Papaverin Suppositories Rectal instructions for use. Candles "Papaverin": appointment, composition, instructions for use and contraindications

The date: 04.11.2019

Composition and form of release of the drug

◊ Suppositories rectal From white to white with a yellowish or cream-shaped color, torpedo-shaped.

Auxiliary substances: solid fat (vytepsol, suposier) - before receiving a suppository weighing 1.25 g.

5 pieces. - Packaging cell contour (2) - packs cardboard.

pharmachologic effect

Dosage

Inside - 40-60 mg 3-5 times / day. Rectally - at 20-40 mg 2-3 times / day.

At a / m, n / k or in / in administration, a single dose for adults is 10-20 mg; The interval between the introductions is at least 4 hours. For elderly patients, the initial one-time dose is not more than 10 mg. For children aged 1 to 12 years, the maximum one-time dose is 200-300 μg / kg.

Side effects

Maybe: Nausea, constipation, drowsiness, increased sweating, arterial hypotension, increase in activity of hepatic transaminases.

With quick / in the introduction, as well as when applying in high doses: Development of AV blockade, rhythm disorders.

Medicinal interaction

With simultaneous use with anticholinergic agents, it is possible to enhance anticholinergic effects.

It is believed that with simultaneous use with alprostadyl, there is a risk of developing priapism.

There are reports of reducing the efficiency of levodopes during its simultaneous use.

Reduces the hypotensive effect.

special instructions

C care to apply under states after the cranial injury, with chronic renal failure, in case of insufficiency of the function of adrenal glands, hypothyroidism, prostate hyperplasia, religative tachycardia, shock conditions.

Papaverin candles are prescribed not only in order to relocate unpleasant sensations at various forms of hemorrhoids, but also to eliminate the uterus hypertonus during the child tooling, as well as to normalize blood pressure.

It is important to take into account a number of contraindications to the use of medication in order to avoid the development of complications.

Composition and action of papaverine with hemorrhoids

Papaverin hydrochloride (opium alkaloid) eliminates spasm arising at the bottom of the abdomen. The active ingredient weakens the reduction of muscle fibers in the intestinal walls, which contributes to the elimination of painful sensations in the anorectal zone.

Pharmacological properties

Pharmacodynamics

The drug reduces the severity of angina.

In the surgery of the Papaverin Suppositories are used for drug preparation of the body to anesthesia.

Pharmacokinetics

After the introduction into the rectum, the suppository is melted. The active component of the means is quickly absorbed from the intestine and enters systemic blood flow. Papaverin is excreted from the body kidneys in the form of intermediate metabolic products (metabolites).

For what candles are prescribed Papaverin

The drug is shown to use:

To remove the excessive voltage of the muscles of the bladder during cystitis.
With inflammation of the gallbladder.
With bronchitis to prevent swelling of the mucous membrane.
To eliminate unpleasant sensations with prostatitis.
In order to increase potency. The active component of the means enhances the blood circulation in the organs of the small pelvis.
With headaches.
To relieve pain syndrome during menstruation.
In order to expand the vessels and improve blood circulation processes, which contributes to a decrease in blood pressure (hypotensive effect).

Is it possible candles papaverin with hemorrhoids

Chronic

The medication is not used as a means for the prevention of hemorrhoids. But suppositories are often used to remove the intestinal hypertonus, which may cause constipation.

Solid hood masses damage the mucous membrane of the rectum, provoking the exacerbation of pathology. Therefore, papaverine in this case will contribute to the normalization of the chair.

With exacerbation

Application of candles papaverin

It is important to follow the instructions for the use of the means to achieve the maximum possible therapeutic effect.

Where they put candles papaverin

How to insert

It is necessary to take the position lying on the side, bending the knees to the body. Smoothly and without sharp movements, enter the candle in the anal hole.

How much to lie after administration

How many times a day

You can use the drug no more than 4 times a day.

How many days to put

The course of treatment with papaverine is about 2 weeks.

Contraindications for the use of Papaverin candles

The drug cannot be used:

Side effects

Such unwanted organism reactions are possible:

vomit urge;
drowsiness;
arterial hypotension;
hyperhydrosis (increased sweating);
chair disorder (diarrhea);
liver dysfunction.

Overdose

It is necessary to clean the blood in case of overdose.

special instructions

It is important to take into account that:

alcohol compatibility and papaverine negative;
it is forbidden to smoke during the use of the tool, because The effectiveness of the therapeutic effects of the medication is reduced;
it is undesirable to use the drug to people whose activities are associated with a high concentration of attention.

Childcare

From 10 years it is allowed to apply 1 suppository twice a day. Newborn papaverin contraindicated. Treatment with the drug of infants is carried out from 6 months under the strict observation of the doctor.

There are no children's candles with papaverine.

During pregnancy and lactation

It is important to take into account a number of such features:

in the early periods (in 1 trimester), papaverine is prescribed simultaneously with a duphaston in order to preserve pregnancy;
in 2 trimester (at 20 weeks), the candles are used in the event of constipation and drawing pain in the lower abdomen;
in the later dates (at 40 week), the drug is prescribed to soften the cervix before childbirth;
with breastfeeding, the use of candles is contraindicated.

After the transfer of embryos in Eco, women are also often prescribed papaverine as an anesthetic.

Medicinal interaction

Papaverin suppositories can be combined with but-spasp and platiphylic to achieve the maximum possible antispasmodic effect.

Analogs

When the abdomen, constipation and intestinal colic can be used by Riabal. And in diseases of the urogenital system, which is accompanied by a spasm of smooth muscles of organs, it is recommended to use spasmolysisin.

Terms and conditions of storage

It is necessary to limit the access of small children to the drug. Means should be used for 2 years.

Conditions of vacation from pharmacies

Doctor's recipe is not required.

How much are

The price of Suppositories from NIPARM is 25 rubles.

Papaverin Hydrochloride Candles Instructions for use

Injection:

papaverin hydrochloride - 20 mg per 1 ml of medicinal liquid;
D, L-methionine;
dinatari Edetat;
water for injections.

Pills:

papaverin hydrochloride - 10 mg in 1 tablet;
rafinated sugar;
potato starch;
acid stearinovaya;
talc.

Rectal suppositories:

papaverin hydrochloride - 0.02 g in 1 candle weighing in 1.25 g;
emulsifier №1;
stearin cosmetic;
solid fat.

Form release

Papaverin in tablets 0.01 g or 0.04 g, depending on the target audience of the patients (the first are used in pediatric practice after 6 months), which are fusing in contour cellular blisters of 10 pieces. Oral shape has a slightly bitter taste, white color and does not smell.
Injecting Introduction Solution 2% in ampoules 2 ml. Cardboard packaging, as a rule, contains 10 pieces and instructions for the use of a pharmaceutical preparation.
Rectal suppositories or candles for the introduction into the rectum of 0.02 g each; Mounted in PVC blisters or aluminum foils for 10 pieces. A plate with a medicinal product and abstract is stacked in the cardboard box.

pharmachologic effect

Papaverin hydrochloride (Wikipedia indicates that the PNH of the drug corresponds to the name of the main active component) - this opium alkaloid acting on smooth muscle elements and concerning their relaxation, because the pharmacological group of the drug is determined as motropic spasmolitis .

The mechanism of the therapeutic effect of the biological substance is to influence the secondary intermediaries (messengers) of the transmission of muscle excitation. Papaverin inhibit FDE (phosphodiesterase), due to which the cage accumulates cAMF (cycloodenozinonophosphate) and decreases the content of ions calcium , in response to such biochemical changes, the smooth muscles of the internal organs (digestive tube, respiratory and urogenital systems and the vascular bed) are relaxing their tone is reduced .

Pharmacopoeia is a set of mandatory rules and official regulations, which are guided by manufacturing, inspection, storage and prescribing patients with medicines. Since the main biologically active component of the pharmaceutical preparation is potent, in respect of papaverine, the pharmacopus hydrochloride includes the following chemical authentication points:

physical characteristics - White crystalline powder without smell, with a weakly bitter taste.
Solubility - in water dissolves for 40 hours, a little soluble in 95% alcohol, soluble in chloroform and practically dissolve on the air.
Acidity 2% solution of hydrochloride papaverine - 3.0-4.5 (determined by the potentiometric method).
Chemical control of authenticity - 0.05 g of the pharmaceutical preparation is placed in a porcelain bowl, wet a pair of high concentration nitric acid drops, after which yellow staining should appear, which, when heated in the water bath, changes to orange.
The presence of organic impurities - Dissolution test and color changes in 5 ml of concentrated sulfuric acid.

Pharmacodynamics and pharmacokinetics

The current component is quickly and almost completely absorbed at any paths of administration of the drug into the body. Finding into the bloodstream, binds to plasma proteins (90% of the total biologically active substance), due to which it easily passes through histohematic barriers. Biotransformation is subject to liver. The half-life is from 30 minutes to 2 hours, depending on the auxiliary components of the pharmaceutical preparation. It is removed mainly by the kidneys in the form of products of metabolic metabolic exchange.

Indications for the use of papaverine

smooth muscle spasm abdominal organs (especially often , spastic or pylorosphazma );
hypertensive crisis (in combined conservative therapy);
enermeritis ;
spasm of peripheral vascular bed;
reducing the lumen of the brain vessels due to the reduction of the muscular layer of the arteries;
bronchospasm ;
reducing the arterial renal influx of vascular genesis;
urinary delay Due to the urinary tract spasm.

Indications for use also include stage premedication before operational surgical interventions in abdominal cavity, proctological and urological manipulations. For what is used - the relaxation of smooth muscle elements (for details, see "Pharmacological action").

Contraindications

the intolerance to the components of the drug components;
violations of intracardiac conductivity, especially atri-Ventricular blockade ;
increased sensitivity to the pharmaceutical preparation;
heavy liver failure ;
elderly age (as there is a significant risk of developing hyperthermic syndrome);
children's age up to 6 months.

Additional restrictions on use (it is recommended to use only under the constant observation of qualified medical workers and regular diagnostic surveys):

recent brain-brain injurya history of
chronic;
shock states;
supported ;
benign ;
insufficiency of the functionality of adrenal glands.

Side effects

From side cardiovascular system and blood: atri-Ventricular blockade , stomatricular Tachycardia decline .
From side gastrointestinal tract: nausea , constipation (), Owl of belly , violation of the passage along the digestive tube, increasing the activity of hepatic transaminases.
Others: , , eosinophilia .

Instructions for use of papaverine (method and dosage)

Papaverin tablets, instructions for use

In tablets, the pharmaceutical preparation can be assigned to both adults and children, even the multiplicity of reception does not change and is 3-4 times a day. The dosage of the oral form of the drug depends on the age-related category of the patient, use the following treatment scheme:

from 6 months to 2 years - 0.005 g at the reception;
3-4 years - 0.005-0.01 g;
5-6 years - 0.01 g;
7-9 years - 0.01-0.015 g;
10-14 years old - 0.015-0.02 g;
adults - 0.04-0.08 g at the reception.

Papaverin candles, instructions for use

- This is an extremely unpleasant proctological disease that is associated with , inflammatory processes and pathological expansion of hemorrhoids of veins, encircling the intelligence of the rectum. This nosological unit is characteristic typical clinical picture which includes disruption of defecation, itching, bleeding from the rear pass. Candles with papaverine will help facilitate the course of the disease.

The current components of the pharmaceutical preparation allow you to relax smooth muscle elements of intestines That facilitates the process of feces, because the lumen of the rectum increases slightly. For the same reason, bleeding is stopped, since the solid carriages do not injure inflamed hemorrhoidal nodes, because candles with papaverine with hemorrhoids are a kind of "magic wand".

In pharmaceutical kiosks, you can find suppositories with a different dosage of a biologically active substance. To begin the course of the conservative replacement should be from 0.02 g, gradually increasing it to 0.04 g, unless fewer pharmaceutical preparation has its own therapeutic effect. It is not recommended to use more than 3 candles per day, it is fraught with the development of adverse side effects and even an overdose state, since all incoming drugs are extremely well absorbed in the rectal region.

How to use the injection solution of papaverine hydrochloride?

The acting component of the pharmaceutical preparation has high bioavailability, because injections can be done, both subcutaneously and intramuscularly and intravenously, the therapeutic capabilities of the drug from this will not be affected, and the end result will be as strong. It should determine that subcutaneous injections of papaverine hydrochloride instruction on application recommends to do not be done in the distal part of the forearm, but in the shoulder or into the outer surface of the hip, since the multiplicity of administration can ensure the appearance of hematoma. The intramuscular injections of papaverine can be carried out according to the standard diagram, that is, use the upper lateral quadrant of the buttock.

Before making intravenous injections, appointed by the doctor, the amount of pharmaceutical preparation should be diluted with 10-20 ml of isotonic solution sodium chloride . It should also be remembered that the hydrochloride hydrochloride should be introduced very slowly, in order not to cause the patient an unpleasant sensation in the injection process.

The contents of 1 ampoule (2 ml) 2% of the hydrochloride hydrochloride solution are subcutaneously, as a rule.

Dosage of the solution in ampoules with intravenous and intramuscular administration:

adults: one-time - 0.1 g, daily - 0.3;
children from 6 months to 1 year: one-time - 0.005 g, daily - 0.01 g;
at the age of 2 years: one-time - 0.01 g, daily - 0.02 g;
3-4 years: one-time - 0.015 g, daily - 0.03 g;
5-6 years: one-time - 0.02 g, daily - 0.04 g;
7-9 years: one-time - 0.03 g, daily 0.06 g;
10-14 years old: one-time - 0.06-0.06 g, daily - 0.1-0.2 g.

Dibazole with papaverine - how to use?

- this is antihypertensive drug from Peripheral Group vasodilators , that is, the current components of the pharmaceutical preparation have vasodilatory influence and largely contribute to the reduction of blood pressure. Papaverin has similar therapeutic properties with respect to the vascular system, because the combination of these medicines is actively used by emergency care workers to eliminate hypertensive crisis .

Dibazole with papaverine intramuscularly or intravenously is introduced, because the necessary pharmacological effects of the current components develop much faster than when orally or any other method of use. The relaxing effect of biologically active components can be combined with physiotherapeutic methods, such as a horizontal position with a lowered foot end, warm baths for legs, massage of the lower extremities, and so on.

The dosage of dibazole with papaverine to eliminate the hypertensive crisis is 3-5 ml of 1% of the dimension of dibazole and 2 ml (the contents of 1 ampuly) 2% solution of the second pharmaceutical preparation. Such a large number of existing components allow not only to reduce blood pressure, but also to stop the feeling of nausea, painful sensations in the heart area and some other manifestations of cardiovascular pathology.

Overdose

Possible symptoms active ingredients of the drug:

diplopia (shots in the eyes) ;
weakness;
reduced arterial pressure ;
increased tired .

Specific pharmaceutical No, therefore applied disintellation therapy and symptomatic treatment . Especially effectively washing the stomach or use of sorbents ( milk , , for example) in the first hours after taking oral forms of hydrochloride papaverine. Also, with an overdose of drugs, it is important to continuously monitor and, if necessary, artificially maintaining blood pressure.

Interaction

- This is an antispasmodic, vasodilant, sedative, that is, by pharmacological abilities close to papaverine. Different drugs only in the mechanisms of therapeutic action, because Platifillain papaverin is used in a combined conservative retention of spastic syndromes, hypertensive crises and other pathological conditions.

With papaverine, like platifillain, interact well, having a synergistic therapeutic effect on smooth muscular elements of the human body. Such a combination of pharmaceutical preparations is particularly often found in obstetric and gynecological hospitals with a tone of the uterus, the threat of spontaneous miscarriage or excessively active early generic activities.

In medical publications, neurological topics have news that the efficiency of application Levodopa some significantly decreases in convective conservative therapy, from which papaverine in tablets or in the form of a solution for injection on the background of drug reservation Use contraindicated.

Simultaneous use of papaverine with anticholinergic drugs It can manifest itself in strengthening the therapeutic effects of the latter, because if necessary, it is necessary to discuss the reduction of dosages or the temporary cancellation of pharmaceutical preparations with a qualified specialist.

Terms of sale

The pharmaceutical drug is known from time immemorial and always famous for its therapeutic action, therefore, earlier in pharmaceutical kiosks, with his purchase, a recipe was required on Latin. Now the procedure for the acquisition of Papaverin has become much easier, however, to present a properly decorated prescription recipe - the patient's responsibility.

Storage conditions

In the dry, protected from direct rays of sunlight place at a temperature mode not higher than 25 degrees Celsius in a tightly packaged package. The pharmaceutical preparation refers to the list B, so it should be carefully monitored for its storage.

Shelf life

special instructions

Papaverin hydrochloride significantly improves peripheral blood circulation, which ensures improvement of trophic processes in separate organs with its local use. This therapeutic ability determines the use of a pharmaceutical preparation in bodybuilding . Practical observations of athletes show that the most efficient use of the drug to increase the specific mass of deltoid and double-headed muscles.

The purpose of athletes is the local impact on a certain part of the muscles, from which injections are conducted intramuscularly. The optimal dosage is 1-2 injections per week, which are held in 15-20 minutes before intensive training. Further, at the very beginning of exercise, all efforts should be aimed at the "enriched" muscle, that is, to engage in the "Pamping" system (blood pumping), since the therapeutic effect of papaverine under local use is short.

The ingenuity and resourcefulness of the female half of humanity does not fell behind the strong floor, because the papaverine hydrochloride is applied even in cosmetology procedures and home skin care. Due to the enhanced blood circulation of peripheral parts of the body under the action of a pharmaceutical preparation, the elimination of the accumulated fluid is improved, swelling is removed and exchange processes are in some extent. Such therapeutic effects allow the use of a drug to combat cellulite , elimination of an unpleasant "orange peel" in the field of buttocks and the rear surface of the hip and even getting rid of the pair of extra kilograms.

To obtain such a result, leading cosmetologists recommend applying cheating caffeine and papaverine which can be carried out even at home. To prepare a miraculous mixture, 2 ml caffeine ampoules will be required, 2 ampoules papaverine hydrochloride in 2 ml and a small amount of hidden honey. Before applying a cosmetic means, skin covers should be prepared, for which it is used to use a light peeling, scrub, or a small local massage.

The mixture should be applied evenly throughout the section of the surface treated with a small layer. Immediately a cosmetics is not absorbed, therefore it is necessary to tightly cover the skin with a polyethylene film (for these purposes, the food film is perfect) and warming up, having wrapped in a cotton blanket or with winter clothes. Wrapping is recommended at least an hour, after which itching the residues of the mixture with warm water and apply moisturizing or feeding cream. The duration of the course is twelve procedures, and the frequency of their holding is every other day.

The current components of the pharmaceutical preparation distribute their favorable influences not only for people, but also on animals, because Papaverin has found wide use in veterinary practice . Especially often the drug is used for cats, as pets fall into the hospital in connection with the spasms of the smooth intestinal musculature. The etiological factor is the hygiene flows of feline, because in the process of "washing", as a rule, there is a swallowing of some amount of wool. Papaverin facilitates the dedication of the contents of the digestive tube.

Analogs

Coincidences on the ATX 4 level code:

Analogs of Papaverin are a variety of pharmaceutical forms of the drug in which it occurs on pharmacy shelves. As a rule, one of the forms is not suitable for the patient and then you should choose another. It can also be replaced with this product, but it should be previously consulted with a qualified specialist in this area, because the basic principle of medicine "not harm" can be easily violated with ignorance.

Similar antispasmodic effect has a pharmaceutical preparation with an international non-patented name which is a wide audience known under the name. It can also be used for pregnant women and for patients of a proctological or urological hospital, and for children in pediatric practice, and for the treatment of headaches at home.

Children

Papaverine hydrochloride is actively used in pediatric practice, starting from age in 6 months.

Papaverin during pregnancy and lactation

Why are candles papaverin during pregnancy?

The uterus, the organ of the female sexual system, in which the intrauterine phase of the fetus develops directly, in its composition it has both striped muscles and smooth muscles. In the process of having a child, an increased tone of this organ often develops, as a result of which spastic pains are possible, early fights , premature oral influence and the birth is not at a planned term. Papaverin hydrochloride has a relaxing effect, which allows you to take the above manifestations of the uterus hypertonus.

Of course, before applying the drug, it is necessary to determine the pharmaceutical form, which will have a maximum of favorable effects and does not harm the developing body of the child and the mother. For pregnant women, the feasibility of using one or another form of papaverine is determined the duration of the nipping of the fruit For example, in early terms, it is recommended to use oral pills, and in the later dates, the intramuscular and subcutaneous administration of injection solutions is much better.

Candles with papaverin during pregnancy

First of all, you should decide on a very logical question for patients - where to insert the candles of papaverine during pregnancy, because, as a rule, this pharmaceutical form of the drug is used rectally However, the therapeutic impact is required not in the final departments of the gastrointestinal tract, but in muscle elements of the urogenital system. This delusion is characteristic of women, absolutely not familiar with the principle of work of local pharmaceutical suppositories.

After the introduction of papaverine, the active components of the candles are actively absorbed and opened at first local blood flow According to the nearby organs, due to which the smooth muscle elements of the uterus are equipped with biologically active substances to the fullest. Another positive point of use of this pharmaceutical form is the high bioavailability of rectal suppositories, that is, a large percentage of the drug enters the microcirculatory course, and not output from outward

Prices for pregnancy

Of course, the most effective way to use papaverine hydrochloride is its intramuscular or even intravenous administration, because in this way bioavailability the drug tends to maximize, and the concentration of the active substance is preserved at the highest point of the longest period of time.
It should be emphasized that the injection form of the pharmaceutical preparation is particularly relevant in late pregnancy, when the uterus hypertonus or spastic, grapple-shaped pains can lead to premature start of labor and the outstanding of spindle water. In the presence of appropriate testimony from the attending physician, it is worth thinking about inpatient treatment, because in this case, pregnant will be under constant control of medical personnel, which cannot but unable confidence.

The dosage of the solution for injecting administration, as well as the multiplicity of the use of the pharmaceutical preparation, is selected individually, as a rule, it ranges from 1 to 10 ml of 2% of the drug 2-4 times a day. In the event of adverse effects of conservative reservation, it is necessary to immediately turn to a qualified specialist.

Papaverin pills hydrochloride, instructions for pregnancy

Since special medical knowledge and skills are needed for the injection of the pharmaceutical preparation, and rectal suppositories can deliver certain inconvenience and unpleasant sensations in the process of using them, then often these pharmaceutical forms of papaverine are replaced with tablets that are administered orally. Of course, the effectiveness of such conservative therapy is somewhat lower than other ways to introduce the current component in the body, but there are no equal to the daily use of the tablets.

Papaverin hydrochloride in oral form is used exclusively according to the testimony, and the criterion of its use is the subjective well-being of pregnant, therefore there is no strict dosage of the pharmaceutical preparation. Specialists in obstetric and gynecological business are not recommended to take more than 4 tablets per day, which should be used 2 hours before meals, in order to increase the pharmacokinetic abilities of the current component.

Papaverin candles are designed to relieve spasms and relax the smooth muscle fibers of the internal organs. With rectal use, the drug is absorbed quickly, so the active ingredients begin to act immediately, which leads to a high therapeutic effect.

The main active substance is papaverine hydrochloride. In one rectal suppository contains 20 mg of this ingredient.

How to act

With pancreatitis, Papaverin suppositories remove spasms and have a good therapeutic effect on blood vessels. Finding into the body, the active substance normalizes the outflow of the bile and the pancreas juice, due to which the pressure is reduced around the organ, so the painful sensations gradually pass.

Pharmacodynamics of the drug Next: Candles contribute to relaxing the smooth muscles of vessels, gastrointestinal tract organs, urinary system, respiratory system and stabilize blood pressure.

Pharmacokinetics of the drug: The basic substance has a good penetration. Biotransformation is carried out in the liver, excreted from the body by the kidneys. The process takes from half an hour to 2 hours.

For what appoints

Candles with papaverine are prescribed at:

spasms of smooth muscles of all organs of the gastrointestinal tract;
problems with urination;
hypertensive crisis;
angina;
bronchospasm;
colic in the kidneys;
hemorrhoid.

Used to reduce temperature. In addition, the drug is recommended before surgery. Also, the drug is used in the complex treatment of prostatitis and with a worsening potency.

How to put candles papaverin

Papaverin suppositories are gently inserted into the rectal area in the lying position. It is preliminarily recommended to empty the intestine yourself or with the help of a cleansing enema.

How much to lie after

How fast act

The rectal drug begins to act within a few minutes, so relief occurs fairly quickly.

How often can be

Adult patients are prescribed 2-3 suppositories per day. The interval between use should be at least 4 hours.

How many days to apply

special instructions

Before using rectal suppositories, carefully read the instructions for use in order to eliminate unwanted consequences.

Pregnancy and lactation

Candles with papaverine are widely used in gynecology, however, during pregnancy, consult with the doctor to determine the desired dosage depending on the hatching period. The drug is often used instead of nos-Py to remove the tone of the uterus. In the early periods of pregnancy in some cases, it is assigned to the threat of miscarriage along with the ureasuala. Also, the candles are used before childbirth for softening the cervix.

During the period of tooling the fetus of many women is worried about nausea, so they cannot drink tablets. In this case, rectal candles are used as an alternative to them. In addition, they are used in chalk problems, which are often present during pregnancy.

In the lactation period, consult your doctor and find out his opinion about the use of the drug at this time.

Childhood

Rectal suppositories can not be used to children in the first six months of life.

Elderly age

The drug is prohibited to apply in old age, since there is a risk of developing hyperthermia (the accumulation of excess heat in the body).

Side effects of candles Papaverin

When using papaverine, the following side effects are possible:

nausea, vomiting;
drowsiness;
difficulties with emptying (constipation);
increased sweating;
eosinophilia;
various allergic reactions.

Contraindications for the use of Papaverin candles

The drug has some contraindications to use:

individual intolerance to the active substance;
increased intraocular pressure - glaucoma;
liver disease.

Interaction with other drugs

The joint use of papaverine with a spasmodic sedative Platifillain gives a good therapeutic effect in hypertensive crises and spastic syndromes.

Rectal suppositories with but-spam are interacting, providing therapeutic effect on smooth muscle elements.

Such a combination is used in obstetric and gynecological practice.

With the interaction of anticholinergic drugs with papaverine, their therapeutic effect is enhanced, so it is important to accurately determine the desired dosage of all drugs so that no overdose occurs.

Compatible with alcohol

Candles are not compatible with alcohol, so at the time of therapy you need to abandon it.

Overdose

The overdose of the medicine is manifested by the following symptoms:

split in the eyes;
weakness and increased fatigue;
hypotension;
strong drowsiness and unreasonable weakness.

At the first signs of overdose, consult medical care, since urgent stomach wash and sorbent reception is necessary. In addition, constantly observe arterial pressure.

Conditions of vacation from pharmacies

The drug is sold in pharmacies for the recipe.

Price of drug

On average, the price of the drug varies from 40 to 90 rubles.

Storage conditions

Shelf life

Manufacturer

Company "BIOKHIMIC", Russia.

Analogs

The drug papaverine is produced in the form of tablets and in the form of injections. A similar action has a but-shpa and candles spasmolyizin.

In this article we will reveal the topic "Papaverin - instructions for use".

Papaverin is an analgesic action preparation, widely used in medicine. Available in various forms and due to this is prescribed to patients individually depending on the susceptibility of the body. Indications for the use of drug Papaverin can be different, therefore, its method is different. Thus, in inpatient treatment, injections are used, with independent treatment it is allowed to receive tablets and candles.

What is Papaverin? What is the means to use? Is it an antibiotic or not?

Papaverine (Papaverine) is a opium alkaloid and refers to myotropic spasmolitics. The drug is not an antibiotic. The papaverine active substance suppresses the activity of phosphodiesterase, contributes to the accumulation of adenosine monophosphate and reduce the level of calcium in the blood, which ultimately leads to the relaxation of smooth muscles of the respiratory, excretory, sexual system, as well as the expansion of arterial vessels and the improvement of blood circulation. The drug has sedative (soothing) and painkillers, removes various kinds of muscle spasms and vessels, reduces the excitability of the heart and contributes to a decrease in blood pressure. It does not have a special influence on the nervous system.

What does the drug Papaverin help? Indications for use

Papaverin hydrochloride, being a spasmolytic that also has an anticonvulsant and hypotensive action is assigned to:

Reducing the tone of smooth muscles of respiratory and excretory systems, as well as hearts;
Rendering a soothing effect;
Expansion of blood vessels;
Elimination of problems with vessels located in the brain;
Improving blood circulation;
Removing the spasms of the abdominal organs, namely, with colitis, cholecystitis and pylorosphasis;
Elimination of a hypertensive crisis;
With renal colic;
Removal of spasms with the difficulty of urination;
Bronchospasm relief at bronchitis;
Treats inflammation;
When coughing;
With angina.

Possessing a special formula, the drug is absorbed in a short time and begins to act for half an hour. The papaverine with urine, through the kidneys, is displayed.

In the acute need to immediately remove the drug from the body, they resort to the dialysis procedure. With its help, harmful substances and toxins are removed from the blood.

Papaverin is used during surgical operations. Anesthesiologist introduces the drug to reduce muscle tone of respiratory tract. It helps the patient to transfer anesthesia easier.

Papaverin during pregnancy

Most pregnant women came across such a problem as a tone of the uterus. This phenomenon is dangerous in that it can provoke a premature interruption of pregnancy or childbirth. Also, with hyperthonus, the bloodstream is disturbed to the fetus, which can entail bad consequences. The fruit ceases to receive the nutrients and elements necessary for its development. To eliminate this problem, gynecologists are often prescribed to the drug papaverine, which also lowers pressure with a possible increase. It should be clarified by a doctor, with what pressure can be taken by the drug. Papaverin helps restore blood flow to the uterus, which has a positive effect on the development of the fetus.

Possessing a sedative action, papaverin reduces the nervous tension, which often accompanies pregnant women and increases the tone of the uterus.

Papaverin candles in gynecology for rectal reception are widely used. The active substance of papaverine during rectal use is quickly absorbed into the blood and saturates the muscles of the uterus in a short time in full.

Feeding Papaverin during pregnancy can entail side effects, namely:

Allergies to the components of the drug, manifested in the form of a skin ferrous (most often, urticaria);
Drowsiness;
Dizziness;
Constipation, can be a stomach;
Violation of heartbeat with the introduction of the drug intravenously.

With a worsening of well-being from Papaverin, it is necessary to suspend the reception of the drug and consult the attending physician.

Contraindications for receiving papaverine

Papaverin is not recommended for individual intolerance to the active substance and components of the drug in order to avoid allergic reactions. When signs of allergies, it is necessary to suspend treatment.

According to the instructions for use of Papaverin contraindicated:

Children to six months;
To old people;
Comatose patients;
In chronic reduced pressure;
If there is an AV blockade;
When glaucoma;
In case of intolerance to the components of the drug;
In the case of hepatic insufficiency of severe form.

With extreme caution, the reception of papaverine is possible:

With prostatic hyperplasia;
With renal failure, which is chronic;
With religation tachycardia;
After transferred to the cranial injury;
Under hypothyroidism;
With impaired adrenal work;
In stressful situations.

Paking papaverine is not compatible with the preparations of the pharmacological group inhibitors of the enzyme monoaminoxidase. Also during the treatment period, the papaverine is strictly forbidden to drink alcohol.

How to take Papaverin? Mode of application

Papaverin tablets take orally up to 4 times a day. The dosage of the drug adult is 40-50 mg per reception. Children's dose of papaverine in tablets is established depending on age: Dose 5 mg is prescribed to children from 6 months to 2 years, from 3 to 4 years - 5-10 mg, from 7 to 9 years - 10-15 mg, from 10 to 14 years - 15-20 mg of the drug. The drug can be drunk both before meat and after. Papaverin is also available in capsules.

Methods for introducing funds in injections are different. A solution of papaverine for injection in ampoules is introduced intramuscularly and subcutaneously to 4 times a day in an amount of 1-2 ml for one application. It is allowed intravenous use of the drug. Before pricking injections of papaverine hydrochloride injection divorces 0.9 percent sodium chloride solution. Injection papaverine is used with a comprehensive treatment of cold and to reduce body temperature. For this, papaverin is mixed with analgin and diphedrol.

Papaverin ointment or gel is prescribed with a complicated form of hemorrhoids accompanied by. Papaverin candles are permissible to take only adults 3 times a day at 20-40 mg. Light Papaverin Light spray has easier.

The course of treatment can be from several days to 3 weeks. In what form and how long it is possible to apply papaverin defines the attending physician.

How much does Papaverin act? The drug is quickly absorbed when using injections intravenously. Also quickly act Papaverin candles, giving the desired effect for a few minutes.

Papaverin dropper is assigned to pregnant women in order to save the fetus. The duration of the course of treatment during pregnancy is established by the attending physician.

Papaverin overdose causes general weakness, drowsiness, and also reduces pressure. Due to the rapid absorption of the drug, an overdose may cause strong poisoning and even lead to death.

Description of side effects

From the side of the cardiovascular system, impaired heart rhythm due to an atrioventricular blockade, when they slow down or the pulses between the atrialists and ventricles are stopped. At the same time, tachycardia can be observed and a pressure reduction.

From the digestive system, it is observed:

Nausea;
Bloating;
Violation of food progress in the intestine;
Constipation, may also be diarrhea.

Allergic reactions, eosinophilia, drowsiness and excessive sweating can also be included in the side effects list. Side effect after receiving the drug is quite rare. In most cases, they are observed with independent treatment without a consultation of the doctor and the dosage of the drug.

How to replace the drug? Papaverin analogues and price

But shpa - analogue of papaverine

There are a number of drugs similar in composition and action with papaverine. Analogs of papaverine that provide identical antispasmodic effects are paraverter and but-shpa (it is the same drootserine hydrochloride), spasp. They can be used during pregnancy, patients of the urological and proctological hospital, in pediatric practice for children. Preparations have a rapid painkillers to remove headaches.

Depending on the release form, papaverin can be purchased at the following prices:

In the form of tablets - 16 rubles;
In the form of Papaverin injection costs 45 rubles per package of 10 ampoules;
The price of candles comes up to 70 rubles.