Composition and release form of the drug
Solution for intravenous administration in the form of a transparent, colorless or slightly colored liquid.
Excipients: propylene glycol - 1 mg, sodium sulfite anhydrous - 1 mg, diluted acetic acid 30% - up to pH 7.8 - 8.6, water d / i - up to 1 ml.
5 ml - ampoules (5) - contoured cell packs (1) - cardboard packs.
5 ml - ampoules (5) - contoured cell packs (2) - cardboard packs.
10 ml - ampoules (5) - contoured cell packs (1) - cardboard packs.
10 ml - ampoules (5) - contoured cell packs (2) - cardboard packs.
pharmachologic effect
Purine nucleoside, ATP precursor. Improves myocardial metabolism, has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium. It has a protective effect on the kidneys in conditions of ischemia during the operation.
Participates in metabolism, increases the activity of a number of enzymes of the Krebs cycle. Stimulates the synthesis of nucleotides.
Pharmacokinetics
Inosine is well absorbed from the gastrointestinal tract. It is metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. It is excreted in small quantities by the kidneys.
Indications
Ischemic heart disease, myocardial dystrophy, condition after myocardial infarction, congenital and, cardiac arrhythmias, especially with glycosidic intoxication, myocarditis, dystrophic changes in the myocardium after heavy physical exertion and transferred infectious diseases or as a result of endocrine disorders; hepatitis, cirrhosis of the liver, incl. caused by alcohol or drugs; prevention of leukopenia with radiation exposure; operations on an isolated kidney (as a means of pharmacological protection in the temporary absence of blood circulation in the operated organ).
Contraindications
Dosage
When taken orally, the initial daily dose is 600-800 mg, then the dose is gradually increased to 2.4 g / day in 3-4 doses.
With intravenous (jet or drip) administration, the initial dose is 200 mg 1 time / day, then the dose is increased to 400 mg 1-2 times / day.
You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the medicine in the text of the message).
Preparations containing Inosine (Inosine, ATC code not assigned, group C01EB)
| Frequent release forms (more than 100 proposals in Moscow pharmacies) | |||||
|---|---|---|---|---|---|
| Name | Release form | Packing, pcs | Manufacturer country | Price in Moscow, r | Offers in Moscow |
| Riboxin | 10 | Various | 20- (average 143↗) -208 | 420↗ | |
| Riboxin | solution for intravenous injection 2% 10ml (200mg in 10ml) | 10 | Various | 76- (average 143) -291 | 420↗ |
| Riboxin | tablets 200mg | 10, 20 and 50 | Various | 15- (average 29) -60 | 555↗ |
| Riboxin-LekT | tablets 200mg | 50 | Russia, Tyumensky KhFZ | 16- (average 39) -99 | 393↗ |
| Rarely found and withdrawn from sales forms of release (less than 100 offers in pharmacies in Moscow) | |||||
| Name | Release form | Packing, pcs | Manufacturer country | Price in Moscow, r | Offers in Moscow |
| Riboxin | capsules 200mg | 50 | Belarus, Minskintercaps | 19- (average 35) -99 | 83↗ |
| Riboxin-Vial | solution for injection 20mg / ml 10ml | 10 | China, Shandong Shenglu | 74- (average 145) -189 | 74 |
| Riboxin-UVI | tablets 200mg | 50 | Russia, Pharmstandard | No | No |
| Riboxin-PNITIA | tablets 200mg | 50 | Russia, Penza Research Institute of Antibiotics | No | No |
| Riboxin-Ferein | solution for intravenous injection 2% 5ml (100mg in 5ml) | 10 | Russia, Bryntsalov | No | No |
Riboxin (Inosine) - instructions for use. Prescription drug, information is intended only for healthcare professionals!
Clinical and pharmacological group:
A drug that normalizes myocardial metabolism, reduces tissue hypoxia
pharmachologic effect
Inosine belongs to a group of drugs that regulate metabolic processes. The drug is a precursor for the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.
It has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative renal ischemia. It is directly involved in the metabolism of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of adenosine triphosphate.
It activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some enzymes of the Krebs cycle. Penetrating into cells, it increases the energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and contributes to a more complete relaxation of the myocardium in diastole, resulting in an increase in the stroke volume of blood.
Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and mucous membrane of the gastrointestinal tract.
Pharmacokinetics
Well absorbed in the gastrointestinal tract. It is metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. It is excreted in small quantities by the kidneys.
Indications for use of the drug RIBOXIN
It is prescribed for adults in the complex therapy of coronary heart disease, after myocardial infarction, cardiac arrhythmias caused by the use of cardiac glycosides.
It is prescribed for hepatitis, cirrhosis, fatty liver disease caused by alcohol or drugs, and urocoproporphyria.
Dosage regimen
For intravenous (jet or drip) administration, the initial dose is 200 mg once a day, then the dose is increased to 400 mg 1-2 times a day.
The duration of the course of treatment is set individually.
When taken orally, it is prescribed for adults, before meals.
The daily dose for oral administration is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). In case of good tolerance, the dose is increased (for 2-3 days) to 1.2 g (0.4 g 3 times a day), if necessary - up to 2.4 g a day.
The duration of the course is from 4 weeks to 1.5-3 months.
With urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.
Side effect
Allergic reactions are possible in the form of urticaria, pruritus, skin flushing (drug withdrawal is required). Rarely, during treatment with the drug, the concentration of uric acid in the blood and exacerbation of gout (with prolonged use) increase.
Contraindications to the use of the drug RIBOXIN
Hypersensitivity to the drug, gout, hyperuricemia. Fructose intolerance and glucose / galactose malabsorption syndrome or sucrase / isomaltase deficiency.
With care: renal failure, diabetes mellitus.
Use of the drug Riboxin during pregnancy and breastfeeding
The safety of using Riboxin during pregnancy and lactation has not been established. The use of the drug Riboxin is contraindicated during pregnancy. During treatment with Riboxin, breastfeeding should be discontinued.
Application for impaired renal function
With caution: renal failure.
special instructions
During the period of treatment with Riboxin, the concentration of uric acid in the blood and urine should be monitored.
Information for patients with diabetes mellitus: 1 tablet of the drug corresponds to 0.00641 bread units.
Does not affect the ability to drive vehicles and control mechanisms that require increased concentration.
Drug interactions
Immunosuppressants (azathioprine, antilympholine, cyclosporine, thymodepressin, etc.), with simultaneous use, reduce the effectiveness of Riboxin.
Conditions of dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
In a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life. 3 years. Do not use after the expiration date printed on the package.
Riboxin review by a cardiologist:
I will be extremely brief: the drug is absolutely useless. Riboxin does not appear in the National Guidelines for Cardiology at all, and even more so in European guidelines.
Long live the placebo effect and the great power of self-hypnosis. Fortunately, Riboxin is very inexpensive.
Riboxin is a drug that improves metabolism in organ cells, accelerates energy metabolism in tissues. According to the manufacturer, the drug reduces hypoxia (oxygen starvation), normalizes the heart rate. The medication restores blood circulation in the coronary vessels, increases the energy balance of the heart muscle. Due to these properties, the drug is used not only to improve the functionality of the heart and digestive organs, but also to increase endurance and physical fitness.
Riboxin is involved in glucose metabolism, stimulates metabolic processes in the absence of adenosine triphosphoric acid (ATP), which is a source of energy in biochemical processes. The drug reduces blood clotting, provokes tissue regeneration. The medicine is prescribed as part of the complex therapy of many diseases.
Description of the dosage form
The main component of the drug is inosine. It looks like a white or yellowish powder with a neutral odor and a bitter taste.
Riboxin solution is administered intramuscularly and intravenously
Riboxin injections contain the following substances:
- inosine;
- caustic soda;
- hexamine;
- sterile liquid.
Injection solution (2%) is injected into a vein or muscle. Colorless liquid is packaged in ampoules of 5 and 10 ml.
Properties of the drug
Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects. Inosine is a chemical precursor of adenosine triphosphate, it participates in glucose metabolism, stimulates metabolic processes against a background of hypoxia.
The solution has antihypoxic and antiarrhythmic effects
The components of the solution for injection stimulate the metabolism of pyruvic acid, as a result, cell respiration is normalized even with ATP deficiency. After the introduction of the drug, its components act on enzymes that are involved in metabolic processes. They activate xanthine dehydrogenase, through which hypoxanthine is converted to uric acid. The solution shows a faster therapeutic effect than Riboxin tablets.
Inosine inhibits the process of platelet adhesion, as a result, the likelihood of a thrombus (blood clot) in the lumen of the vessel decreases. This is a kind of prevention of thrombosis and thromboembolism (blockage of a blood vessel by a thrombus). Under the action of the drug, the processes of regeneration of the tissues of the myocardium and the inner membranes of the digestive organs are started.
After intravenous administration, the drug enters the tissues that need ATP. The remains of the drug are excreted in urine, feces, bile.
Pros and cons of the medication
The advantages of Riboxin include the effect of inosine on metabolic processes in the heart muscle. The drug increases the energy balance of the muscle cells of the heart, accelerates the formation of nucleoside phosphates (phosphoric esters of nucleosides), as a result, accelerates the regeneration of heart tissue. The drug normalizes the contractile activity of the heart muscle and the full course of diastole (relaxation of the myocardium between contractions).
The disadvantages of Riboxin include its property to change the natural sequence of the metabolic cycle. This means that inosine, coming from the outside, corrects metabolic processes. Doctors try not to interfere with human physiology, since the medicinal properties of drugs can provoke dangerous complications. But if there is a pathological process in the body that causes destructive changes in the myocardium, then it is simply necessary to change the metabolism. In the absence of intervention, the likelihood of death increases.
Riboxin is prescribed for ischemia, arrhythmias, porphyria, cirrhosis, etc.
Appointment of Riboxin
According to the instructions for the use of Riboxin in ampoules, the medication has the following indications:
- Ischemia of the heart (complex therapy). The drug is used regardless of the stage of the disease, as well as during recovery after a heart attack.
- Primary myocardial damage of unexplained etiology. Then Riboxin is used for a long time.
- With arrhythmias, the drug helps to normalize the heart rate. The best effect can be achieved during the treatment of a disease that has arisen as a result of an overdose of medications.
- Congenital porphyria.
- Cirrhosis, steatosis (replacement of liver cells with adipose tissue), hepatitis, etc. In these diseases, Riboxin is used as part of complex therapy.
- Open-angle glaucoma (complex therapy).
- Radiation therapy is also an indication for use. The medicine facilitates the perception of the procedure, reduces the severity of adverse reactions.
- Long-term intense physical activity that negatively affects the general condition.
- Pregnant women are prescribed the drug exclusively by the attending physician, who then monitors the patient's condition.
These are the main indications for the use of the medication.
No prescription is required to buy Riboxin.
Precautionary measures
Instruction for the use of injections states that the medication is prohibited from taking in the following cases:
- Intolerance to inosine and other components of the drug.
- Gouty arthritis.
- During pregnancy and breastfeeding.
- Patients under 12 months of age.
Riboxin in the form of a solution is contraindicated for gout, pregnancy, hepatitis B, hypersensitivity to the components
In functional kidney failure, the drug is used when the potential benefit outweighs the potential risk. The decision on the appointment of a medication is made exclusively by the attending physician.
For the period of therapy, you need to systematically take a blood test. This is necessary in order to control the concentration of uric acid.
The drug is contraindicated for pregnant and lactating women. This is because the drug has not been tested on this group of patients. But despite this, the medication is prescribed to future and new mothers, taking into account the possible benefits and potential danger.
Patients in the younger age category are not prescribed the drug due to the lack of information about its safety. The reaction of the child's body to the drug is unpredictable, so you should not risk it.
Riboxin does not cause drowsiness, for this reason it is used before attention-related activities.
Usually, patients tolerate the action of the solution well, but sometimes it still provokes negative reactions:
- lowering blood pressure;
- increased concentration of urea and its salts;
- cardiopalmus;
- a rash on the skin that itches;
- redness of the skin;
- nettle fever;
- general weakening of the body;
- with prolonged therapy, gout worsens.
If the above symptoms occur, you must stop taking the medication and consult a doctor. The specialist will conduct a second examination and determine the tactics of action.
Drug interactions
Riboxin interacts in different ways with other medicines:
- Β-adrenergic receptor blockers. Riboxin can be combined with drugs from this group.
- Cardiac glycosides. This combination prevents arrhythmia and makes the inotropic effect more pronounced. Riboxin enhances the effect of heparin for a long time. Nitroglycerin, Nifedipine, Furosemide, Spironolactone can be combined with Riboxin.
- Alkaloids. This is a prime example of incompatibility, when substances react, the base of the alkaloid is separated, as a result of which insoluble compounds are formed.
- Tannin. When combined, a precipitate is formed.
- Acids, alcohols, heavy metal salts. Complete incompatibility.
- Pyridoxine (vitamin B6). Do not use together, as both compounds are deactivated.
Any combinations of Riboxin with other drugs are created by the attending physician
Solution dosage
Riboxin in ampoules is administered intramuscularly and intravenously. Rapid jet injections are injected at a minimum dosage of 10 ml of solution (2%) once. Then, if the patient has tolerated the medicine well, the dose is increased to 20 ml 1 or 2 times a day. The therapeutic course lasts from 10 to 15 days. The dose of the drug is increased only if the patient tolerates Riboxin well.
In acute cardiac arrhythmias, 10 to 20 ml of the solution is injected once.
To protect the kidneys affected by ischemia, the drug is injected with a syringe at a dosage of 60 ml 10-15 minutes before the doctor squeezes the renal artery. Then it is necessary to inject another 40 ml of the medicine immediately after the resumption of blood circulation.
Parenteral administration is a method of administering a solution using a dropper. Before the introduction of the solution, it must be mixed with glucose (5%) or 250 ml of sodium chloride. The rate of drug administration by the drip method is from 40 to 60 drops per minute.
Riboxin during pregnancy and lactation
According to the instructions for use, Riboxin is forbidden to use during gestation and breastfeeding. However, despite this, doctors prescribe the drug to future and new mothers. Many women are afraid to take medicine so as not to harm the child. But according to doctors, therapeutic doses of the drug will only be beneficial.
The drug improves the metabolism and energy supply of tissues, that is, the body of a woman and a fetus is more actively saturated with useful substances during their deficiency. This is one of the main benefits of Riboxin.
During gestation, a woman often suffers from oxygen deficiency. This is a very dangerous condition, since during pregnancy, the respiratory organs of the expectant mother must provide oxygen not only to their body, but also to the fetus. Often, the lungs and the bronchial tree are not able to saturate 2 organisms with oxygen. Riboxin has an antihypoxic effect, the drug minimizes the effects of oxygen starvation, saturates the body with the necessary gas.
Riboxin in injections is taken during pregnancy and HB only under medical supervision
The drug restores the normal contractile activity of the heart muscle. The drug regulates the metabolism of myocardial muscle cells, stimulates trophic processes. That is why Riboxin is used to prevent arrhythmias, tachycardia and other disorders of myocardial functionality.
Riboxin for animals
The pharmaceutical origin of Riboxin is non-specific, for this reason it is used in veterinary medicine. The drug is often prescribed to treat heart disease in cats and dogs. In this case, the medication has the following indications:
- Functional heart failure.
- Myocarditis.
- Endocarditis.
- Myocardosis (to improve the metabolic capacity of the heart).
- Heart defects.
These are the most common heart problems in older animals.
The solution is administered intramuscularly, as this is the most rational route of administration for animals. The daily dosage of the drug is from 100 to 200 mg / 10 kg of the total weight three times. The therapeutic course lasts no longer than 4 weeks. If necessary, the veterinarian will prescribe a second course in order to more carefully adjust the metabolism or eliminate severe dystrophic changes.
Patients about Riboxin
Many patients and doctors speak well of the action of the liquid dosage form of Riboxin. Usually the drug is well tolerated by patients and has a wide spectrum of action. The medication has a beneficial effect on the heart muscle, stomach, intestines.
Riboxin is a medical drug that has a positive effect on metabolic reactions in the human body. In simple terms, Riboxin helps to improve metabolism in the cells of organs and tissues. The manufacturer of this medication also claims that the use of the medication helps to eliminate oxygen starvation, as well as to normalize the heart rate. The effectiveness of the drug is so high that it is even used to increase endurance and physical strength.
Forms of drug release
Riboxin is available in the form of a solution for injection, and inosine is the main component of the drug. This substance, which has the form of a white powder with a yellow tint and odorless, is contained in one milliliter in an amount of 20 mg. Riboxin in the form of injections for injection is available in 10 ml ampoules.
Riboxin injections are intended to be injected into a vein. Most sources claim that the medication must be used exclusively in a vein. Instructions for the use of Riboxin injections states that the solution is intended for intravenous administration by jet or drip. Nothing is said about the prohibition of intramuscular use, therefore, its introduction into the muscle is ineffective and irrational. The drug is produced by various pharmaceutical companies in countries such as Russia, Belarus and Ukraine.
It's important to know! In addition to the injection form, Riboxin is also available in the form of tablets. In what form to use the medication, it is exclusively a specialist who decides. The difference between these forms of release lies in the speed of delivery of the main component of the drug inosine to the internal organs.
In addition to the main component of inosine, Riboxin injections include:
- caustic soda;
- hexamine;
- sterile liquid.
The packages of the drug contain 5 or 10 ampoules of the drug, the volume of which is 5 or 10 ml.
Features of the drug Riboxin
Riboxin is anabolic, that is, it has antiarrhythmic and antihypoxic effects. The main component inosine is actively involved in glucose metabolism, as well as in stimulating metabolic processes.
Through the components of the solution, cell respiration is normalized even with ATP deficiency. After using the medication, the substances of the agent act on the enzymes involved in metabolic processes.
Due to the positive effect of inosine, the process of platelet joining is inhibited, as a result of which the likelihood of blood clots in the lumens of blood vessels is significantly reduced. The use of Riboxin intravenously allows for the prevention of diseases of thrombosis and thromboembolism. In addition, under the influence of the components of the drug, the processes of degeneration of the tissues of the myocardium and the digestive system are launched.
It's important to know! Immediately after the introduction of the drug intravenously, it is transported to the tissues that need ATP. Excessive amounts of the drug are excreted naturally through urine, feces and bile.
Advantages and disadvantages of Riboxin
Riboxin has many advantages due to its positive effect on the body for various ailments and diseases. The benefits include:
- Increasing the energy balance of the muscle cells of the heart.
- Prompt formation of nucleoside phosphates.
- Acceleration of the renewal of the tissues of the heart muscle.
With this medication, the contractile activity of the heart muscle is normalized. Despite the positive effect of the drug on the human body, Riboxin also has disadvantages. The disadvantages include:
- Such a property of a medicine as a change in the natural sequence of the metabolic cycle is negatively reflected on a person. This means that inosine affects metabolic processes, carrying out their arbitrary correction.
- Arbitrary correction of metabolic processes can negatively affect human physiology, therefore, the development of serious complications is not excluded.
- The drug should not be used for a person who does not have pathological abnormalities for prophylactic purposes.
The drug Riboxin was created in order to help people avoid death in the development of pathological processes. For the correct use of Riboxin, the need for its administration intravenously or intramuscularly should be decided by a medical specialist after examining the patient.
Indications for use
Indications for the use of the drug Riboxin are as follows:
- Ischemic heart disease. The medication is used regardless of the stage of the disease. It is also prescribed after a heart attack has occurred.
- Myocardial damage. If the reasons for the development of the myocardium are not identified, then the medication is prescribed for use over a long period.
- With congenital porphyria. This is a disease that is a violation of pigment metabolism.
- Arrhythmia. Allows you to quickly normalize the heart rate.
- For the normalization of vision in the diagnosis of open-angle glaucoma.
- Diseases: cirrhosis, steatosis and hepatitis. It is used as part of complex therapy.
- During pregnancy. The need to use the medication is prescribed by the doctor.
A more detailed list of indications for the use of the medication in question can be found in the instructions attached to it. When buying a medication, there is no need to present a prescription from a doctor.
Contraindications for injections
In addition to the fact that Riboxin is prohibited to use in the absence of indications, there are also contraindications to its use in the presence of one of the above diseases. Contraindications include:
- Individual intolerance to the substances that make up the medication. For this, it is important to familiarize yourself with the composition of the product before using it.
- With an excess amount of urea in the blood and urine.
- With problems with the kidneys and liver, if there are malfunctions in their functioning.
- It is forbidden to administer the drug to children under 3 years of age.
- When carrying and breastfeeding. It is used for individual indications and only as prescribed by a doctor.
- In the presence of diseases of the joints and tissues, for example, with gout.
In addition, experts do not recommend administering the drug to people who have diabetes. If there are contraindications about the need or possibility to use the medication, the doctor decides. In most cases, the medication is used only in cases where the benefit will outweigh the potential risk. Before the introduction of the medication, the patient must donate blood without fail.
Features of the use of Riboxin
Injecting Riboxin in a stream is allowed only with the development of acute cardiac arrhythmias in a single dosage. This dosage ranges from 200 to 400 mg or 10-20 ml of solution. In a jet method, the medication is used to ensure the pharmacological protection of the kidneys.
Parenteral administration of the drug is carried out slowly and drip at a rate of 40 to 60 drops per minute. The therapy of intravenous administration of Riboxin begins with 200 mg once a day. If the drug is well tolerated by the patient, then the dosage increases to 400 mg 1-2 times a day. The course of such treatment usually lasts from 10 to 15 days.
It's important to know! Before injecting the drug by intravenous drip, it is diluted in 5% dextrose (glucose) solution. Instead of glucose, you can use saline in an amount of not more than 250 ml.
The instructions for use do not say anything about the fact that Riboxin can be injected intramuscularly. Nothing is said about the prohibition of such use, therefore, if necessary, such a method can be carried out, however, only according to the doctor's prescription and appropriate indications. It is also worth noting that with intramuscular administration of the drug, the development of pain syndrome will be observed. Typically, the indication for intramuscular administration is to increase endurance and muscle building.
Development of side symptoms
Indications for the use of Riboxin do not mean at all that after the injection, there will be no side symptoms. In most cases, side effects after injection are manifested in the following ways:
- Development of allergic reactions.
- The appearance of a rash on the skin.
- An increase in the level of blood flow, manifested in the form of pronounced redness of the skin.
- Hives.
- Soreness of the injection site and palpitations.
- Headaches and dizziness.
- Vomiting and nausea.
- Excessive sweating.
- Excess acid in the urine.
- Weakening of the body.
- Skin irritation and burning.
If side symptoms occur, then you need to warn the doctor about this. The doctor will identify the cause of the side symptoms, after which he will decide on the need for further therapy.
Effect on the body during pregnancy
Studies on the effect of Riboxin on pregnant and lactating women have not been conducted. To exclude the development of side symptoms and complications, it is not recommended to use the medicine during these periods. The exceptions are cases when the positive effect of the funds will help save a woman's life. The decision on the need to administer Riboxin to a woman is decided by the strictly attending physician. During breastfeeding, the child should be transferred to artificial feeding, after which the medication should be administered.
It's important to know! Riboxin is forbidden to be used for children under 3 years old, since its effect on the action of the child's body has not been studied.
Interaction with other means
Riboxin is allowed to be used in combination with other medicines. Some combined use of drugs improves the therapeutic effect. These drugs include:
- Heparin. When used together, the effect of Heparin is enhanced, and the duration of exposure is also increased.
- Cardiac glycoside. Joint use contributes to a positive inotropic effect.
- Beta-blockers. Joint use does not have any negative effect of medicines on each other.
In exceptional cases, it is allowed to use Riboxin together with nitroglycerin, furosemide and spironolokton. Joint administration of Riboxin with alkaloids, acids and heavy metal salts is contraindicated.
It is also important to note the fact that the combined use of Riboxin with alcohol can cause the development of side symptoms, as well as lead to a variety of complications and pathological abnormalities. The word "alcohol" means all types of alcoholic beverages, ranging from low alcohol.
Overdose
In case of an overdose, side symptoms will not be long in coming. The injection must be strictly controlled by a specialist, so the slightest overdose can cause itching, allergies, redness of the skin, and heart severity.
The drug is excreted naturally, so in most cases you just need to wait. The exception is allergic reactions, in the event of which it is required to immediately resort to the use of antiallergic drugs.
It's important to know! Medical studies have not revealed a single case of Riboxin overdose.
Cost and storage features
On average, the cost of the drug Riboxin in the form of injections is 100-150 rubles per package. The package contains 10 ampoules of a 2% solution. There are packs of 5 ampoules of the medication. The cost of such a package ranges from 50 to 80 rubles, which depends on the manufacturer of the medicinal product.
Riboxin does not contain strains of live bacteria, so it can be stored outside the refrigerator, but it is important that the storage temperature does not exceed 25 degrees. Such storage allows you to extend the life of the medication.
The shelf life of Riboxin from the date of production is 4 years, but if a sediment is found on the bottom of the ampoules, it should be disposed of. After the expiration date, the medication is prohibited to use.
Riboxin for animals
The non-specific origin of Riboxin indicates that it can be used even in veterinary medicine. It is used to treat heart ailments in pets: cats and dogs. The main indications for the administration of Riboxin for animals are:
- Myocarditis.
- Insufficiency of the heart muscle.
- Myocardosis.
- Endocarditis.
- Heart defects.
Such ailments are often inherent in aged pets. For animals, Riboxin is administered exclusively intramuscularly. The dosage is adjusted by your veterinarian. The course of treatment should not exceed 4 weeks. Taking a course of treatment with pets allows you to correct metabolism, as well as exclude dystrophic disorders.
It's important to know! The veterinarian must inform the pet about the need to administer the medication.
Riboksin's analogs
If the drug Riboxin was not in the pharmacy, then the possibility of replacing it with analogues should be clarified with the attending physician. If the doctor allows you to replace the medication with analogues, then you need to pay attention to the following drugs:
- Adexor;
- Vasonat;
- Kardazin;
- Metamox;
- Metonate;
- Mildronate;
- Nuklex;
- Mildralex.
Country of origin
China Republic of Belarus RussiaProduct group
Cardiovascular drugsA drug that normalizes myocardial metabolism, reduces tissue hypoxia
Forms of issue
- 10 - contour cell packs (5) - cardboard packs. 10 ampoules of 10 ml in a box, 10 ml - ampoules (10) - cardboard packs 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (5) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (5) - cardboard packs. 10 ml - ampoules (10) - contoured plastic packaging (1) - cardboard packs 10 pcs. - contour cell packs (5) - cardboard packs 5 ml - ampoules (10) - cardboard packs. 5 ml - ampoules (5) - contoured plastic packaging (2) - cardboard packs. 50 - dark glass jars (1) - cardboard packs. 10 - packings, cell contour (5) - packs of cardboard 50 tabs per pack Solution for intravenous administration 20 mg / ml - 10 ml in ampoules - 10 pcs per pack. Solution for intravenous administration 20 mg / ml - ampoules of 10 ml - 10 pcs per pack. Solution for intravenous administration 20 mg / ml, 10 ml in ampoules made of low density polyethylene or polypropylene - 10 pcs. in pack. Solution for intravenous administration 20 mg / ml, 5 ml in ampoules made of low density polyethylene or polypropylene - 10 pcs. in pack. pack of 10 ampoules of 5ml
Description of the dosage form
- Transparent colorless or slightly colored liquid. Round, biconvex film-coated tablets, from light yellow to yellow-orange. On the cross-section, two layers are visible: the inner one is white, the outer one is from light yellow to yellow-orange. Transparent colorless or slightly yellowish liquid. transparent colorless or slightly colored liquid. Transparent or almost transparent colorless or slightly colored liquid. Transparent or almost transparent colorless or slightly colored liquid. transparent, colorless or weakly colored liquid Solution for intravenous administration solution for injection Tablets are round, biconvex, film-coated, yellow. The cross-section shows two layers of a yellow coated tablet, round with a biconvex surface. Film-coated tablets. Film-coated tablets.
pharmachologic effect
Riboxin - a derivative (nucleoside) of purine - a precursor of adenosine triphosphate (ATP). Refers to a group of drugs that regulate metabolic processes. It has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the consequences of intraoperative renal ischemia. It takes a direct part in the metabolism of glucose and promotes the activation of metabolism in conditions of hypoxia and in the absence of ATP. It activates the metabolism of pyruvic acid, which is necessary to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some enzymes of the Krebs cycle. Penetrating into cells, it has a positive effect on metabolic processes in the myocardium - it increases the strength of heart contractions and promotes a more complete relaxation of the myocardium in diastole, as a result of which the stroke volume increases. The mechanism of antiarrhythmic action is not fully understood. Reduces platelet aggregation, activates tissue regeneration (especially myocardium and gastrointestinal mucosa).Pharmacokinetics
Well absorbed in the gastrointestinal tract. It is metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. It is excreted in small quantities by the kidneys.Special conditions
Riboxin is not used for emergency correction of cardiac dysfunction. In case of renal failure, the use of the drug is possible only if, according to the doctor, the expected positive effect outweighs the possible risk from the use. During long-term treatment, it is advisable to control the concentration of uric acid in the blood and urine. Influence on the ability to drive vehicles and control mechanisms There is no data indicating a negative effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactionsComposition
- 1 ml 1 amp. inosine 20 mg 200 mg 1 amp. inosine 200 mg 1 tablet contains Active ingredient: riboxin (inosine) - 200 mg Excipients: core - potato starch, methylcellulose, sugar, polyvinylpyrrolidone (povidone), tween - 80 (polysorbate), stearic acid, sodium carboxymethyl starch (primogel); shell - methylcellulose, hyprolose (hydroxypropylcellulose), titanium dioxide, tween - 80 (polysorbate), silicone emulsion, tropeolin O. 1 ml of solution contains 20 mg of riboxin (inosine) as an active substance; excipients: hexamethylenetetramine (methenamine), sodium hydroxide solution 1 M, water for injection. 1 ml of solution contains: active substance: riboxin (inosine) -20 mg, excipients: sodium hydroxide - 4.8 mg, diluted hydrochloric acid - up to pH 8.5 to 9.5, sodium chloride - 8.5 mg, water for injection - qs up to 1 ml 1 ml contains inosine (riboxin) 20 mg excipients: hexamethylenetetramine, 1M sodium hydroxide solution, water for injections. 1 tab. inosine 200 mg 1 tablet contains the active substance riboxin (inosine) - 200 mg; auxiliary substances: potato starch, water-soluble methylcellulose, sucrose (refined sugar), stearic acid; the shell contains: water-soluble methylcellulose, polysorbate 80 (tween-80), titanium dioxide (titanium dioxide), tropeolin O, beeswax. 1 coated tablet contains Riboxin 0.2 g; , Auxiliary substances: sucrose, potato starch, povidone K-30, stearic acid. inosine 20g, Auxiliary substances: hexamethylenetetramine, sodium hydroxide solution, Inosine water - 100 mg in 5 ml of solution; excipients - hexamethylenetetramine, sodium hydroxide, water for injection. Riboxin / Inosine / 20MG; Auxiliary substances: methenamine, sodium hydroxide solution, riboxin / inosine / water; hexamethylenetetramine; sodium chloride; water d / in riboxin 0.2 g; Auxiliary substances: potato starch, methylcellulose, sugar, stearic acid
Riboxin indications for use
- Ischemic heart disease, myocardial dystrophy, condition after myocardial infarction, congenital and acquired heart defects, cardiac arrhythmias, especially with glycosidic intoxication, myocarditis, dystrophic changes in the myocardium after heavy physical exertion and transferred infectious diseases or as a result of endocrine disorders; hepatitis, cirrhosis of the liver, fatty degeneration of the liver, incl. caused by alcohol or drugs; prevention of leukopenia with radiation exposure; operations on an isolated kidney (as a means of pharmacological protection in the temporary absence of blood circulation in the operated organ).
Riboxin contraindications
- Hypersensitivity to the drug, gout, hyperuricemia, renal failure, pregnancy, lactation, children under 1 year of age
Riboxin dosage
- 20 mg / ml 200 mg
Riboxin side effects
- Allergic reactions are possible in the form of urticaria, pruritus, skin flushing (drug withdrawal is required). Rarely, during treatment with riboxin, the concentration of uric acid in the blood and exacerbation of gout (with prolonged use) increase.
Drug interactions
When used as part of complex therapy, Riboxin increases the effectiveness of antiarrhythmic, antianginal and inotropic drugs. Enhances the effects of anabolic steroids and non-steroidal anabolic drugs when used simultaneously. Weakens the bronchodilator effect of theophylline and the psychostimulating effect of caffeine. No clinically significant interaction of riboxin with drugs of other groups has been described.Overdose
Currently, no cases of overdose have been reported.Storage conditions
- store in a dry place
- keep away from children
- store in a dark place
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