Instruction
The drug is a spasmodic of myotropic action. It is used in various pathological conditions, accompanied by spasms, painful sensations. The medicine quickly provides a positive effect, but care should be exercised during therapy due to the risk of developing various negative reactions.
Pharmacological group
Antispasmodic.
Structure
As an active ingredient, papaverine hydrochloride is used. In 1 suppository contains 20 mg of this substance.
Additionally, the composition includes solid fat.
Due to this component, the necessary consistency of the drug is obtained, but it does not contribute to the increase in pharmacological action. Suppositories can be purchased in the package (10 pcs.).
How to act Papaverin candles
The main property of the drug is antispasmodic. At the same time, the drug contributes to the relaxation of the walls of the vessels.
Pharmacodynamics
Papaverin (candles) is a opium alkaloid. The positive effect of therapy is achieved by the ability of the substance to have a relaxing effect on the muscles of the internal organs and the walls of the vessels. As a result, the stress in soft tissues is reduced, a slight decrease in blood pressure is noted.
The mechanism of the action of papaverine is based on the inhibition of phosphodiesterase - substances that promotes potassium output from cells and reduce the calcium content. As a result, a relaxing effect is ensured, a weak effect on the central nervous system is noted. Papaverin also has an impact on the ability of the heart muscle to excitement - when applied, intracardiac conductivity can slow down.
The drug is not analgesic, but manifests an anesthetic effect. Such an effect is ensured by eliminating spasm.
Pharmacokinetics
Rectal suppositories are quickly absorbed by mucous membranes. Papaverin bioavailability is 54%.
The substance penetrates blood through histohematic barriers.
As a result, the binding of the drug with blood proteins increases (90%). Transformed with the participation of the liver. The active substance is derived from the body for 50-120 minutes. In some cases, 24 hours leaves for the excavation of the main component.
For what candles are prescribed Papaverin
It is permissible to use the drug with such pathological conditions:
- spasm of abdominal organs with colitis, cholecystitis;
- renal colic;
- high degree of voltage of peripheral vessels;
- breast pain caused by developing ischemic disease;
- spasm of brain vessels;
- impaired respiratory function, for example bronchospasm;
- outdoor, internal hemorrhoids;
- spasm of urinary tract;
- violation of potency when the cause is a spastic state.
Contraindications
Papaverin is not assigned in such cases:
- intolerance of the active substance;
- diseases accompanied by an increase in intraocular pressure;
- atrioventricular blockade;
- severe liver damage;
- elderly age, in this case the risk of heat accumulation is increasing, which leads to hyperthermia (body temperature increases).
How to take ppaverine candles
Enter 1 candle 2-3 times a day. If necessary, a single dose increases to 2 suppositories, while the reception frequency is reduced during the day.
Is it possible to use candles vaginally?
In the manufacturer's instructions, there is no information on the use of medication in gynecology. However, in some cases, intravaginal can be used as an exception.
Candles are injected into the vagina with the tone of the uterus and for softening the cervix.
A positive result is noted when the menstrual disorders of the menstrual cycle, if severe pain appear.
Where and how to enter?
The drug is applied rectally. To increase the efficiency of the drug, it is recommended to use suppositories after defecation or pre-make a cleansing enema.
How fast do candles act?
Improvement occurs within the first 30 minutes after the introduction of the medicine into the rectum.
How many candles can be per day?
Duration of application
The course of therapy depends on the initial data: the age of the patient, the condition of the body, the type of pathology, accompanied by spasm and pain, as well as the presence of other diseases.
The average duration of treatment is 5 days.
During this time, acute signs of pathology are eliminated. Sometimes the course of therapy is prolonged up to 7 days.
With cystitis
Apply a standard treatment scheme (20 mg 2-3 times a day). The length of the course of therapy varies from 5 to 10 days. In chronic genital infections, the duration of treatment can be increased.
Application in children
The drug is not appointed to children under 6 months.
Side effects
During treatment, such negative reactions may appear:
- atrioventricular blockade;
- allergic reactions: itching, rash, redness of external covers;
- violation of the reduction process of the heart, which provokes the development of arrhythmias;
- hypotension;
- the difficulty of death of feces;
- drowsy state;
- the amount of eosinophils in the blood increases;
- the activity of hepatic transaminase increases.
Overdose
When using a large number of suppositories, there is a strengthening of some symptoms: drowsiness, allergies. Given that the drug is introduced rectally and quickly absorbed by the walls of the rectum, the washing of the stomach in this case will not provide the desired result. It is necessary to conduct symptomatic therapy.
Features of application
The drug is used with caution in patients in a weakened state (after illness), with impaired kidney function, endocrine system, adrenal cortex, with prostate tissue hypertrophy, anaphyactic shock, tachycardia. In these cases, the drug is not prohibited, since it improves peripheral blood circulation, but it should be more carefully observed for the condition of the body.
Papaverin in the form of candles does not apply under therapy of athletes. A more convenient form of release - solution, pills.
During pregnancy and lactation
Studies of the effect of papaverine on the fruit were not conducted. For this reason, this tool can be appointed if positive effects are stronger than possible harm. In the early time it is better not to use candles, since the threat of miscarriages increases.
The agent is used in 2 and 3 trimesters.
In case of breastfeeding, the drug is prescribed at the discretion of the doctor, since the safety of use during this period is not established.
Influence on the concentration of attention
It is not recommended to engage in activities requiring increased care, with the treatment with the product under consideration. This is due to the ability of hydrochloride papaverine to influence the concentration of attention, the rate of reactions.
Medicinal interaction
With other drugs
The intensity of the effects of anticholinergic agents on the body increases.
With the simultaneous use of papaverine and Levodopa, there is a decrease in the efficiency of the latter. The activity of the components of methyldopes exhibiting a hypotensive effect is also reduced.
Compatible with alcohol
If alcohol-containing drinks are used during papaverine treatment, the likelihood of the development of hypotension and the occurrence of a fainting state increases.
Terms and Storage Terms
Conditions of vacation from pharmacies
Do you sell without a recipe?
The drug is a non-advice.
How much is
The average price is 80 rubles.
Analogs
Papaverin suppositories can be replaced by another form of a given means with a solution or tablets. Other common analogues:
- But-shp;
- DROTAVERIN;
- Spasmol.
Papaverin Hydrochloride Candles Instructions for use
But-shp. What you have not already knew about. Pressure reduced drug.
These drugs contain the same active component - drochloride hydrochloride. This is an effective antispasmodic substance, it just like Papaverin is a myotropic agent. These analogues contain an active ingredient in the same dose - 40 mg, which makes them interchangeable.
Papaverin is an effective drug, widely used in medicine to remove spasms and pain.
The tool relaxes well muscles of all organs and vessels, while not affecting the nervous system. Papaverin candles, penetrating the intestine, quickly activate, improvements are noticeable after a few minutes.
Papaverin candles have become an integral preparation in all areas of medicine. Thanks to the components in its composition, patients are practically no allergies. The content of papaverine in one suppository 20 mg or 40 mg is produced in two dosages.
White suppositories, medium sized, in the form of a cone, have a smooth surface, dense, odorless. The drug is produced in the form of candles, 10 pieces per pack. Each candle is placed in a separate cell.
In a box to a blister with candles, an instruction is attached with which you need to get acquainted. Papaverin, being the main active substance, inhibits the enzyme phosphodiesterase in the cells of the smooth muscles of the inner hollow organs, due to which the muscles are quickly relaxed, spasms stop. The remedy is effectively relaxing the muscles of the stomach, intestines, genitous organs of a small pelvic.
The active ingredient reduces muscle spasm, expands the lumen in the walls of the hollow organs. Papaverin relaxes smooth muscles in the arteries. With the elevated content of papaverine in the blood, the sensitivity of the nerve pulses in the cardiovascular system may decrease. After the penetration of the substance into the rectum, it is dissolved in the blood, the components are distributed over the tissues, therefore, in pregnant women, papaverin easily penetrates over the placenta, also in breast milk when feeding the child. Sends substance on the walls of the liver, is displayed with urine. Indications for use. Papaverin candles are appointed to fully relax the muscles of hollow organs.
It is widely used in surgery, gynecology, urology:
- Papaverin is effective with hemorrhoids of all types, first of all, softens cals, stops spasms in the colon.
- The drug is widely used in gynecology, especially during pregnancy, in cases where premature uterine tone arises.
- After surgical surgery, candles are used to prepare an organism for anesthesia.
- Under angina, papaverine is used to reduce the pressure pain in the heart, which occurs due to the narrowing of the vessels, the circulation of blood flow in them.
- In the gastrointestinal spa, with inflammation of the gallbladder, colitis.
- Papaverin quickly relieves pain in menstruation, facilitates stools during constipation, eliminates elevated gases in the intestine.
- With bronchitis, papaverine is assigned to reduce spasm, prevent swelling of the mucous membrane.
- For diseases of the urinary tract, namely, uretrite, cystitis, stones in the bladder, pyelonephritis.
- Papaverin greatly relieves kidney colic, reducing the activity of the muscles of smooth muscles.
- The active ingredient quickly relieves pain in diseases of organs in the abdominal cavity.
- Papaverin eliminates spasms of vessels in the brain.
- For the treatment of hypertension, papaverin is used in the complex with dibazole.
After using candles, a person quickly comes into shape, facilitates the state of the intestines, in the organs of the small pelvis, the digestion is normalized, as a result of a chair. It seemed a completely harmless composition of papaverine candles makes it possible to take them in any disease, but it is not.
Papaverin cannot be applied in the following situations:
With caution or under the strict control of the doctor, the drug is accepted with the following diseases:
- thyroid disease;
- after the trap injuries obtained;
- acute renal failure;
- prostate disease;
- in cases of weak or strong adrenal insufficiency.
Papaverin can not be treated without the purpose of a specialist, since the symptoms can hide the exact disease, the use of candles can aggravate the situation, at best, do not give the desired effect from treatment.
Despite the vacation of the drug without a doctor's prescription, buying Papaverin is also not necessary, there is a possibility to get dependent on it. Doctors are convinced that using papaverin during constipation several times, you can get used to easy defecation, in the future go to the toilet only after using the suppository.
In rare cases, papaverine can cause nausea, vomiting, constipation, drowsiness, scattering, decline in blood pressure, sweating. If the drug caused similar adverse reactions, independently stop the reception of papapaver candles should not, only the doctor can give instructions, as well as a specialist should see how the side effects are expressed. If a person has a weakly manifest, the patient continues to take medicine.
Overdose is eliminated symptomatically, and it is also possible to purify the blood. Most often stomach is washed, after which sorbents are accepted, for example, activated carbon.
Papaverin can well interact with the following drugs:
- But-shpa, most often accepted with Papaverin, which causes the relaxation of the smooth muscles of hollow organs. This combination is most often found in gynecology, obstetrics, when a pregnant woman has a strong tone of the uterus, which can cause premature childbirth or abortion in other cases.
- Platifille - an effective spasmolytic, has a sedative effect, according to pharmacological data similar to papaverine. It differs from the last only a therapeutic effect, so platiphiline is prescribed in a complex with papaverine in a hypertensive crisis.
Papaverin Candles: Instructions for use with hemorrhoids
The drug reduces the bouts of the pain in the hemorrhoid, thus, there is a relaxation of the muscles of the smooth muscles of the lower organs.
In this case, papaverine is appointed only if the pain began due to colon spasms. Remove the pain in the anus, stop the bleeding, tighten the cracks, squeeze the hemorrhoidal knot itself papaverine is not capable. Before inserting papaverin candles in the rectum, instructions for use should be carefully studied. First of all, candles with a similar disease help get rid of the constipation, which begins due to intestinal spasms.
Papaverin with hemorrhoids is used first with a low dosage, if necessary, if there is no result, the dosage can be increased. Candles need to be entered into an anal hole quickly, as the suppository quickly melts in the hands. It should be entered, not to get up after the introduction of 25 minutes so that the contents do not flow. You can enter the drug every 4-5 hours. A day is allowed to apply no more than three suppository.
The general course of treating papaverine with hemorrhoid does not exceed two weeks. In childhood, papaverine can be assigned to the symptoms of hemorrhoids, frequent constipation. Candles are also introduced into the colon. Children over 10 years old are prescribed 1 suppository in the morning and in the evening. Babies up to 1 year old Papaverin is contraindicated. During pregnancy and lactation. Candles with papaverine during pregnancy are inserted into the colon. In this period, Papaverin is appointed in almost every case, the medicine is well relaxing the uterus, reduces its tone.
The tone of the uterus can cause a spontaneous abortion in the early deadlines or cause childbirth before the deadline. If pregnant women have frequent Papaverin constipation softens the chair, the woman does not have to strain during defecation. When feeding a child with breast milk, papaverin is allowed to be used only by appointment of a doctor, as well as if the benefit for the parent body is higher for the fetus. In the case when papaverin must be taken, the child gives a mixture during the entire course of treatment, excluding breast milk.
Papaverin candles and their analogues
Until recently, the suppository was acquired only by the doctor's prescription, currently Papaverin candles can be bought in free form without giving a prescription pharmacist. Papaverin candles should be protected from moisture, stored in a dark place, the temperature should not be higher than +25 degrees. Shelf life - 2 years.
Before using papaverine candles, you need to carefully examine the instructions, as well as pay attention to the instructions:
Analogs
Riabal is assigned to the X-ray study of the colon. The drug is appointed with vomiting, bloating, spasms of hollow organs, intestinal colic, constipation, hemorrhoids. Sportsmolyizin - are used during pains, which are caused by the spasm of smooth muscles of hollow organs, namely, with ulcer of stomach, pancreatitis, proctitis, constipation, colic, also after transferred operations.
Effective spasmoline with cholecystitis, diseases of the gallbladder, diseases of the urogenital system, is constantly used in gynecology. Niaspam - helps in intestinal spasms, colic, strong, sharp pain in the stomach. Spasquocel - the remedy is prescribed during spasms in the stomach, the uterine tone, in the urinary tract.
There are antispasmodic activity with respect to the smooth muscles of the gastrointestinal tract and vessels. After the use of the drug, there is a decrease in blood pressure, improved cerebral circulation and elimination of spasmodic pain in the abdominal area. It is possible to interact with other drugs. The drug is allowed to use in children.
Description and composition
As an active substance in each candle contains 20 mg.
Candles of torpedo-shaped, white, yellowish or creamy shade is allowed.
Pharmacological group
With parallel purpose with heart glycosides, the contractile function of myocardium is enhanced due to a decrease in the total peripheral resistance of the vessels.
In combination therapy with rokaipamide, quinidine sulfate, tricyclic antidepressants, the reserp is the potentiation of hypotensive action.
special instructions
Nicotine reduces the therapeutic effect from the use of candles, as it accelerates the metabolism, which provokes a decrease in its level in the bloodstream.
Against the background of therapy, it is forbidden to drink alcoholic beverages, as the spasmolitic potentials the effect of alcohol.
During therapy, caution should be taken when driving motor transport and when working on potentially dangerous production.
Before the introduction of a candle in the rear pass, the anus needs to be labeled with cold water so that the infection does not get inside. The hands before the introduction of the suppositories must be washed with soap, they should not be too warm and otherwise the candle melts when contacting them.
You can enter the suppository into the rectum from various positions: lying on the side and bent the lower limbs in the knees, lying on the back and lifting a little pelvis, etc. But in any case, the muscles of the rear pass should be relaxed, otherwise they can be injured.
In one hand you need to take a medicine, the second push the buttocks and quickly introduce the suppository with a sharp end in the rectum so that it does not have time to melt. After that, it is necessary to close the buttocks tightly so that the drug does not have time to pour back.
To achieve the greatest therapeutic effect, insert the suppository is necessary or after spontaneous intestinal cleansing or after the enema.
As auxiliary substances, the candles include paraffin and various oils, which are melted at the body temperature and flow out, they can dump underwear.
Overdose
Candle overdose can manifest themselves as follows:
- violation of vision (bounce in eyes);
- weakness;
- a drop of blood pressure;
- drowsiness.
No antidote. The victim prescribe medicines to eliminate the symptoms of intoxication, including drugs that increase pressure.
Storage conditions
Store suppositories are needed in place, inadequate for children. Temperature storage may differ depending on the manufacturer. For example, the candles of production "NIPARM" must be stored in a place protected from light at a temperature not higher than 25 degrees, and produced by OAO Dalkhimfarm - at a temperature of a maximum of 15 degrees.
To date, almost every woman in the period of tooling the fetus makes injections or put droppers. Doctors associate such a need with a bad environmental situation, a large number of GMO in food, the presence of chronic diseases and strong emotional voltage. Papaverin is special candles during pregnancy,which significantly reduce the risk of premature labor. Instructions for use contains complete information about the features of the drug.
In contact with
Description
For convenience of use, the manufacturer offers several drug options, the release form can be any:
- pills,
- injection fluid,
- candles.
Important! During the extension period, the woman is most often assigned to the latter, which is characterized by a small percentage of suction of the active substance. To eliminate spasms of this volume is enough.
Injection, injections are also used in medical practice, which are intramuscularly or intravenously are performed in a hospital or home. The appointment directly depends on the general clinical picture.
Papaverin: Candles
Papaverin hydrochloride is the main operating component,the preparation . Significantly reduces the tension of the muscles of internal organs. Due to this, the body begins to produce progesterone naturally. For the first time the drug appeared in the twentieth century. From this period is actively used to ensure a favorable course of pregnancy. Later, its composition lay down the basis of no less popular but-shpa tablets.
Among the additional benefits of Papaverin should be noted that it cannot affect the skeleton and muscles, so in the process of treatment there is no obvious signs of weakness. Spasms in the uterus decrease due to the removal of calcium cells from its cells. Relaxation goes to blood vessels, because blood pressure is significantly reduced.
Scope of application
Hyperthonus of the uterus during pregnancy occurs against the background of a lack of progesterone organism. This hormone is needed in sufficient quantities for the correct course of pregnancy. Thanks to him, it is possible to minimize the likelihood of spasms in the uterus. However, if its amount drops sharply, then a woman may have premature labor. Prevent the undesirable situation will allow correctly selected medicines. Instructions for use says that to prevent the fetal loss to use papaverin.
What does this medication apply for:
- on the smooth muscles of certain internal organs, spasms arise. Such pathologies are characteristic of the diseases of the gall, intestines. Negative symptoms are also observed with cholecystitis;
- periodic appearance of spasm in the urinary path;
- constant colic in the kidneys;
- in the brain and peripheral vessels there is also a negative clinical picture with spasms;
- previously diagnosed hypertension or prestosis;
- doctors observe the uterus hypertonus, which can lead to miscarriage.
Important! Studies confirmed that papaverine improves the patient's condition and minimizes the likelihood of miscarriage.
Instructions for the drug
The drug leads to significant muscle relaxation, blagodar What can eliminate the symptoms of gestosis. Health persists from mother and child. At the same time, the drug does not have a negative impact on the formation of organs and fetal systems.
Early
The existing components are positively affected by the vessels and a smooth muscles. When forming the fetus, the first trimester plays the key value. During this period, all internal organs of the child occurs. That is why drugs should be taken only in case of extreme need.
Important! Papaverin during early pregnancy helps to quickly and effectively remove the uterine tone. Thanks to this, the kid's body will receive all the components necessary for its correct growth and development. Otherwise, the detachment of the placenta or fruit eggs can begin. Sprupping genera may be provoked.
Papaverin hydrochloride helps to keep pregnancy,in this case, the likelihood of harm to the fetus is minimized. The effect of the drug is directed to weakening the walls of the uterus. Due to this, the blood circulation process is improved and spasms are completely left. Woman no longer feels pain. Candles, mortar or tablets can be used for this purpose.
Reception in late pregnancy
The need for a drug intake can occur at any time when entering the fetus. Papaverin in later pregnancy is advisable to appoint in the following cases:
- the uterus is strongly tense, and before childbirth there is still an impressive time. In addition, in this case, you need to take steroid hormones. Due to this, it will be possible to improve the clinical picture;
- recognition of false battles. If after their introduction to the body, the intensity decreased significantly, it means that the baby is not yet ready to appear;
- preparation of the cervix to childbirth. In this case, the candles are appointed to a woman not 39 pregnancy week;
- to reduce painful sensations during battles.
Papaverin during pregnancy
Drug with uterus tone
The tool helps to quickly and effectively get rid of discomfort in the muscles. Papaverin with a tone of the uterus during pregnancy can be assigned at any time. It has a large number of positive properties that allow it to be actively used in gynecology. It has the ability to relax any smooth muscles, while the influx of oxygen and other substances required for the correct operation increases. This medicine is often prescribed enough if you need to remove the hypertonus of the uterus.
Papaverin is included in the complex of medicines, which are prescribed in the case of diagnosed hypertension or gestosis. The positive effect is also achieved in the case of treating various pathologies of bile or kidney. The doctor prescribes the physician in the presence of colic in the liver. The drug is used not only to eliminate acute manifestations of the disease, but also helps to effectively deal with chronic forms. Correct the course of treatment, to evaluate its feasibility, only a doctor will be able to risk.
How to enter candles
All women are always recommended to have candles of papaverin during pregnancy, where to insert them should be recognized in advance. Candles are designed for rectal administration.
A woman can eliminate negative symptoms. Thanks to the method of use, the positive effect will be noticeable for only a few minutes.
If pregnant is discomfort, then she should immediately consult a doctor. The specialist carefully examines it and, if necessary, prescribe therapeutic measures. The gynecologist can assign a course of treatment with papaverine, determines the dose and duration of the reception.
As a rule, the doctor prescribes the introduction of the candle rectally three times a day. Rrecommended in advance to determine equal intervals.
Contraindications
Before the beginning of the medical course, you should ask whether Papaverin has contraindications. Otherwise, therapeutic composition can apply only harm to the body. The drug receives positive feedback from doctors and future mothers. However, it is thoughtlessly used. Any medication can bring not only the benefit, but also harm. A woman should be accurate to follow the recommendations of the doctor, then it will be possible to minimize the likelihood of side effects.
From using papaverine should be refused if such pathologies occur:
- bronchorate syndrome;
- increased sensitivity or allergic reaction to drug components;
- kidney and liver diseases;
- high eye pressure;
- pathology in the work of the thyroid gland;
- reduced blood pressure;
- violations of the functioning of the respiratory organs.
Papaverin has contraindications
The medicine is assigned to solve many gynecological problems during pregnancy. During the reception of the drug Papaverin, side unwanted actions may occur:
- apathy, drowsiness and general weakness;
- violations of organs of vision;
- disorders of the chair and nausea;
- improper liver operation;
- arrhythmia or tachycardia;
- the appearance of urticaria or swelling on the skin.
In case of overdose, take the necessary measures in time. This process is characterized by split vision, changing blood pressure or severe skin redness. If you do not consult a doctor in time, then the work of the heart changes for the worse.
Papaverin Hydrochloride Candles Instructions for use
Thank you
The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!
Papaverine (Latin - Papaverine) is a widespread medicinal substance with antispasmodic, vasodilatory and hypotensive effects. By origin and chemical structure, Papaverin is alkaloid Opium poppy, that is, it turns out from the poppy straw, but is not a narcotic substance.Varieties, titles, form of release and composition of papaverin preparations
Papaverin is simultaneously the trade name of some drugs, and the international name (MNN) of the active substance that is part of many drugs. Preparations with the trading name "Papaverin" are the same with the active substance "Papaverin". This substance is called either just papaverine or papaverin hydrochloride. Moreover, papaverine hydrochloride is the chemical name of papaverine, and from the point of view of a doctor or patient between these terms there is no difference. Currently, in the countries of the former USSR, drugs, which include only Papaverin, are usually called "Papaverin" as an active ingredient. In some cases, letters or abbreviations, encrypting the name of the manufacturer of the manufacturer of the drug, for example, "Papaverin MS", "Papaverin Buffus", and others can be added to the word Papaverin, and others. However, in all cases, we are talking about the same drug produced by different plants. but containing the active component of Papaverin.
In addition, there are multicomponent drugs with other names containing simultaneously several active substances, among which there are papaverine. These are drugs such as Papazole, Andipal, TEOODIBAVERIN, etc. However, in this article we will consider exclusively monocomponent drugs containing only papaverin as an active substance and having the same name accordingly. To distinguish and not to confuse the active substance and the name of the drug, the first will write with a small letter, and the second - with a big one.
Monocomponent preparations containing only papaverine as an active substance are currently being produced under the following commercial names:
- Papaverine;
- Papaverin buffus;
- Papaverin MS;
- Papaverin hydrochloride.
Accordingly, the composition of three dosage forms as an active substance contains papaverine hydrochloride in the following dosages:
- Adult tablets - 40 mg;
- Tablets for children - 10 mg;
- Injection solution - 20 mg per 1 ml;
- Rectal suppositories - 20 mg per candle.
Since the pharmacological effect of papaverine is multidirectional, it is attributed simultaneously to two groups of drugs, such as vasodilators (vasodilators) and spasmolytiki. Accordingly, papaverine is used as a spaspolytic to the treatment of functional disorders of the gastrointestinal tract, and as a vasodilator - in the therapy of erection violations.
Therapeutic effects of Papaverin
Papaverin due to blocking the work of a number of enzymes reduces the tone and relaxes the smooth muscles of all internal organs. The fact is that internal organs (stomach, intestines, blood and lymphatic vessels, bronchi, light, urethra, etc.) are equipped with exceptionally smooth muscles, due to the work of which their total tone rises or decreases. With an increase in the tone, the organ is compressed, that is, its spasm arises, and when it decreases, on the contrary, there is relaxation and expansion of the existing lumen. For example, with increasing the tone of the smooth muscles of the intestines, the bronchi or gallbladder, the organs are strongly compressed, characteristic spastic pain appear and the promotion of their enlightenment is disturbed. That is, the intestine is delayed the promotion of the food lump, it ceases to relete the bile from the gallbladder, and the required amount of air cannot pass through the bronchi. In addition, any spasm of internal organs is accompanied by pain syndrome of various intensity. Papaverin removes spasm, relaxes organs, thereby restoring their function and binding pain syndrome. Since the drug is not elected, he effectively stops spasm and pain of any internal organ, and therefore applied very widely. In principle, Papaverin has the same properties and therapeutic effects as the well-known but-shp.
Papaverin has a relaxing effect on the internal organs, since it affects smooth muscles and does not affect the transverse-striped. The fact is that on the human body and in the heart there are only cross-striped muscles, which have other properties and react to completely different irritants and substances. Therefore, antispasmodics acting on smooth muscles do not affect the reduction of skeletal and heart muscles. Thus, Papaverin is able to remove spasm and relax the muscles of internal organs without affecting myocardium and muscles of the body.
Summing up the effects described, the following main therapeutic effects of papaverine can be distinguished:
- Relaxes smooth muscles and removes the spasms of smooth muscles of blood vessels, organs of the digestive, respiratory and urogenital system;
- Due to the relaxation of the muscles of blood vessels and their subsequent expansion reduces blood pressure;
- High doses reduce the excitability of the heart muscle and slow down the healing of the heart;
- In high dosages, has a sedative effect on the central nervous system.
Papaverin is quickly absorbed into the bloodstream at any route of administration (tablets, rectal candles, intramuscular injections) and is excreted by the kidneys. Half of the administered dose of the drug is output after 0.5 - 2 hours.
Papaverin (tablets and injections) - Indications for use
Indications for the use of pills, injections and rectal papaverine suppositories are completely the same, since regardless of the dosage form, the drug is absorbed into the blood and has systemic therapeutic effects.Tablets, injections and pipaverin suppositories are shown in use in the following diseases and states:
- Spasms of smooth muscle elements of the gastrointestinal tract organs with various diseases, such as pylorospasm, colitis, cholecystitis, cholangitis, etc.;
- Spastic pains (for example, with colitis, meteorism, menstruation, irritable intestinal syndrome (CRC), constipation, etc.);
- As part of the complex therapy of cholecystitis and renal colic, as an anesthetic and removable spasm of the drug organ;
- Spasms and pain in the organs of the urogenital system (cystitis, pylitis, kidney stones or in urethra, etc.);
- Bronchospasm;
- Spasm of brain vessels;
- Spasm of peripheral vessels, for example, with endarting and other diseases;
- As part of the complex therapy of angina;
- As an auxiliary drug during preliminary preparation (premedication).
Papaverin (papaverine hydrochloride) - instructions for use
Consider the rules and nuances of the use of each dosage form of papaverine (tablets, candles and injection solutions) separately.Papaverin Tablets - Instructions for use
Tablets should be taken inside, swallowing entirely, not chewing, not scholarsing and non-shredding in other ways, but drinking enough water (approximately 200 ml). Papaverin can be taken regardless of food, and as needed, that is, when spastic pains or painful spasms arise. However, if there are spastic pains in the organs of the gastrointestinal tract, it is better to take Papaverin for 15 - 30 minutes before meals so that the drug stopped the symptoms, and the person could easily eat and drink. In case of spasms and spastic pains of internal organs, adults and adolescents are recommended to take papaverin at 40 - 60 mg (1 - 1.5 tablets) 3-4 times a day. Children should give pills with a special children's dosage of 10 mg. And the dosage of papaverine for children is determined by age:
- 6 - 24 months - 5 mg (1/2 of a children's tablet) 3-4 times a day;
- 2 - 4 years - at 5 - 10 mg (1/2 - 1 children's tablet) 3-4 times a day;
- 5 - 6 years - 10 mg (1 children's tablet) 3-4 times a day;
- 7 - years - 10 - 15 mg (1 - 1.5 children's pills) 3-4 times a day;
- 10 - 14 years - 15-20 mg (1.5 - 2 children's tablets) 3-4 times a day.
Papaverin in ampoules - instructions for injection
The ampoules contains a sterile-ready for the introduction of a 2% solution of papaverine, containing 20 mg of active substance in 1 ml. Since there are 2 ml of solution in Ampoule, the total dosage of papaverine in a whole ampoule is 40 mg, which is equivalent to one adult tablet. The solution can be administered in solid form subcutaneously or intramuscularly, and after dilution - intravenously. Adults and adolescents over 10 years old, the solution is introduced 2 - 4 times a day, and for children under 10 years old - 2 times a day. The single dosage of papaverine is determined by age:
- 6 - 24 months - 0.25 ml of a solution of 2-4 times a day;
- 2 - 4 years - 0.25 - 0.5 ml of solution;
- 5 - 6 years - 0.5 ml of solution;
- 7 - years - 0.5 - 0.75 ml of solution;
- 10 - 14 years - 0.75 - 1 ml of solution;
- 15 years and older - 1 - 2 ml of solution.
For subcutaneous or intramuscular administration, primarily choose the injection site. Intramuscularly optimally enter the solution into the upper-block outer surface of the hip or the outer upper part of the shoulder, and subcutaneously to the area around the navel. Before performing injection, the skin is wiped with an antiseptic, after which the desired amount of solution is gained into the syringe and introduced into the prepared place. For intramuscular injection, the needle is introduced deep into the fabric perpendicular to the surface of the skin. And for subcutaneous injections, first capture approximately 1 cm of the skin with a large and index finger, making a fold from it. After that, the syringe needle is set to approximately at an angle of 45 o to the skin surface and introduced into this fold. The solution is released in the tissue and gently take out the needle, after which the injection site is again wiped with an antiseptic. Each time you can enter a solution to a point, which is at a distance of at least 1 cm from other traces from past injections.
For intravenous administration, it is necessary first the desired amount of papaverine dilute in 10-20 ml of physiological solution. Then this mixture is administered intravenously, slowly. Intravenous injections should be performed only in the hospital, and the subcutaneous or intramuscular can be done at home on their own, if a person has mastered their technique and does not experience fear.
Papaverin - Instructions for the use of candles
Candles are injected into the rectum, carefully pushing the index finger through the anus. Introducing the candles should be definitely clean, just flushed with soap hands or in sterile gloves. Dosage of suppositories with various diseases accompanied by spasms and spastic pains is determined by age and amounts to 1 - 2 candles 2 - 3 times a day for adults, and 1 candle 2 times a day for children over 10 years. Children under 10 years old candles are cut into 2 or 4 equal parts and administered with these pieces containing the required amount of active substance. So, children under 4 are administered by quarter or half a candle, and from 5 to 10 years old - half a suppository 2 times a day. Dosage for various diseases
Dosage of papaverine in all dosage forms is the same with various diseases and conditions, and differs only depending on the age of a person using the drug. So, one-time dosages of the solution, suppository and Papaverin tablets for people of different ages are as follows:- 6 - 24 months - 5 mg;
- 2 - 4 years - 5 - 10 mg;
- 5 - 6 years - 10 mg;
- 7 - years - 10 - 15 mg;
- 10 - 14 years - 15-20 mg;
- Over 14 years old - at 20 - 60 mg.
The maximum allowable single dosage of papaverine is the greatest dose specified for each age multiplied by four. That is, for an adult, the maximum allowable one-time dosage is 60 * 4 \u003d 240 mg, for a child from 10 to 14 years - 20 * 4 \u003d 80 mg, etc. The maximum allowable daily dosage is equal to the maximum one-time multiplied by three.
special instructions
With any diseases that are indicated to use Papaverin, you can choose that dosage, the form that seems to be the most convenient time. For example, if a person is most convenient to take tablets, you should choose this particular form.If it is necessary to quickly achieve the therapeutic effect, especially in the first days of exacerbation of the disease, then injections should be used. After 2 - 3 days, if a person can swallow, should be replaced by the injections with pills or rectal candles. The entire course of therapy is not recommended using subcutaneous or intramuscular injections, as it entails large risks compared to the reception of tablets. Therefore, injections should be set only if the candles and tablets cannot be applied for any reason. In general, doctors recommend to be guided by a simple rule in the choice of the form of the drug - always use either candles, or tablets, and shots apply only if it is necessary to obtain a rapid therapeutic effect, but at the first opportunity to replace them with pills or suppositories.
If a person suffers from the gastrointestinal spasms, it can use papaverine both in candles and in tablets, based exclusively on personal preferences. However, it should be remembered that when using Papaverin candles, the clinical effect comes faster than from tablets. Therefore, if you need to get a quick effect, it is better to use candles. It is also recommended to choose candles if a person for any reason cannot swallow pills.
In spastic pains in the urinary system organs, the optimal option is papaverine suppositories, since when they were introduced into the rectum, the active substance very quickly reaches the affected tissues and has a powerful therapeutic effect. If for some reason the candles are impossible to enter the rectum or difficult, then it should be replaced with pills.
In children, it is recommended to use papaverine in the form of suppositories or special children's tablets with a low dosage of active substance in 10 mg. Do not have children to give halves or quarters of papaverine pills for adults, which contain 40 mg of active substance.
Papaverin is not a drug intended for long term applications, so it is used exclusively for one-time removal of spastic pains against the background of the exacerbation of the disease or state. This means that independently tablets, candles or injections of papaverine can be used within 2 - 3 days, after which the improvement is required to appear, expressed in the decrease in spastic pains and unpleasant sensations in the localization of the pathological process. If there is no improvement, then immediately consult a doctor, as this may indicate the development of severe surgical pathology, for example, appendicitis, bleeding, peritonitis, etc.
For the purpose of the doctor, Papaverin is usually used within 7 - 14 days or a little longer, right up to completely relieve painful spastic pain. If a person has been suffering from any chronic disease for a long time, for example, cholecystitis, it perfectly knows the symptoms of its exacerbation and the dynamics of improvements advancing against the background of admission of papaverine, and therefore can independently determine the duration of the drug.
If a person faced spastic pain for the first time, then the first course of therapy should be carried out exclusively under the supervision of a doctor and independently fix their own sensations, as well as a positive trend. In the future, when aggravating the disease, the relief of spasms will also be made by antispasmodics, and their dynamics will not differ fundamentally from the one that was fixed for the first time. And a person who remembers the dynamics of reducing spastic pain and normalization of the state, during periods of exacerbation in the future will be able to independently control how correctly the treatment is going, without visiting the doctor for this and does not go to the hospital. In addition, he will be able to record any distinctive manifestations of treatment dynamics and report them to a doctor who, in turn, will be aiming to look for their cause and engage in the problem of diagnosing a combined or atypical pathology.
Overdose
Papaverin overdose is possible and manifests itself by the appearance of two eyes, weakness, drowsiness and a decrease in pressure. For the treatment of overdose, stomach washing, after which it gives a sorbent (activated carbon, polysorb, etc.) and milk, and maintain pressure at a normal level.Interaction with other medicines
Papaverin reduces the therapeutic effect of Levodopa and methyldopes.In addition, but-shap with papaverine is often used to prepare the cervix to childbirth, for which women take 1 tablet or administer 1 candle of each drug 2 times a day for 2 weeks before the expected date of delivery. This practice is widespread, however, these drug preparation drugs are more harmful than good, since just before childbirth, when the uterus should actively shrink and prepare, it is artificially "inhibited by" spasmolitis, relaxing muscles and reducing the tone. As a result of the use of but-ships with papaverine "For the preparation of the cervix" increases the likelihood of the weakness of generic activity and, accordingly, the use of rhodtle, relativesexpension and the imposition of obstetric tongs or vacuum. That is, there is no preparation of the cervix, but the oppression of generic activity.
The use of but-ships with papaverine does not reduce the risk of breaks, which in most cases depend only on competent knowledge of the childhood by the doctor. And for the preparation of the cervix to childbirth, which is carried out only during the rejunction or necessity of urgent delivery against the background of the threat of mothers's life, completely different drugs are used (soda, etc.) and non-drugs (laminaries, Foley catheter, etc.).
Papaverin Children
Papaverin in any dosage form can be used in babies from three months. The instructions usually indicate that the drug is allowed to use from 6 months, but Pediatrician practitioners based on perennial observations for the use of papaverine are considered justified and secure its application from 3 months. Indeed, the composition of the popular drug of the Ofonna, used for childbing, also includes papaverin.The kids of the first year of life, Papaverin is used mainly to relieve spastic pain and intestinal colic, and in children of older age - for removing bronchospasm, as well as in complex therapy of pancreatitis, liver colic and urethra spasms. In addition, if a child has a high temperature and white, cold hands and legs, then papaverin is given to expand the vessels for 15 to 20 minutes to the antipyretic drug. In a situation where the hands and feet are cold, and the temperature is very high, antipyretic without prior admission of antispasmodics (papaverine, but-shops, drootaverine, etc.) will not act, because the narrowed, spashed vessels will not give excess warmth and cool the body .
Papaverin in children is used in all three dosage forms in the dosages depending on age:
- 6 - 24 months - 5 mg (1/2 of a children's tablet, 0.25 ml of solution or 1/4 candles) 2 times a day;
- 24 years - at 5 - 10 mg (1/2 - 1 children's tablet, 0.25 - 0.5 ml of solution or 1/4 - 1/2 candles) 2 times a day;
- 5 - 6 years - 10 mg (1 children's tablet, 0.5 ml of solution or half of the candle) 2 times a day;
- 7 - 9 years - 10-15 mg (1 - 1.5 children's tablets, 0.5 - 0.75 ml of solution or 1/2 - 2/3 of the candles) 2 - 3 times a day;
- 10 - 14 years - 15-20 mg (1.5 - 2 children's tablets, 0.75 - 1 ml of solution, 2/3 - 1 candle) 2 - 3 times a day;
- Teens older than 14 years - 20 to 40 mg (1 adult tablet, 1 - 2 ml of solution or 1 - 2 candles) 3-4 times a day.
Papaverin from pressure
Papaverin expands blood vessels and moderately reduces blood pressure, but it does not use it as a specific antihypertensive drug for long-term treatment courses. Papaverin in combination with dibazole is usually injected with hypertensive crisis - Increased sensitivity to components of drugs;
- AV blockade;
- Liver failure;
- Old age over 65 years old;
- Children's age under 6 months.
- Transferred over the past 6 months the cranopy and brain injury;
- Shock states;
- Chronic renal failure; 1.
Biospa pills;
2. Vero-drootaverin pills;
3. Dwarvery solution for injections, tablets;
4. DROTAVERINA MS, DROTAVERIN FORTER, DROTAVERIN-UFF, DROTAVERIN-TEVA AND DROTAVERIN-FPO - Tablets;
5. DROTAVERIN-ELLARA Solution for injections;
6. Nikoverin pills;
7. But-ship tablets and injection mortar;
8. But shpa forte pills;
9. Nos-sray solution for injections and tablets;
10. Papazole and papazole-UFF pills;
11. Platifillin with papaverine pills;
12. Ple Spa Tablets;
13. Spasp solution for injection and tablet;
14. Spasmodes and spasmodes forte pills;
15. Spaser tablets;
16. Spakoving solution for injection and tablet.
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