In the spring and autumn with a sharp transition from low temperatures to high, and on the contrary, our body is most weakened and susceptible to disease. Most often it is ORZ and ORVI (flu).

When to take remantadin and its features

The ARZ virus caused and the ARVI is treated with antiviral drugs. They can also be taken to prevent influenza. These include remantadine. It is shown to use children and adults for the treatment and prevention of viral infection (influenza). In cases of ARZ mixed etiology, you can use comprehensive therapy based on antibiotics and remantine.

Features and reception remantadine:

• The active substance of rimantadine - hydrochloride is derivative of Amantadine.
• Produced in the form of tablets, capsules in the dosage of 50 and 100 mg. Packing for 10 or 20 tablets.
• It is used for early treatment and prevention of influenza A, herpes viruses of the first type and for the prevention of tick-borne encephalitis.
• The symptoms of influenza is: lethargy, malaise, temperature, sneezing, cough, mucous discharge from the nose and throat.
• The prophylactic efficacy of the drug is explained by the fact that it circulates in the body for a long time due to slow metabolism. The drug is absorbed in the intestines, and the maximum concentration of the drug in the blood occurs after 1-4 hours.
• It is worth remembering that the use of paracetamol and acetylsalicylic acid along with rematadine reduces the maximum concentration of the latter by 10-11%.
• With care to take with epilepsy and hypertension.

Contraindications of the use of remand palp

Before the start of use, it is worth knowing that he is contraindicated:

• with renal failure;
• with liver failure;
• thyrotoxicosis;
• pregnant and during lactation;
• children under 7 years old;
• persons who have sensitivity to Remantadine.

Method of using remantadadine for the treatment and prevention of influenza

The course of treatment and dosage is individual depending on the degree of development of the disease and the age of the patient.

• The drug is accepted inside, 20-30 minutes after meals. The tablet is powered by a sufficient amount of water.
• Adults take 100 mg (1 tablet) twice a day.
• Children up to ten years 5 mg per 1 kg of weight 1 time per day (the highest daily dose should not be more than 150 mg).
• Duration Course for prevention from 10 to 15 days.
• Prevention is carried out during the epidemic season or with direct contact with the infection carrier.
• Treatment is advisable for the first time 24-48 hours after the manifestation of influenza symptoms or colds, the course of treatment is usually 5-7 days.

The treatment is carried out according to the following scheme:

• Day 1: 100 mg (1 tablet) 3 times a day, the interval between receptions is about 4-6 hours.
• 2-3 days: 100 mg (1 tablet) 2 times a day, the interval is 6-8 hours.
• 4-5 days: 100 mg once.
• When preserving the symptoms or weakness, continue to accept remantatadine once a dosage of 100 mg once a day 2-3 days.

Side Effects from Remanthadine

Most often, side effects in patients are not observed. Rarely after taking headache, dizziness, insomnia, nausea, vomiting, allergic reactions, fatigue, drowsiness, dry mouth.

When side effects appear, it is worth the treatment immediately and consult a doctor.
Remantadine is used for treatment at the initial stages, but some types of influenza have developed stability to it. With a debt of preservation of symptoms consult with a doctor.

Many modern pharmacy assortment facilities for preventing and treating colds and influenza often have a relatively high cost. But there is a well-known drug tested by any generation. "Remantadin" is an antiviral medicine that will save from the disease in the cold season and will not hit the wallet.

Release form and composition

It should be understood that Remantadin is the trade name of the drug. Its acting substance is Rimantadina hydrochloride, or Rimantadine.

The drug is produced in two forms:

1. Tablets "Remantadin". Plane-cylindrical white tablets contain 50 mg of rimantadine hydrochloid, starch, milk sugar, calcium stearate, povidone. The agent is released in blisters or bottles of dark glass placed in a cardboard box.
2. Remantadine capsules. Contain 100 mg of active substance, starch, milk sugar, dye. Capsules themselves consist of gelatin and titanium dioxide, which gives them white. A medicine is produced in blisters placed in a box of cardboard.

Pharmacological properties and pharmacokinetics

Active component of the drug - Rimantadine. The mechanism of its action lies in the suppression of the process of breeding (replication) of the virus.

When the virus penetrates the cage, a peculiar capsule is formed around it - endosome. The casing of the viral particle merges with the membrane of the endosome, as a result of which the RNA of the causative agent enters the space of the host cell. Remantadine increases the pH value in the endosome, making it impossible to interact the shell of the virus and the membrane of the endosome. Also, the agent prevents the spread of the virus to healthy cells.

Remantadin medicine shows a pronounced effectiveness against the influenza of the type of type A. The means is adversely acting on the tick-borne encephalitis virus, which is most common in Russia in spring and summer. With influenza type in Remantadin, it helps to eliminate toxins.

The active substance of the drug has a special structure, due to which it is in the plasma of blood for a long time. This explains the effectiveness of "remantadin" when used in order to prevent influenza in the seasons of high morbidity.

Despite this, Remantadin is great for the prevention of influenza.

In addition, its use with a cold and flu at the stage of initial manifestations often gives a positive trend. After 2 days of reception, the alend's symptoms are significantly weakened.

Remanthadine Instructions

Information on how to accept "Remantadin" is contained in the attached instruction, which should be studied before the start of treatment. A single and daily dose, the duration of the reception is determined by the age of a person and the purpose of use. Drink medicine after meals, with sufficient water. At the first manifestations of the ailment, the application should be started as soon as possible, preferably during the first 18 hours from the moment of symptoms.

For adults

After the tick bite, the medicine is used according to the recommendations of the specialist. As a rule, adults in order to prevent the cleaner encephalitis "Remantadin" is prescribed in a dosage of 100 mg. It should be drinking twice a day, every 12 hours. The duration of use is 3 days. If necessary, a specialist can increase the course.

For children

For influenza therapy in children, the following dosing modes are assigned:

• for children 7-10 years old: 50 mg / 2 times a day;
• for children 10-14 years old: 50 mg / 3 times a day.

Studies on laboratory animals have shown that the active substance overcomes the placental barrier and adversely affects the development of the fetus. Also, the means after receiving is found in breast milk in a significant concentration.

Drug interaction with other drugs

Deciding to be treated by "remantine", it is important to take into account the possibility of drug interactions that may arise with its joint reception with the following fund groups:

• drugs used in epilepsy ("Remantadine" reduces their therapeutic effect);
• sorbents and drugs protecting the gastrointestinal mucosa (some antacids and drugs of plant origin that have an enveloping effect) reduce the absorption of antiviral;
• paracetamol, acetylsalicylic acid reduces the quantitative content of antiviral blood;
• cimetidine reduces the rate of the removal of rimantadine from biological fluids;
• ascorbic acid, ammonium chloride increase the rate of reducing the active substance by the urinary system, reducing its therapeutic effects;
• acetazolamide, sodium bicarbonate (food soda) strengthen the effect of antiviral, slowing down its removal by the urinary system.

The possibility of joint reception of "remantaddine" with these groups of drugs should be found in the attending physician.

Is it possible to eat alcohol when taking an antiviral drug

Official instructions for use does not contain information on the interaction of ethanol and rimantadine. Experts do not recommend drinking alcohol during antiviral treatment. Since both mentioned substances are metabolized in the liver, their joint techniques significantly increases the load on the body. As a result, the detoxification function of the liver is disturbed, and it is unable to properly neutralize ethanol and metabolizing the antiviral agent. Because of this, the likelihood of side effects increases and the negative effect of alcohol on the body increases.

Contraindications, side effects and overdose

In addition to Remantadina, the following drugs are produced, the active substance of which Rimantadine is:

1. Rimantadin, Rimantadine Velfarm, Rimantadin STI, Rimantadine Aveksim, pills with a dosage of 50 mg.
2. Rimantadin Kids, Orvimime, Alginim, Syrup. Forms are assigned to children over 1 year old. 1 ml of medication contains 2 mg of the active component.

"Remantadina" analogues differ slightly from each other.

Also, Rimantadina hydrochloride is present in the Comprehensive Means "Anvimax", which is produced in capsules, effervescent tablets and powders. It is intended to facilitate the symptoms and therapy of early manifestations of cold and flu.

One tablet contains

active substance - Rimantadina hydrochloride 50 mg,

auxiliary substances: Monohydrate lactose, Potato starch, Stearinic acid

Description

White or almost white plane-cylindrical pills with a chamfer

Pharmacotherapeutic group

Antiviral preparations for systemic use. Direct action antiviral drugs. Cyclic amines. Rimantadin.

ATH code J05Ac02

Pharmacological properties

Pharmacokinetics

After receiving inside remantadin, it is well absorbed in the gastrointestinal tract, it has a high bioavailability, well penetrates into all the fabrics and fluids of the body, in the liquor. About 40% of the active substance binds to blood plasma proteins. The maximum blood plasma concentration is achieved in 5-7 hours. The active intensity is intensively metabolized in the liver, exposed to hydroxylation, conjugation and glucuronization. The half-life is on average in adults 25 hours, in the elderly - 32 hours, in children - 13-38 hours. It is displayed mainly with urine, 15% - unchanged through the kidneys.

Pharmacodynamics

Remantadine - Adamantane derivative, has antiviral activity. The drug is effective against the influenza type A virus, and also has an antitoxic effect with influenza, caused by V. Remantadin virus inhibits virus replication in the early stages of the cycle, possibly disrupting the formation of a viral shell. In antiviral action of remantadaddine in relation to the influenza virus, the specific genetic genet of the virion is important. In vitro remantadin inhibits the replication of the three antigenic subtypes of the influenza a - h1n1, h2n2 and h3n2. Remantadine does not affect the immunogenetic properties of an inactivated influenza vaccine A. Remantadine-resistant viruses were allocated when remantadadine is used in a closed medium.

Remantadine is also effective against arboviruses that are causative agents of tick-borne encephalitis.

Indications for use

For the treatment of influenza at an early stage of the disease to adults and children

Adults for influenza prevention during epidemics

Adults for the prevention of tick-borne encephalitis of viral etiology.

Method of application and dose

Remantadine take inside after eating, drinking water.

The use of the drug must be started immediately after the appearance of the first symptoms of influenza. The therapeutic effect is more pronounced if the application has begun during the first 48 hours of the disease.

Treatment with influenza: adults on the first day - 100 mg (2 tablets) three times a day, on the second and third day - 100 mg twice a day, on the fourth and fifth day - 100 mg once a day. On the first day of the disease, it is possible to use the drug 3 tablets twice a day or
6 tablets for one reception.

Children: Aged 7 to 10 years old are prescribed 50 mg twice a day, from 11 to 14 years old - 50 mg three times a day, over 14 years old - doses for adults.

The duration of the course of treatment is 5 days.

Influenza prevention: adults 50 mg once a day duration up to 30 days.

Prevention of tick-borne encephalitis of viral etiology after squeezing a tick: adults at 100 mg twice a day for three days, in some cases (by appointment of a doctor) - 5 days.

The use of remantadadine should be started immediately after the tick bite, but not later than after 48 hours.

In some cases (risk groups, campaigning participants in a wooded overgrown area, for accommodation in tents, etc.) adults are allowed to prevent tick-borne encephalitis (without tick bite) remantyin one tablet twice a day to 15 days.

Side effects

Dizziness, headache

Anxiety

Tinnitus

Skin rash

Nausea, vomiting, diarrhea, loss of appetite, abdominal pain.

Contraindications

Hypersensitivity to the derivative of the Adamantane group or the components of the drug

Acute diseases of the liver

Acute and chronic kidney disease

Thyrotoxicosis

Children's age up to 7 years

Pregnancy and lactation period

Hereditary intolerance to galactose, lactase deficiency.

Medicinal interactions

Remantadine reduces the effectiveness of antiepileptic drugs.

Adsorbents, binders and enveloping agents reduce absorption remantadine.

Paracetamol and acetylsalicylic acid reduce remantadine concentration in blood plasma and reduce its effectiveness.

Cimetidine reduces the elimination of the active substance from the body.

Alcohol use should be avoided, because Unwanted reactions from the central nervous system may occur.

special instructions

Precautions

Careful patients with diseases of the gastrointestinal tract should be taken, impaired liver functions, severe heart disease and heart rate disorders, elderly persons. In these cases, it is recommended to reduce the dose of the drug.

When indicating an anamnesis on epilepsy and the conductive anticonvulsant therapy, against the background of the use of remantadadine, the risk of developing epileptic seizure increases. In these cases, the remant palp dose is reduced to 100 mg per day. If the attack is developing, remant palpatin is stopped.

Lactose. One tablet contains 74.5 mg of lactose. It should not be used to patients with a rare congenital intolerance to galactose, lapp lack lactase or glucose-galactose malabsorption.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

Remantadine does not affect the ability to control the vehicle or potentially hazardous mechanisms, but to persons who have dizziness, headache or other side effects from the central nervous system, caution should be taken.

Trade name of the drug: Remantadin®.
International UnPatented Name: Rimantadin
Dosage form: pills.
Composition on one tablet:
active substance: Rimantadina hydrochloride 50.0 mg;
excipients: Lactose is 74.5 mg, starch potato 24.0 mg, the acid of stearin 1.5 mg.

Description: Round plane-cylindrical tablets of white or almost white color with a chamfer.
Pharmacotherapeutic Group:antiviral agent.
ATH code :.

Pharmacological properties

Pharmacodynamics. Remantadin® is active with respect to various strains of influenza a virus (especially A2 type).
Being a weak basis, Remantadin® is valid by increasing the pH endos, having a vacuole membrane that surround the viral particles after their penetration into the cell. Preventing acidification in these vacuoles blocks the fusion of the viral shell with the endosome membrane, thus preventing the transmission of the viral genetic material into the cytoplasm of the cell. Remantadin® also oppresses the yield of virus particles from the cell, i.e. Interrupts the transcription of the viral genome.
Pharmacokinetics.
After receiving inside remantadin® almost completely absorbed in the intestine.
Absorption is slow. Communication with plasma proteins is about 40%. Distribution volume: adults - 17-25 l / kg, children - 289 l / kg. The concentration in the nasal secret is 50% higher than in plasma. The maximum concentration (Cmax) of the active substance in the blood plasma at a dose of 100 mg once a day is 181 ng / ml, at 100 mg twice a day - 416 ng / ml.
Metabolized in the liver. Half-life - 24-36 hours; 75-85% of the adopted dose is excluded by the kidneys mainly in the form of metabolites, 15% - unchanged.
In chronic renal failure The half-life increases by 2 times. In people with renal failure and in individuals of elderly, it can accumulate in toxic concentrations, if the dose is not corrected in proportion to the reduction of creatinine clearance (CC).

Indications for use

Prevention and early treatment of influenza and in adults and children over 7 years old.

Contraindications

• acute diseases of the liver
• acute and chronic kidney disease
• thyrotoxicosis
• increased sensitivity to Rimantadina
• pregnancy and lactation period
• children under 7 years

With caution in arterial hypertension, atherosclerosis of brain vessels, hepatic insufficiency, epilepsy, diseases of the gastrointestinal tract.

Method of application and dose

Inside, after eating, drinking water.
The treatment of flu should be started within 24-48 hours after the appearance of symptoms of the disease.
Adults On the first day they are prescribed 100 mg 3 times a day; in the second and third days 100 mg 2 times a day; On the fourth and fifth day of 100 mg once a day. On the first day of the disease, the drug is possible once in a dose of 300 mg.
Children aged from 7 to 10 years old are prescribed 50 mg 2 times a day; From 11 to 14 years old - 50 mg 3 times a day. Over 14 years old - doses for adults. Accept for 5 days.
For influenza prevention Adults are prescribed 50 mg once a day for up to 30 days.
Children over 7 years old - 50 mg 1 time per day for up to 15 days.

Side effects

Remantadine® is usually well tolerated. Sometimes observed:
from the gastrointestinal tract: dry mouth, nausea, vomiting, loss of appetite, pain in epigastria, meteorism;
from the central nervous system: Headache, dizziness, insomnia, neurological reactions, disruption of the concentration of attention, drowsiness, anxiety, increased excitability, fatigue;
others: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Overdose

Symptoms: Excitation, hallucinations, arrhythmia.
Treatment:stomach washing, symptomatic therapy: activities to maintain vital functions. Rimantadine is partially excreted during hemodialysis.

Interaction with other medicines

Remantadin® reduces the effectiveness of antiepileptic drugs.
Paracetamol and acid ascorbic reduce the maximum concentration of rimantadine in the blood plasma by 11%.
Cimetidine reduces remantadadin® clearance by 18%.
Adsorbents, binders and enveloping agents (acetazolamide, sodium hydrocarbonate, etc.) reinforce the efficiency of Remanthadina® due to the decrease in its kidney release.
Urban remedies (for example, ascorbic acid) reduce remantadadine efficiency due to the enhancement of its kidney removal.

special instructions

When using remantadadin® it is possible to exacerbate chronic concomitant diseases. Elderly patients with arterial hypertension increases the risk of hemorrhagic stroke.
When indicating an epilepsy anamnesis and conductive anticonvulsant therapy, against the background of remantadadin®, the risk of developing epileptic seizure increases. In such cases, Remantadin® is applied at a dose to 100 mg per day at the same time with anticonvulsant therapy.
With a flu virus, remantadin® has an antitoxic effect.
Preventive reception is effective in contact with sick, in the spread of infection in closed collectives and at a high risk of the disease during the flu epidemic.
The appearance of viruses resistant to the drug is possible.
Remantadin® does not affect the ability to control the vehicle, but to persons who have dizziness, headache or other side effects on the part of the central nervous system, caution should be taken.
With care to take with lactase insufficiency, lactose intolerance, lactose / isomaltose malabsorption syndrome, because The preparation includes lactose.
Form release
Tablets 50 mg. 10 tablets in contour cell packaging.
2 contour cellular packages No. 10, together with the instructions for use, are placed in a pack of cardboard.
Shelf life
5 years. Do not use the expiration date.
Storage conditions
In a dry protected place.
Keep out of the reach of children.
Conditions of vacation from pharmacies
Without a doctor's prescription.
Manufacturer
JSC "Olainfarm", Latvia.
Consumer claims should be directed to the representative office of JSC "Olainfarm" in the Russian Federation at the address: 115193 Moscow, ul. 7th Kozhukhovskaya, D.20.

Viruses are infectious agents that can carry out their reproduction solely inside the living cells, and they can affect absolutely all types of organisms, and a person is no exception. Today, one of the most famous viruses is flu, which is trying to defend all people in the autumn-winter period. This agent has many different types, and to combat each of them a separate means is created. So, we suggest familiarizing yourself with the features of the use of Tablets Rimantadine.

Rimantadine is an antibiotic or not?

Antibiotics are a group of medicines that are therapy of infections of bacterial origin. Remantadine is a drug that belongs to the group of antiviral funds, and was obtained by synthetic in 1963. Thus, the tablets under consideration are not an antibiotic remedy, since it is impact not on bacteria, but on specific viral agents.

Composition and mechanism of action of the drug

The active component in the composition of the drug is the rimantadine hydrochloride (standard dosage - 50 mg). The remedy has a pronounced antitoxic effect, and its main purpose is to destroy the A-type influenza virus. In addition, scientists discovered the activity of the means relative to herpes and tick-borne encephalitis. The substance works as follows:

• blocks the possibility of the virus to propagate and infect healthy cells - due to this tablet, it is considered an effective means of preventing infection;
• the substance is also able to prevent the yield of viral agents from already infected cells - it reduces the total number of their number in the body and has a positive effect on recovery.

Auxiliary components: Potato starch, talc, calcium stearate and milk sugar. After taking the drug, it is almost completely absorbed in the intestine, but rather slowly. Metabolized means in the liver and half-life is a day - one and a half (if there is impaired liver, this period is doubled). About 15% of the drug is removed unchanged.

For which Rimantadine is prescribed: indications for use

Rimantadine tablets are appointed to receive:

1. Patients with the goal of treatment (including in early detection, during epidemics and progressive flow) and the prevention of infection with the influenza virus A.
2. For adult patients, the tool can be used as a method for preventing the development of tick-borne encephalitis of viral origin.

Instructions for use, dosage and reception scheme

Regardless of the age of the patient, there are basic rules for receiving tablets. Thus, the course of therapy is usually 5 days, throughout which the agent is taken on a clearly described scheme inside after meals, drinking with plenty of water. When preventive treatment with smaller dosages, the course may be longer - from 10 days to two weeks.

How to take adults

The feature of the use of antiviral tool is that it is required to be used according to a special scheme to obtain the desired effect on therapy. So, usually the doctor prescribes the order of receiving the pills after their purpose in each particular case, however, the instruction provides a general, standard scheme that is taken as a basis (only for patients older than 14 years):

• after the first signs of infection with the virus appeared, the first day is accepted by 300 mg of the drug (this is 6 tablets of 50 milligrams). This dose can be divided into several techniques for convenience;
• the second and third day of therapy - the dosage is reduced by a third, up to 200 mg, and is divided into two receptions during the day;
• the last two days of the therapeutic course - the reception of 1 tablet is required twice a day (only 100 mg of active substance per day).

Within the framework of the preventive course, it is required to receive 1 medicine tablets once a day. If we are talking about the bite of a tick, then the patient needs to take two tablets in the morning and in the evening throughout the period from 3 to 5 days. Prevention of viral encephalitis lasts two weeks, during which the patient should drink 1 tablet twice a day.

How to drink medicine kids

Age, with what is possible to use the drug under consideration, according to the instructions, is 7 years. For patients, children use other dosages of the drug, namely:

• as part of the treatment of influenza in the age range from 7 to 10 years, 100 mg of the active substance is used per day, that is, on one tablet in the morning and in the evening;
• aged 10 and up to 14 years - 150 mg, that is, on a tablet three times a day;
• for patients older than 14 years old, adult dosage of the drug is prescribed.

Preventive measures imply the calculation of the dosage on the basis of the proportion of 5 mg of the active substance per 1 kilogram of the child's weight, but not more than 50 mg (that is, one tablet).

Overdose and side effects

In the overwhelming majority of cases, remantaddine is transferred to patients well, and side effects are extremely rare. However, the instructions indicate what you can expect:

• nest headache;
• sleep disorders;
• elevated level of fatigue;
• problems with concentration of attention;
• dizziness;
• flatulence;
• stomach pain;
• dryness mucous membranes in the mouth, nausea;
• skin manifestations of allergic reactions (redness of the skin, itching, rash).

Taking into account the fact that some patients showed allergies to the drug, it is tested before use to intolerance, and in the case of hypersensitivity refuse to use the means. In the case when side symptoms appears, it is required to stop receiving the means and consult a doctor.

The state of overdose is characterized by the formation of pronounced side effects, which will require washing the stomach and symptomatic effects (there is no special antidote). Do not think that an increase in dose can speed up recovery - it will only aggravate the situation.

Contraindications for medication Remantadine

The use of an antiviral drug is possible not for all patients, before appointment and use, it is important to take into account the presence of the following contraindications:

• liver disease and urinary system in acute and chronic flow;
• thyrotoxicosis;
• age up to seven years;
• during pregnancy and breastfeeding (during breastfeeding in the acute need to use the drug, breastfeeding temporarily suspend);
• the intolerance of at least one of their components of the composition of the means - both the active substance and the auxiliary ingredients.

The described situations are absolute contraindications, but in addition to them, a number of conditional contraindications can be distinguished, the presence of which requires special caution when taking the drug:

• diseases of the cardiovascular system, in particular with obvious violations of the heart rhythm;
• high blood pressure;
• inflammatory processes in the gastrointestinal tract, especially at the moments of exacerbation;
• epilepsy.

Analogs of Antoviral Preparata Remantadin

The drug with antiviral activity can be replaced by means with the same active substance in the composition (it is worth noting that depending on production can be quite a large gap in value):

• Rimantadine (concentration is also 50 mg in 1 tablet);
• Alginim (syrup, on 5 ml of which accounts for 10 mg of active substance);
• Remavir (in one tablet - 50 mg of the active ingredient).

A similar action, but by another component composition, have Amaxin, Arbidol, Kagole and Inhavirin - are all endowed with antiviral properties.

The use of remantadine should be made only on the prescription of the doctor and in those quantities in which a specialist prescribed. It takes into account not only the patient's health state, but also other drugs that it takes. For example, the antiviral agent under consideration reduces the effectiveness of drugs against epilepsy, and absorbents reduce the degree of absorption of remant palp.

Doctors also do not recommend combining an antiviral drug and alcohol - the combination of this kind significantly increases the likelihood of the development of side effects, namely nausea, vomiting and diarrhea. In the event that there was a fact that the reception of alcohol beverages, the tablet can be enhanced not earlier than after 6 hours. The inverse situation requires even more long pause - after taking the drug alcohol can be used no earlier than after 12 hours.

Video on the use of remantadadin with influenza and ORVI

The question of the effectiveness of antiviral drugs for influenza today is one of the most frequently discussed in medical circles. Some talk about the uselessness of such funds, while others are about the acute need for their destination. In this video, it is covered by one of the positions of the immunologist's doctor on this issue.

Remantadin- Antiviral drug for systemic use.

Remantadine is effective in respect of various strains of influenza a virus (especially and 2 types). Active in relation to the viruses of tick-borne encephalitis (Central European and Russian Spring-summer), which belong to the group of arbovirus family Flaviviridae. The main mechanism of antiviral action is to inhibit the early stage of the specific reproduction after the penetration of the virus into the cell and to the initial RNA transcription. The pharmacological efficacy of the drug is ensured by inhibiting the reproduction of the virus in the initial stage of the infectious process. Remantadine has antitoxic effect with influenza, caused by V. virus is not effective at other ORVI.

Pharmacokinetics

.

Remantadine is good, but slowly absorbed from the gastrointestinal tract. Most of the drug is intensively metabolized. The half-life of blood plasma is 24-36 hours. Excreted with urine: less than 15% dose - unchanged, about 20% - in the form of hydroxyl metabolites. In renal failure, the half-life increases by approximately 2 times.

Indications for use

A drug Remantadinit is used in children from 7 years old and adults for treating influenza. Adults are used as a prophylactic intake during the flu epidemic, for the prevention of tick-borne viral encephalitis.

Mode of application

Tablets swallowed, drinking water. Become Remantadinafter meal.

Prevention of influenza

Adults for 1 month to 1 tablet (50 mg) 1 time per day. If for some reason there was a pass of a tablet, the next tablet takes in normal mode without conducting an increase in dosage. It is recommended before receiving a consultation with a doctor.

Physic treatment in the early stages

Children's age: from 7 to 10 years, the drug is prescribed 2 times a day at 1 tablet (50 mg); From 11 to 14 years old - 1 tablet (50 mg) 3 times a day. Adults during the first day of the disease 2 tablets (100 mg) 3 times a day. You can take a daily dose at once - 6 tablets (once) or a daose dose to divide into 2 receptions (3 tablets 2 times a day). On the 2nd and 3 days of the disease - 2 tablets (100 mg) 2 times a day. During the fourth and fifth days - 2 tablets (100 mg) 1 time per day.

Prevention of tick-borne viral encephalitis

Children are appointed only by a doctor. The drug is taken immediately after the tick bite. Adults - 2 times a day for 2 tablets (100 mg) for 3 days. On the recommendation of the doctor in some cases, reception is allowed within 5 days. It is impractical to accept Remantadin, if over 48 hours passed after the bite. People entering groups of risk, as well as those who participate in hikes on plants covered with plants or forest living in tents allowed prevention of tick-borne viral encephalitis and without a tick bite for 15 days by 50 mg (1 tablet) 2 times a day (This scheme is used exclusively for adults).

Side effects

Remantadinit is fine. Possible side effects include:

Disorders from the gastrointestinal tract: diarrhea, dyspepsia.

Skin disorders: rash.

Violations by the nervous system: drowsiness, violation of attention, ataxia, assessment, violations of gait for the type of swinging, hyperkinosis, depression.

Violations by the hearing body: noise in the ears.

Violations by the respiratory system: voice hoarseness.

If other side effects appear, this should notify the doctor.

Contraindications

:

Contraindications for the use of the drug Remantadinare: chronic and acute kidney diseases; acute liver diseases; Pregnancy and breastfeeding; Increased sensitivity to adamantane derivative, active substance or other remantadine components; thyrotoxicosis.

Pregnancy

:

Remantadincontraindicated for pregnant women in any trimester.

Interaction with other medicines

It is recommended not to drink alcohol during treatment. RemantadineAlthough the information about the unwanted interactions of alcohol and remantaddine is not. The remantadadine combination with alcohol can cause various reactions from the nervous system. The effectiveness of the preparation of acetylsalicylic acid and paracetamol.

Overdose

If poisoning occurred RemantadineIt is necessary to support the functions of vital organs and systems. In the literature, no cases of overdose by remantine are not described, but there is information about the poisoning of Adamantan derivative - Adamantadin. In this case, hallucinations, excitement, arrhythmia of the heart and death were observed. If remantyin poisoning is accompanied by reactions from the nervous system, a physostigne treatment is recommended at a dose of 1-2 mg for adults and 0.5 mg for children. If necessary, the introduction of a physostigmine can be repeated, but in the dosage no more than 2 mg of physostigmine per hour.

Remantadine - antiviral remedy, which has an immunomodulatory and antitoxic effect.

The drug lowers the risk of influenza disease, and if it is presented, it contributes to rapid recovery. It is also used to prevent tick-borne encephalitis.

For the first time, the drug was obtained as a result of chemical synthesis in 1963 in the United States, and on the territory of the Soviet Union, the obtained formula was significantly improved in 1969 - this final version of the drug under consideration and is now produced by the pharmacological industry.

Clinical and Pharmacological Group

Antiviral remedy, a derivative of Adamantan.

Terms of sale from pharmacies

You can buy without a doctor's prescription.

Price

How much is Rimantadin in pharmacies? The average price is at the level of 100 rubles.

Composition and form of release

Rimantadine tablets have white or light yellow staining, round-cylindrical shape. On one side, the separation risk is applied to conveniently flushing the tablet in half.

• Active substance: Rimantadina hydrochloride - 100 mg in 1 capsule, 50 mg in 1 tablet.

Additional components Capsules Remantadin:

• Auxiliary substances: Potato starch, stearic acid, monohydrate lactose, dye sunny sunset yellow (EUROLAKE SUNSET Yellow HS (ELLO));
• The composition of the capsule: gelatin, titanium dioxide (E 171).

Remantadine Tablets Auxilia: Potato starch, magnesium stearate, microcrystalline cellulose, monohydrate lactose.

pharmachologic effect

Remantadine is a chemotherapeutic preparation with antiviral activity, which is the derivative of Amantadin and Midtenan. This medicine is used as an anti-aircinsonic agent.

It is active in the virus of tick-borne encephalitis, as well as influenza A. The drug has an antitoxic and immunomodulatory effect on the human body. Since the long-term circulation of medication in the body is provided by its polymer structure, the long half-life makes it possible to assign this tool not only with a therapeutic target, but also in order to prevent influenza and encephalitis. The use of remantadine contributes to an increase in the functionality of lymphocytes, the development of interferon alpha and gamma, as well as the suppression of the specific reproduction of viruses at the initial stage. This medication does not allow viral particles to exit cells.

Remantadine reduces the risk of influenza disease. In the presence of this ailment, the above medicine contributes to a speedy recovery. The most actively drug shows its action in the first 18 hours of poor well-being. The initial stage of the influenza is the main indication for remantadine. The preparation is adsorbed in the gastrointestinal tract 2-4 hours after oral administration. The current component is metabolized in the liver. The half-life of the drug is 25-30 hours.

Indications for use

Remantadin must be taken only by appointment of a specialist. Ignoring the prescriptions of the doctor or self-use can provoke exacerbation of pathologies.

for adults:

Adult patients receiving remantadaddine are prescribed with the following states:

• the prevention and therapy of the influenza caused by the strain of the type A virus, in the early stages of the disease;
• prevention of tick-borne encephalitis of viral nature.

for children:

Children from 7 years prescribe a reception agent for the prevention and treatment of influenza caused by the type A. virus

Remantadine is also prescribed as a medicine for the prevention of infection with the encephalitis virus during tick bite.

For children under 7 years old, the use of means is contraindicated.

Contraindications

Tablets are prohibited in the following cases:

• chronic kidney disease;
• chronic liver diseases;
• intolerance to one or more medication components;
• thyroid diseases;
• pregnancy.

Use tablets is necessary with extreme caution and only after the doctor's appointment to those people who have increased pressure, atherosclerosis is present or epilepsy. Please note that remantadine use can lead to exacerbation of chronic diseases. People of old age can have a slow removal of medication components. A group of people having liver disease can appear poisoning.

Appointment during pregnancy and lactation

Remantadine is categorically contraindicated for use on any gestation and during lactation. This is your foundations. The medicine has side effects associated with pain in the stomach, nausea and vomiting, which can aggravate toxicosis.

Dosage and method of application

As indicated in the application instructions, remantadine should be taken inward, after eating: swallow capsules / tablets entirely and drink water.

With influenza, treatment should begin within 1-2 days after the first symptoms appear.

• adults and adolescents older than 14 years old: the first day - 100 mg 3 times / day or 300 mg once, 2-3 days - 100 mg 2 times / day, 4-5 days - 100 mg 1 time / day;
• children 10-14 years old: 50 mg 3 times / day;
• children 7-10 years old: 50 mg 2 times / day.

The total duration of treatment is 5 days.

Elderly people, patients with epilepsy and severe liver failure dose reduce up to 100 mg 1 time per day.

For the prevention of influenza, adults should be taken at 50 mg 1 time per day for 30 days, children over 7 years old - 50 mg 1 time per day by course up to 15 days depending on the epidemiological situation.

Side effect

In general, Rimantadine is transferred to patients well, and the appearance of side effects is extremely rare. But against the background of the reception of the antiviral agent under consideration may appear:

• dry mouth, nausea and vomiting;
• increased gas formation;
• pain in the area of \u200b\u200bthe anatomical location of the stomach;
• dizziness and disruption of the concentration of attention;
• headache of non-intensive character and insomnia;
• nervousness and unmotivated fatigue;
• classical allergic reaction - urticaria, skin itch.

With the appearance of at least one of the listed side effects, the reception of Rimantadina should be immediately terminated and consulted with the attending physician about the feasibility of the further course of receiving the antiviral agent under consideration. Most often, experts either conduct a complete replacement of the drug, or adjust the dosage.

Overdose

If the drug poisoning occurred, it is necessary to support the functions of vital organs and systems. In the literature, no cases of overdose by remantine are not described, but there is information about the poisoning of Adamantan derivative - Adamantadin. In this case, hallucinations, excitement, arrhythmia of the heart and death were observed.

If remantyin poisoning is accompanied by reactions from the nervous system, a physostigne treatment is recommended at a dose of 1-2 mg for adults and 0.5 mg for children. If necessary, the introduction of a physostigmine can be repeated, but in the dosage no more than 2 mg of physostigmine per hour.

special instructions

Rimantadine is used with care with arterial hypertension, epilepsy (including in history), atherosclerosis of the brain vessels.

When using Rimantadina, the aggravation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension increases the risk of hemorrhagic stroke. When indications of an epilepsy anamnesis and anticonvulsant therapy conducted, against the background of the use of Rimantadin, the risk of developing epileptic seizure increases. In such cases, Rimantadine is used in a dose to 100 mg / day simultaneously with anticonvulsant therapy.

In the influenza caused by the virus B, Rimantadine has an antitoxic effect.

Preventive reception is effective in contact with sick, in the spread of infection in closed collectives and at a high risk of the disease during the flu epidemic. The appearance of viruses resistant to the drug is possible.

Interaction with other drugs

When using the drug, it is necessary to take into account interaction with other drugs:

1. With the simultaneous use of Rimantadine reduces the effectiveness of anti-epileptic drugs.
2. Adsorbents, binders and enveloping agents reduce the absorption of Rimantadine.
3. Paracetamol and acetylsalicylic acid reduce Cmax Rimantadine by 11%.
4. Cimetidine reduces Rimantadine clearance by 18%.
5. Means lacking urine (acetazolamide, sodium hydrocarbonate) increase its efficiency (reducing the excretion by the kidneys).
6. Means whining urine (ammonium chloride, acid ascorbic acid) reduce the effectiveness of Rimanthadine (due to the strengthening of its excretion by the kidneys).

Remantadin (Remantadinum)

Remantadin (Remantadinum) Synonyms: Rimantadine.

pharmachologic effect. It has antiviral activity against all strains of the influenza of type A virus and to a lesser extent type V.

Indications for use. Treatment in the initial stage (1-20 days) of influenza and the prevention of influenza and sharp viral respiratory diseases during the flu epidemic.

Method of application and dose. Remantadin inside (after meals), drinking water, according to the following scheme: adults are given in the 1st day of the disease of 100 mg (2 tablets) 3 times; In the 2nd and 3rd days - 100 mg 2 times; In the 4th day - 100 mg 1 time. In the 1st day of the disease, the preparation can be taken once at a dose of 300 mg (6 tablets).

Children from 7 to 10 years are prescribed 50 mg (1 tablet) 2 times a day; 11-14 years - 50 mg 3 times a day. Take for 5 days.

In order to prevent influenza daily 1 tablet for 5-7 days with constant contact with patients (focal prophylaxis) or within 10-15 days with episodic contacts (planned prevention).

Form release. Tab. On 0.05 g. Storage conditions. List B.

Remantadine is one of the first antiviral drugs that appeared in the 60s in the United States and then the deep research by Russian scientists. As a result, Remantadin was recognized very effective, and since 1977 began to appoint adults, and since 1986, children.

In recent years, this drug, along with other antiviral drugs, has become particularly popular, since information about new types of influenza and other viral ailments appears, and people prefer to take action as soon as possible. Prevention becomes the most important task of many in the period when viral infections are especially common.

Remantadine is a derivative of amantadine - a strong prophylactic agent effective in combating some strains of the virus group A.

How does remantadine act?

Remantadine is a drug strictly aimed at affected and viral cells, and we are not only about influenza a, but also about herpes viruses and tick-borne encephalitis. Moreover, being a stronger means compared to amantadine, remantadine is able to substantially alleviate the state with influenza type V.

This medicine reduces intoxication from the vital activity of viruses cells and contributes to the production of interferon by the body, which, in turn, does not allow viral cells to spread and multiply further.

It is worthwhile that the drug is only an antitoxic and antiviral agent, without removing such symptomatic manifestations, such as, for example, a runny nose and sore throat.

Remantadin, falling into the human body, the maximum concentration reaches after two or four hours, and is output through one and two days.

Indications for the use of remant palp

Remantadine is often prescribed as a preventive agent during the early epidemic of the influenza and ARVI. It is important to pre-examine the instructions and not to overdo it - adults are appointed on one tablet twice a day, or for some reception is quite enough. The duration of reception is usually from five to twenty days.

If the symptoms of the impending disease have already become a reality, to speak late prevention. It's time to proceed with the same remantine, or its analogues. In this case, in the first two days it is worth taking two tablets three times a day, and then three more days - on one tablet three times a day. For more than five days, it makes no sense to be treated with remantadadine, as ineffective and its reception with complications after influenza. The drug suspends the development of the virus and activates the protective forces of the body, so it benefits only at the initial stages of disease.

Children up to seven years and pregnant women do not prescribe this drug. When breastfeeding it, it is also impossible to take it. Contraindications for receiving remanptine are jade, hepatitis, renal failure and thyrotoxicosis.

Side effects remand palp

In some cases, there are such negative symptoms such as pain in the stomach, nervousness and insomnia, headache, dizziness, scattered attention are possible during Remanthadine. In such cases, therapists or reduce the dosage of the drug, or cancel it and assign another tool.

As studies have shown, side effects and a negative reaction from the nervous system most often occur with a serious overdose of the drug. In such cases, it is necessary to immediately stop taking the drug and seek medical attention.

It is important to remember that remantadine should be appointed only by a doctor on the basis of the identification of the patient's anamnesis and the individual characteristics of the body.