Amiksin suspension. Antiviral immunostimulating agent amiksin for children

• If hepatitis is detected in a child, therapy is prescribed only after specifying the strain of the pathogen. The course in this case is selected strictly individually. Amiksin is taken in the morning after a meal.
• For simple forms of acute respiratory viral infections, acute respiratory infections and influenza: 60 mg (1 tab) once on the 1st, 2nd and 4th days of treatment. General course - 180 mg (3 pieces)
• In case of complications after suffering from influenza, acute respiratory infections or acute respiratory viral infections, such as tonsillitis and pneumonia: 60 mg (1 piece) once on the 1st, 2nd and 4th and 6th days of treatment. The general course is 240 mg (4 pills).

Adults in therapy and for the prevention of various diseases, Ameksin is used with a dosage of 125 mg (no prescription is required to purchase it).

It is advisable to take the drug Amiksin after meals.

Use the following therapeutic instructions for the use of Amixitsilin:

1. For the implementation of nonspecific preventive measures of viral hepatitis A - a dose of 125 mg once a week, 6 weeks in a row. The total dose of the course is 750 mg (6 tablets).

2.In the treatment of viral hepatitis A (as a component in complex therapy), the instructions for use are as follows: on day 1 125 mg twice a day, later they switch to this scheme 125 mg after 48 hours. The general course is 1.25 g, which is 10 tablets ...

3.In the treatment of hepatitis (acute forms):

• hepatitis B and instructions for use: on days 1 and 2, a daily dose of 125 mg / day, later 125 mg every 48 hours. The general course is 2 g (16 pieces).
• hepatitis C looks like this: on the 1st and 2nd days of treatment, a dosage of 125 mg / day is prescribed, later 125 mg every 48 hours. The general course is 2.5 g (20 pills).

4. In the treatment of hepatitis (chronic form):

• hepatitis B - at the first stage of treatment: a total dose of 2.5 g (20 pills). And it is applied as follows: the first 2 days 250 mg per day, then 125 mg every 48 hours. With the continuation of therapy: the total dose is from 1.25 g (10 pcs.) To 2.5 g (20 pcs.), 125 mg each (1 pc. .) weekly. The total course dose of Amiksin is in the range from 3.75 to 5 g, the total duration of therapy is from 3.5 to 6 months. It is selected on the basis of laboratory studies (immunological, biochemical and morphological), which illustrate the degree of activation of the process.
• hepatitis C - at the beginning of treatment, the total dose is 2.5 g (20). During the first 2 days, take 250 mg / day (2 pills), then 125 mg (1 tablet) every 48 hours.When continuing therapy, the total dose is 2.5 g (20 tablets), 125 mg (1 tab) times per week The general course is 5 g (40), the duration of treatment is about 6 months. It is selected on the basis of laboratory studies (immunological, biochemical and morphological), which illustrate the degree of activation of the process.

5. In the treatment of neuroviral infections, the instruction is as follows - take 125-250 mg / day (1-2) in the first 2 days of therapy, later 125 mg (1tab) every 48 hours. Dosed strictly individually. The total duration of the course is 3-4 weeks.

• For the treatment of cytomegalovirus and herpes - a therapeutic dose in the first 2 days 125 mg (1 tab), then 125 mg (1 tab) every 48 hours. The general course is 1.25-2.5 g (10-20 tab.).
• When carrying out complex therapy of tuberculous lung injuries - in the first 2 days, drink 2 tabs (250 mg) per day, then 125 mg every 48 hours. The general course of administration is 2.5 g (20 tab.).
• With chlamydia of various etiology - in the first 2 days - 125 mg / day, later 125 mg every 48 hours. The total dose per course is 1.25 g (10 pieces).
• For the treatment of acute respiratory infections, acute respiratory viral infections and influenza - during the first two days of illness, 125 mg (1 tablet) per day, then 125 mg every 48 hours. The total dose of the course is 750 mg (6 tablets).
• For preventive measures against influenza, acute respiratory infections and acute respiratory viral infections - 125 mg (1 tab) once a week. a month and a half. The total dose of the course is 750 mg (6 pieces).

Amiksin instructions for use for adults

Amiksin - international name (INN):

• Tilorone (Tilorone) is a low molecular weight synthetic drug. Once in the body, it induces interferon and stimulates the formation of α-, β-, γ-interferons.

The maximum values ​​of interferon production after administration is determined in the period from 4 to 24 hours. Here the sequence is as follows: intestines, liver, blood.

Amiksin is available in tablet form with a dosage of 60 mg (for children) and 125 mg. According to the instructions approved in 2008 for the use of the drug "Amiksin", the conditions for dispensing in pharmacies: dosages of 60 mg are dispensed upon presentation of a prescription, and dosages of 125 mg are dispensed without presentation of a prescription.

Amiksin is banned in Europe, since targeted clinical trials have not been conducted in the direction of ARVI prevention. Its effectiveness in this capacity has therefore not been proven. As an anticancer drug (there were such studies), it showed no effect.

It is used on the territory of Russia, Ukraine and Kazakhstan.

In adults, it is widely used in the treatment of:
SARS, acute respiratory infections or influenza, as well as their prevention;
herpes;
cytomegalovirus;
chlamydia of various etiologies;
pulmonary tuberculosis (in combination therapy);
in the treatment of hepatitis;
HIV infections (in combination therapy)
as well as for the treatment of encephalomyelitis of various etiologies (in complex therapy).

Amiksin for children how to take - dosage of Amiksin for children

Amiksin is strictly forbidden to be taken by children under 7 years of age. For children over seven years old, amiksin is prescribed for the treatment of acute respiratory infections, acute respiratory viral infections, influenza (various strains) and hepatitis. In pediatrics, a special pediatric dosage of 60 mg is used, which is dispensed by pharmacies exclusively with a prescription.

Instructions for use for children are agreed with the attending physician. Amiksin is taken in the morning after a meal in the following dosages:

• In case of complications after influenza or acute respiratory viral infections: 60 mg (1 tab) once on the 1st, 2nd and 4th and 6th days of treatment. The general course is 240 mg (4 tabs).
• For simple forms of ARVI and influenza: 60 mg (1 tab) once in the 1st, 2nd and 4th days of treatment. The general course is 180 mg (3 pieces).
• If hepatitis is detected, therapy is prescribed only after specifying the type of pathogen. The course in this case is selected individually.

Attention!

Even if the child is over 7 years old, contraindications for the use of the medication are possible, namely:

• insufficient physical development (dystrophy of varying degrees),
• mental lag
• psycho-emotional development,
• severe allergic reactions.

To avoid this, you must not only follow the instructions for use for children, but also remember that the medicine can be used only as directed by a doctor.

For swine flu, colds

With complex therapy, Amiksin or Amiksin ai si is prescribed simultaneously with antibiotics, other antiviral drugs and symptomatic treatment.

Often, in the treatment of viral diseases, immunomodulators work well only if the reception is started in the first hours of the disease, and later they are useless. However, amiksin does not have such a time frame. It can be used at the onset of the disease and with delayed treatment.

Adults instruction:

• For preventive measures against influenza, acute respiratory infections and acute respiratory viral infections - take 1 piece (125 mg) weekly for 1.5 months. General course 750 mg (b).
• For the treatment of acute respiratory viral infections, acute respiratory infections or influenza - during the first two days of illness - 125 mg (1) per day, then 125 mg every 48 hours. The general course is 750 mg (b).

Children over 7 years old:

• For simple forms of acute respiratory viral infections, acute respiratory infections or influenza, the instructions for use are as follows: 60 mg (1) once on the 1st, 2nd and 4th days of treatment. The general course is 180 mg (3 tablets)
• In case of complications after influenza or acute respiratory viral infections, such as tonsillitis and pneumonia: 60 mg (1) once in the 1st, 2nd, 4th and 6th days of treatment. The general course is 240 mg (4).

Composition, antibiotic or not?

Amiksin is NOT an antibiotic. It interacts well as an integral part of complex therapy, with the use of antibiotics such as amoxicillin, fuflomycin, flemoxin salutab, etc. (in their various forms: tablets, syrup, injections), symptomatic treatment and other antiviral drugs. Such combinatorics do not cause harm and negative consequences.

How much is?

The price of amiksin varies (depending on the manufacturer) and is on average for various dosages:

• RUB 685 (60 mg No. 10);
• 760 rubles (125 mg No. b);
• 1140 rubles (125 mg No. 10).

Analogues are cheaper

An analogue means a drug that has a different trade name, but a similar therapeutic effect due to the same active substance. Medicines-analogues have a single code according to the international anatomical-therapeutic-chemical (ATC) classification.

Amiksin has several analogues, the price of which is sometimes much lower than that of the original (according to the pharmacies of the Gorzdrav network). These are drugs such as:

• levomax,
• anaferon,
• whocell,
• arbidol,
• isoprinosine,
• remantadine.

The above list of analogs and generics will make it possible for buyers to choose a similar substitute at a lower cost, which will help to cope with the disease with high efficiency. However, after replacing amiskin, it will be correct to consult with specialists, since the instructions for use and indications for taking medications may still differ.

Are the pills compatible with alcohol?

Amiksin is NOT compatible with alcohol. Amiksin, when taken together with alcohol, can give a pronounced picture of food dyspepsia: cramps in the abdomen, abundant waste of bile and indigestion. In this case, alcohol (even in the smallest doses) completely neutralizes the therapeutic effect of taking the drug.

During early pregnancy, can I take Amiksin?

According to the annotation that is attached to the drug, taking Amiksin during all trimesters of pregnancy, as well as during breastfeeding, is strictly prohibited. But there are times when threats to the health of the expectant mother force the doctor to take risks and use antiviral agents. This primarily concerns pregnant women belonging to the risk group (with high titers of hepatitis and negative indications of liver function tests). In such cases, a woman is placed in the infectious diseases department of the hospital and antiviral therapy is carried out there (with strict control of blood biochemistry indicators).

In situations where the use of amiksin is acutely necessary during lactation, breastfeeding should be stopped immediately.

Amiksin side effects and drug reviews

According to the reviews of patients who took amiksin during treatment according to the instructions for use, this drug has no pronounced side effects. In rare cases, patients experience the following consequences:
loss of appetite and diarrhea (only in the first 2 days of admission and only when taking large doses with a possible overdose);
discomfort in the small intestine (1-2 hours after ingestion, they pass on their own);
slight chills and low-grade fever (should be taken as an increase in the immune response);
hives (the rash is treated with antihistamines and topical ointments)

Contraindications to the use of amiksin, even according to the instructions:

Individual intolerance;
children's age (up to seven years);
pregnancy;
breastfeeding.
There is no official information about the dangers of taking amixin in diabetes mellitus, however, in severe forms of it, you should consult an endocrinologist.

How to take Amiksin for the prevention of colds?

As a method of preventive measures against influenza, acute respiratory infections and acute respiratory viral infections, instructions for using Amiksin offer the following course of treatment: 125 mg (1 tab) once a week in the morning after meals for 1.5 months (1 pack of 125 mg No. 6 is enough).

According to Russian experts, based on a number of laboratory studies, taking amixin for prophylactic purposes gives the body the opportunity to normalize the activity of its own immune system and reduce the likelihood of getting flu, acute respiratory infections or ARVI.

Amiksin is a drug for the prevention and treatment of viral infections. The instructions for use recommend tablets for adults (125 mg) and children (60 mg). Patient reviews suggest that the remedy really helps to recover faster. How effective is Amiksin? Instructions for use - what important information does it give? And how to apply the medicine for influenza and other viruses?

Amiksin: history of invention

The drug Amiksin is registered only on the territory of the post-Soviet states - Russia and Ukraine. In the pharmaceutical industry, it was named "Amiksin ic". The drug was developed for use in emergency situations when it is not possible to consult a doctor, but effective therapy for infections and inflammations is needed (during war, in refugee camps, in major disasters). Therefore, the action of amiksin is directed against a wide range of viruses and a number of bacterial infections.

Amiksin belongs to the achievements of Russian military pharmacology. It seemed impossible for army units operating in "hot spots" to avoid contact with pathogens of hepatitis, carriers of influenza and ARVI, herpes, etc. The vaccines used at that time had a large number of side effects, which, at times, negated the fighter's ability to perform service. In 1975, by order of the GRU, a universal antiviral agent Amiksin was developed, devoid of the disadvantages of vaccinations, especially in terms of side effects.

Amiksin: instructions, price, reviews

The drug amiksin is an antiviral agent of immunomodulatory action. It does not supply foreign immune cells to the human body, but stimulates the production of its own interferon.

The active ingredient of amiksin is tilorone. The tablets of the drug contain tilorone inside the shell. Its presence prevents the decomposition of the substance in the stomach (under the action of hydrochloric acid). The shell dissolves only in the intestine. Here, tilorone stimulates the epithelial cells to increase the production of interferon. In addition to intestinal cells, T-lymphocytes, hepatocytes, granulocytes, neutrophils are included in the process of synthesis of a protective protein.

This modulation of immunity causes fewer side reactions than direct intake of ready-made interferon. Treatment with someone else's (in medical terminology, exogenous interferon) has a wide list of side effects and contraindications. The heart rhythm is often disturbed, and an unusual taste appears in the mouth (a sign of indigestion). Therefore, drugs with interferon are carefully used to treat people with chronic diseases of the heart, liver, and kidneys.

60% of tilorone from amixin enters the bloodstream. Here it enhances the synthesis of interferons of three types (α, β, γ). The active substance is concentrated in the blood plasma within 24 hours after absorption in the intestine. Therefore, the time interval between taking the pills is quite large - one or two days.

Note: the action of amixin affects the additional suppression of viruses and a decrease in the area of ​​inflammation. Also, the drug inhibits the development of tumors.

The effectiveness of the drug is confirmed by practicing doctors in outpatient clinics. They talk about a reduction in the duration of the disease and a decrease in the number of complications in those patients who were given amixin in the treatment of viral infections. Despite the lack of large-scale medical research, the drug is in demand during periods of influenza epidemics. This is also facilitated by the affordable price of amixin (compared with its counterparts).

Amiksin use: a list of infections

Amiksin is a means of treatment and prophylaxis. It is used for various viral infections and some inflammations caused by bacterial pathogens.

The use of amiksin is indicated for the following infectious diseases:

• Herpes-type infections - labial, genital herpes, cytomegalovirus.
• Hepatitis type A, B, C.
• SARS, flu.
• As well as bacterial infections - tuberculosis, chlamydia.

Reception of amiksin is indicated in the treatment of complex infections such as meningitis, encephalitis... And also to maintain the body after surgery, radiation, chemotherapy.

It is important to know: the drug is used primarily for the treatment of adults.

Amiksin can be combined with antibiotics. This allows for complex therapy for unexplained causes of inflammation (using the drug Amiksin). The antibiotic provides antibacterial action, and tiloron- antiviral and immunomodulatory. The immunomodulator itself is not an antibiotic, although it suppresses the synthesis of some pathogenic bacteria. After amiksin, there is no need to restore intestinal flora and take probiotics.

Advice: Amiksin tablets cannot be broken. The active substance is enclosed in a shell to protect against gastric juice. When a tablet is broken, tilorone is destroyed by hydrochloric acid, and the treatment is ineffective.

The use of immunity modulators in the treatment of influenza and other viruses allows you to avoid complications and quickly cope with the infection. However, many drugs are not recommended for the treatment of children (due to insufficient knowledge, lack of systemic studies of side effects). Therefore, the question arises when choosing a drug amiksin - is it possible to give children this immunomodulatory agent?

More often amiksin is used to treat adults. In pediatrics, it is used only after 7 years of age.... At the same time, the instructions for the drug allow the use of tablets in children only for the treatment of influenza viruses (ARVI). Other infectious diseases in children are treated with similar drugs.

Amiksin: instruction, application and dose selection

Amiksin is a medicine for oral administration (it is consumed through the mouth, then the drug enters the intestines through the stomach, where it is absorbed, enters the liver and blood). The bioavailability of amixin is 60% (this is the amount of tilorone that is absorbed and has an immunomodulatory effect, stimulates the production of interferon in the intestines and blood). The remaining 40% are excreted unchanged by the excretory organs within two days.

The effectiveness of treatment depends on the correct choice of dose and treatment regimen.... What are the recommendations in the instructions for the drug Amiksin? How many tablets are needed for prevention and treatment?

Child and adult dose

Amiksin for children is 60 mg tablets. Amiksin adult - tablets of 125 mg. Adult and children's amiksin is distinguished by a list of diseases for which their use is permitted. Amiksin for children(instructions for use allow the use of the drug in pediatrics) limited to colds viruses- treatment and prevention of influenza during epidemics. Amiksin adult is used against various viruses and bacteria - herpes, hepatitis, tuberculosis, chlamydia.

Amiksin for influenza in adults

For the treatment and prevention of influenza in adults, amiksin 125 mg tablets are used. During treatment, the pill is swallowed once a day during the first two days of the illness. Then the tablets are taken every other day. The total amount of amixin, which is recommended for the treatment of influenza or other acute respiratory viral infections in an adult, is 0.75 mg (6 tablets of 125 mg).

How to take Amiksin to prevent a viral infection during a flu epidemic? If prophylaxis is needed, then 1 tablet of 125 mg is swallowed weekly (prophylaxis course - 6 weeks).

Amiksin for influenza in children

60 mg tablets are amiksin for children. Instructions for its use allows the treatment of children over the age of 7 years, while - only for respiratory infections... The child is given 1 tablet of 60 mg three times: on the first, second and fourth day of treatment. If complications arise, the drug intake is increased for one more day (they give the pill on the 6th day of treatment).

Amiksin for hepatitis

Acute manifestations of hepatitis B infection are treated in the same way as influenza- 125 mg on the first and second day of the start of treatment. After the drug is given every other day. Due to the severity of the infection, the course of treatment takes a long time. The total dose of the drug is 2 g (16 tablets for 1 month of active therapy). If necessary, the total dose is increased to 2.5 g (21 tablets, almost 1.5 months of treatment).

If the terms of treatment with amiksin are missed and hepatitis B has become chronic, then first use the scheme of treatment of acute hepatitis (125 mg in the first two days, then - every other day for 1.5 months, so that the total amount of the drug that has entered the digestive tract is 2.5 g). After - they switch to long-term use - 125 mg every week. In this case, the total amount of amixin, which is used in the second stage of treatment, is from 3.75 to 5 g of the drug (from 30 to 42 tablets of 125 mg, the duration of the course is from 8 to 11 months of treatment).

Hepatitis C is more severe. Therefore, it uses the maximum dosages for its treatment.... The total amount of the drug for the treatment of acute hepatitis C is 2.5 mg (the first two tablets - every day, the rest - every other day). In chronic hepatitis C, the total amount of amixin reaches 5 g (taken once a week, treatment lasts almost a year).

Amiksin for herpes and cytomegalovirus

Amiksin is most effective against the first two types of herpes - oral and genital... It is also used to treat cytomegalovirus... These infections are chronic for most people (although many are not aware of the virus carrier). Oral herpes is especially common, which infects almost all people in childhood. The presence of herpes inside makes itself felt by periodic rashes (during colds and other diseases). Treatment of rash with amiksin can reduce the frequency of relapses by 4 times.

The treatment regimen for herpes is similar to the treatment of hepatitis C in the acute stage of the disease.... Labial, genital herpes and cytomegalovirus use only 2.5 g of the drug (two tablets in the first two days of illness, and then every other day).

Amiksin against chlamydia and genital infections

The total dose of the drug for treatment is 1.25 g. Treatment regimen - 1 tablet of 125 mg for the first two days, the remaining 8 tablets every other day.

Raising and maintaining immunity

To restore immunity after chemotherapy or radiation, concentrated doses of the drug are used - up to 250 mg (2 tablets) weekly for 6 weeks. It is necessary to use up to 1.5 g of amixin. If necessary, repeat the course of treatment, take a break for 4 weeks, and then resume taking the pills for another 6 weeks.

Contraindications

Instructions for the use of amixin regulate the drug as an ideal medicine, which has practically no contraindications ( except for pregnancy and preschool age). However, the amount of research that has been done on tilorone is small. European studies focused on the antitumor effect of the substance and its effectiveness in the treatment of urethritis. Studies in Russia and Ukraine were conducted without placebo control (the effect of psychological confidence in the action of the drug). Many results of the effectiveness of amixin against various viruses are still voiced with the addition of "advertising words", which indicates the unproven effect of the drug. In this regard, the immunomodulator is not recommended for the treatment of children under 7 years of age. How was the dose of the drug chosen?

After the invention of tilorone, experiments were carried out with its use on rats. Conclusions were obtained on the most effective dosage of the active substance. The result of the study was the data that the body needs not less than 150 mg of tilorone for every kg of a person's weight. That is, for a woman weighing 60 kg, the required dose is 10 g, and for a man weighing 80 kg - 12 g. However, with an increase in the dose, the toxicity of the drug and the likelihood of side effects increase. Therefore, the amount of tilorone in tablets was reduced to safe (10 times) to ensure low toxicity and minimum contraindications. The current instruction for the drug lists the following contraindications for treatment with tilorone (amixin):

• Pregnancy - Amiksin has a toxic effect on the fetus in the womb.
• Lactation
• The child's age is under 7 years old.
• Individual allergic reaction.

Amiksin should not be taken against the background of alcohol intoxication. Both substances have a toxic effect, reinforce each other and complicate the liver.

Side effects

The instruction regulates the following side effects (their manifestation is optional):

• Digestive disorders: loose stools (due to the fact that tilolron is excreted mainly in feces, less in urine).
• Chills and fever(these symptoms are due to the stimulating effect on the hematopoietic system).
• Allergic reaction(due to the presence of toxic substances or their individual intolerance).

Interesting to know: in Europe and America, the drug is not used due to the large number of side effects.

Amiksin's analogs

The question of replacing the drug with its analogues arises either in the absence of a drug in pharmacies, or when it is expensive, or in case of an allergic reaction, or the need to treat a preschool child.

Cheap analogs of amiksin are ergoferon and cycloferon. Their price is slightly higher (within reason). On the Internet pharmacies, the cost of ergoferon is comparable to the price of amixin. More expensive analogs are Ingavirin, Kagocel. Their cost significantly exceeds the price of amiksin (3-6 times). A number of drugs are expensive, but approved for use in young children(for babies from 6 months, or children 3 years old). This is their advantage over amiksin.

For the correction of weakened immunity in children over 7 years old, the therapeutic and prophylactic drug Amiksin is used. The principle of action of the drug is to enhance the production of interferon.

Respiratory viral diseases occupy the leading positions among infectious diseases. The susceptibility to respiratory diseases is very high, especially in children. Viral diseases often cause complications (inflammation of the paranasal sinuses, pneumonia, otitis media) and exacerbation of chronic pathologies of the respiratory system, for example, bronchial asthma.

A child can get a respiratory infection several times during the season. This is facilitated by the following factors:

• a wide variety of types and subspecies of viruses;
• short-term immunity after a respiratory infection;
• fast variability of viral particles.

Specific vaccines are used only to prevent various types of influenza. The range of drugs that act destructively on the pathogen and do not cause serious side effects in children is still narrow. The therapeutic and prophylactic drug Amiksin affects the innate defense mechanisms of the body against viruses, increasing the production of interferon.

When a viral particle is introduced into the body, the production of several types of interferons starts. γ-interferon activates defense reactions in cells already infected with the virus. α- and β-interferons block the activity of the virus at all stages of its life cycle, starting from the introduction into the cell and ending with the budding of already multiplied viral particles. Thus, interferons provide a natural antiviral response.

Due to their variability, respiratory viruses have learned to suppress the natural production of interferon. According to the manufacturer's instructions, Amiksin corrects the immune system of children, causing the production of a sufficient amount of interferon, a natural antiviral factor.

The mechanism of action of the drug

Amiksin begins to act immediately after taking the pill inside: interferons begin to be produced in the epithelial cells of the intestine. Absorbed into the body, the drug causes the synthesis of interferon in liver cells - hepatocytes, and then in blood cells: T-lymphocytes, neutrophils and granulocytes. The maximum concentration of the active substance in the body is observed 4-24 hours after taking the drug.

According to the manufacturer, Amiksin effectively stimulates bone marrow stem cells when the immune system in children is in a suppressed state for the following reasons:

• lack of nutrition, vitamins and minerals;
• nervous stress;
• treatment with hormonal and chemotherapy drugs;
• chronic infections (ascariasis, frequent relapses of herpes);
• endocrine diseases (diabetes mellitus, hyperthyroidism).

In special types of leukocytes - B-lymphocytes - children's Amiksin increases the formation of immunoglobulins, which recognize and neutralize disease-causing viral particles. Immunoglobulins in the blood are carried throughout the body, penetrate into all biological fluids and create protection against a viral attack.

Amiksin enhances the activity of macrophages - special protective cells that can capture and absorb substances that are foreign and toxic to the body. Amiksin has an anti-inflammatory effect, blocks the multiplication and growth of tumor cells. Children's Amiksin is rapidly absorbed from the digestive tract, excreted from the body with urine and feces, practically without undergoing any changes in the body. The drug is not involved in metabolic processes and does not accumulate in tissues and organs.

Release form and application

Amiksin tablets of yellow-orange color contain a synthetic active ingredient tilorone and auxiliary components. For children, Amiksin is available in a dosage of 60 mg, for adults, tablets are used that contain 125 mg of tilorone.

Outside, the tablet is coated with a membrane that dissolves only in the intestine and protects the drug from the action of gastric juice. Tablets can be packed in plastic blisters or polymer cans and cartons. The drug must be protected from direct sunlight, the storage temperature should not exceed 25 ˚С.

Before the seasonal rise in the incidence of respiratory infections, children begin to give Amiksin 1 tablet 1 time per week after meals. The duration of the prophylactic course is 4-6 weeks (in total, 4-6 tablets are drunk). Amiksin manufacturers note the protective effect of the drug for another 1 month after taking the last pill.

In rare cases, children's Amiksin causes unwanted side effects:

• disorders of the digestive system;
• temperature rise to 37 ˚С, slight chills;
• rash like urticaria.

Symptoms of dyspepsia usually occur in the first two days after taking the drug and do not require withdrawal.

Contraindications to the use of Amiksin are:

• children under 7 years of age;
• lack of body weight in a child;
• serious mental disorders;
• tendency to allergic reactions.

Medicinal use

Amiksin is allowed to be used not only for prevention, but also for the complex therapy of acute respiratory infections. The drug is well combined with antibiotic treatment and symptomatic therapy. According to research, Amiksin increases the sensitivity of pathogenic bacteria to antibiotics.

For children, Amiksin can be used in parallel with influenza vaccination, this enhances the overall effect of prevention. It is not recommended to use Amiksin with medications containing alcohol in the composition - unwanted side effects (upset stools, pain and spasms along the intestines) may increase.

Children are allowed to start treatment with Amiksin at any stage of the infectious process. The total course dose for a child is 6 tablets of 60 mg each. The drug serves for the prevention of severe bacterial complications in children, reduces the number of exacerbations of chronic diseases of the respiratory system.

Of all the synthetic drugs that activate the production of interferons, Amiksin is the most studied. Over the years, physicians from leading medical institutions in Moscow and St. Petersburg have experienced its effect on themselves and noted the positive preventive effect.

The active ingredient Amiksin was synthesized in the United States back in 1968, but at the moment the drug is used for therapeutic and prophylactic purposes only in the CIS countries. Doctors recommend using no more than 2-3 courses of prophylaxis per year in children and increasing the body's defenses not only with immunocorrecting drugs, but also with the help of hardening.

Description up to date on 09.11.2015

• Latin name: Amixin
• ATX code: L03AX
• Active substance: Tilorone
• Manufacturer: Dalkhimfarm, Pharmstandard-Tomskhimfarm OJSC (Russia)

Compound

Amiksin contains 125 mg of the active ingredient tilorone (tilaxin) , also additional substances: potato starch, calcium stearate, sodium croscarmellose, MCC, povidone.

Amiksin for children contains 60 mg of active ingredient tilorone (tilaxin) , also additional components: potato starch, croscarmellose sodium, MCC, povidone, calcium stearate.

Release form

Amiksin is produced in pill form.

Preparation 60 mg- These are tablets of light pink color, with a shell, biconvex, round. There may be orange or white blotches on the fracture. Packed in contour packs of 10 pcs. or 6, 10, 20 pcs. to banks.

Preparation 125 mg- These are orange-colored tablets with a shell, biconvex, round. At the break, the tablet is orange, inside there may be orange or white blotches. Packed in contour packs of 10 pcs. or 6, 10, 20 pcs. to banks.

pharmachologic effect

The drug Amiksin acts in the body as antiviral and immunomodulatory means.

The drug is a synthetic low molecular weight inducer , which in the body stimulates the production of interferons.

Under influence tilorona interferon in the body is produced by intestinal cells, hepatocytes , neutrophils , T-lymphocytes , granulocytes .

Induces the process of synthesis of interferon in leukocytes, reduces immunosuppression ... Enhances education , provides stimulation of bone marrow cells. Also helps to restore the ratio T-suppressor and T-helpers.

This antiviral drug is effective against various viral infections, suppressing the process of viral reproduction by inhibiting the translation of virus-specific proteins in cells that have been infected.

Pharmacokinetics and pharmacodynamics

After the tablets have been taken orally, the maximum production of interferon occurs in the following sequence: initially in the intestine, then in the liver and in the blood after 4-24 hours.

It is absorbed quickly from the digestive system, the level of its bioavailability is about 60%. The connection with proteins is about 80%.

It does not accumulate in the body, its biotransformation does not pass.

The active substance is excreted from the body almost unchanged. Excretion passes through the intestines and kidneys. The half-life is 48 hours.

Indications for the use of Amiksin

Amiksin is indicated for use in adult patients in the following cases:

• for the purpose of prevention, as well as therapy and ;
• for the treatment of viral hepatitis A, B and C;
• for therapy ;
• for the treatment of infection ;
• as a drug in the complex therapy of encephalomyelitis of allergic and viral origin;
• as a drug in complex treatment , respiratory and urogenital;
• as medicine for lungs as part of complex treatment.

The indications for the use of Amiksin for children after 7 years of age are determined - the treatment of colds and flu.

Contraindications

The tool is contraindicated for use:

• during and at;
• the patient's age up to seven years;
• high level of sensitivity sensitivity to the components of Amiksin.

Side effects

Before taking Amiksin, it should be noted that certain side effects may develop in the course of treatment:

• digestive system: manifestation of symptoms of dyspepsia;
• other manifestations:, short-term manifestation chills .

Instructions for use of Amiksin (Way and dosage)

The medicine must be taken orally after a meal.

Instructions for the use of Amiksin for children

For the treatment of colds and flu, children are prescribed one tablet of Amiksin once a day for two days. Next, you need to take 4 more table. every other day, 1 pc.

Instructions for use Amiksin IC

For the purpose of prevention viral hepatitis A you need to drink 1 table. 125 mg once a week for 6 weeks. For the treatment of this ailment, 2 tablets are prescribed on the first day, after which one tablet should be taken 48 hours later. A total of 10 pieces should be taken.

For therapy hepatitis B in acute form, you need to drink 1 table in the first two days. 125 mg, then 1 tab. after 48 hours. A total of 16 pieces should be taken. In the chronic course of the disease, the doctor may prescribe a longer treatment - up to 6 months.

Patients with acute hepatitis C in the first two days of treatment, you need to drink 125 mg, then 1 table. after 48 hours. A total of 20 pieces should be taken. Amiksina. In the case of hepatitis C, chronic treatment may be longer - the course of therapy includes taking 40 tablets - 1 pc. after 48 hours.

The use of Amiksin for treatment neuroviral infections suggests taking 125-250 mg per day in the first 2 days, then 1 table. after 48 hours. Treatment can last 3 to 4 weeks.

For treatment colds and flu in adults, 1 table is prescribed. in the first 2 days, after which - 1 table. after 48 hours. In total, you need to drink 6 tablets. For the prevention of these ailments, 1 table is prescribed. once a week, course duration - 6 weeks.

Patient with cytomegalovirus, herpes infection takes 1 table. in the first 2 days, then - 1 table. after 48 hours. In total, you should take 10-20 pcs. The treatment regimen for respiratory and urogenital chlamydia ... The course includes 10 Amiksin tablets.

For the purpose of treatment tuberculosis patients are prescribed 250 mg of drugs in the first 2 days, then 125 mg after 48 hours. For the course - 20 tab.

Overdose

To date, there is no data on an overdose of Amiksin and Amiksin IC in adults and children.

Interaction

There were no manifestations of clinical interaction when taking Amiksin and , which are used to treat infectious diseases.

Terms of sale

Can be purchased without a prescription.

Storage conditions

Belongs to list B. Keep out of children, from moisture and light, at t not higher than 30 ° C.

Best before date

You can save the medicine for 3 years.

special instructions

Many patients ask doctors whether it is Amiksin or not. You should know that the drug is not an antibiotic, from which you need to take this into account when taking the medicine. It is an immunomodulatory drug.

Amiksin's analogs

Matching ATX level 4 code:

Amiksin's analogs - drugs Actaviron , , Tilaxin , Tiloron , Tiloram ... The optimal drug should be chosen by the attending specialist.

For kids

Parents should take into account that drugs should not be taken by children under 7 years of age. Reviews of Amiksin for children indicate that the remedy is often used both for treatment and for the prevention of colds and flu in schoolchildren. However, most parents consider it to be an effective drug.

With alcohol

Their compatibility with alcohol should be considered before starting treatment. Amiksin and alcohol should not be taken, since alcohol significantly reduces the effectiveness of the active substance of the drug.

During pregnancy and lactation

You can not prescribe Amiksin during pregnancy, as well as women who practice breastfeeding.

Reviews about Amiksin

Many reviews of doctors about Amiksin inform that the medicine should not be used uncontrollably, without the preliminary appointment of a specialist. Users leave both positive and neutral reviews. Many write that with the help of the drug it was possible to quickly get rid of the unpleasant symptoms of colds and flu, strengthen ... At the same time, negative phenomena rarely develop. But there are opinions that the medicine turned out to be practically useless.

Amiksin's price where to buy

You can buy the drug at any pharmacy. The price of Amiksin tablets depends on the packaging. On average, purchase a package of 10 pcs. 60 mg tablets can be purchased for 600 rubles, a pack of 10 pcs. 125 mg - at a price of 900 rubles.

• Online pharmacies in Russia Russia
• Online pharmacies of Ukraine Ukraine

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Amiksin tab. p.p. 125mg n6

Amiksin tab. p.p. 125mg n10Pharmstandard-Tomskkhimfarm / Pharmstandard-Leksredstva OJSC

Amiksin tab. p.p. 60mg n10Pharmstandard-Tomskkhimfarm / Pharmstandard-Leksredstva OJSC

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Amiksin (tab. 125mg No. 10 (blister))

Amiksin (tab. 125mg No. 6)

Amiksin tablets 60mg No. 10 blister

Amiksin tablets 60mg No. 10

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Amiksin 60 mg n10 tabPharmstandard-Tomskkhimfarm / Pharmstandard-L

Amiksin 125 mg n6 tab FS-Leksredstva

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According to the WHO, more than 300,000,000 people are ill with ARVI every year. In Moscow alone, during the 2014-2015 epidemic season, 2,542,880 patients were registered, and this is only registered! The number is 2% more than in the previous epidemic season. The amazingly high incidence (more than 21 thousand per 100 thousand of the population!) Makes one think about the prevention of ARVI in seasons that are dangerous to health, but statistics suggest otherwise.

The problem of vaccination against influenza viruses and other acute respiratory viral infections is that the strains mutate rapidly, adjusting to new conditions every year, and it is impossible to predict with certainty which of the strains will be in the respiratory tract of a particular patient. Interferon inducers come to the rescue - drugs that stimulate the production of interferons by the human body.

One of the safest and most effective inducers of interferon is the drug Amiksin. At the same time, contrary to general fears, one should not be afraid to use Amiksin for prophylaxis, since the production of protective proteins is under the control of special repressor proteins. They will not allow the production of excessive amounts of interferons, which could lead to side effects: furunculosis, itching and burning of the skin, rash, damage to the central nervous system, etc.

Amiksin's composition

The active ingredient of Amiksin is tilorone. It is available in adult (125 mg) and pediatric (60 mg) dosages of Amiksin. More details about excipients can be found in the instructions, and it should be noted that the composition does not contain glucose and sucrose, so the drug can be taken by people with impaired carbohydrate metabolism.

Pharmacological action of Amiksin

When Amiksin enters the stomach, after a period of time from 4 to 24 hours, the maximum production of interferons is noted. Interferons actively fight the virus in different directions: alpha and beta interferons block the reproduction of viruses, the development of complications is prevented by gamma interferons, and lambda prevents the attachment of viruses to the mucous membrane, thereby preventing them from penetrating inside.

In addition to the properties of an immunomodulator, Amiksin is able to directly fight the virus. When multiplying, the virus copies its genetic information many times, collecting similar particles for itself. These particles are protein. Amiksin blocks the synthesis of "spare parts" for new viruses, thus suppressing its reproduction.

How does Amiksin differ from most drugs?

Amiksin has several advantages over similar drugs.

• Convenient reception scheme. Amiksin for the prevention and treatment of an adult is available in a dosage of 125 mg, the package consists of 6 tablets. For treatment in the first two days, you need to drink one tablet, and then the remaining four - every 48 hours. For prophylaxis, the regimen is even simpler - once a week, one tablet. The concentration of the drug will be sufficient to maintain the required level of interferons during the epidemic.
• No residue packaging. A package of 6 tablets is designed in such a way that after a course of treatment or prophylaxis, there are no blisters with single tablets that can lie for years (usually half of the pharmacy cabinets are filled with them). There is also a pack of 10 tablets, but it is intended for the treatment of herpes infection.
• With regard to the treatment, the drug is effective even if you missed taking Amiksin on the first day of the illness and started taking it 2-3rd from the onset of the illness.
• Fast effect. As already mentioned, Amiksin begins to act 4-24 hours after administration. This means that prophylaxis can be started immediately after contact with the patient - the drug is suitable for both planned and emergency prophylaxis.
• Scientifically proven effectiveness. Many studies have been carried out to study all the possibilities of Amiksin, as a result of which it was recognized as an effective drug for the prevention of ARVI, regardless of the type of virus (influenza virus, parainfluenza, adenovirus, etc.). Moreover, it was the full prophylactic course of Amiksin that led to a pronounced decrease in morbidity during the entire time of its administration (3.4 times compared with the control group), and even 2 weeks after the end of the course.

What diseases does Amiksin prophylaxis help against?

Amiksin is taken to prevent all acute respiratory viral infections. Several diseases belong to them, some of them are presented in the table. It is important to recognize the first symptoms of SARS in order to choose the right tactics, and already the type of virus will play a secondary role.

SARS are transmitted mainly by airborne droplets (less often by contact). Basic hygiene rules are partly the prevention of acute respiratory viral infections and other diseases in principle - covering your nose or mouth with something when coughing or sneezing, washing your hands, consuming enough vitamins (during periods of an epidemic, vitamin C is especially important, which has a beneficial effect on immunity).

And the eternal - to quit smoking. Infectious agents, entering the respiratory tract, settle on the mucous membranes of this area. Smoking by itself irritates the respiratory tract, lowers immunity both locally and at the level of the whole organism.

	Symptoms	Prevention scheme
	A sharp rise in temperature to 39 o C -40 o C, headache (mainly in the forehead), after 1-2 days nasal congestion, "scratching" in the throat, cough with phlegm, sweating join. The pulse quickens.	Amiksin, 125 mg - once a week for 6 weeks.
Parainfluenza	The gradual development of the disease. Hoarseness appears, a rough barking cough, then nasal congestion and runny nose join. The temperature rises slightly. Persistent cough remains the main symptom.
Rhinovirus infection	It is also called "contagious rhinitis". It is manifested by nasal congestion and dryness in it, abundant, gradually thickening nasal discharge. Possible headache, hoarseness. The most striking sign of rhinovirus infection is the almost complete absence of symptoms of intoxication in combination with powerful rhinorrhea and possible pharyngitis.
Adenovirus infection	In adults, the temperature is not prone to strong rises, nasal congestion, runny nose, pain and sore throat, inflammation of the tonsils, swollen lymph nodes, conjunctivitis.
MS infection	More common in children. Light chills, temperature up to 37 o C -38 o C. On 2-3 days nasal discharge joins. An important symptom is a dry, persistent, long cough and shortness of breath.

How to take Amiksin correctly for prophylaxis?

One package of 6 tablets (dosage - 125 mg) of Amiksin is needed for the prevention of ARVI. You need to drink one tablet a week for six weeks (course dose - 750 mg of tilorone). It can be taken on a planned basis during periods of epidemics and urgently, after contact with a patient. It is not recommended to interrupt the course, since, according to studies, the incidence depended on the duration of the drug intake, and those subjects who stopped taking Amiksin 3-4 tablets fell ill more often than those who completed the full course.

Unfortunately, not as much attention is paid to ARVI prevention as we would like. The incidence rates are high, children are at risk, in whom some ARVIs are more severe than in adults.

Research confirms the effectiveness of prevention, everyone knows very well about the methods of strengthening the immune system from articles and from tabloids about a healthy lifestyle. And it is better not to jeopardize your health, the health of a child who can get infected from you, and at least during periods of epidemics, reduce the risk of contracting any respiratory virus by taking Amiksin.