Pills Guinea-Tartiferon Antianamemic drug - "How to raise hemoglobin during pregnancy and breastfeeding? Avoid anemia will help Gino Tartiferon. A pleasant bonus in the composition is folic acid. "

  • The date: 05.03.2020

This article allows you to familiarize yourself with the instructions for the use of the drug. Tardiferon. Reviews of site visitors - consumers of this medicine, as well as the opinions of doctors of specialists in the use of Tardiferon in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Tardiferon and Guinea Tardeferon in the presence of available structural analogues. Use for the treatment of lack of iron and iron deficiency anemia in adults, children, as well as during pregnancy and breastfeeding.

Tardiferon - Antianemic drug whose action is due to the properties of the components included in its composition.

Iron sulfate - iron salt, the trace element required for the synthesis of hemoglobin. Iron is part of the hemoglobin, myoglobin and a number of enzymes. When applying iron in the form of salts there is a rapid replenishment of its deficiency in the body, which leads to gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory symptoms of anemia.

Mukoprostosis provides better tolerability of the drug and increases bioavailability and gradual release of bivalent iron (Fe2 +) from the preparation.

Ascorbic acid helps to improve the absorption of iron.

Folic acid (in the drug Gino Tartiferon) is necessary for the normal ripening of megaloblasts and the formation of normural. Stimulates erythropoes, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. During pregnancy, protects the body from teratogenic factors.

The special neutral shell of tablets provides absorption of active ingredients, mainly in the distal portion of the small intestine. The absence of a local irritant action on the mucous membrane of the stomach contributes to good tolerability of the drug from the gearbox.

Composition

Iron sulfate + auxiliary substances (Tartiferon).

Iron sulfate hydrate + folic acid (vitamin Bc) + excipients (GINOT-TARDIFERON).

Pharmacokinetics

After taking the drug inside the iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows you to prolong its absorption, mainly in the distal division of the small intestine. Folic acid is absorbed mainly from the upper sections of the gastrointestinal tract (duodenum). The binding of iron with plasma proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in cells of the system of phagocytic macrophages, a minor amount - in the form of myoglobin in the muscles. The binding of folic acid with plasma proteins is 64%; Biotransformation occurs in the liver. Iron is excreted with feces, urine and sweat. Folic acid is excreted mainly by the kidneys, partly - through the intestines.

Indications

  • treatment and prevention of iron deficiency states of different etiology (incl. during pregnancy and during lactation, reducing the absorption of iron from the gastrointestinal, with long bleeding, defective and unbalanced nutrition).

Forms of release

Tablets of prolonged action (retard) coated with sugar shell (Tartiferon and Guinea Tartiferon).

Other dosage forms, whether drops or a solution at the time of publication of the drug did not exist in the directory.

Instructions for use and dosage

Tardiferon

Adults and children over 6 years old: Tablets take inside (not chewing). It is advisable to take the drug, drinking water, before meals or during meals. Application for therapeutic purposes: Children over 6 years old - 1 tablet per day, children over 10 years old and adults - 1-2 tablets per day.

Application in preventive purposes: Pregnant women are 1 tablet per day or every other day throughout the last two trimesters of pregnancy (or starting from the 4th month).

Duration of reception

Adult patients should take a drug over a period that provides a correction of anemia and restoring iron reserve in the body. The dose for women is 600 mg, for men - 1200 mg.

With iron deficiency anemia, the duration of reception ranges from 3 to 6 months, depending on the degree of depletion of iron reserve: if necessary, in the absence of adequate control of anemia, it is necessary to increase the duration of the drug.

Gino Tardiferon

With the easiest course of anemia, the drug is prescribed 1 tablet per day before breakfast; With a moderate course of anemia - 1 tablet 2 times a day; With a severe course of anemia - 1 tablet 3 times a day for several weeks (on average 4-5 weeks) - until the normal level of hemoglobin is restored. After restoring the normal level of hemoglobin, the reception should continue 2-3 months to replenish iron reserves.

For the prevention of iron and folic acid deficiency during pregnancy and during lactation, the drug is prescribed 1 tablet per day at 2 and 3 trimesters and the postpartum period during breastfeeding.

Side effect

  • nausea;
  • pain in epigastrics;
  • diarrhea, constipation.

Contraindications

  • anemia not related to iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with an isolated vitamin B12 deficiency);
  • increased iron content in the body (hemosiderosis);
  • violation of iron utilization mechanisms (anemia caused by lead poisoning, sideroachrisian anemia);
  • fructose intolerance, glucose and galactose absorption impairment syndrome, invertase / isomaltase failure syndrome;
  • stenosis of the esophagus and / or obstructive changes of the gastrointestinal tract;
  • children's age (under 6 years for Tardiferon and under 18 for Guinea Tartiferon);
  • increased sensitivity to the components of the drug.

Application in pregnancy and breastfeeding

Application in preventive purposes Tardiferon tablets: Pregnant women are 1 tablet per day or every other day for the last two trimesters of pregnancy (or starting from the 4th month).

For the prevention of iron and folic acid deficiency during pregnancy and during lactation, the drug Gino Tartiferon is prescribed 1 tablet per day at 2 and 3 trimesters and the postpartum period during breastfeeding.

Application in children

Tartiferon is contraindicated for children under 6 years old. Children over 6 years old: Tablets take inside (not chewing). It is advisable to take the drug, drinking water, before meals or during meals. Application for therapeutic purposes: children over 6 years old - 1 tablet per day, children over 10 years old - 1-2 tablets per day.

Gino Tartiferon is contraindicated to children and adolescents under the age of 18.

special instructions

Before starting therapy, the drug requires determination of iron and ferritin in serum.

During the reception period, it is necessary to take into account that coffee, milk, vegetables, grain grains reduce the absorption of iron.

During the reception period, dark staining of the chair may be observed, which is due to the elimination of not attempted iron and has no clinical value.

Caution should be taken to take the drug under inflammatory diseases of the intestines, alcoholism, hepatic or renal failure.

Due to the presence of sucrose preparation, it is contraindicated by its use by persons with fructose intolerance, glucose and galactose suction impairment syndrome or invertase insufficiency syndrome / isomaltase (rare exchange disorders).

Medicinal interaction

Reduce iron absorption:

  • antacid drugs containing salts of aluminum, calcium, magnesium, calcium preparations, etyhydric acid, drugs that reduce the acidity of gastric juice (including cimetidine);
  • medicines containing carbonates, hydrocarbonates, phosphates, oxalates;
  • pankreatin, panolipase.

Mutually reduce suction when sharing:

  • tetracyclines, D-penicillamine, tea, egg yolk.

If it is necessary to combine with the drugs listed above or food, iron preparations should be taken 1 h to or 2 hours after their use.

Enhance suction:

  • ascorbic acid, ethanol (alcohol) (including increases the risk of toxic complications).

The iron preparation in large doses reduces zinc absorption.

You can not appoint together with other gland products, incl. For parenteral use, in order to avoid overdose.

Analogs of the Medicinal Tardiferon

Structural analogues for the acting substance:

  • Gemifier prolongate;
  • Gino Tartiferon;
  • Ferrogradmet.

Analogs on therapeutic effect (means for the treatment of iron deficit):

  • Akimerrin;
  • Actiferrin composites;
  • Biovital;
  • Biofer;
  • Voovefer;
  • Vitrum Super Stress;
  • Vitruum Zirkus;
  • Hemoofer;
  • Gino Tartiferon;
  • Cosmofer;
  • Licferre 100;
  • Malto;
  • Malto Foul;
  • Miazenova;
  • Monofer;
  • Junik peak;
  • Sideral Forte;
  • Sorbifer Duruless;
  • Special Dragee Merz;
  • Stress formula with iron;
  • Supradin Kids Junior;
  • Totema;
  • Feneuls;
  • Ferlam
  • Faltum Foul;
  • Ferretab;
  • Ferrinat;
  • Ferro Folgamma;
  • Ferrogradmet;
  • Ferrone;
  • Ferroplex;
  • Ferrum Lek;
  • Heferol;
  • Enefamil Premium 2;
  • Enfamil with iron.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Active substances

Iron Sulfate X 1 1/2 H 2 O (Ferrous Sulfate)
- Folic acid (WIT. B C) (FOLIC ACID)

Release form, composition and packaging

Tablets of prolonged action covered with shell from white to light beige, double-screw, with a smooth surface; On cross-section - brown with white edging.

Auxiliary substances: ascorbic acid, mucoproteoz (anhydrous), starch potato, eudragit S, dibutyl phthalate, talc, talc, magnesium stearate, hydrogenated, magnesium trisilicate.

The composition of the shell: Talc, titanium dioxide, bee white wax, paraffin solid, eudragit e, sucrose.

10 pieces. - Blister (3) - Cardboard packs.

pharmachologic effect

Combined anti-diamemine, the action of which is due to the properties of the components included in its composition.

Iron sulfate - iron salt, the trace element required for the synthesis of hemoglobin. Iron is part of the hemoglobin, myoglobin and a number of enzymes. When applying iron in the form of salts there is a rapid replenishment of its deficiency in the body, which leads to gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory symptoms of anemia.

Folic acid is necessary for the normal ripening of megaloblasts and the formation of normural. Stimulates erythropoes, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. During pregnancy, protects the body from teratogenic factors.

Mukoproteoza, being a natural high molecular weight fraction obtained from animal intestinal mucosa and having a certain content of amino-amahar and organically bound sulfate, provides better portability of the drug from the gastrointestinal tract and increases the bioavailability of iron ions. It helps to improve iron absorption. The special neutral shell of the tablets ensures the absorption of active ingredients, mainly from the upper portion of the small intestine. The absence of a local irritant action on the mucous membrane of the stomach contributes to good tolerability of the drug from the gearbox.

Pharmacokinetics

After taking the drug inside the iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows you to prolong its absorption, mainly in the distal division of the small intestine. Folic acid is absorbed mainly from the upper sections of the gastrointestinal tract (duodenum).

The binding of iron with proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in cells of the system of phagocytic macrophages, a minor amount - in the form of myoglobin in the muscles.

The binding of folic acid with plasma proteins is 64%; Biotransformation occurs in the liver.

Iron is excreted with feces, urine and sweat.

Folic acid is excreted mainly by the kidneys, partly - through the intestines.

Indications

- Treatment and prevention of iron deficiency anemia of various etiologies (including during pregnancy, with irregularities of iron absorption from the gastrointestinal tract, with long bleeding, with defective and unbalanced nutrition).

Contraindications

- anemia not related to iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with an isolated deficit of 12);

- increased iron content in the body (hemosiderosis);

- violation of iron utilization mechanisms (anemia caused by lead poisoning, sideroahastic anemia);

- stenosis of the esophagus and / or obstructive changes of the gastrointestinal tract;

- children's age (under 18);

- Increased sensitivity to the components of the drug.

Dosage

For Easy under anemia The drug is prescribed NO1 tab. / Sut before breakfast; for the average and agery course of anemia - 1 tab. 2 times / day; for Severe course of anemia - 1 tab. 3 times / day for several weeks (on average 4-5 weeks) - until the normal hemoglobin level is restored. After restoring the normal level of hemoglobin, the reception should continue 2-3 months to replenish iron reserves.

For prevention of iron deficiency and folic acid during pregnancy and during lactation The drug is prescribed 1 tab. / Sut in the II and III trimesters and the postpartum period during breastfeeding.

Side effects

From the digestive system: Rarely - nausea, pain in epigastria, diarrhea, constipation.

Overdose

Symptoms: It is possible to strengthen the manifestations of the side effects described.

Treatment: Washing the stomach with 1% aqueous solution, symptomatic therapy. Antidote - deferoxamine.

Medicinal interaction

Not compatible with other medicines:

Reduce Suction: Antacid drugs, calcium preparations, Ethydron acid, drugs that reduce the acidity of gastric juice (including Cimetidine, drugs containing carbonates, hydrocarbonates, phosphates, oxalates), pancarbonats, pancreatium, coffee, tea, milk, milk , vegetables, bread cereals, egg yolk (iron preparations should be taken 1 hour or 2 hours after their use).

Increase the absorption - ascorbic acid, ethanol (incl. Increases the risk of toxic complications).

The drug reduces the absorption of fluoroquinolones, penicillamin, tetracycline, reduces the absorption of zinc drugs in large doses (they are recommended for 2 hours to or 2 hours after taking the drug iron).

At the started stage, the hemorrhoids often occur bleeding. This process adversely affects the body, because against the background of this, anemia and insufficiency of vitamin B is developing. In order to prevent the emergence of complications and fill the loss of trace elements, anti-diamemine iron-based drugs are prescribed by doctors.

Gino-Tartiferon with hemorrhoids - composition and effect of the drug

The medication refers to the category of combined means. It includes iron and folic acid. 1 tablet contains 256 g of iron sulphate and 350 μg of folic acid. There are auxiliary ingredients in the form of dibutyl phthalate, ascorbic acid, stearinovascular magnesium, castor oil, talc, anhydrous mucoproteozoas. The shell is located. It includes beeswax and titanium dioxide. It is prescribed as a healing and prophylactic agent for anemia and long bleeding against the background of a launched hemorrhoid.

Form release

Gino Tartiferon is sold in tablets. Pills are distinguished by a bicow-shaped shape, a smooth surface and a light shade. On the inner cut, they have brown and white edging. Thanks to a special shell, a long and prolonged effect of the drug is ensured. There are 30 tablets in 1 pack.


pharmachologic effect

The drug is considered to be a hematopois stimulant. Refers to the category of anti-diamemine drugs.
Iron sulfate is responsible for blood hemoglobin. Also this component is available in myoglobin and enzymes. When taking tablets, it is possible to quickly fill it with a shortage.

Folic acid is responsible for the formation of normoblasts, ripening megaloblasts. It helps in synthesizing nucleic acids, amino acids, pyrimidines.

Thanks to the neutral shell, the absorption of active ingredients occurs gradually in the subtle separation of the intestinal channel.

Pharmacodynamics and pharmacokinetics

The absorption of active substances occurs in the initial division of the small intestine. Iron salts interact with plasma proteins by 90%. Persisted in the form of hemosiderin and ferritin. Some part enters muscle structures. Iron is excreted with urinous and wheel masses.
Folic acid binds to plasma proteins by 64%. Transformation of this substance occurs in the liver. It turns out through the kidneys and intestinal tract.


Indications for use Gino Tartiferon

The use of the medication is required when a lack of iron and folic acid as a result of the development of anemia.
This process is observed in such cases as:

  • the period of tooling the fetus;
  • minor or abundant bleeding;
  • irrational nutrition;
  • violation of iron absorption in the intestinal channel.

Used not only for treatment, but also prevention of iron deficiency anemia.

With hemorrhoids

The drug is prescribed when it appears in feces. In exacerbation, it quickly fills the shortage of iron and folic acid. But the tool can cause constipation and sealing of the carts. Therefore, therapeutic therapy should include the use of candles.
The medication is used for prevention in the chronic form of the disease, as well as after surgical intervention. This allows you to improve the overall condition of the patient, get rid of fatigue and dizziness. Hemorrhoidal nodes are reduced in size, and bleeding is suspended.

Contraindications

Although the medicine is considered effective, it can be applied to treat not all patients.
The instructions are spelled out several contraindications in the form:

  • oversupply iron in the body;
  • obstruction of the digestive tract;
  • sideroicreastic anemia;
  • development of anemia against the background of lead poisoning;
  • specific anemia;
  • increased susceptibility to the active ingredients of the medication;
  • stenosis of the esophagus.

With caution, the drug is prescribed with alcoholism, renal and liver failure, stomach disease, infectious damage to the casing of the digestive tract.

Side effects from Guinea Tartiferon

While taking a medication can manifest side symptoms. This process is accompanied by:

  • stool violation;
  • meteorism;
  • painful feeling in the epigastric region;
  • nausea and urges to vomit.

In many cases, there is a change in the shade of carts. They acquire a black or dark color. In such cases, no cancellation of the drug is required.
Rarely takes the darkening of dental enamel, urticaria, itching and bronchospasm. Sometimes anaphylactic shock, weakness, heat tides are developing.

Overdose

If strictly adhere to all recommendations, the overdose does not occur. With an increase in dose and long-term use, an amplification of the vomit reflex, nausea, collapse is observed. A dose of 180-300 mg per 1 kg of weight can result in death.
With a strong overdose, the patient is prescribed deferoxamine intramuscularly or intravenously in the form of infusion. Also carried out symptomatic therapy. Hemodialysis is effective.

How to take Gino Tartiferon?

With minor bleeding from hemorrhoidal nodes, 1 tablet is prescribed daily in the morning before meals.
With strong bleeding and severe patient's condition, you need to take 1 pc. 3 times a day.
For prophylaxis with chronic form of diseases, it is recommended to take 1 tablet 1 time per day. The course continues within 1-3 months, repeated 2-3 times a year.

Interaction

Increasing the absorption of active substances occurs when a combination with ascorbic acid and ethanol. This may result in toxic complications.
Reducing the absorption of iron and folic acid occurs while using calcium, antacid drugs, pancreatin.

Absorption reduction is observed when drinking tablets during meals. Therefore, at the time of treatment it is worth eliminating the diet of cereals, vegetables, tea, coffee, milk and egg yolk.

special instructions

During the period of treatment, the stool is painted in black or dark color. This does not affect the overall condition of the body and does not carry a threat to life.
During anti-diamemine therapy, rheumatoid arthritis can occur. This is due to calcium deficiency.

Childcare

The instructions for use says that it is not recommended to give the drug to children under 18 years old.


For newborns

If the newborn has a deficiency of iron, then it is better to choose a safer remedy. Only a pediatrician will help this.

During pregnancy and lactation

Tablets are allowed to take pregnant women. With a lack of iron, hypoxia has a fetus and mother. So that this does not happen, the medicine is advised to use as prevention.
During the lactation period, the medication should be used with caution and only after consulting with a specialist.

Analogs

If there is no medicine on sale or not suitable, then you can purchase analogues:

  1. Malto.
  2. Akiterrin.
  3. Ferrum Lek.
  4. Ferretab.

Before use, you should familiarize yourself with annotation.

Tartiferon and Gino Tartiferon: Differences

Preparations are distinguished by the fact that folic acid is additionally included in the second medication. Thus, the composition of the blood is completely restored, the signs of oxygen starvation and the work of the nervous system disappear.
Both medications in their composition have ascorbic acid. It helps to improve iron absorption.

Terms of sale

Buy tablets without a doctor's prescription.

Price

The cost of the drug depends on the region. In Russia, the drug is sold for 245-268 rubles. In Ukraine, medication is implemented for 115-118 hryvnia.

Storage conditions and shelf life

Tablets are stored in a darkened place at temperatures up to + 25 ° C, away from children. The drug is suitable for 5 years from the date of manufacture.

Medical use instructions for the drug

Description of pharmacological action

Indications for use

Prevention and treatment of iron / folio-productic anemia.

Form release

tablets covered with a shell, prolonged action; Blister 10 pack cardboard 3;

Tablets covered with a shell, prolonged action; Blister 10 box (box) cardboard 100;

Pharmacodynamics

Combined anti-diamemine, the action of which is due to the properties of the components included in its composition.

Iron sulfate - iron salt, the trace element required for the synthesis of hemoglobin. Iron is part of the hemoglobin, myoglobin and a number of enzymes. When applying iron in the form of salts there is a rapid replenishment of its deficiency in the body, which leads to gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory symptoms of anemia.

Folic acid is necessary for the normal ripening of megaloblasts and the formation of normural. Stimulates erythropoes, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. During pregnancy, protects the body from teratogenic factors.

Pharmacokinetics

After taking the drug inside the iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows you to prolong its absorption, mainly in the distal division of the small intestine. Folic acid is absorbed mainly from the upper sections of the gastrointestinal tract (duodenum).

The binding of iron with plasma proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in cells of the system of phagocytic macrophages, a minor amount - in the form of myoglobin in the muscles.

The binding of folic acid with plasma proteins is 64%; Biotransformation occurs in the liver.

Iron is excreted with feces, urine and sweat.

Folic acid is excreted mainly by the kidneys, partly - through the intestines.

Use during pregnancy

For the prevention of iron and folic acid deficiency during pregnancy and during the lactation period, the drug is prescribed 1 tab. / Sut in the II and III trimesters and the postpartum period during breastfeeding.

Contraindications for use

Hypersensitivity, hemolytic, aplastic, megaloblastic, B12 deficient anemia, hemosiderosis, hemochromatosis.

Side effects

Dyspeptic phenomena (rarely), darkening feces.

Method of application and dose

Inside. With the easiest course of anemia, the drug is prescribed 1 table. daily before breakfast; With a moderate course of anemia - 1 Table. 2 times a day; With a severe course of anemia - 1 table. 3 times a day for several weeks (on average 4-5 weeks) - until the normal level of hemoglobin is restored. Then - another 2-3 months to replenish iron reserves.

For the prevention of iron deficiency and folic acid during pregnancy and during lactation, 1 table. Daily in the II and III trimesters and in the postpartum period during breastfeeding.

Interactions with other drugs

Incompatible with tetracycles and antacids (absorption), iron preparations for parenteral administration.

Special guidelines when taking

Before starting therapy, the drug requires determination of iron and ferritin in serum.

During the reception period, dark staining of the chair may be observed, which is due to the elimination of not attempted iron and has no clinical value.

Caution should be taken to take the drug under inflammatory diseases of the intestines, alcoholism, hepatic or renal failure.

Storage conditions

List B.: At a temperature not higher than 25 ° C.

Shelf life

Belonging to ATX classification:

** Drug reference is intended exclusively for informational purposes. For more information, please contact the manufacturer's annotation. Do not self-medicate; Before the use of the drug Gino Tartiferon, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace the doctor's advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this reference book is intended for medical professionals and should not be the basis for self-treatment. The description of the drug Gino Tartiferon is given to be familiarized and is not intended to appoint treatment without the participation of the doctor. Patients need a specialist consultation!


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tab. Prolongir. Actions, PC. Shell 256.3 mg + 350 μg: 30 pcs.
Reg. No: 1864/96/01/07/12/15 dated 06.09.2012 -

Tablets of prolonged action covered with shell from white to light beige, double-screw, with a smooth surface; on cross-section - brown with white edging; Black splasions are possible.

* As part of the kernel
** As part of the shell

Excipients: kernel - ascorbic acid, mucoproteoz (anhydrous), starch potato, eudragit S, dibutyl pleatelate, povedium, talc, magnesium stearate, oil castor, magnesium trisilicate; Shell - Talc, Titanium Dioxide, White Bee Wax, Solid Paraffin, Eudragit E, Sakharoza.

10 pieces. - Blister (3) - Cardboard packs.

Description of the medicinal preparation Gino Tardiferon Based on officially approved instructions for the use of the drug and made in 2009. Renewal date: 09.11.2009


pharmachologic effect

Combined anti-diamemine, the action of which is due to the properties of the components included in its composition.

Iron sulfate - iron salt, the trace element required for the synthesis of hemoglobin. Iron is part of the hemoglobin, myoglobin and a number of enzymes. When applying iron in the form of salts, a rapid replenishment of its deficiency in the body occurs, which leads to gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.

Folic acid is necessary for the normal ripening of megaloblasts and the formation of normural. Stimulates erythropoes, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline. During pregnancy, protects the body from teratogenic factors.

Mukoproteoza, being a natural high molecular weight fraction obtained from animal intestinal mucosa and having a certain content of amino-amahar and organically bound sulfate, provides better portability of the drug from the gastrointestinal tract and increases the bioavailability of iron ions. Ascorbic acid helps to improve the absorption of iron.

The special neutral shell of the tablets ensures the absorption of active ingredients, mainly from the upper portion of the small intestine. The absence of a local irritant action on the mucous membrane of the stomach contributes to good tolerability of the drug from the gearbox.

Pharmacokinetics

After taking the drug inside the iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows you to prolong its absorption, mainly in the distal division of the small intestine. Folic acid is absorbed mainly from the upper sections of the gastrointestinal tract (duodenum). Iron connection with plasma proteins - 90% or more. Deposited in the form of ferritin or hemosiderin in cells of the system of phagocytic macrophages, a minor amount - in the form of myoglobin in the muscles. The binding of folise acid with plasma proteins is 64%; Biotransformation occurs in the liver. Iron is excreted with feces, urine and sweat. Folic acid is excreted mainly by the kidneys, partly - through the intestines.

Indications for use

  • treatment and prevention of iron deficiency anemia of various etiologies (incl. during pregnancy, with impaired absorption of iron from the gastrointestinal tract, with long bleeding, with defective and unbalanced nutrition).

Dosing mode

For easy under anemia The drug is prescribed 1 tab. daily before breakfast; for the average and agery course of anemia - 1 tab. 2 times / day; for severe course of anemia - 1 tab. 3 times / day for several weeks (on average 4-5 weeks) - until the normal hemoglobin level is restored. After restoring the normal level of hemoglobin, the reception should continue 2-3 months to replenish iron reserves.

For prevention of iron deficiency and folic acid during pregnancy and during lactation The drug is prescribed 1 tab. Every day in the II and III trimesters and the postpartum period during breastfeeding.

Contraindications for use

  • anemia not related to iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with an isolated vitamin deficiency in 12);
  • increased iron content in the body (hemosiderosis);
  • violation of iron utilization mechanisms (anemia caused by poisoned lead, Sideroichreniy anemia);
  • stenosis of the esophagus and / or obstructive changes of the gastrointestinal tract;
  • increased sensitivity to the components of the drug.

special instructions

Before starting therapy, the drug requires determination of iron and ferritin in serum.

During the preparation period, dark staining of the chair may be observed, which is due to the removal of non-obscure iron and has no clinical value.

Caution should be taken to take the drug under inflammatory diseases of the intestines, alcoholism, hepatic or renal failure.