Afobazole instructions for use contraindications side effects. "Afobazol": side effects

Afobazole is a drug from the group of anxiolytics (tranquilizers) of a non-bezodiazepine structure, which has a moderate activating effect in combination with relief of anxiety.

It has a very mild, compared with benzodiazepines, action, does not cause the development of drug dependence and does not provoke withdrawal syndrome after cessation of therapy.

The use of Afobazol for persons with asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, a tendency to emotional stress reactions.

The result of therapy is already noticeable on the 5-7th day of treatment. Maximum effect achieved by the end of the 4th week and persists after the end of treatment up to 2 weeks.

Afobazole is a 2-mercaptobenzimidazole derivative, a selective anxiolytic that does not belong to the class of benzodiazepine receptor agonists. Prevents the development of membrane-dependent changes in the GABA receptor.

After oral administration, Afobazole is well and rapidly absorbed from the gastrointestinal tract. Cmax in plasma - (0.13±0.073) µg/ml; Tmax - (0.85±0.13) h.

Afobazole is available in tablet form. Tablets are flat, cylindrical, chamfered, packed in 10 or 25 pieces in blisters. Their color can vary from white to white with a creamy tint.

Indications for use

What helps Afobazol? The drug is prescribed in the following cases:

• anxiety states in adults:
• generalized anxiety disorders;
• neurasthenia;
• in patients with various somatic ( bronchial asthma, irritable bowel syndrome, SLE, coronary artery disease, arterial hypertension, arrhythmias), dermatological, oncological and other diseases;
• sleep disturbances associated with anxiety;
• cardiopsychoneurosis;
• premenstrual tension syndrome;
• alcohol withdrawal syndrome;
• relief of the withdrawal syndrome when quitting smoking.

The action of the drug is realized mainly in the form of a combination of anxiolytic (eliminates anxiety) and stimulating (activating) effects.

Instructions for use Afobazol and dosage

Accept inside, after food.

A single dose is 10 mg; daily dose- 30 mg divided into 3 doses throughout the day.

The duration of course therapy is 2-4 weeks. If necessary, the daily dose of Afobazole can be increased to 60 mg, and the duration of treatment up to 3 months.

Contraindications

Hypersensitivity to Afobazole components.

The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not be prescribed the drug.

special instructions

There are several special instructions, which are important to consider when starting to take Afobazol tablets, these include:

• Strengthening the anxiolytic action of diazepam and the anticonvulsant effect of carbamazepim.
• The drug does not affect a person's ability to perform work, associated with increased attention and the need for a sufficient speed of psychomotor reactions.

Overdose

With a significant overdose and intoxication, the development of a sedative effect and increased sleepiness without signs of muscle relaxation.

As emergency care caffeine sodium benzoate 20% solution in ampoules of 1.0 ml is used 2-3 times a day subcutaneously.

Application during pregnancy

It is forbidden to use Afobazole during pregnancy. If necessary, the appointment during lactation should be discontinued. breast-feeding for the entire period of drug therapy, as it passes into breast milk.

Side effects

When prescribing Afobazol, the development of side effects is possible:

• Allergic reactions.
• Rarely - headache, which usually resolves on its own and does not require discontinuation of the drug.

According to doctors, Afobazole therapy is well tolerated in the vast majority of cases.

Afobazole, unlike other tranquilizers, is not able to enhance the narcotic effect of alcohol, so taking alcohol during treatment with the drug will not cause negative consequences. However, drinking alcoholic beverages can significantly reduce therapeutic effect drug or reduce the effect of its use to zero, as they have the opposite effect on the nervous system.

Sedatives found today widest application due to their popularity and relevance to a large number of situations. One of the drugs is afobazole. Instructions for use, price, reviews, analogues- all this will be considered within the framework of the material. With a competent approach to the therapeutic complex, one can achieve good result followed by improved well-being.

Each tablet form of the drug contains 5 or 10 mg of the main substance afobazole per 1 pc. The auxiliary elements are such as lactose, starch, cellulose and others. The release form is represented by tablets that have a white, creamy color with a hint in the form of a cylinder. The manufacturer offers 10 or 25 tablets, enclosed in a PVC contour or blister pack. There are also funds in a polymer bank - 30, 50 or 100 pieces. Afobazole has a broad sedative effect, it is a selective anxiolytic that is not related to the class of agonists of receptor functions. The tool has an obstacle in terms of development of changes depending on the state of the membrane.

The drug traditionally does not have muscle relaxant qualities, does not adversely affect memory and attention functions. If it is used, drug dependence is not carried out, the withdrawal syndrome does not appear. The action occurs solely through the targeted effects of the drug. After 5-7 days of therapy, which is supposed these pills, there are several positive effects.

The maximum effect is observed after a month of taking the remedy. The property is preserved after therapy for a crescent. What does it heal drug - it is mainly indicated to be used to eliminate asthenic personality traits, with anxious suspiciousness, uncertainty and vulnerability. The time during which the half-life of the drug occurs is about 0.7 hours. The maximum level of content is from 0.13 μg / ml, it is retained in the body for 0.8 hours. In the body there is an effective distribution of the entire drug.

Indications for use means are as follows:

Compliance with the rules for the use of the drug guarantees good and operational result from the therapeutic procedures. The cost of the drug is about 270-300 rubles.

Considering the main contraindications to the use of the composition, several dominant factors can be noted. You can not take pills, being in certain phenomena and conditions.

• gestation;
• lactation;
• individual lack of portability;
• age category up to 18 years.

In addition to restrictions in admission, the tool has some side effects , it is important to take them into account.

• sensitivity to the components of the means of an individual plan;
• manifestation of allergic reactions on the skin.

Reviews narcologists and other specialists testify to cases of drug overdose. At which the rapid development of the effect of a sedative plan is possible, as well as an increase in drowsiness. As an emergency, other drugs can be used, mainly sodium benzoate 20%. The agent has no effect on the narcotic properties of ethanol, can cause an increase in the action when taking diazepam, and can also be used as a potentiator when using carbamazepine.

Afobazole instructions for use

For kids- persons of minor age - a drug not registered. If we consider the question of who is prescribed remedy, then it is prescribed to persons suitable for some of the indications for use. Based on their data official instructions, the optimal indicator of the dose of the drug is the use of 10 mg.

The treatment process lasts in courses, only if the dosages are observed, you can achieve a good result and stable work. nervous system and other organs.

Afobazole analogues and substitutes

There are a few similar drugs, similar in effect, but more cost-effective.

• TENOTEN;
• PERCEN;
• PHENAZEPAM;
• GRANDAXIN.

These funds have similar properties and relation to tranquilizers of sedative, anticonvulsant action. This remedy is prescribed for conditions after a violation of the blood circulation of the brain, as well as for intoxication and starvation in terms of oxygen supply. The remedy reduces the number of brain cells that are damaged. Unlike the main drug under consideration, this remedy can be used in childhood. The drug costs cheaper of the funds in question, about 200 rubles must be paid for packaging.

Both drugs are related to the group of tranquilizers, equipped with a good sedative effect. The effect of the drugs is aimed at relieving the tension factor and the nervous phenomenon, and the drugs effectively fight fatigue and excessive irritation. Medications provide normalization and activation brain activity, improve the thought process and contribute to the restoration of memory functions. Compared with the drug in question, Persen contains only natural elements. plant origin, so its effect is very strong. Price - from 200 rubles.

The cost of this drug is from 80 rubles, that is, it is more cheapmedications. The tool has a unique ability to instantly eliminate irritability, factors of nervousness and fatigue. It also helps with sleep problems, autonomic disorders and headaches. The difference between the drugs is not only in price, but also in more restrictions on the use of phenazepam.

The action of the funds is the same and is aimed at general stress relief, elimination of neurosis, sleep problems and pain in the head. The drug in question has a milder effect, but creates more problems in the form of side effects. Grandaxin is allowed for use during pregnancy, but has a high price - from 800 rubles per pack.

Afobazole or Novopassit which is better

Novopassit is another remedy that helps to calm and improve overall well-being. Considering the question of what to choose between two drugs, it is worth studying their characteristics in more detail. The properties of these drugs are similar, both drugs are aimed at getting rid of irritants, fatigue and help with insomnia. Also difference consists in the fact that the remedy in question, novopassitis, contains exclusively components of plant origin, therefore it is aimed at getting rid of only mild disorders. For example, it can be drunk for prevention before the exam not to worry. He is also assigned with VVD, PMS, menopause, headaches.

Such a drug falls into the group of tranquilizers, but at the same time it has a very mild effect on the human body. It does not cause addiction in the patient and does not provoke the development of a withdrawal syndrome at the end of therapy. In order to receive only pluses from taking the remedy, you must strictly follow the instructions for the use of Afobazol.

To date single form release of "Afobazole" - tablets. They are white/cream colored. There are two dosing options active substance in pills - 5 and 10 mg. Tablets are packaged in blisters or glass jars (from 10 to 100 pieces, depending on the packaging option).

The main active component of the drug was fabomotizol. The product also includes auxiliary ingredients: starch (potato), lactose monohydrate and some others. The composition was the same for both dosage options.

Pharmacological properties and indications for use

Main active ingredient The drug reduces a person's feeling of anxiety, calms, eliminates irritability and even has a positive effect on mood. At the same time, unlike most analogues, the drug does not cause memory loss, does not reduce brain activity and concentration, does not lead to the development of drowsiness and other similar effects. In addition, it does not form drug dependence.

In addition to eliminating anxiety, the drug has the following effects on the patient's body:

• struggles with bad feelings, feelings of concern, fear, etc.;
• improves night sleep(without morning and afternoon sleepiness);
• relieves psycho-emotional stress;
• helps relax.

The medicine leads to a decrease in spasm of the muscles of the genital organs, reduces sweating, relieves dizziness and dry mouth.

It is especially important to use such a remedy for anxious, suspicious people with increased emotionality.

Shortly after taking the drug active substance completely absorbed into the blood and rapidly distributed throughout the body. Excreted by the kidneys.

Specialists prescribe pills for the following problems:

• sleep disturbance caused by anxiety;
• disorder of social adaptation of a person;
• severe premenstrual syndrome;
• "breaking" in the fight against alcoholism and smoking;
• cardiopsychoneurosis.

Often, the drug in question is used as part of a complex therapy various serious illnesses. For example, with asthma (bronchial), some problems with the heart and blood vessels (when oxygen and nutrients enter the heart muscle in an amount insufficient for its normal functioning), increased blood pressure and some others. The medicine helps to cope with tearfulness, capriciousness, depression, which are typical for patients suffering from various diseases hearts.

Pills are also prescribed for ailments that cause a person to feel inferior and doubt the ability to be in society.

Instructions for use "Afobazole"

It is very important to know exactly how to take Afobazol according to a scheme that is safe for the patient's body. Such tablets, unlike other tranquilizers, are allowed to be consumed immediately in a full portion, and not to increase the dosage slowly and gradually. This is due to the mild effect of the drug. It doesn't take time to get used to it. It is allowed to use the drug once, because it does not cause addiction in patients.

It must be remembered that after the completion of taking the remedy, its effect will persist for another 10 to 15 days. During this period, other drugs with a similar effect should be abandoned.

The drug is suitable only for adult patients. The tablet should be taken shortly after a meal. It is consumed whole (without chewing and other damage). The medicine is washed down with water without sugar and gas. A small amount of liquid is enough.

• If this is the 10 mg option, then 1 pill is consumed three times a day.
• If 5 mg, then 2 tablets in the same number of doses.

It is desirable to observe approximately equal intervals between pills.

The standard course of therapy with this drug is 14 - 28 days. After the maximum period has elapsed, the reception must be stopped for a while. You can repeat the course not earlier than in another month.

It is allowed to increase the duration of treatment and dosage only under the strict supervision of an experienced specialist.

Can I take during pregnancy and lactation

The medicine in question is a tranquilizer. It is strictly forbidden to take it during pregnancy, regardless of its duration. It is better for a woman to cope with anxiety during the period of bearing a baby with the help of folk remedies and special herbal medicines.

Forbidden medicine and during lactation. If a young mother decides to start taking the drug, she will have to transfer the baby to artificial feeding.

Compatibility "Afobazole" and alcohol

Main active ingredient the drug under discussion does not react with ethyl alcohol. But this does not mean at all that Afobazole and alcohol can be safely drunk together.

Such information from the instructions for the remedy only suggests that the drug can be taken, for example, with a hangover. It helps to cope with the unpleasant symptoms that accompany this condition.

"Afobazole" stimulates the nervous system, slows down the process of absorption of alcohol that has already entered the stomach, accelerates the process of excretion of substances formed during the breakdown of alcohol from the body. However, for the treatment alcohol addiction at any stage the drug is not suitable. It can only stop the main symptoms of a hangover and improve general state the patient at the same time. For this purpose, it is taken no more than 2 times a day for 10-20 mg.

It must be remembered that alcohol neutralizes the healing effect of the drug on many systems and organs. For example, if the remedy is used by women to improve their condition during menopause.

Just one serving alcoholic drink significantly reduce the effectiveness of "Afobazol" and lead to the fact that all unpleasant symptoms problems come back.

It is especially dangerous to combine the drug and alcohol in case of problems with the heart and blood vessels, lungs, bronchi. Such a “neighborhood” can also strengthen the neurotic states of the patient.

Drug interactions with other drugs

As noted above, the components of the drug do not interact with ethyl alcohol. Therefore, it can be combined with certain alcohol-based medications.

Using the tool in parallel with "Diazepam" and "Carbamazepine", you need to remember that it enhances their effect.

Contraindications, side effects and overdose

The drug under discussion also has a whole list of contraindications. It must be carefully studied before starting the reception.

The medicine is strictly prohibited with the following features of the patient's body:

• hypersensitivity, intolerance to individual components of the drug or allergic reactions to them;
• lactase deficiency;
• childhood.

If the patient is taking any medications (including to alleviate the symptoms of chronic ailments), he should definitely inform the doctor who recommends taking Afobazole. This may cause changes in the regimen for taking new pills or even a delay in starting therapy.

Cases of drug overdose are rare, as correct scheme therapy with such pills is simple and understandable. Usually the problem appears with the erroneous simultaneous use of pills in large quantities. If for a long time the patient slightly overestimates the dosage of the drug, then an overdose will not develop, because its components do not accumulate in the tissues of the body.

When a problem occurs, a person will notice the following symptoms:

• drowsiness without weakness in the muscles (it can occur even immediately after getting out of bed in the morning);
• excessive calmness and even “inhibition”.

To cope with an overdose will allow a solution of caffeine sodium benzoate (20 percent). The drug is administered by injection 2 to 3 times a day, and always subcutaneously.

Patients treated with Afobazol, in rare cases, may experience side effects of the drug. First of all, among them it is necessary to single out migraine and all kinds of allergic reactions(often expressed as skin rash). Such manifestations do not require special treatment. There is no need to cancel the drug.

It happens that patients notice an increase in their sexual desire soon after the start of therapy with the discussed tablets. This is not a side effect of the drug, but a consequence of the removal of anxiety and nervous tension.

Analogues

Modern pharmacies present a large number of analogues of "Afobazol". Among the cheapest can be noted the Belarusian "Fenibut". It is also prohibited for pregnant women.

Other analogues of "Afobazole": "Mebikar" (produced in Russia), "Anvifen", "Atarax", "Tenoten", "Persen". Novo-Passit is also particularly popular among buyers.

Anxiolytic (tranquilizer)

Active substance

Fabomotizole (fabomotizole)

Release form, composition and packaging

◊ Tablets

Excipients: potato starch - 48 mg, microcrystalline cellulose - 40 mg, lactose monohydrate - 48.5 mg, medium molecular weight (medium molecular polyvinylpyrrolidone medical, collidon 25) - 7 mg, magnesium stearate - 1.5 mg.

◊ Tablets white or white with a creamy tint, flat-cylindrical, with a chamfer.

Excipients: potato starch - 48 mg, microcrystalline cellulose - 35 mg, lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone, collidon 25) - 7 mg, magnesium stearate - 1.5 mg.

10 pieces. - cellular contour packings (3, 5, 10) - packs of cardboard.
20 pcs. - cellular contour packings (1, 2, 3, 4, 6) - packs of cardboard.
25 pcs. - cellular contour packings (2, 4) - packs of cardboard.
30 pcs. - cellular contour packings (1, 2, 3, 4) - packs of cardboard.
30 pcs. - polymer cans (1) - packs of cardboard.
50 pcs. - polymer cans (1) - packs of cardboard.
100 pieces. - polymer cans (1) - packs of cardboard.
120 pcs. - polymer cans (1) - packs of cardboard.

pharmachologic effect

Afobazole is a selective non-benzodiazepine anxiolytic. acting on sigma-1 receptors nerve cells brain, Afobazole stabilizes GABA / benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators. Afobazole also increases bioenergy potential neurons and has a neuroprotective effect: restores and protects nerve cells.

The action of the drug is realized mainly in the form of a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects. Afobazole reduces or eliminates feelings of anxiety (concern, bad forebodings, fears), irritability, tension (shyness, tearfulness, anxiety, inability to relax, fear), depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory), incl. arising from stress disorders (adaptation disorders). Especially indicated is the use of the drug in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, a tendency to emotional stress reactions.

The effect of the drug develops on the 5-7th day of treatment. The maximum effect is achieved by the end of 4 weeks of treatment and persists after the end of treatment for an average of 1-2 weeks.

Afobazole does not cause muscle weakness, drowsiness and does not negative influence on concentration and memory. When it is used, addiction, drug dependence is not formed and the “withdrawal” syndrome does not develop.

Pharmacokinetics

Suction

After oral administration, Afobazole is well and rapidly absorbed from the gastrointestinal tract. Cmax - 0.130±0.073 µg/ml; T max - 0.85±0.13 h.

Metabolism

Afobazole undergoes a "first pass" effect through the liver, the main metabolic pathways are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment. Afobazole is intensively distributed over well-vascularized organs, it is characterized by rapid transfer from the central pool (blood) to the peripheral (highly vascularized organs and tissues).

breeding

T 1/2 of fabomotizole when taking the drug orally is 0.82 ± 0.54 hours. Short T 1/2 is due to the intensive biotransformation of the drug and rapid distribution from blood plasma to organs and tissues. The drug is excreted mainly in the form of metabolites and partly unchanged in the urine and feces.
With prolonged use does not accumulate in the body.

Indications

Afobazole is used in adults with anxiety states:

- generalized anxiety disorders;

- neurasthenia;

- adaptation disorders;

- in patients with various somatic diseases: bronchial asthma, irritable bowel syndrome, coronary artery disease, hypertonic disease, arrhythmias;

- in dermatological, oncological and other diseases.

During treatment:

- sleep disturbances associated with anxiety;

- neurocirculatory dystonia;

— premenstrual syndrome;

- alcohol withdrawal syndrome;

- to alleviate the "withdrawal" syndrome when quitting smoking.

Contraindications

— hypersensitivity to the components of the drug;

- galactose intolerance, lactase deficiency or glucose-galactose malabsorption;

- pregnancy;

- lactation period (breastfeeding);

- children's age up to 18 years.

Dosage

The drug is used orally, after meals.

Optimal single doses - 10 mg; daily - 30 mg, divided into 3 doses during the day.

The duration of the course of the drug is 2-4 weeks.

Side effects

Maybe: allergic reactions.

Rarely:, which usually resolves on its own and does not require discontinuation of the drug.

Overdose

Symptoms: with a significant overdose and intoxication, a sedative effect and increased drowsiness may develop without manifestations of muscle relaxation.

Registration number: LS-000861
Trade name of the drug: Afobazol®
INN or grouping name: fabomotizole
Dosage form: tablets

Composition per tablet:

Active substance: fabomotizole (fabomotizole dihydrochloride) - 5 mg and 10 mg. Excipients: potato starch - 48 mg, microcrystalline cellulose - 40 mg (for a dosage of 5 mg) and 35 mg (for a dosage of 10 mg), lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone medical, collidon 25) - 7 mg, magnesium stearate - 1.5 mg.

Description: white or creamy white tablets, flat-cylindrical, bevelled .

Pharmacotherapeutic group: anxiolytic agent (tranquilizer).

ATX code: N05BX.

Pharmacodynamics:

Afobazol® is a selective non-benzodiazepine anxiolytic.

Acting on sigma-1 receptors in the nerve cells of the brain, Afobazole® stabilizes GABA / benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators. Afobazol® also increases the bioenergetic potential of neurons and has a neuroprotective effect: it restores and protects nerve cells.

The action of the drug is realized mainly in the form of a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects. Afobazole® reduces or eliminates anxiety (concern, bad forebodings, fears), irritability, tension (shyness, tearfulness, anxiety, inability to relax, insomnia, fear), depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory), incl. arising from stress disorders (adaptation disorders). Especially indicated is the use of the drug in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, a tendency to emotional stress reactions.

The effect of the drug develops on the 5-7th day of treatment. The maximum effect is achieved by the end of 4 weeks of treatment and persists after the end of treatment for an average of 1-2 weeks.

Afobazole® does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and memory. With its use, addiction, drug dependence is not formed and the “withdrawal” syndrome does not develop.

Pharmacokinetics:

After oral administration, Afobazol® is well and rapidly absorbed from the gastrointestinal tract.

The maximum concentration of the drug in plasma (Cmax) - 0.130 + 0.073 μg / ml; the time to reach the maximum concentration (Tmax) - 0.85+ 0.13 hours.

Metabolism: Afobazole® undergoes a “first pass effect” through the liver, the main directions of metabolism are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment.

Afobazole® is intensively distributed over well-vascularized organs, it is characterized by rapid transfer from the central pool (blood plasma) to the peripheral (highly vascularized organs and tissues).

The half-life of Afobazol® when taken orally is 0.82 + 0.54 hours. The short half-life is due to the intensive biotransformation of the drug and the rapid distribution from blood plasma to organs and tissues. The drug is excreted mainly in the form of metabolites and partly unchanged in the urine and feces.

Indications for use:

Afobazole® is used in adults with anxiety conditions: generalized anxiety disorders, neurasthenia, adjustment disorders, in patients with various somatic diseases (bronchial asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic disease heart disease, hypertension, arrhythmias), dermatological, oncological and other diseases. In the treatment of sleep disorders associated with anxiety, neurocirculatory dystonia, premenstrual syndrome, alcohol withdrawal syndrome, to alleviate the “withdrawal” syndrome when quitting smoking.

Contraindications:

Individual intolerance to the drug. Galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Pregnancy, lactation. Childhood up to 18 years old.

Use during pregnancy and during breastfeeding:

The use of the drug Afobazol® is contraindicated during pregnancy. If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

Dosage and administration:

It is applied inside, after eating.

Optimal single doses - 10 mg; daily - 30 mg, divided into 3 doses during the day. The duration of the course of the drug is 2-4 weeks.

Side effects:

Allergic reactions are possible.

Rarely - headache, which usually resolves on its own and does not require discontinuation of the drug.

Overdose:

With a significant overdose and intoxication, the development of a sedative effect and increased drowsiness without manifestations of muscle relaxation is possible. As an emergency, caffeine 20% solution is used in ampoules of 1.0 ml 2-3 times a day subcutaneously.

Interaction with other drugs:

Afobazole® does not interact with ethanol and does not affect the hypnotic effect of thiopental. Enhances the anticonvulsant effect of carbamazepine. It causes an increase in the anxiolytic action of diazepam.

Influence on the ability to drive vehicles, mechanisms: