Sumamed for a child 4 years what dosage. During pregnancy and lactation

There are many various ailmentsthat cannot be cured without antibacterial therapy. The prescribed drug will cope with the disease in the shortest possible time and will prevent possible complications. Any caring mother must have an idea of \u200b\u200bmodern antibiotics.

One of the most common and efficient antibacterial drugs is Sumamed. In which cases it is necessary to take Sumamed, how to take it so that the benefits be maximum, and the harm is minimal? All this will be recognized today by carefully having learned the instructions for use for children, we also learn about the forms of release (in tablets and in suspension). Of course, uncontrolled reception And, moreover, self-examination is simply not allowed.

Release form and composition of the drug

For ease of use, Sumamed has such forms of release:

• Suspension - to receive the drug in liquid form for the smallest patients, has a pleasant cherry banana taste, a measured spoon and / or a syringe for easy dosage compliance are included;

• Pills, containing 125 mg, 250 mg and 500 mg active substance.

Active substance - azithromycin.

The suspension is 100 mg of azithromycin per 5 ml. Excipients: flavors (vanilla, cherry, banana), sucrose, hydroxypropylcellulose, sodium ishydrous phosphate, silicon colloidal dioxide, xanthan gum. Powder has white or light yellow color, the diluted suspension has a pale yellow color.

In tablets with dosages 125 mg, 250 and 500 mg contains an appropriate amount of azithromycin. Additional substances: Corn, hydroxypropylmethylcellulose starch, hydroxypropylmethylcellulose, Calcium Phosphate Anhydrous Bible, Cellulose Microcrystalline, Sodium Laurilsulfate, Starch Modified, Magnesium Stearate, Preservatives, Talc. Round tablets, blue color, at a break white color. On one side of the tablet, there is an inscription "Pliva", on the other - the number corresponding to the dosage.

Indications

Sumamed is a universal antibiotic, an active substance - azithromycin. It has an antibacterial effect in the focus of inflammation.
Of course, bacteria that caused infection should be sensitive to this antibiotic. This medicine is prescribed for diseases, the cause of which can be streptococci groups CF and G, gram-positive coils, anaerobic organisms, some gram-negative bacteria.

The most common infections caused by these bacteria:

• Respiratory infections (tonsillitis, angina, scarletine, pneumonia, bronchitis), otitis, otitis the middle ear, sinusitis;
• Skin infectious diseases (impetigo, face), other skin diseases;
• Urinary infectious disease and sexual infections (urethritis, inflammation of the cervix, Lyme disease);
• Prank ulcer and duodenal gutprovoked Helicobacter pylori..

Important!Viral infections, such as, are not treated with the appointment of antibiotics. Antibiotics are connected to the treatment of these diseases in the case of complications in the form of a bacterial infection.

It is most often prescribed to children in the treatment of angina, bronchitis, sinusitis, it is effective in treating and. For effective treatment Angina needs to take Bakposposev to determine the bacterium-causative agent of angina, since not all bacteria causing an angina are sensitive to azithromycin. Read more about Angina in the article, which will give you all the necessary information about this very common disease.

How to give Sumamed to children

It should be immediately noted that this antibiotic is shown to children with weight more than 5 kg and older than 6 months old.
At the age of half a year, up to 3 years is prescribed in the form of a suspension.

To make a suspension, you need to add so much water as indicated in the instructions, and the solution thoroughly break (water is added room temperature).
The resulting volume by 5 ml is more than the stated - so the manufacturer compensates for possible losses.

The finished solution is stored no more than 5 days at room temperature. Before using the drug, the diluted suspension needs to be gently shake, to score the right amount of medication and give a crier.

How to give a child a drug in the form of a suspension:

• Place the baby, for feeding;
• Place the tip of the measuring syringe in the mouth and give the child to swallow the medicine;
• To wash off the remnants of the drug, give a little juice or water.

A suspension has a pleasant fruit fragrance, it is easy to give to small children, counting the necessary dose based on the weight of the baby. After each application, a measured spoon or a syringe is thoroughly clean. After the end of the course is the bottle, the measured spoon and the syringe are disposed of.

Children from 3 years can receive a tablet shape, drinking a small amount of liquid (water or juice).
You can always calculate the necessary dosage in this way: 10 mg of the active substance per 1 kg of the child's mass.

Contraindications

The medicine has such sideflines:

• abdominal pain;
• diarrhea;
• nausea;

• heart rate violation;
• skin rash.

When complying with dosage and reception rules, the drug is carried out normally, and the appearance side Effects It happens in rare cases.
If nevertheless your baby has a chair disorders, nausea, vomiting appeared on the background of the drug, vomiting - it is necessary to stop taking medication and consult a doctor to replace the antibiotic.
Azithromycin accumulates in the liver and comes out with bile, so Sumamed is not intended for patients with serious liver function disorders.

There are also contraindications:

• In the intolerance of azithromycin or auxiliary components drug;
• With severe disorders of the kidneys;
• During pregnancy and breastfeeding;
• With weight up to 5 kg in the form of suspension;
• At the age of 3 years in 125 mg tablets;
• At the age of 6 years old in 250 mg tablets;
• At the age of under 12 years and / or body weight, less than 45 kg in 500 mg tablets.

Features of use

• Reception: once a day, which is very convenient for children who are poorly taken medication (heavily swallow them).
• It is necessary to observe the time interval and give the drug at the same time: between meals (per hour or 2 hours after the kid pointed).
• In the treatment of infections in children respiratory tract, Lor organs, skin and soft tissues. Treatment period is only 3 days at a daily dose of 10 mg of azithromycin per 1 kg of body weight.
• In the treatment of Lyme disease in the first day, the drug is given in a dosage of 20 mg per 1 kg of mass, then the dosage decreases by 2 times and the course lasts another 4 days.
• The medicine aggressively affects the gastrointestinal tract (there is diarrhea and meteorism). For the treatment of dysbacteriosis caused by intake of antibiotics, the course of probiotics is usually assigned.
• If the baby in the next six months passed the course of the Summen, then his reinstatement will not be effective. This applies to the majority of antibiotics.
• This is a powerful antibiotic, improvements may occur after one-time reception. But it is not a reason for the cessation of the course. High efficiency and effect are associated with dosage and duration of treatment.

Important!In order to simplify the reception of the Summen, calculate the dose of the drug necessary for children, and purchase a medicine in the dosage of 125 mg, 250 mg or 500 mg, depending on age, mass and disease (carefully follow the instructions).

Sumamed - imported drug, its price both on a suspension for children and on tableted forms above the price domestic analogs, such as Slums and Summama. However, it should be taken into account that the analogues of the Sumamed for children can have another dose of azithromycin, not such auxiliary substances. When recommendations, alternatives in the pharmacy, be sure to consult a doctor who assign you Sumamy to confirm the replacement.

Sumamed for children - video

Look in a short video, how to just prepare a suspension. You will also learn that on the authentic preparation of Summen must be 2 protective stickers, the removal of which is impossible without damaging the packaging. Therefore, when buying, pay attention to such stickers.

Now you know that in some bacterial infections It is necessary to use an antibiotic. One of the modern universal antibiotics is Sumamed. It has a short application course, in general, well tolerated by kids and highly efficient.

Never search for self-medication and do not take such serious preparations like Sumamed, without appointing a doctor! It will examine an anamnesis, appreciate the condition of the baby and will decide on the appointment. In the comments, share what diseases of your baby you managed to overcome with the help of Summen.

- the main active substance Sumamed ®, refers to antibacterial agents wide spectrum. Depending on the concentration in the infectious focus, the means is able to exhibit both bacteriostatic and bactericidal mechanism actions. Azithromycin (Sumamed ®) is a representative of the subclass of azalides included in the group of macrolidal antibiotics.

The effectiveness of antimicrobial action is caused by its ability to bind 50-S ribosomal subunits, coal peptidranslochase bacteria and preventing proteins synthesis, suppressing the processes of growth and fission of microbes.

Sumamed ® has a high degree of binding with fabrics and low indicators of non-centers in plasma blood elements. Due to this, the antibiotic is longer excreted from the body and has a prolonged action, while maintaining effective bactericidal co-centers in the affected organs and tissues.

From the body of Sumamed ® is removed with urine and bile in the non-modified form for up to seven days.

Pharmacological group

Antibiotics azalide macrolides.

Sumamed ® is an antibiotic or not?

Sumamed ® - release form and prices

Manufacturer Sumamed is an Israeli pharmaceutical campaign of Pliva Khrvatska D.O.O®.

The price of an antibiotic in Russian pharmacies is about:

• 280 rubles per bottle of suspension hundred milligrams in 5 ml;
• 430 rub. for 6 tablets of 125 mg;
• 580 rubles for packaging 3 Table. 500 mg or 6 caps. 250mg;
• 690 rubles. for the bottle with a suspension Forte (200 mg in 5 ml);
• 1300 rubles - three tables. 1000 Miligram (dispersible tablets);
• 1750 rubles for 5 flac. With a lyophilisate for the manufacture of an infusion solution of 500 mg.

Packaging photos of Summen ® in the form of 500 mg tablets

Sumamed ® recipe in Latin

Rp: SumaDi 0.25.
D. T. d. N. 5 In TAB.
D. S. 1 Table. Once a day an hour before meals.

The composition of the drug Sumamed ®

In tab., In addition to maintaining the main active component Azithromycin dihydrate in a dosage of 0.125 or 0.5 grams, also indicate the presence of additional ingredients: the resulting FOPATS CA of a two-one, corn and modified cramps, microcrystalline cellulose, sodium laurelsulfate, MG steak, talc, and eighty polysulf.

In capsules containing 0.25 grams of Azithromycin, indicate the content of gelatin, sulfur dioxide, indigocarmin, titanium dioxide, sodium and microcater cellulose microfer cellulose.

In the instructions for use children's Sumameda ® It is indicated that the suspension of 100 milligrams of the antibiotic in five millilitals, as well as the form of forte (200 mg in 5 ml) additionally contain sucrose, xutan copper, aromatizers, etc.

Lifacts contained 0.5 grams of azithromycin in the form of dihydrate, citric acid as a monohydrate, as well as sodium hydroxide.

Current Sumamed ® from what helps?

Azithromycin has a wide range of antimicrobial effects and is active against most intra and extracellular pathogens. Its spectrum of action includes chloamiy, micoplasma, legonella, strepto and staphylococci, hemolytic wand, Moraxella, Bordetella, Ureaplasma, Treplem, etc.

When appropriate, it is necessary to take into account the possibility of cross-resistance to the drug: -, - and enterococci.

Azitromycin does not work against strains resistant to erythromycin preparations.

Pharmacodynamics

Azithromycin has a higher bioavailability and complete suction in the gastrointestinal tract than erythromycin. Fast and complete absorption during oral administration is due to the high lipophilicity of the antibiotic and its acid resistance. Plasma concentration indicators reach their maximum three hours after taking medication.

The most efficient ashithromycin indicators are observed in the respiratory tract, the urinary system, skin and PJC. Good accumulation in tissues and prolonged effect are due to low-binding macrolide with plasma elements of blood. Also, the specific features of azithromycin include its ability to penetrate into eukaryotic cells and accumulate in media with low pH, surrounding lysons. Such a distribution of the drug causes it high efficiency In the fight against intracellular causative agents.

In focus inflammatory process Azithromycin is delivered by phagocytes, the release of the antibiotic in the phagocytosis process takes place. An important feature The drug is that after its release from phagocytes in an infectious foam, under the influence of bacterial stimuli, there is a reverse capture of the phagocytes of the densely antibiotic residues. At the same time, it does not have a significant effect on the basic functions of phagocytes.

It should also be noted that the degree of accumulation of azithromycin in tissues is determined by the severity of the inflammatory process. In healthy tissues, the antibiotic accumulates almost 35% less than in the inflamed.

Sumamed ® Indications for use

• Azithromycin is prescribed for disease therapy caused by sensitive flora. It is effective in pathologies of the breath. Systems and varying severity, that is, used for therapy, and. Highly effective in respiratory and.
• It can also be used to prevent rheumatic complications instead of Bicyllin, if the patient, and the treatment of tonsillitis was carried out by another antibiotic.
• Used in prevention (postcontact) and treatment.
• Azitromycin preparations are shown in defeat skin Pokrov and PGC. May be assigned at the initial stage of Lyme disease.
• Sumamed ® is also used in dermatological practice for treating varying severity. Low toxicity of the drug allows its long-term courses.
• In venererastics, the antibiotic is used to treat PPP infections, uncomplicated and complicated urethritis and chlamydia and hymealic etiology.
• If necessary, appointed in the schemes - for treatment peptic disease The stomach and the 12-mounted intestine, when the appointment of clarithromycin is impossible.
• It is used in stepped therapy, that is, Sumamed ® can be appointed parenterally, followed by the transition to the tablet with the reception.

Sumamed ® Dosage for Adults

The standard Dosage of Summen ® for adults is 500 mg 1 time per day at a three-day course. Or 500 mg in a 1st day, followed by 250 mg (0.25 g) with a five-day course.

For severe course Diseases The duration of treatment can be increased. The arrival rate of Sumamed ® with pneumonia is seven or ten days (five hundred Mg). Antibiotics with a hymorite in adults are also not recommended to prescribe short courses, it is preferable to take the drug 5-7 days to 0.5 g.

For uncomplicated, lightweight IMWPs are enough of the 3-day course of treatment for 0.5 g. With a moderate and severe course, the duration of treatment increases.

In case of infectious damage to the skin and PJC, a five-day azithromycin rate is prescribed at a dose of 1 g in the first day and 0.5 g of another four days.

When the Helicobacter eradication, the antibiotic is prescribed by gram, a three-day course.

Sumamed ® - Contraindications for use

• Absolute contraindications to the use of this antibiotic are: individual intolerance to macrolide preparations and ketolides or auxiliary components of the drug;
• severe liver diseases accompanied by its dysfunction;
• simultaneous use with ergotamine and dihydroergotamine drugs;
• malabsorption syndrome associated with Disacharidaz deficiency.

By age restrictions, Sumamed ®:

• the suspension does not give kids to 6 months;
• 125 MG tablets - patients under three years;
• capsules Sumamed ® 250 mg children up to 12 years old;
• table. 500 mg - kids up to 12 years;
• parenteral purpose (Sumamed ® in the form of lyophilisate) - up to 16 years.

In the instructions for applying Summen Forte ® for children (suspension), also indicates age limit - 6 months.

Sumamed ® during pregnancy applies strictly according to the testimony, after a comprehensive assessment by the doctor's ratio of expected benefits and alleged risk. It is important to remember that any antibiotics during pregnancy is always risk, so their appointment should be strictly reasonable and weighted. Independent use of drugs, as well as a change in the dose prescribed by the doctor and the duration of the course - is unacceptable.

Sumamed ® with breastfeeding is prescribed under the condition of temporary cessation of breastfeeding

Also, with caution, the drug can be used in patients with miastenia, medium liver dysfunctions light degree gravity, terminal failure to work kidney, diabetes, pathologies of the SCC, accompanied by rhythm disorders and an extended interval QT, patients receiving treatment with antiarrhythmics of class 1a and 3.

Sumamed ® during pregnancy and breastfeeding

Sumamed ® during pregnancy can only be used by the decision of the attending physician and under his supervision. Macrolids belong to the categories of drugs that are used in such cases. However, it is important to remember that any antibiotics during pregnancy must be appointed by the doctor strictly according to the testimony.

Most often, Sumamed ® during pregnancy is used in infections gOOD SYSTEMas well as diseases Loro organs and respiratory tract, patients having allergies on beta-lactam preparations.

Given the ability of the antibiotic in small doses to penetrate breast milk, breastfeeding must be temporarily stopped.

Sumamed ® and alcohol- compatibility

What will happen if you accept Sumamed ® with alcohol?

First, considering the mechanism of removal of azithromycin (through the kidneys and liver), such a combination will strengthen toxic action On the liver and can lead to medicinal hepatitis.

Secondly, the combination with alcohol makes the medication absolutely useless, leading to its inactivation.

That is, it is impossible to combine Sumamed ® with alcohol, as it does not only level efficiency from treatment, but also may be life-threatening.

Sumamed ® - Side effects

The drug is small toxic and, as a rule, is well tolerated by patients. Side Actions Sumamed ® can manifest itself with a feeling, stool disorders, stomach pains, flatulence. Antibiotic-associated diarrhea and pseudomambranous colitis are extremely rare.

Vaginites are often observed quite often.

Instructions for the use of Sumamed ® Suspension for children

For children, the drug is prescribed from the calculation of ten Mg per kilogram of mass, with a three-day course and on the 10th Mg / kg in the 1st day, followed by the transition to the 5th Mg / kg at a five-day course.

With migratory erythene, on the first day, the 20th Mg is appointed per kg, then 4 days for ten Mg per kg.

With pneumonia, the course - from seven to ten days. For the treatment of infections of the small pelvis authorities - seven days. The duration of taking medication during hymorite depends on the severity of the disease. Minimum course - 5 days.

How to take Sumamed ®

Consider the frequently asked questions to pharmacists and doctors in azitromycin.

Sumamed ® must be taken before eating or after?

Instructions for the use of Summen ® (including children's forms) indicates that the tool must be used 1st once a day for 1 nd. Before or after 2 hours after receiving food.

How to prepare a suspension of 100 mg in 5 ml for children?

In the vial you need to add eleven ML boiled water and mix the mixture well. The suspension can be stored for five days.

How to breed Sumamed Fort ® 200 milligrams in 5ml (15 and 3 ml in the bottle)?

In a bottle with content:

• 600 mg of azithromycin It is necessary to add 6 ml of boiled water.;
• 800 mg of antibiotic - 8 ml;
• 1400 mg -14.5 ml.

The resulting mixture must be thoroughly shaken. The shelf life of the prepared means is -5 days.

How to give a suspension to a child?

Ready suspension must be carefully stolen before use. The required number of drug from the vial is gaining a dosing syringe or molded into a special spoon (they are included). After applying, they must be rinsed with water and dry. After the child drinks the drug, it is necessary to give it boiled water so that he swallowed the remaining in oral cavity Part of the suspension.

Sumamed ® - Adult reviews and children

Patients who are prescribed this drug are often wondering: when is an improvement in the azithromycin accept?

Patients who took Wed, celebrate in their reviews fast effect From its application. In the treatment of respiratory tract, temperature stabilization and improvement general happens on the second day of admission.

However, it is important to remember that the rate of recovery, as well as the duration of treatment, depends on many factors (nature of the pathogen, the localization of the infectious focus, the severity of the disease, the presence of complications and associated pathologies complicating the course of the disease, etc.).

It is necessary to understand that each person is individual and one disease in any patients can have a different flow, and, accordingly, the reaction to the drug may also differ. For example, for the treatment of bacterial, uncomplicated bronchitis with a light flow, indeed a three-day course, and the effect will be noticeable after a day.

However, in case of moderate severity, it is advisable to apply a five-day course of therapy, and the improvement from the Sumamed reception can be noticeable by the end of the second day. Treatment of respiratory chlamydia takes from two weeks, respectively, and improvement will come more slowly than in previous cases.

A significant advantage over other drugs is good tolerability and low toxicity of Sumameda ®, which allows you to prescribe it to children and pregnant, as well as use extended courses in the eradication of intracellular pathogens (chlamydia, mycoplasma, legionell).

The page provides instructions for use. Summen. It is produced in various dosage forms Preparation (forte, tablets 125 mg and 500 mg, 250 mg capsules, suspension, injections in ampoules for injection), and also has a number of analogues. This abstract is checked by specialists. Leave your feedback on the use of Summen, who will help other site visitors. The drug is used for various diseases (angina, bronchitis, pneumonia and other infections). The tool has a number of side effects and features of interaction with other substances. Doses of the drug differ for adults and in children. There are restrictions on the use of medication during pregnancy and during breastfeeding. Treatment by Sumamian can be appointed only by a qualified physician. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage

The drug is prescribed inside 1 time per day, at least 1 hour before or 2 hours after meals. Tablets take no chewing.

Adults (including the elderly) and children over 12 years old with a mass of the body more than 45 kg, the drug is prescribed in the form of tablets and capsules.

Children at the age of 6 months and older the drug should be prescribed in the form of a suspension for intake, children at the age of 3 years and older, the drug can also be prescribed in the form of 125 mg tablets. The preparation in the form of tablets 125 mg is dosed taking into account the mass of the body's body.

In case of infections of the ENT organs, the upper and lower airways, skin and soft tissues (with the exception of chronic migrating erythema) adults and children over 12 years old with a body weight of more than 45 kg, the drug is prescribed at a dose of 500 mg 1 time per day for 3 days , Course dose - 1.5. Children at the age of 6 months and older are prescribed at the rate of 10 mg / kg body weight 1 time per day for 3 days, a term dose - 30 mg / kg.

For diseases of the stomach and duodenal intestine associated with Helicobacter Pylori, the drug is prescribed in the form of a powder in a dose of 1 GV for 3 days in combination with antisecretory means and other medicinal preparations.

With migratory erythene, the drug is prescribed 1 time per day for 5 days. Adults and children over 12 years old with a mass mass of more than 45 kg are appointed in the 1st day - 1 g, then from 2 to 5 days - 500 mg; Course dose - 3rd children at the age of 6 months and older are appointed in the 1st day at a dose of 20 mg / kg body weight and then from 2 to 5 days - daily at a dose of 10 mg / kg body weight, term dose - 60 mg / kg.

With the acne rash, the gravity of the gravity term dose is 6.0. Adults and children over 12 years old with a body weight of more than 45 kg are prescribed at a dose of 500 mg 1 time per day for 3 days, then 500 mg 1 time per week for 9 weeks. The first weekly dose should be taken 7 days after receiving the first daily dose (8th day from the start of treatment), the following 8 weekly doses should be taken at an interval of 7 days.

In sexually transmitted infections, for the treatment of uncomplicated urethritis / cervicitis caused by chlamydia trachomatis, the drug is prescribed in a dose of $ 1; For the treatment of complicated long-term flowing urethritis / cervicitis caused by chlamydia trachomatis, prescribed PO1 G3 times at intervals of 7 days (1, 7, 14 days), term dose - 3 g.

For patients with moderate impairment of kidney function (QC\u003e 40 ml / min) Dose correction is not required.

How to breed and take a suspension

In the vial containing 17 g of powder, 12 ml of water distilled or boiled. The volume of the suspension obtained is 23 ml. The shelf life of the prepared suspension is 5 days. Before taking the contents of the bottle, carefully shake up to obtain a homogeneous suspension. Immediately after receiving the suspension, the child gives a drink a few sips of tea in order to wash and swallow the remaining amount of suspension in the oral cavity.

After using the syringe, disassemble and washed with running water, dried and stored in a dry place together with the preparation.

Sumamed Forte (in the form of a suspension)

Inside, 1 time per day, at least 1 hour before or 2 hours after meals.

In case of infection of the upper and lower respiratory tract, skin and soft tissues (with the exception of chronic migrating erythema) - the total dose of 30 mg / kg, i.e. 10 mg / kg once a day for three days.

With chronic migrating erythene, the total dose of the drug is 60 mg / kg: in the 1st day - once 20 mg / kg; In the following days (from the 2nd to the 5th) - 10 mg / kg.

In the diseases of the stomach and duodenal intersection associated with Helicobacter Pylori: 20 mg / kg once a day in combination with an antisecretory agent and other drugs on the recommendation of the doctor.

In the event that the dose of the drug was skipped, it is necessary, if possible, take immediately, and then the subsequent doses - with an interval of 24 hours.

In sexually transmitted infections

Uncompressed urethritis / Cervicitis -1 g, one-time.

Method for preparing suspension

For preparation of 15 ml of suspension (nominal volume), it is necessary to via a bottle containing 800 mg of azithromycin, add 8 ml of water (actual volume - 20 ml of suspension).

To prepare 30 ml of suspension (nominal volume), it is necessary to via a bottle containing 1400 mg of azithromycin, add 14.5 ml of water (actual volume - 35 ml of suspension).

For the preparation of 37.5 ml of suspension (nominal volume), it is necessary to via a bottle containing 1700 mg of azithromycin, add 16.5 ml of water (actual volume - 42.5 ml of suspension).

In each bottle, there must be suspensions of 5 ml more course dose to more complete the drug from the bottle.

The shelf life of the prepared suspension is 5 days, at a temperature not higher than 25 ° C.

Using a dosing syringe, measure the required amount of water, add to the bottle with a powder. Before taking the contents of the bottle, carefully shake up to obtain a homogeneous suspension.

For dosing of the finished suspension, a syringe or a measuring spoon is used.

Immediately after receiving the suspension, the child gives a drink several sips of tea or juice, in order to wash and swallow the remaining amount of suspension in the oral cavity.

After using, the syringe is disassembled and washed with flowing water, dried and stored with the preparation.

Forms of release

Tablets covered with film shell 125mg and 500 mg.

250 mg capsules.

Lyophilisate for the preparation of a solution for infusion (injections in ampoules for injection) 500 mg.

Powder for the preparation of a suspension for reception inside 100 mg / 5 ml.

Sumameried - Bacteriostatic antibiotic of a wide range of action from the group of macrid-azalides. Azithromycin action mechanism ( active substance The preparation of Sumamed) is associated with the suppression of the microbial cell protein synthesis. By contacting the 50s subunit of ribosomes, inhibits peptidranslocase at the transmission stage and suppresses protein synthesis, slowing down the growth and reproduction of bacteria. In high concentrations has a bactericidal action.

Microorganisms can be initially resistant to the action of an antibiotic or may acquire resistance to it.

In most cases, the Sumamed preparation is active with respect to aerobic gram-positive and gram-negative bacteria, anaerobic bacteria, other microorganisms: Chlamydia trachomatis (chlamydia), Chlamydia Pneumoniae, Chlamydia Psittaci, Mycoplasma Pneumoniae (mycoplasma), Mycoplasma Hominis, Borrelia Burgdorferi.

Pharmacokinetics

After receiving inside, the Summen is well absorbed and quickly distributed in the body. Transported by phagocytes to the place of infection, where it is released in the presence of bacteria. Easily penetrates through histohematic barriers and enters the tissue. The concentration in tissues and cells is 10-50 times higher than in the plasma, and in the focus of infection - by 24-34% more than in healthy tissues. In the liver dememilated, losing activity. The therapeutic concentration of azithromycin is preserved up to 5-7 days after receiving the last dose. Azithromycin is output, mainly unchanged - 50% via the intestines, 6% by the kidneys.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of the upper respiratory tract and LOR-organs (pharyngitis / tonsillitis, sinusitis, average otitis);
• infections of the lower respiratory tract ( acute bronchitisExacerbation chronic bronchitis, pneumonia, incl. caused by atypical pathogens);
• diseases of the stomach and duodenal intersection associated with Helicobacter Pylori (for powder);
• skin and soft tissue infections (angry rash of medium gravity, face, impetigo, secondaryly infected dermatoses);
• the initial stage of Lyme disease (borreliosis) is a migrating erythema (Erythema Migrans);
• infection urinary tractcaused by chlamydia trachomatis (urethritis, cervicitis).

Contraindications

• severe disorders of the liver and kidney function;
• lactation period (breastfeeding);
• simultaneous reception with ergotamine and dihydroergotamine;
• increased sensitivity to antibiotics of a group of macrolides;
• children's age up to 12 years old and body weight less than 45 kg (for capsules and 500 mg capsules);
• children's age up to 3 years (for tablets 125 mg).

special instructions

In the case of passing a reception of one dose of the drug - the missed dose should be taken as early as possible, and the subsequent - with interruptions of 24 hours.

Also, when carrying out any antibiotic therapy, with azithromycin treatment, it is possible to attach superinfection (including fungal).

In the treatment of pharyngitis / tonsillites caused by Streptococcus Pyogenes, as well as for the prevention of acute rheumatic fever, Penicillin is usually the drug. Azithromycin is also active in relation streptococcal infection In these cases, however, it is ineffective to prevent the development of acute rheumatic fever.

The patient should be prevented about the need to inform the doctor about the emergence of any side effect.

The negative effect of the joint admission of the Summen and alcohol (hepatotoxic action) is noted.

Impact on the ability to control vehicles and mechanisms

The drug does not affect the ability to drive vehicles and other activities requiring the high concentration of attention and the velocity of psychomotor reactions.

Side effect

• thrombocytopenia, neutropenia, eosinophilia;
• dizziness;
• headache;
• drowsiness;
• convulsions;
• insomnia;
• hyperactivity, aggressiveness, anxiety, nervousness;
• noise in ears;
• reversible hearing impairment up to deafness (when taking high doses for a long time);
• violation of the perception of taste and smell;
• heartbeat;
• arrhythmia, including ventricular tachycardia;
• nausea, vomiting;
• diarrhea, constipation;
• abdominal pain and spasms;
• flatulence;
• anorexia;
• hepatitis;
• itching, skin rashes;
• angioedema edema;
• hives;
• anaphylactic reaction (in rare fatal cases);
• joint pain;
• vaginitis;
• candidiasis.

Medicinal interaction

Antacid agents do not affect the bioavailability of azithromycin, but reduce Cmax in the blood by 30%, so the Sumamed preparation should be taken at least 1 hour before or 2 hours after taking these drugs and food.

With simultaneous use, azithromycin does not affect the concentration of carbamazepine, didanosine, rifabutin and methylprednisolone in the blood.

In parenteral use, Sumamed does not affect the concentration in the blood plasma of cimetidine, efavirenz, fluconazole, indinavir, midazolam, theophylline, triazolam, trimethopris / sulfametoxazole in the case of combined therapy, but should not be excluded by the possibility of such interaction when appointing the Tsamed drug inside.

Azithromycin does not affect the pharmacokinetics of theophylline, however, with joint admission with other macrolides, the concentration of theophylline in the blood plasma can increase.

If it is necessary to jointly apply with cyclosporin, it is recommended to control the content of cyclosporine in the blood. Despite the fact that there is no data on the influence of azithromycin to change the concentration of cyclosporine in the blood, other representatives of the macrolide class are able to change its concentration in the blood plasma.

With a joint reception of digoxin and Sumamed, it is necessary to control the concentration of digoxin in the blood, because Many macrolides increase the absorption of digoxin from the intestines, thereby increasing its concentration in the blood plasma.

If you need to share with warfarin, it is recommended to conduct careful control of prothrombin time.

It was found that simultaneous reception of thermal terphenadine and antibiotics of the macrolides causes arrhythmia and elongation of the Qt interval. Based on this, it is impossible to exclude the development of these complications with joint admission of thermopholdin and azithromycin.

With a joint admission of azithromycin and zidovudine, azithromycin does not affect the pharmacokinetic parameters of the Zidovudine in the blood plasma or to bring the kidney and its metabolithic glucurone. However, the concentration of active metabolite increases - phosphorylated zidovudine in mononuclear cells peripheral vessels. The clinical significance of this fact is not clear.

With simultaneous reception of macrolides with ergotamine and dihydroergotamine, there is a manifestation of their toxic action.

Analogs of the Medicinal Treatment Sumamed

Structural analogues for the acting substance:

• Azivok;
• Azimycin;
• Azistral;
• Azitroces;
• Azithromycin;
• Azithromycin fort;
• Azithromycin dihydrate;
• Azitrus;
• Azitrus Forte;
• Azicid;
• Verozithromycin;
• Zetamax Retard;
• Skin;
• Zitrolide;
• Zitrolide Forte;
• Zitrocin;
• Mad;
• Sauklid;
• Sumamed Fort;
• SUMAMET;
• Summamen Forte;
• Sumamoks;
• Solutab Solotab;
• Tremba Sanovel;
• Chemomycin;
• Ecomed.

Application in children

It is contraindicated for children under 12 years old and a body weight of less than 45 kg (for capsules and 500 mg capsules) and under 3 years old (for pills 125 mg).

Application in pregnancy and breastfeeding

During pregnancy, the use of the drug is possible only if the potential benefit of therapy for the mother exceeds possible risk For fetal.

If necessary, the use of the drug during lactation breast-feeding should be stopped.

Application of Summen Tablets 125 mg in children gives excellent results, this is evidenced by parental reviews. This drug is able to cure green snot and bronchitis, get rid of the protracted cough. But only a doctor can assign an antibiotic.

Form release

"Sumamed" is produced in tablets at 125 and 500 mg, as well as in the form of a capsule of 250 mg. The tablets of a smaller dosage and capsules are packaged in blisters of 6 pieces, and a larger dosage tablets - in blursters 3 pieces.

Structure

The "Sumamed" includes one active substance - a semi-synthetic antibiotic azithromycin dihydrate, which is more often called azithromycin. It was synthesized over 35 years ago, in 1980. Since then, azithromycin is part of widespread preparations both in Europe and the United States and in Russia.

Tablets "Sumamed" contain auxiliary components: calcium hydrochlorophosphate, several types of starch, microcellulose, magnesium stearate. Some of these substances are food additives, others are called upon to maintain the effectiveness of the main active substance during the entire expiration date.

Operating principle

Azithromycin is an antibiotic of a wide range of action. It is able to deal with infections that cause various organisms, including anaerobic energy-receiving energy without the presence of oxygen, intracellular and many others, in contrast to specialized antibiotics acting against a certain type or group of infections.

If a person invested in the human body, azithromycin suppresses protein synthesis in the causative agents of the disease, as a result of which they lose the ability to reproduce. Thus, the infection ceases to capture new human cells and gradually dies.

An important quality of azithromycin is its ability to penetrate through cell membranes. Moreover, studies show that in the foci of infection, the antibiotic concentration is at times exceeds its average content in the blood of a person taking the drug. This explains high efficiency medication against many diseases.

However, there are causative agents that initially, and not as a result of addiction, demonstrate sustainability to azithromycin. This, for example, some types of staphylochets. The half-life of blood plasma is 35-50 hours, from tissues - longer. The drug is derived through the kidneys and intestines.

Indications

Due to the ability to influence many types of infections, azithromycin infections are used to treat a wide range of diseases. For example, children "Sumamian" are treated infectious diseases Nasopharynx and upper respiratory tract: tonsillites, sinusites, rhinitis, otitis, sinusitis, pharyngitis.

Sumamed is prescribed children with lower respiratory tract infections. It can be acute bronchitis or aggravation of chronic, pneumonia, chronic obstructive pulmonary disease.

It is good to treat the "Sumamian" disease Lyme. The drug is also effective in infectious lesions of soft tissues. Much worse treatment Amented by sexually transmitted diseases, for example, handmidia. In adolescents, with the help of this drug, they treat acne severe or moderately.

From what age are prescribed?

You can give children a tablet "Sumamed" from 3 years by weight of the body more than 18 kg. If the child younger or weighs less, then it is better to give him a children's format - the Summen Forte suspension, cooked from the powder.

IN some cases The doctor can appoint an antibiotic to a child under 3 years old, but only according to individual indications and under observation.

It is not recommended to give antibiotics to children of any age.

Contraindications

Take the "Sumamed" at any age, if the patient was previously identified individual sensitivity or even intolerance to any component of the drug. This can be both azithromycin and one of the auxiliary components. Caution is prescribed "Sumamed" to children with impaired liver or kidney function.

Do not prescribe children who have not yet been 12 years old, Sumamed tablets are 500 mg, since the dosage of the main component in them is too large and is designed for adolescents and adults.

If the child has a heart disease, it passes the appropriate treatment, takes drugs, has a tendency to arrhythmia, then when appointing "Summen" need to be warned by a doctor.

Side effects

In some cases, when taking the "Summen", side effects arise. Most often they are associated with individual sensitivity to the drug, but manifest themselves in other cases.

Parent need to carefully treat the appearance of a child who takes the drug, dizziness, drowsiness, headaches, poor sleep. If the child is small and cannot clearly formulate a complaint, then you need to pay attention to anxiety, frequent crying, rejection of familiar food.

An older child may also complain about violations when the items lose clarity, noise in the ears, worsening hearing, abdominal pain, which are accompanied by flatulence, belching, sometimes nausea and even vomiting.

Some children appear shortness of breath, bleeding from the nose or urticaria. Often, children complain of back pain, neck, fatigue, general ailment. In severe cases, there is a swelling of a person, hyperemia, chest pain, hepatitis and jaundice.

If a child has manifested itself one of the listed or any other uncharacteristic symptom, parents, even if they do not associate it with the drug treatment, the treatment of "Sumamen" should be stopped and seeking medical help. Only a doctor can compare symptoms with the drug intake, assign appropriate analyzes and decide whether these features are the consequence of drug intake or caused by other reasons.

Instructions for use

Accurate dosages of the drug contains instructions for use. We give them in the table.

Table. Dosage of the preparation "Sumamed"

These dosages give children with infections that struck the respiratory tract, the nasopharynx, soft fabrics and skin. If the child is sick with tonsillitis or pharyngitis, as a rule, prescribe a dosage calculated by the formula: 20 mg per 1 kg of weight per day.

The course of treatment should not exceed three days.

Overdose

Under the overdose of "Sumamian" there is a strengthening of symptoms side effects. Most often disorders from gastrointestinal tract: Nausea, vomiting, diarrhea. In case of an overdose, you need to immediately stop taking medication and seek medical attention.

Interaction with other drugs

Azithromitsn is able to interact with many drugs. If the doctor appoints a child "Sumamed", it is necessary to warn about the reception of other medicines. Perhaps the treatment will need to adjust. For example, a medicine should not be taken simultaneously with antacid drugs, since this reduces the content of the drug in the blood by 30%. Accordingly, the effectiveness of treatment is reduced. In the same time

Terms for sale and storage

Despite the popularity of the drug "Sumamed", he is released in pharmacies for a doctor's prescription, like most antibiotics. This is due to the fact that uncontrolled medication can harm health.

At home, the drug is stored at a temperature not higher than 25 s, that is, it is not necessary to put it in the refrigerator, it is enough to store in any cool place. The shelf life of the tablets is 3 years from the date of release. The date of production is indicated on the packaging of tablets and blister. Cannot be treated with children with an expired shelf life.

Choosing a dosage

The drug is prescribed inside 1 time / day, at least 1 hour before or 2 hours after meals.
Tablets and capsules
Adults (including older patients) and children over 12 years old with body weight more than 45 kg
In case of infections of the ENT organs, the upper and lower airways, skin and soft tissues, the drug is prescribed at a dose of 500 mg 1 time / day for 3 days, a term dose - 1.5 g.
With migrant erythene, the drug is prescribed 1 time / day for 5 days: in the 1st day - 1 g, then from 2 to 5 days - 500 mg; Course dose - 3 g
With acne rash, the gravity is prescribed at a dose of 500 mg 1 time / day for 3 days, then 500 mg 1 time per week for 9 weeks. Course dose - 6 g. The first weekly dose should be taken 7 days after the reception of the first daily dose (8th day from the start of treatment), the following 8 weekly doses should be taken with an interval of 7 days.
The urinary tract infections caused by chlamydia trachomatis (urethritis, cervicitis): with an uncomplicated urethritis / Cervicitis, the drug is prescribed in a dose of 1 g once.
Children aged 3 to 12 years old with body weight less than 45 kg
In case of infections of the ENT organs, the upper and lower airways, skin and soft tissues (with the exception of chronic migrating erythema), the drug is prescribed at the rate of 10 mg / kg of body weight 1 time / day for 3 days, a term dose - 30 mg / kg . The preparation in the form of tablets 125 mg is dosed taking into account the mass of the body of the child, as presented in Table 1.
Table 1.
Body mass
Azitromycin dose (in 125 mg tablets)
18-30 kg
2 tablets (250 mg)
31-44 kg
3 tablets (375 mg)
≥45kg
adult doses recommended for adults

With migrant erythene, prescribed in the 1st day at a dose of 20 mg / kg 1 time / day, then from 2 to 5 days - at the rate of 10 mg / kg 1 time / day. Course dose - 60 mg / kg.
Tablets take no chewing.
For ease of use in children, the course dose of 60 mg / kg is recommended to use Summen in the form of a powder for preparing a suspension for intakes of 100 mg / 5 ml.
Suspension
Prescribe children aged from 6 months to 3 years.
The required dose is measured with a syringe or a measuring spoon embedded in packaging with the drug: for children with a body weight up to 15 kg, a syringe is used, with a body weight of more than 15 kg - a dimensional spoon.
In the infections of the upper and lower respiratory tract, the ENT organs, the skin and soft tissues, the drug is prescribed at the rate of 10 mg / kg 1 time / day for 3 days (term dose of 30 mg / kg). The calculation scheme is presented in Table 2.
Table 2. Calculation of the required amount of the drug when prescribed in a dose of 10 mg / kg
Body mass
Summer suspension volume 100 mg / 5 ml per 1 reception (ml)
5 kg
2.5 ml (50 mg)
6 kg
3 ml (60 mg)
7 kg
3.5 ml (70 mg)
8 kg
4 ml (80 mg)
9 kg
4.5 ml (90 mg)
10 kg
5 ml (100 mg)
With pharyngitis / tonsillitis caused by Streptococcus Pyogenes Summen are prescribed at a dose of 20 mg / kg / day for 3 days. Course dose - 60 mg / kg. The maximum daily dose is 500 mg.
For initial stage Lyme disease (borreliosis) - migrating erythene the drug is prescribed in the 1st day at a dose of 20 mg / kg / day, then from 2 to 5th day - daily at a dose of 10 mg / kg / day. Course dose - 60 mg / kg.
Rules of preparation and dosing suspension for intake
To the contents of the vial, intended for the preparation of 20 ml of the suspension (nominal volume), with a syringe for dosing, add 12 ml of water and shackle to obtain a homogeneous suspension. The volume of the resulting suspension will be about 25 ml, which exceeds the nominal volume of approximately 5 ml. This is provided for compensating for the inevitable losses of the suspension when dosing the drug. The prepared suspension can be stored at a temperature not higher than 25 ° C not more than 5 days.
Before each drug intake, the contents of the bottle are thoroughly shaken until a homogeneous suspension is obtained. If the required volume of the suspension was not selected from the vial within 20 minutes after scarring, the suspension should be shaken again, select the required volume and give the child. The required volume of the suspension is taken from the bottle using a syringe or a measuring spoon. Immediately after receiving the suspension, the child gives a drink a few sips of water so that he can swamp the remaining amount of suspension in the oral cavity.
After using a syringe (previously disassembled it) and the measuring spoon is washed with running water, dried and stored in a dry place until the next taking of the drug.
For adults and children with moderate disorders of the kidney function (QC\u003e 40 ml / min) or with a violation of the liver function, the dose correction of the Tsamed is not required.