Analgin - indications, dosage, interaction. Analgin tablets: instructions, reviews, analogues Terms and conditions of storage of Analgin

   Metamizole sodium.

Dosage form:

  solution for intravenous and intramuscular administration.
Description:  Transparent, colorless or slightly colored liquid.

Structure
active substance:  metamizole sodium - 250 mg or 500 mg;
excipient:  water for injection - up to 1 ml.

Pharmacotherapeutic group:

  non-narcotic analgesic.
ATX Code

Pharmacological properties
Pharmacodynamics
  It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis. It is a derivative of pyrazolone.
Pharmacokinetics
  With intravenous administration: the onset of action after 5-10 minutes, the maximum effect after 5-30 minutes, the duration of action is up to 2 hours. It is metabolized in the liver, a small concentration of unchanged metamizole sodium is found in plasma, excreted by the kidneys. In therapeutic doses, it passes into breast milk.

Indications for use
  Pain syndrome (mild to moderate severity): incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, injuries, burns, decompression sickness, herpes zoster, orchitis, radiculitis, myositis, postoperative pain, headache, toothache, algomenorrhea. Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., post-transfusion complications).
  The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications
  Hypersensitivity to pyrazolone derivatives (phenylbutazone, tribuzon), tendency to bronchospasm.
Severe impairment of liver and / or kidney function, glucose-6-phosphate dehydrogenase deficiency, blood diseases, inhibition of hematopoiesis (agranulopitosis, cytostatic or infectious neutropenia), as well as anemia and leukopenia. Bronchial obstruction, rhinitis, urticaria provoked by the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history), active liver disease, condition after coronary artery bypass grafting; confirmed hyperkalemia, erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal bleeding, inflammatory bowel disease. Infant age up to 3 months.
  Use during pregnancy and lactation.
  It can not be used during pregnancy (especially in the first 3 months and last 6 weeks) and during lactation.

Carefully
  Coronary heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 ml / min. anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, the presence of H. pylori infection, old age, prolonged use of non-steroidal anti-inflammatory drugs, severe somatic diseases, concomitant use of oral glucocorticosteroids (including prednisone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetip, sertraline).
  Particular caution is required when prescribing to patients with systolic blood pressure below 100 mm RT. Art. or with instability of blood circulation (for example, with myocardial infarction, multiple trauma, beginning shock), with anamnestic indications of kidney disease (pyelonephritis, glomerulonephritis) and with a long alcohol history.

Dosage and administration
  The drug is administered in / in (with severe pain) or in / m 1 to 2 ml of 250 mg / ml or 500 mg / ml of the solution 2-3 times a day, but not more than 2 g per day.
  Children are administered at the rate of 0.1 - 0.2 ml of a 500 mg / ml solution or 0.2 - 0.4 ml of a 250 mg / ml solution for every 10 kg of a child’s body weight 2-3 times a day.
  For children under 1 year of age, the drug is administered only in oil, the course is no more than 3 days.

Side effect
In therapeutic doses, the drug is well tolerated. When using the drug in some patients, adverse reactions may occur: allergic reactions (skin rash, Quincke's edema; rarely anaphylactic shock, Stevens-Johnson and Lyell syndromes, bronchospasm); with prolonged use, agranulocytosis, leukopenia, thrombocytopenia, arterial hypotension, interstinal nephritis can occur. Impaired renal function, oliguria, anuria, proteinuria, urine staining in red.
  With a tendency to bronchospasm, provoking an attack is possible. With i / m administration, infiltrates at the injection site are possible.

Overdose
Symptoms  nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, respiratory muscle paralysis.
Treatment:  induction of vomiting, trans-probe gastric lavage, saline laxatives, activated charcoal; conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - in / in the introduction of diazepam and high-speed barbiturates.

Interaction with other drugs
  Due to the high likelihood of pharmaceutical incompatibility, it cannot be mixed with other drugs in the same syringe. Enhances the effects of ethanol; simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.
X-ray contrast agents, colloidal blood substitutes, and penicillin should not be used during treatment with metamizole sodium. With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from a protein bond, increases their activity. Phenylbutazone, barbiturates, and other hepatoinductors with simultaneous administration reduce the effectiveness of metamizole sodium. Simultaneous administration with other non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptives and allopurinol can lead to increased toxicity. Sedatives and tranquilizers enhance the analgesic effect of sodium metamizole. Tiamazole and sarcolisin increase the risk of developing leukopenia. The effect is enhanced by codeine, histamine H2-blockers and propranolol (slows inactivation). Myelotoxic drugs increase the manifestation of hematotoxicity of metamizole sodium.

special instructions
  When treating children under 5 years old and patients receiving cytotoxic drugs, analgin should be administered only under the supervision of a doctor. Patients with atopic bronchial asthma and pollinosis have an increased risk of hypersensitivity reactions. With prolonged (more than a week) use, monitoring of the peripheral blood picture and the functional state of the liver is necessary. Against the background of taking analginum, the development of agranulocytosis is possible, in connection with which, if there is an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as with the development of vaginitis or proctitis, immediate drug withdrawal is necessary. Intolerance is very rare, however, the risk of shock after intravenous administration of the drug is relatively higher than after taking the drug inside. It is not permissible to use to relieve acute abdominal pain (until the cause is clarified). For intramuscular administration, a long needle must be used.

Release form
  A solution for i / v and i / m administration of 250 mg / ml or 500 mg / ml (ampoules) - 1 or 2 ml. 10 ampoules together with an ampoule or scarifier knife and instructions for use in a pack of cardboard.
  5 ampoules per blister pack. 2 contour cell packs together with an ampoule or scarifier knife and instructions for use in a pack of cardboard. When packing ampoules with a point or ring of a break, an ampoule knife or a scarifier is not inserted.

Storage conditions
List B. In a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life
  3 years. Do not use after the expiration date indicated on the package.

Holidays from pharmacies
  Release by prescription.

Claim Manufacturer / Organization
  FSUE Armavir Biological Factory
  Address: 352212, Krasnodar Territory, Novokubansky District, pos. Progress, st. Mechnikova, d.11

Metamizole sodium is known to everyone under the name "analgin" is widely used in modern medicine and pharmacology.

Today we will tell you why this drug is needed, from what diseases, with what it is combined, side effects from taking it.

  What helps, the main indicators:

1. Analgesic effect.
2. Decrease in body temperature.
3. It neutralizes inflammation in the body.
4. Reduces spasm of blood vessels.
5. Removes toothache.

It has many analogues now - Tempalgin, Baralgin-M, Pentalgin, which include metamizole sodium (Metamizole sodium).

Pros, cons

Doctors still prescribe at high temperature in combination with aspirin. It is a quick antipyretic.

Advantages in application:

1. Elimination of high temperature, toothache, headache.
2. Freely sold on sale (can be bought without a doctor’s prescription).
3. The cheapness of the drug.

1. Side effects, including effects on the cardiovascular system.
2. Violation of blood circulation and coagulability.
3. The level of leukocytes in the blood can sharply decrease and such a hemolytic disease as agranulocytosis can develop.
4. Lowering the temperature to a minimum - up to 34.5 ℃.
5. Liquid analgin (solution for injection) contributes to anaphylactic shock.

Therefore, in many cities and countries it is prohibited. An overdose is fatal.

Who is assigned

  The action of the drug can stop the following symptoms:

• From toothache, quickly stops, completely neutralizes it.
• When the head promotes vasodilation.
• During menstruation.
• From high temperature.
• Neuralgia.
• Sciatica, spinal injury.
• Muscle pain (myalgia).
• Orchitis.
• Burn shock.
• Postoperative condition.
• Anesthetic effect in oncology.
• Muscle myositis.
• Colic - biliary, intestinal, renal (analgin for injection + antispasmodic - nosh-pa).
• Infections and viruses accompanied by fever.

Instructions for use

Indications

1. The drug is not recommended for children under 6 years old, at a high temperature (38.5–39.0 ℃) it is 0.5 tablets + paracetamol + nosh-pa. Alternate with Ibufen, Panadol.
2. Dose for an adult 1 tablet. + Antispasmodic. To increase the daily norm, you need a doctor's consultation. Take when temperature is above 39.0 ℃. The maximum intake of the drug is 1000 mg per day. 1 tablet of analginum contains 500 mg of metamizole sodium.
3. Adults and children strictly according to the instructions and as directed by a doctor. Do not exceed a dose that is hazardous to health.

Contraindications

1. Do not take in children under 6 years old without a doctor's prescription.
2. Pregnant and lactating mothers.
3. Contraindicated in people with circulatory disorders.
4. Renal and hepatic pathology.
5. It is not recommended to drink with broad-spectrum antibiotics.
6. Do not take if necessary if the temperature has reached a maximum (39.0 ℃);
7. Analgin does not treat, but relieves pain and acts as an antipyretic in combination with other antispasmodic drugs.

Side effects

• Urticaria, allergic reaction, anaphylactic shock.
• Choking, asthma attack.
• Angioneurotic edema.
• Toxic epidermal necrolysis.
• Malignant exudative erythema (Stevens-Johnson syndrome).
• A sharp drop in white blood cells.
• Thrombosis, thrombocytopenia.
• Leg cramps.
• Migraine.
• Lowering blood pressure.
• Urinary retention - oliguria.
• Lack of urine excretion.
• Jade, damage to the kidneys and liver.
• Violation of the digestive tract.
• Arthritis, a drop in temperature to a minimum (hypothermia).

Interaction

The medicinal effect of some drugs is enhanced specifically by metamizole sodium. What connections and what affects, we will now tell.

Diphenhydramine

This combination is often used by emergency doctors to reduce fever in children and adults (over 39.5 ℃). It is life-threatening, therefore it is done in emergency cases upon arrival of an ambulance! Doctors know how much to inject.

• After 14 - 1 ml.
• For children under 14 years of age, the dosage is based on 1 kg of the baby. Analgin \u003d up to 10 mg / 1 kg, diphenhydramine \u003d up to 2-5 mg / 1 kg.

Intramuscular injection is carried out by sequential manipulation, first analgin, then the second medicine. In no case do not inject simultaneously with vasodilator drugs, this can lead to irreversible consequences and complications.

Triad

  This combination is used during first aid in emergency cases to achieve the desired effect in a short time. Only a doctor can calculate the right dose of drugs.

Thanks to this combination, spasm, hepatic or renal colic, pain with appendicitis, high fever after 39.5 устран are eliminated. No-spa with analgin is also a good cure for spasms.

With papaverine - a lytic mixture, an analogue of the full combination of painkillers and antipyretic drugs. Everything is used in the same cases as with the addition of no-shpa and diphenhydramine.

Single dose:

1. Analgin - up to 10 mg / 1 kg.
2. Papaverine - 0.1 ml / 1 year.
3. Diphenhydramine - 0.4 ml / 1 year.

Paracetamol

  This combination is the most popular among antipyretic drugs for children and adults. In Russia, this combination was officially banned, because it causes many complications and side effects such as:

1. Anaphylactic shock.
2. Allergic reaction.
3. Decrease in temperature to low limits (hypothermia).
4. Decreased white blood cell count (agranulocytosis).
5. Fatal outcome (10% of cases).

This combination can not be given to children, it is better to replace them - Ibuprofen, Ibufen, Panadol and other antipyretic drugs.

Aspirin

  The combination of these drugs is used in the initial stages of ODS, acute respiratory infections, influenza, tonsillitis and other infectious diseases that occur with high temperature. He is not promoted to accept even with severe pain, so you need to be careful with him.

Especially for children and people suffering from cardiovascular diseases. Since 1992, in the CIS countries it has not been recommended for consumption, especially with alcohol, other drugs and antibiotics.

Use with aspirin only in emergency cases, with severe pain and temperature above 39.5 ℃.

Suprastin

  Suprastin is the modern name for Diphenhydramine. The performance characteristics are not inferior to its counterpart.

Novocaine

  These two drugs together with each other enhance the effect of the analgesic, antipyretic effect. It is also necessary to use it in rare critical cases and, if possible, replace it with other modern medicines - Lidocaine, Bulivacaine, Melivacaine.

Analgin, but shpa, suprastin

This combination is used for:

1. "White" fever - cold hands and feet, pale skin, weakness and chills of the patient.
2. Very high temperature - 39.5 ℃.
3. To prevent seizures.

Dosage:

• "Analgin" - up to 8 years - weight / kg * up to 10 mg, but not more than 0.1 g.
• "Suprastin" - from 0-12 months. - the fourth part (1/4), from 1 year-6 - 1/3, from 6 - ½.
• “No-shpa” - from 12 months-6 - ¼; up to 12 - 1 t., after 12 - 2 t.

In addition to medicines, in parallel, use alternative methods, rubbing limbs with vinegar with diluted water.

Do not exceed the amount of the drug, because it may be fatal for the child and for you. An allergy leads to suffocation, urticaria, and anaphylactic shock.

Ultra

This combination is also prescribed for the removal of pain, high temperature. Indication:

1. Renal, hepatic colic.
2. Gallstone, passage of stones along the ducts.
3. Migraine, toothache.
4. Traumatic shock and burns. A day, a single dose to an adult should not exceed 0.3 g.

Candles

Assign to young children to relieve pain and as an antipyretic. 0.1 g and 0.25 g are produced. 1 suppository -0.1 g of metamizole sodium:

1. 6 months-12 months \u003d ½.
2. 12 months-3 \u003d 1 pc.
3. 3-7 \u003d up to 2 per day;
4. 7 and older \u003d up to 3 x 0.25 g.

The procedure is performed on the side of the bed - rectally. After introducing a candle, the child needs to lie in bed for complete dissolution and the onset of its action.

Grinding for joints

Over time, the body wears out, various pathologies of bones and cartilage begin. To relieve pain, the ideal tool is grinding.

• “Analgin” - record (10 tablets);
• Camphor alcohol 10% - 15 ml;
• Iodine solution 5% - 1 bottle;
• Ethyl (medical 70%) - 0.3 l. Stir, dissolve, store in a dry and cool place.
• Use as necessary, for aching and dull pain - externally.

Injections

They are done in two ways - intravenously, intramuscularly. It is advisable to carry out this procedure under the supervision of doctors. Because it is not known how the body will react. The ampoule contains 0.25 g and 0.5 g of metamizole sodium.

Analgin is a non-narcotic painkiller. It has analgesic, antipyretic and antispasmodic effects.

Release form and composition

Analgin is available in the following dosage forms:

• Flat cylindrical tablets of 500 mg of white or yellowish color with a bitter taste, 10 pieces in a blister strip or non-cell packaging;
• Suppositories for rectal administration of 100 mg, 5 pieces in contour packaging;
• Solution for injection 25% and 50%, in ampoules of 1 ml or 2 ml;
• A solution for intramuscular and intravenous administration of 250 mg / ml and 500 mg / ml, in ampoules of 1 ml or 2 ml.

The active substance is metamizole sodium (analgin).

Excipients:

• Sugar;
• Potato starch;
• Talc;
• Calcium stearate.

Indications Analgin

The use of Analgin is indicated for pain syndromes of various etiologies:

• Infectious and inflammatory processes;
• Bites of insects - mosquitoes, bees, gadflies and others;
• Post-transfusion complications;
• Neuralgia;
• Myalgia;
• Arthralgia;
• Biliary colic;
• Intestinal colic;
• Renal colic;
• Injuries
• Burns;
• Decompression illnesses;
• Tinea versicolor;
• Orchitis;
• Radiculitis;
• Myositis;
• Postoperative pain syndromes;
• Headaches;
• Toothache
• Algodismenorea.

Contraindications

Analgin is contraindicated in:

• Hypersensitivity;
• Prolonged abuse of ethanol;
• Agranulocytosis;
• Infectious or cytostatic neutropenia;
• Liver or kidney failure;
• Hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase;
• Bronchial asthma induced by acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs;
• Anemia
• Leukopenia;
• Pregnancy, especially in the first trimester and in the last 6 weeks;
• Lactation

In addition, intravenous administration of Analgin to patients with systolic blood pressure below 100 mmHg or with unstable blood circulation due to myocardial infarction, shock, multiple trauma is prohibited.

The instructions to Analgin indicate that it should be prescribed with caution to infants up to 3 months old, as well as to patients with kidney diseases - pyelonephritis and glomerulonephritis, including a history.

Method of application and dosage of Analgin

Analgin in tablets is taken orally, 2-3 times a day, 250-500 mg each. The maximum dose should not exceed 1 g in 1 dose and 3 g in 1 day.

A single dose for children from 2 years old is 50-100 mg, from 4 years old - 100-200 mg, from 6 years old - 200 mg, from 8 to 14 years old - 250-300 mg 2-3 times a day.

Intramuscularly or intravenously, adults are prescribed 250-500 mg 3 times a day. The maximum daily dose is 2 g.

Children's dosage is calculated by body weight and is 5-10 mg / kg 2-3 times a day. For children under the age of 1 year, Analgin is administered only intramuscularly.

The injection for administration should have a body temperature. More than 1 g should be administered intravenously, while conditions should be provided for anti-shock therapy.

The intravenous administration of Analgin, according to the instructions, must be done slowly, not faster than 1 ml / min, in the supine position and under the control of blood pressure, respiratory rate and heart rate. These precautions are related to the fact that a high injection rate is the main reason for a sharp decrease in blood pressure.

The adult dosage for rectal administration is 300, 650 and 1000 mg, and the children's dosage depends on the nature of the disease and age. In particular, children from 6 months to 1 year are prescribed 100 mg, from 1 year - 200 mg, from 3 years - 200-400 mg, from 8 to 14 years - 200-600 mg. After applying Analgin in suppositories, you must be in bed.

Side effects of Analgin

Analgin may cause the following side effects:

• Impaired renal function;
• Oliguria;
• Anuria
• Interstitial nephritis;
• Proteinuria;
• Urine staining in red;
• Urticaria (including on the mucous membranes of the nasopharynx and conjunctiva);
• Angioedema;
• Toxic epidermal necrolysis;
• Malignant exudative erythema;
• Bronchospastic syndrome;
• Anaphylactic shock;
• Agranulocytosis;
• Leukopenia;
• Thrombocytopenia;
• Lowering blood pressure;
• Infiltrates at the site of intramuscular injection.

An overdose of Analgin can be accompanied by a number of symptoms:

• Nausea
• Vomiting
• Gastralgia;
• Oliguria;
• Hypothermia;
• Lowering blood pressure;
• Tachycardia;
• Shortness of breath;
• Tinnitus;
• Drowsiness
• Delirium;
• Impaired consciousness;
• Acute agranulocytosis;
• Hemorrhagic syndrome;
• Acute renal and / or liver failure;
• Cramps;
• Paralysis of the respiratory muscles.

Treatment consists of washing the stomach, prescribing activated charcoal and saline laxatives, as well as conducting forced diuresis and hemodialysis. With the development of convulsive syndrome, intravenous administration of diazepam and high-speed barbiturates is necessary.

special instructions

Analgin intolerance is rare, but the risk of anaphylactic shock after intravenous administration of the drug is higher than after taking the tablets.

With atopic bronchial asthma and pollinosis, the likelihood of allergic reactions increases.

Before determining the causes of acute abdominal pain, the drug should not be used.

Due to the release of metabolites, urine may turn red (it does not matter).

For intramuscular administration, a long needle should be used.

Analogs of Analgin

Metamizole sodium is the active ingredient in Baralgin tablets.

Analogin analogues are:

• Antipyrine;
• Baralgetas;
• Quintalgin;
• Maxigan
• Pentalgin;
• Revalgin;
• Spasmalgon;
• Tempalgin;
• Sedalgin.

Terms and conditions of storage

Store in a dry, dark place. Keep out of the reach of children.

Shelf life is 5 years.

Analgin is a popular drug with a pronounced analgesic effect, an effective antipyretic.

Pharmacological action of Analgin

The active ingredient of Analgin is metamizole sodium, a chemical compound from the group of pyrazolones, a non-steroidal anti-inflammatory drug (NSAID). Reduces the production of prostaglandins - specific mediators of inflammation (anti-inflammatory effect), enhances the body’s heat transfer (antipyretic effect), increases the sensitivity threshold of the thalamus pain centers and creates obstacles to the conduct of pain impulses in the central nervous system (central analgesic effect). The anti-inflammatory effect is less pronounced than that of other NSAIDs, and the antipyretic is stronger; metamizole sodium is the strongest antipyretic in this group. Practically does not irritate the mucous membrane of the digestive tract and does not lead to disruption of water-salt metabolism. It has antispasmodic activity against smooth muscles of the biliary and urinary tract.

Analgin begins to act 20-30 minutes after ingestion, reaching a peak after 1-2 hours. It is easily absorbed in the gastrointestinal tract, it is well soluble in almost all medical solutions, which makes it convenient for use both internally and parenterally.

Release form

The drug is available in the form of powder, tablets, injection and suppositories.

Tablets for adults: 1 tablet contains 500 mg of metamizole sodium, 10 pcs. in a blister.

Analgin for children is released in the form of tablets with an active substance content of 50, 100 and 150 mg; and also in the form of suppositories - 1 suppository contains 10 mg of metamizole sodium.

Injection: 1 ml contains 500 mg (50% solution) or 250 mg (25% solution) metamizole sodium; produced in ampoules of 1 or 2 ml, 10 pcs. in a cardboard package, each package contains instructions for the use of Analgin.

Indications Analgin

• Fever of various origin (infectious and inflammatory diseases, complications after blood transfusion, insect bites, etc.);
• Neuralgia
• Arthralgia;
• Myalgia;
• Sciatica
• Headache;
• Toothache;
• Algodismenorea;
• Biliary colic;
• Renal colic;
• Intestinal colic;
• Shingles;
• Pain syndrome with all types of injuries;
• Postoperative pain syndrome;
• Decompression sickness.

Analgin is prescribed for children according to the same indications as adults - for febrile conditions and pain syndrome of various origins.

Side effects of Analgin

When used according to the indications and dosage selection in accordance with the instructions for use, Analgin is well tolerated by patients, both adults and children, and rarely causes unwanted effects.

Long-term use of Analgin can cause a violation of blood formation, especially for granulocytes. In some countries, the drug was banned, as it caused suspicions that its use leads to the occurrence of agranulocytosis - a blood disease that directly threatens life. However, after a series of studies, it was found that the danger was significantly overestimated. Currently, it is rated as extremely low, however, such a possibility is not excluded.

Also, instructions for the use of Analgin indicate the possibility of allergic reactions in case of individual intolerance to the drug, to a greater extent this refers to a drug administered by the parenteral method (intravenously).

Contraindications Analgin

In accordance with the instructions for use, Analgin is contraindicated in the following cases:

• Individual intolerance to metamizole sodium and other pyrazolone derivatives;
• Blood disorders and blood diseases;
• Insufficiency of the enzyme glucose-6-phosphate dehydrogenase (hereditary hemolytic anemia);
• History of aspirin asthma;
• Lack of liver and / or kidney function;
• First trimester and last 6 weeks of pregnancy;
• The period of breastfeeding (Analgin passes into breast milk).

Analgin for children is prescribed according to indications no earlier than 3 months of age.

With caution, the drug is used in patients with a history of kidney disease, chronic alcoholism, low blood pressure (systolic blood pressure below 100 mmHg), with multiple trauma, cardiogenic shock, and other situations that are characterized by unstable blood circulation.

Instructions for use Analgin

Analgin can be prescribed in the form of tablets, suppositories, intramuscular or intravenous injection. Subcutaneous injections are unacceptable because of the high risk of complications associated with irritation of superficial tissues, for the same reason, a long needle must be chosen for intramuscular injection.

Adults - 250-500 mg 2-3 times a day before the relief of pain or hyperthermia;

Analgin for children in the form of tablets is prescribed at a dose of 5-10 mg of the drug per 1 kg of weight per day, divided into 3-4 doses.

Tablets should be taken after a meal with a sufficient amount of clean still water.

In the form of suppositories, Analgin is administered rectally to children in the following dosage:

From 6 months to 1 year - ½ suppository per day;

From 1 year to 3 years - 1 suppository per day;

From 4 to 7 years - 2 suppositories per day.

After the introduction of a suppository with Analgin, children need to lie for half an hour.

Parenteral drug is administered in the following dosage:

Adults 1-2 ml of 50% Analgin solution 2-3 times a day;

Analgin for children - at the rate of 0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution for every 10 kg of body weight.

The maximum allowable dose for adults is 1000 mg - single, 2000 mg - daily.

special instructions

Attention! The use of Analgin in the presence of acute pains of an unexplained nature before examination by a doctor is unacceptable!

Long-term use of the drug requires periodic monitoring of the white blood cell count.

In some cases, the administration of Analgin can stain the urine red, which is not a sign of negative effects, is associated with the release of an intermediate metabolic product of metamizole sodium and does not require discontinuation of the drug.

This product is not compatible with alcohol.

It is unacceptable to mix Analgin with other drugs in the same syringe.

It interacts with other medicinal substances, changing them and their therapeutic activity, therefore, when taking other medications, it is necessary to inform the attending physician about the use of Analgin.

Terms and conditions of storage Analgin

Analgin is required to be stored in a dry place out of direct light, with an air temperature of 8 -15 ° C. With undamaged packaging, the shelf life is 3 years.

Keep out of the reach of children!

It is released on prescription.

in a contour bezeljacheykovy or cell packaging 10 pcs .; in a pack of cardboard 1, 2, 3 or 5 packs.

Description of the dosage form

Tablets of white or slightly yellowish color, flat-cylindrical, with a risk and a facet, bitter taste.

pharmachologic effect

pharmachologic effect  - analgesic.

Pharmacodynamics

Metamizole sodium is a pyrazolone derivative. It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of GHG synthesis. The pharmacological effect develops 20-40 minutes after taking the drug and reaches a maximum after 2 hours.

Indications Analgin

Pain syndrome of various etiologies:

headache;

migraine pain;

toothache;

neuralgia;

algodismenorea;

postoperative pain;

renal and biliary colic (in combination with antispasmodics);

febrile conditions in infectious and inflammatory diseases.

Contraindications

hypersensitivity to pyrazolone derivatives (butadion, tribuzon);

bronchial asthma;

diseases accompanied by bronchospasm;

"Aspirin asthma";

inhibition of hematopoiesis (agranulocytosis, neutropenia, leukopenia);

severe impaired liver or kidney function;

blood diseases;

hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase;

pregnancy (especially in the first trimester and in the last 6 weeks);

lactation period.

With caution - infant age (up to 3 months).

Pregnancy and lactation

Contraindicated during pregnancy (especially in the first trimester and in the last 6 weeks). At the time of treatment should stop breastfeeding.

Side effects

Allergic reactions: skin rash, Quincke's edema; rarely - anaphylactic shock, toxic epidermal necrolysis (Lyell syndrome), in rare cases - Stevens-Johnson syndrome.

With prolonged use, leukopenia, thrombocytopenia, agranulocytosis may occur.

With a tendency to bronchospasm, provoking an attack is possible; decrease in blood pressure.

Possible impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, staining of urine in red due to the release of the metabolite.

About all side (unusual) effects, including not listed above, you should inform your doctor and stop taking the drug.

Interaction

The simultaneous use of Analgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.

Tricyclic antidepressants, contraceptives for oral administration and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Barbiturates and phenylbutazone weaken the effect of analgin.

Analgin enhances the effects of alcohol-containing drinks.

X-ray contrast agents, colloidal blood substitutes, and penicillin should not be used during treatment with metamizole.

Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the protein bond, increases their activity.

The simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Tiamazole and sarcolisin increase the risk of developing leukopenia. The effect is enhanced by codeine, propranolol (slows inactivation).

Sedatives and tranquilizers enhance the analgesic effect of analgin.

Dosage and administration

Inside  adults - 1 tablet. 2-3 times a day after meals. The maximum single dose is 1 g (2 tablets), daily - 3 g (6 tablets). With prolonged (more than a week) use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Children are prescribed 5-10 mg / kg of body weight 3-4 times a day for no more than 3 days (pre-grinding tablet).

Do not use (without consulting a doctor) for more than 3 days when prescribed as an antipyretic and more than 5 days when prescribed as an anesthetic.

Overdose

Symptoms  with prolonged use of the drug (more than 7 days) in large doses - nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, cramps, paralysis of the respiratory muscles.

Treatment:  induce vomiting, do gastric lavage, take saline laxatives, activated charcoal. In the conditions of a medical institution - conducting forced diuresis, hemodialysis, with the development of a convulsive syndrome - in / in the introduction of diazepam and barbiturates.

special instructions

In patients suffering from bronchial asthma and pollinosis, the development of hypersensitivity reactions is possible.

With prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood.

Do not use to relieve acute abdominal pain (until the cause is clarified).

In the treatment of children under 5 years of age and patients receiving cytotoxic drugs, metamizole sodium should be administered only under medical supervision.

Particular care is required when prescribing to patients who abuse alcohol.

Children and adolescents under 18 years of age should only be used as directed by a doctor.

Storage conditions for the drug Analgin

In a dry, dark place.

Keep out of the reach of children.

Shelf life of the drug Analgin

5 years.

Do not use after the expiration date indicated on the package.

Medical instruction

  P N003134 / 01 dated 2009-07-15
Analgin - instructions for medical use - RU No. P N001051 / 02 from 2016-08-22
Analgin - instructions for medical use - RU No. LS-002585 from 2006-12-29
Analgin - instructions for medical use - RU No. P N001942 / 01 from 2017-07-27
Analgin - instructions for medical use - RU No. P N001286 / 02 from 2009-02-05
Analgin - instructions for medical use - RU No. P N001051 / 01 from 2018-01-18
Analgin - instructions for medical use - RU No. LS-000487 from 2018-06-27
Analgin - instructions for medical use - RU No. P N001780 / 02 from 2008-11-20
Analgin - instructions for medical use - RU No. P N001286 / 01 from 2008-11-18
Analgin - instructions for medical use - RU No. P N000597 / 01 from 2012-02-29
Analgin - instructions for medical use - RU No. P N003281 / 01 from 2009-04-07
Analgin - instructions for medical use - RU No. LS-000487 from 2010-05-31
Analgin - instructions for medical use - RU No. P N001780 / 01 from 2015-08-12
Analgin - instructions for medical use - RU No. LS-002585 from 2011-12-29
Analgin - instructions for medical use - RU No. P N001942 / 01 from 2006-12-08

Synonyms of nosological groups

Heading ICD-10	The synonyms of diseases according to ICD-10
G43 Migraine	Migraine pain
	Hemicrania
	Hemiplegic migraine
	Migraine-like headache
	Migraine
	Migraine attack
	Serial headache
G54.1 Lesions of the lumbosacral plexus	Root Neuralgia
	Pathology of the spine
	Lumbosacral radiculitis
	Radiculitis of the lumbosacral
	Radiculoneuritis
K08.8.0 * Toothache	Dental anesthesia
	Pain syndromes in dental practice
	Dentin pain
	Pulpitis pain
	Pain after removal of tartar
	Pain after dental surgery
	Tooth extraction pain
	Dentinal pain
	Toothache
K82.8.0 * Dyskinesia of the gallbladder and biliary tract	Biliary obstruction
	Biliary reflux gastritis
	Biliary Reflux Esophagitis
	Biliary sludge
	Hypermotor biliary dyskinesia
	Gallbladder hypokinesia
	Hypomotor gallbladder dyskinesia
	Biliary dyskinesia
	Gallbladder dyskinesia
	Biliary Dyskinesia
	Biliary colic
	Gall reflux
	Bile secretion
	Violation of the outflow of bile
	Subacute and chronic biliary tract disease
	Spasm of the biliary tract
	Biliary tract spasm
	Spastic biliary dyskinesia
	Spastic dyskinesia of the gallbladder
	Spastic conditions of the gastrointestinal tract
M60 myositis	Soft tissue inflammatory disease
	Myositis
	Fibrositis
	Fibromyositis
M79.1 myalgia	Muscular-articular pain syndrome
	Muscle pain
	Muscle soreness
	Muscle soreness during heavy physical exertion
	Painful conditions of the musculoskeletal system
	Musculoskeletal pain
	Muscle pain
	Pain at rest
	Muscle pain
	Muscle pain
	Musculoskeletal pain
	Myalgia
	Myofascial pain syndromes
	Muscle pain
	Muscle pain at rest
	Muscle pain
	Muscle pain of non-rheumatic origin
	Muscle pain of rheumatic origin
	Acute muscle pain
	Rheumatic pain
	Rheumatic pain
	Myofascial syndrome
	Fibromyalgia
M79.2 Neuralgia and neuritis, unspecified	Pain syndrome with neuralgia
	Brachialgia
	Occipital and intercostal neuralgia
	Neuralgia
	Neuralgic pain
	Neuralgia
	Intercostal neuralgia
	Neuralgia of the posterior tibial nerve
	Neuritis
	Traumatic neuritis
	Neuritis
	Neurological Pain Syndromes
	Neurological contracture with cramping
	Acute neuritis
	Peripheral neuritis
	Post-traumatic neuralgia
	Severe neurogenic pain
	Chronic neuritis
	Essential neuralgia
N23 Renal colic, unspecified	Renal colic pain
	Pain syndrome with spasms of smooth muscles
	Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain syndrome with spasms of smooth muscles of internal organs
	Pain syndrome for spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Renal colic
	Ureteric colic
	Renal colic
	Renal colic with urolithiasis
	Kidney stone disease
	Smooth muscle spasm in diseases of the urinary system
	Urinary tract spasm
	Ureter Spasm
	Ureter Spasm
	Urinary tract cramps
	Urinary tract spasms
N94.0 Pain in the middle of the menstrual cycle	Algomenorrhea
	Painful menstruation
	Menstruation pain
	Menalgia
N94.6 Dysmenorrhea, unspecified	Algodismenorea
	Algomenorrhea
	Pain syndrome with spasms of smooth muscles
	Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain syndrome with spasms of smooth muscles of internal organs
	Pain syndrome for spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Menstruation pain
	Menstruation pain
	Dysalgomenorrhea
	Dysmenorrhea
	Dysmenorrhea (essential) (exfoliative)
	Menstrual disorder
	Menstrual Krampi
	Menstruation painful
	Metrorrhagia
	Menstrual irregularities
	Menstrual irregularities
	Primary dysalgomenorrhea
	Prolactin-dependent menstrual irregularities
	Prolactin-dependent menstrual dysfunction
	Menstrual disorders
	Spastic dysmenorrhea
	Functional disorders of the menstrual cycle
	Functional disorders of the menstrual cycle
R10.4 Other and unspecified abdominal pain	Abdominal pain syndrome
	Abdominal pain
	Childhood colic
	Gastrointestinal spasm
	Intestinal colic
	Intestinal colic
	Colic in young children
	Colic in newborns
	Fullness of stomach
	Abdominal cramps
	Smooth muscle spasm in diseases of the digestive tract
	Spasm of the biliary tract
	Biliary tract spasm
	Bowel spasm
	Spasm of the digestive tract
	Spasms of the smooth muscles of the gastrointestinal tract
	Stomach cramps
	Gastrointestinal spasms
	Spastic conditions of the gastrointestinal tract
	Intestinal tenesmus
	Feeling full of stomach
R50 Fever of unknown origin	Malignant hyperthermia
	Malignant hyperthermia
R51 Headache	Pain in the head
	Sinusitis pain
	Nape pain
	Headache
	Headache of vasomotor origin
	Headache of vasomotor origin
	Headache with vasomotor disorders
	Headache
	Neurological headache
	Serial headache
	Cephalgia
R52 Pain, not elsewhere classified	Radicular pain syndrome
	Pain syndrome of low and medium intensity of various origins
	Pain syndrome in superficial pathological processes
	Radicular pain on the background of osteochondrosis of the spine
	Radicular pain syndrome
	Pleural pain
	Chronic pain
R52.9 Pain, unspecified	Obstetric and gynecological pain
	Pain syndrome
	Postoperative pain
	Postoperative pain after orthopedic surgery
	Pain syndrome of inflammatory genesis
	Pain syndrome of non-cancer genesis
	Pain after diagnostic procedures
	Pain after diagnostic interventions
	Pain after surgery
	Pain after surgery
	Pain after orthopedic surgery
	Pain after injury
	Pain after removal of hemorrhoids
	Pain after surgery
	Pain syndrome with non-rheumatic inflammation
	Pain syndrome in inflammatory lesions of the peripheral nervous system
	Pain syndrome in diabetic neuropathy
	Pain syndrome in acute inflammatory diseases of the musculoskeletal system
	Pain syndrome in tendon pathology
	Pain syndrome with spasms of smooth muscles
	Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain syndrome with spasms of smooth muscles of internal organs
	Pain syndrome for spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain syndrome with injuries
	Pain syndrome in injuries and after surgery
	Pain syndrome in chronic inflammatory diseases of the musculoskeletal system
	Pain with duodenal ulcer
	Pain with gastric ulcer
	Pain syndrome in peptic ulcer of the stomach and duodenum
	Pain
	Pain during menstruation
	Pain syndromes
	Pain conditions
	Painful leg fatigue
	Sore gums when wearing dentures
	Soreness of exit points of cranial nerves
	Painful irregular menstruation
	Painful dressings
	Painful muscle spasm
	Painful tooth growth
	Pain
	Pain in the lower extremities
	Pain in the area of \u200b\u200bthe surgical wound
	Postoperative pain
	Body aches
	Pain after diagnostic procedures
	Pain after orthopedic surgery
	Pain after surgery
	Pain after cholecystectomy
	Flu pain
	Pain in diabetic polyneuropathy
	Burn pain
	Pain during intercourse
	Pain during diagnostic procedures
	Pain during therapeutic procedures
	Cold sore pain
	Sinusitis pain
	Pain in injuries
	Shooting pains
	Traumatic pain
	Pain
	Postoperative pain
	Pain after diagnostic procedures
	Pain after sclerotherapy
Pain after surgery
Postoperative pain
Postoperative and post-traumatic pain
Post-traumatic pain
Pain when swallowing
Pain in infectious inflammatory diseases of the upper respiratory tract
Burn pain
Muscle trauma pain
Trauma pain
Tooth extraction pain
Pain of traumatic origin
Pain due to smooth muscle spasm
Severe pain
Severe pain syndrome of traumatic origin
Non-malignant pain syndrome
Polyarthralgia with polymyositis
Postoperative pain
Postoperative pain
Postoperative pain
Postoperative pain
Post-traumatic pain
Post-traumatic pain syndrome
Torpid pain syndrome
Traumatic pain
Traumatic pain
Moderate pain
Moderate pain
Moderate pain
Z100 * CLASS XXII Surgical Practice	Abdominal surgery
	Adenomectomy
	Amputation
	Coronary Artery Angioplasty
	Carotid angioplasty
	Antiseptic skin treatment for wounds
	Antiseptic Hand Treatment
	Appendectomy
	Atheectomy
	Balloon coronary angioplasty
	Vaginal hysterectomy
	Coronary Bypass
	Interventions on the vagina and cervix
	Bladder interventions
	Oral intervention
	Reconstructive surgery
	Hand hygiene of medical personnel
	Gynecological surgery
	Gynecological interventions
	Gynecological surgery
	Hypovolemic shock during operations
	Purulent wound disinfection
	Disinfection of wound edges
	Diagnostic interventions
	Diagnostic procedures
	Diathermocoagulation of the cervix
	Long Surgery
	Fistula Catheter Replacement
	Orthopedic Surgery Infection
	Artificial heart valve
	Cystectomy
	Short-term outpatient surgery
	Short-term operations
	Short-term surgical procedures
	Cricothyrotomy
	Blood loss during surgery
	Bleeding during surgery and in the postoperative period
	Cultocentesis
	Laser coagulation
	Laser coagulation
	Retinal laser coagulation
	Laparoscopy
	Laparoscopy in gynecology
	Liquor fistula
	Small gynecological operations
	Minor surgery
	Mastectomy and subsequent plastic surgery
	Mediastinotomy
	Microsurgical operations on the ear
	Mucogingival surgery
	Stitching
	Minor surgery
	Neurosurgery
	Eyeball immobilization in ophthalmic surgery
	Orchiectomy
	Complications after tooth extraction
	Pancreatectomy
	Pericardectomy
	Rehabilitation after surgery
	Convalescence period after surgery
	Percutaneous transluminal coronary angioplasty
	Pleural thoracocentesis
	Postoperative and post-traumatic pneumonia
	Preparation for surgical procedures
Preparation for surgery
Preparing surgeon's hands before surgery
Preparation of the colon for surgery
Postoperative aspiration pneumonia in neurosurgical and thoracic operations
Postoperative nausea
Postoperative bleeding
Postoperative Granuloma
Postoperative shock
Early postoperative period
Myocardial revascularization
Root apex resection
Stomach resection
Bowel resection
Uterus resection
Liver resection
Small bowel resection
Gastric resection
Reclusion of the operated vessel
Bonding of tissues during surgical interventions
Stitch removal
Condition after eye surgery
Condition after surgery
Condition after surgery in the nasal cavity
Condition after gastrectomy
Condition after resection of the small intestine
Condition after tonsillectomy
Condition after removal of the duodenum
Condition after phlebectomy
Vascular surgery
Splenectomy
Sterilization of a surgical instrument
Sterilization of surgical instruments
Sternotomy
Dental surgery
Dental intervention on periodontal tissues
Strumectomy
Tonsillectomy
Thoracic surgery
Thoracic surgery
Total gastrectomy
Transdermal Intravascular Coronary Angioplasty
Transurethral resection
Turbinectomy
Removal of a tooth
Cataract removal
Cyst removal
Tonsil Removal
Fibroid removal
Removing mobile deciduous teeth
Polyp Removal
Tooth extraction
Removal of the uterus
Stitch removal
Urethrotomy
Fistula of cerebrospinal fluid paths
Frontoetmoidogymorotomy
Surgical infection
Surgical treatment of chronic limb ulcers
Surgery
Surgery in the anus
Colon surgery
Surgical practice
Surgical procedure
Surgery
Gastrointestinal Surgery
Urinary Surgery
Urinary Surgery
Genitourinary surgery
Heart Surgery
Surgical procedures
Surgery
Vein surgery
Surgical intervention
Vascular surgery
Surgical treatment of thrombosis
Surgery
Cholecystectomy
Partial gastrectomy
Peritoneal Hysterectomy
Percutaneous transluminal coronary angioplasty
Percutaneous transluminal angioplasty
Coronary artery bypass grafting
Tooth extirpation
Extirpation of deciduous teeth
Pulp extirpation
Extracorporeal circulation
Tooth extraction
Tooth extraction
Cataract extraction
Electrocoagulation
Endourological interventions
Episiotomy
Ethmoidotomy