigastrium), less often diarrhea or constipation may develop.
Liver and biliary tract - a reversible increase in the activity of liver transaminase enzymes (ALT, AST) in the blood, indicating damage to liver cells, an increase in plasma urea concentration.

Appearance side effects And negative reactions is the basis for discontinuation of the drug.

Children, during pregnancy and lactation

Safety of using Isoprinosine during pregnancy and during breastfeeding not installed. Tablets are not prescribed in childhood up to 3 years (body weight up to 15-20 kg).

special instructions

Before you start using Isoprinosine tablets, you should carefully read the instructions. There are several special instructions Things to watch out for include:

The drug does not have a direct effect on the speed of psychomotor reactions and the ability to concentrate.

After taking Isoprinosine tablets for 2 weeks, it is advisable to conduct laboratory monitoring of the level of uric acid in the blood.

It is necessary to carry out additional monitoring of the level of uric acid in the blood when using Isoprinosine tablets together with drugs that increase its level.

In the case of using the drug for more than 1 month, laboratory monitoring of indicators of the functional activity of the liver is necessary.

drug interaction

Uricosuric drugs (including diuretics), as well as xanthine oxidase inhibitors, increase the risk of an increase in serum uric acid concentration during Isoprinosine therapy. Immunosuppressants reduce the effectiveness of the drug.

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At modern treatment Many diseases with a viral nature of origin are widely used by doctors Isoprinosine, synthesized in the late 70s of the last century. In Russia, the drug has been used for the treatment and prevention of viral infections for a little less than 20 years.

In addition to antiviral activity, Isoprinosine has immunomodulatory properties, which greatly expands the scope of its use and makes the drug analogues less effective in the treatment of severe viral diseases. Instructions for the necessary use contains all the necessary information about the composition of the drug, indications for use, dosage and possible side effects.

In this article, we will consider why doctors prescribe Isoprinosine, including instructions for use, analogues and prices for this medicine in pharmacies. If you have already used Isoprinosine, leave feedback in the comments.

Forms of release and composition

Clinical and pharmacological group: immunostimulating drug.

Each tablet of the drug "Isoprinosine" from "Teva" contains 500 mg of the main active ingredient - inosine pranobex. The preparation contains a number of auxiliary components.

Tablets "Isoprinosine" whitish-cream shade, convex, have a barely perceptible amine flavor, packed in blisters of 10 pieces. The carton may contain 2, 3 or 5 such blisters of "Isoprinosine" (500 mg).

What is Isoprinosine used for?

Therapeutic therapy, as well as prevention using the drug "Isoprinosine" is indicated for a number of ailments and pathological conditions:

papillomavirus infections of the skin and mucous membranes: genital warts, papillomavirus - infection of the vulva, vagina and cervix (as part of complex therapy);
viral infections caused by a virus herpes simplex 1st and 2nd type, virus chicken pox, cytomegalovirus, Epstein-Barr virus, measles virus, mumps virus, including in patients with - immunodeficiency states;
acute viral encephalitis (as part of complex therapy);
viral hepatitis (as part of complex therapy);
subacute sclerosing panencephalitis (as part of complex therapy);
viral respiratory infections.

pharmachologic effect

Isoprinosine refers to antiviral agents with immunomodulatory properties. The drug normalizes dysfunction or deficiency of cellular immunity at the individual level, inducing the maturation and differentiation of T-lymphocytes and T-helper 1, potentiating the induction of lymphoproliferative responses in mitogenic or antigen-active cells.

Isoprinosine enhances the action of neutrophils, phagocytosis and chemotaxis of monocytes and macrophages. The drug inhibits the synthesis of the virus by incorporating inosine-orotic acid into the field of the ribosome, which is affected by the cell virus and inhibiting the attachment of adenylic acid to viral mRNA.

The drug builds the cytotoxic function of T 8 suppressors and T 4 helpers, T-lymphocytes and natural killers, and also increases the amount of immunoglobulin G and compliment surface markers. Isoprinosine increases the synthesis of interleukin-1 and the synthesis of interleukin-2, regulates the expression of IL-2 receptors. Isoprinosine significantly increases the secretion of endogenous interferon gamma and reduces the production of interleukin-4 in the body.

Instructions for use

Tablets are taken after meals with a small amount of water. The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses (for adults - 6-8 tablets / day, for children - 1/2 tablet per 5 kg of body weight / day).

With papillomavirus infection for adults, the drug is prescribed 2 tab. 3 times / day, children - 1/2 tab. per 5 kg / body weight / day in 3-4 doses for 14-28 days as monotherapy.
For recurrent genital warts, adults are prescribed 2 tablets. 3 times / day, children - 1/2 tab. 5 kg / body weight / day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a three-fold repetition of the indicated course at intervals of 1 month.
In case of herpetic infection for adults and children, the drug is prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 tab. 2 times / day for 30 days to reduce the number of relapses.
With cervical dysplasia associated with the human papillomavirus, 2 tablets are prescribed. 3 times / day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.
In chronic recurrent diseases in adults and children, treatment should be continued in several courses of 5-10 days with a break in admission of 8 days.
For maintenance therapy, the dose can be reduced to 500-1000 mg / day (1-2 tablets) for 30 days.

In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg body weight / day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children - 50 mg / kg / day.

The duration of treatment for acute diseases in adults and children is usually from 5 to 14 days. Treatment should be continued until the disappearance of clinical symptoms and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

Contraindications

Isoprinosine according to the instructions is contraindicated in:

Urolithiasis;
arrhythmias;
Chronic renal failure;
Gout;
Hypersensitivity to the components of Isoprinosine.

Also, the drug is not prescribed for children under 3 years of age (or with a body weight of less than 15 kg).

Pregnancy and lactation

The safety of the use of Isoprinosine during pregnancy and lactation has not been established, so the use of the drug is not recommended.

Side effects

When taking the drug, the manifestation of multiple negative manifestations is possible, quite often they are diagnosed:

Hepatobiliary system: increased activity of liver enzymes.
Allergy: urticaria, the presence of a maculopapular rash, swelling.
CNS: fatigue, lethargy, headaches, overexcitation, dizziness, worsening sleep.
Gastrointestinal tract: loss of interest in food, pain in the epigastric region, nausea, urge to vomit, disruption of the intestines.
Musculoskeletal system: pain in the periarticular region, exacerbated gout.
Genitourinary system: polyuria.

Analogues

Currently, the entire set of analogues of any drug, including Isoprinosine, is divided into two large groups - synonyms and, in fact, analogues. Synonyms are called medications containing the same active substance. For Isoprinosine, a synonym is Groprinosin. But there are no other synonymous drugs for Isoprinosine.

When searching for drugs with similar action You may be offered the following medications:

Allokin-Alpha;
Amiksin;
Amizon;
Arbidol;
Lavomax;
Panavir;
Kagocel;
Proteflazid, etc.

Prices

The average price of ISOPRINOZINE in pharmacies (Moscow) is 600 rubles.

Storage conditions

Shelf life 5 years. Do not use late indicated on the package. List B. Store at a temperature not exceeding +25 ° C in a dry, dark place. Keep out of the reach of children.

General characteristics. Compound:

Active substance: Inosine Pranobex (Isoprinosine) - 500 mg; Excipients: mannitol, wheat starch, povidone, magnesium stearate.
Description: White or almost white oblong biconvex tablets white color with a slight amine smell, with a notch on one side.

Pharmacological properties:

Isoprinosine is a synthetic complex derivative of purine with immunostimulatory activity and nonspecific antiviral activity. It restores the functions of lymphocytes under conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killers, the function of T-suppressors and T-helpers, increases the production of immunoglobulin (Ig) G, interferon-gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines - IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages. The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and virus, human T-cell virus type III, polioviruses A and B, ECHO-virus (human enterocytopathogenic virus), encephalomyocarditis and equine. The mechanism of the antiviral action of Isoprinosine is associated with inhibition of viral RNA and the dihydropteroate synthetase enzyme involved in the replication of some viruses, enhances the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of viral RNA biosynthesis and translation of viral proteins, increases the production of lymphocytes with antiviral properties of interferons -alpha and gamma. With a combined appointment, it enhances the effect of interferon-alpha, antiviral agents acyclovir and zidovudine.

Pharmacokinetics. After oral administration, the drug is well absorbed from gastrointestinal tract. The maximum concentration of ingredients in the blood plasma is determined after 1-2 hours.

Rapidly metabolized and excreted through the kidneys. It is metabolized similarly to endogenous purine nucleotides with the formation of uric acid. N-N-dimethylamino-2-propranolone is metabolized to N-oxide, and para-acetamidobenzoate is metabolized to o-acylglucuronide. No accumulation of the drug in the body was found. The elimination half-life is 3.5 hours for N-N-dimethylamino-2-propranolone and 50 minutes for para-acetamidobenzoate. Elimination of the drug and its metabolites from the body occurs within 24-48 hours.

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Tablets are taken orally after meals with a small amount of water.

The recommended dose for adults and children from 3 years of age (body weight from 15-20 kg) is 50 mg / kg per day, divided into 3-4 doses. Adults - 6-8 tablets per day, children - 1/2 tablet per 5 kg / body weight per day. In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg of body weight per day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children - 50 mg / kg / day.

Duration of treatment:

Acute diseases: The duration of treatment in adults and children is usually 5 to 14 days. Treatment should be continued until the disappearance of clinical symptoms and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic recurrent diseases in adults and children, treatment should be continued in several courses of 5-10 days with a break in admission of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

In case of herpetic infection, adults and children are prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

With papillomavirus infection, adults are prescribed 2 tablets 3 times a day, children - 1/2. tablets per 5 kg / body weight per day in 3-4 doses for 14-28 days as monotherapy.

In case of recurrent genital warts, the drug is prescribed for adults 2 tablets 3 times, for children - 1/2 tablet per 5 kg / body weight per day in 3-4 doses per day, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a threefold repetition of the specified course at intervals of 1 month. With cervical dysplasia associated with the human papillomavirus, 2 tablets are prescribed 3 times a day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.

Application Features:

After 2 weeks of using Isoprinosine, the concentration of uric acid in the blood serum and urine should be monitored.

At long-term use after 4 weeks of use, it is advisable to monitor the functions of the liver and kidneys every month (transaminase activity in blood plasma, creatinine, uric acid).

It is necessary to control the level of uric acid in the blood serum when isoprinosine is prescribed in combination with drugs that increase the level of uric acid or drugs that impair kidney function.

Influence on the ability to control vehicles and other mechanisms. There are no special contraindications.

Side effects:

The incidence of side effects after the use of the drug is classified according to WHO recommendations.

Often:>=1%and<10%.

Sometimes: >=0.1% and<1%.

From the gastrointestinal tract: often - epigastric pain, sometimes -,.

From the side of the liver and biliary tract: often - a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

On the part of the skin and subcutaneous fat: often - itching.

From the nervous system: often - weakness; sometimes drowsiness, insomnia.

From the urinary system: sometimes -.

From the musculoskeletal system and connective tissue: often - joint pain, exacerbation.

Interaction with other drugs:

Immunosuppressants may reduce the effectiveness of the drug. Xanthine oxidase inhibitors and uricosuric agents (including diuretics) may contribute to the risk of elevated serum uric acid levels in patients taking Isoprinosine.

Contraindications:

Hypersensitivity to the components of the drug;
- gout;
- ;
- ;
- chronic;
- children's age up to 3 years (body weight up to 15-20 kg).

The use of the drug during pregnancy and lactation. It is not recommended to use the drug during pregnancy and lactation, as the safety of use has not been studied.

Overdose:

Not described.

Storage conditions:

Shelf life 5 years. Do not use after the expiration date indicated on the package. List B. Store at a temperature not exceeding +25 ° C in a dry, dark place. Keep out of the reach of children.

Leave conditions:

On prescription

Package:

Tablets 500 mg.10 tablets in PVC/PVDC blister and aluminum foil. 2, 3 or 5 blisters in a cardboard box along with instructions for use.

In viral diseases, drugs are in demand that have activity against viruses, as well as the ability to stimulate the immune system of a sick person so that it quickly copes with the infection. One of them can be called Isoprinosine. Is such a medication allowed for the treatment of children, when is it used and in what dosage is it prescribed for a particular disease?

Release form

Isoprinosine is available in only one form, which is almost white tablets that have a slight amine odor. They are distinguished by an oblong convex shape and the presence of a risk on one of the sides, along which the preparation can be divided into halves. One blister includes 10 tablets, and one pack may contain from 2 to 5 blisters. Isoprinosine does not have such dosage forms as a suspension, powder, dragee, syrup, capsules or injections.

Compound

The active ingredient of the drug is a substance called "inosine pranobex", which is also called "inosiplex" or "isoprinosine". This is a complex of several compounds presented in one tablet at a dose of 500 mg.

In addition to it, the medication includes wheat starch and magnesium stearate. Also inside the medicine is povidone and mannitol. Thanks to these additional ingredients, the firmness of the tablet is ensured, but occasionally allergies can occur, so it is important to consider these substances when choosing medicines for allergic children.

Operating principle

Isoprinosine has an immunostimulating effect, which consists in the following effects:

Restoration of the oppressed function of lymphocytes.
Stimulation of the formation of monocytic cells.
Activation of receptors on T-helper membranes.
Prevention of a decrease in lymphocyte activity during treatment with glucocorticoid hormones.
Normalization of thymidine incorporation into lymphocytes.
Stimulation of the activity of natural killers, as well as T-cells with a cytotoxic effect.
Supports the function of T cells such as helpers and suppressors.
Increased production of immunoglobulin G.
Activation of the formation of interleukins (types 1 and 2), as well as gamma-interferon.
Blocking the synthesis of cytokines that increase inflammation.
Increased chemotaxis of macrophages and other white blood cells.

Due to this effect, the drug helps to fight viral infections, affecting:

The causative agent of measles.
Polioviruses.
Herpes viruses.
Influenza pathogens.
ECHO viruses.
Cytomegaloviruses.
The causative agents of T-lymphoma and some others.

In addition to enhancing the immune response, the drug affects the RNA and enzymes in the cells of some pathogens, which blocks their replication. Inosine pranobex affects other viruses through increased production of alpha and gamma interferon, which has antiviral activity.

Indications

From what age can you take it?

Pediatricians prescribe medication from the age of three, but the annotation contains a warning not to give such pills to babies weighing less than 15 kg. If the child is already 3 years old, but his weight is lower, treatment with Isoprinosine is contraindicated. For those babies over 3 years old who weigh more than 15-20 kg, the drug is allowed.

Contraindications

Medicine is not given in such cases:

If the child has hypersensitivity to any of its ingredients.
If the work of the baby's kidneys is severely impaired (chronic insufficiency is diagnosed).
If a small patient has arrhythmia.
With urolithiasis or gout.

Side effects

Some patients may experience negative symptoms due to Isoprinosine, such as:

Skin itching.
Feeling of nausea.
Pain in the upper abdomen.
Pain in the head.
An attack of vomiting.
Feeling of weakness.
Dizziness.
Pain in the joints.

After taking the tablets in the blood test, there may be an increase in the level of urea, as well as an increased activity of liver enzymes. Sometimes the drug provokes constipation or loose stools, insomnia or drowsiness, an increase in urine volume.

Instructions for use

The tablet should be given to the child after a meal, offering to drink the medicine with clean water in a small amount. If a small patient still cannot swallow the drug whole, the tablet can be crushed in a spoon to a powder state, and then given to the child in crushed form, mixed with a small amount of non-carbonated water.

Dosage

To determine the right dose in childhood, it is important to know the weight of a small patient in kilograms. It is multiplied by 50 and the daily dose of isoprinosine in mg is obtained, which is then divided into 3 or 4 doses.

You can also focus on this ratio - half a tablet for every 5 kilograms of a child's weight. For example, a child weighs 30 kilograms, which means that he needs 50 * 30 \u003d 1500 mg of the active compound per day. This is 3 tablets of Isoprinosine, so this patient should be given one tablet three times a day.

If a child over 12 years of age has a severe infectious disease, then the doctor may prescribe a higher dosage of the drug per day at the rate of 100 mg of the active substance per kilogram of weight. The received number of milligrams is divided into 4, 5 or 6 doses. For example, body weight is 40 kg. Multiplying 40 * 100, we get 4000 mg, that is, 8 Isoprinosine tablets per day. It turns out that such a child can be given medication 2 tablets four times a day or one and a half tablets 6 times a day.

How long to give?

The duration of use in acute diseases, for example, in the treatment of mononucleosis, is usually 5-14 days. Tablets are given to the child until the symptoms of the disease disappear and for another two days.
If Isoprinosine treats a chronic pathology with relapses, the drug is prescribed in courses lasting from 5 to 10 days, and between them they take a break of 8 days.
Treatment of a herpes infection is often carried out according to this scheme.- tablets are given in a therapeutic dose for 5-10 days, and then, to prevent relapses, they continue to be taken in an individually determined maintenance dosage for up to 30 days.
If a child has a papillomavirus infection, Isoprinosine monotherapy is prescribed for a course of 2-4 weeks.
In cases where the drug is prescribed for a long period, two weeks after the start of treatment, it is important to do a blood test to find out the concentration of uric acid. Four weeks after the start of treatment, you need to evaluate the performance of the kidneys and liver, and then repeat such tests every month.

Overdose

The manufacturer does not mention cases when too high a dose of tablets harmed the health of a child or an adult patient. However, if you accidentally take the drug in large quantities, it is recommended to induce vomiting and consult a doctor.

Interaction with other drugs

The effectiveness of Isoprinosine will decrease if drugs of the immunosuppressant group are given simultaneously with this medicine.
Co-administration with acyclovir, zidovudine or alpha-interferon preparations enhances the effect of treatment with such agents.
If Isoprinosine is administered together with diuretics or xanthine oxidase inhibitors, this will increase the risk of an increase in the concentration of uric acid in the blood of a small patient.

Terms of sale

To buy a pack of Isoprinosine at a pharmacy, you first need to visit a doctor and get a prescription for this medicine. The average price of a package with 20 tablets is 700 rubles, and for a pack in which 50 tablets are placed, you need to pay about 1400 rubles.

Storage features

Isoprinosine at home should be kept in a place hidden from children, where sunlight does not reach. The recommended storage temperature of the medication is below +25 degrees Celsius. The expiration date from the date of issue of the drug is 5 years and must be marked on the pack. If the marking has been erased or the period has expired, it is unacceptable to give pills to a child.

Reviews

There are very different reviews about the use of Isoprinosine in children. In positive mothers, they say that the medication helped to recover faster with cytomegalovirus infection, herpes conjunctivitis, SARS and other diseases. Parents note that the general condition of the child after taking the pills quickly returned to normal, and the unpleasant symptoms of the infection soon disappeared.

However, there are also negative opinions that mention the ineffectiveness of the medicine for some children. Also, many mothers complain about the high cost of the drug, and the form of the medication is called very inconvenient, since it is difficult for many children to swallow a solid tablet, and it crumbles in a spoon with great difficulty. In addition, some reviews note a deterioration in health after a course of Isoprinosine. In such patients, after treatment, ARVI more often occurred or problems with the liver began.

The attitude of doctors to Isoprinosine is also different. Some doctors often prescribe it for influenza, mononucleosis, measles or herpes, noting a good therapeutic effect in some patients.

Others, including Dr. Komarovsky, are in favor of evidence-based medicine and argue that the action of Isoprinosine has not been sufficiently studied, therefore its use is ineffective.

Positive opinions about such a drug are found mainly on the part of practitioners who prescribe medicine to patients and monitor the condition of patients. They emphasize that pills are effective, but not always, so situations where Isoprinosine does not help are not uncommon.

The opinion of Dr. Komarovsky on immunomodulatory drugs in the following video.

Analogues

A drug from the company Gideon Richter called Groprinosin is capable of replacing the drug. This medicine also contains inosine pranobex in each tablet of 500 mg. It, like Isoprinosine, is allowed to be given to children over three years old, provided that the child's weight is more than 15 kilograms. Contraindications, recommended doses, possible side effects and indications for such drugs are the same. The price of these funds is also about the same.