Dangerous consequences of taking diprospan. Diprospan - reviews Side effects of diprospan how to treat

Date of: 02.11.2023

Before the era of non-steroidal anti-inflammatory drugs, glucocorticosteroids were most often used for the treatment of osteochondrosis and other pathologies of the musculoskeletal system. In modern medicine, these drugs have also not lost their importance, but they are used much less frequently and only for certain indications, since they have a lot of side effects and have an impressive list of contraindications. However, in severe inflammatory processes combined with severe pain, which often occurs with osteochondrosis and other diseases of the spine and joints, the prescription of glucocorticosteroids is justified. One of the most popular remedies in this series is Diprospan.

Diprospan packaging option

Description

The drug is a transparent, colorless suspension with a yellowish tint, a slightly viscous consistency, which contains easily suspended whitish particles. There are no foreign impurities in the liquid. Shaking leads to the formation of a stable suspension of yellowish or white color. The drug is available in the form of an injection solution.

Composition and pharmacological action

The active component of Diprospan is betamethasone. It is contained in the drug in two forms:

betamethasone disodium phosphate, which ensures rapid achievement of the effect;
betamethasone dipropionate, which prolongs the therapeutic effect.

The drug exhibits high glucocorticoid and low corticoid activity. The effect of Diprospan in osteochondrosis is due to its influence on various types of metabolism and a pronounced anti-inflammatory effect: its active components suppress the production of substances leading to the development of the inflammatory process. The drug also has an immunosuppressive and antiallergic effect.

Pharmacokinetics

Ampoule with suspension

Betamethasone sodium phosphate has good solubility. Subject to hydrolysis in a short time. Thanks to the rapid absorption of Diprospan, a high rate of achievement of the therapeutic effect is ensured, which is very important during an acute attack of osteochondrosis, accompanied by severe pain. Betamethasone sodium phosphate is almost completely eliminated from the body within 24 hours after use.

Betamethasone dipropionate has slightly different qualities: the process of its absorption from the depot occurs slowly. The substance is metabolized gradually, resulting in a long-lasting effect. It takes more than 10 days to remove this component.

Metabolism occurs in the liver, excretion occurs through the kidneys.

Indications for use

When prescribing Diprospan for the treatment of osteochondrosis, other pathological conditions and diseases in which glucocorticoid therapy makes it possible to achieve the desired result, an important point must be taken into account: for many diseases, such therapy can only be used as an addition to standard treatment.

Diprospan is taken for soft tissue damage

Diseases of the musculoskeletal system for which Diprospan is prescribed include:

spinal osteochondrosis in localized or widespread form;
joint damage of a rheumatoid nature;
lesions of soft tissues and ligaments;
arthritis;
Bekhterev's disease.

In addition, Diprospan is used in the treatment of the following diseases:

allergic;
dermatological;
systemic pathologies of connective tissue;
hemoblastoses;
adrenal insufficiency;
some other diseases and conditions that require treatment with systemic glucocorticosteroid drugs.

Contraindications

For osteochondrosis and any other diseases, there are certain restrictions on the use of Diprospan. In particular, the drug is not prescribed for:

systemic mycoses;
infectious arthritis and joint instability (in case of intra-articular injection);
hypersensitivity to the components of the drug or other glucocorticosteroids.

The use of Diprospan is prohibited in childhood. The drug is not administered subcutaneously or intravenously.

It is prescribed with caution in the presence of the following diseases and conditions:

If Diprospan is used for osteochondrosis or articular pathologies, its further use is considered inappropriate if the two previous administrations were not effective enough or produced a short-term effect. Do not inject the drug into the intervertebral space or infected surfaces.

Pregnancy

During pregnancy, the use of Diprospan for osteochondrosis is not recommended. If the medication is prescribed during lactation, breastfeeding must be stopped.

Use for osteochondrosis

When treating osteochondrosis, the choice of drug is often determined by the preferences of the doctor and his clinical experience. Often, when new tools appear, experts show conservatism. However, in the case of Diprospan, everything turned out quite successfully: the drug won the recognition of doctors in a short time. Their reviews are overwhelmingly positive and indicate the high effectiveness of the drug, which provides a powerful and long-lasting anti-inflammatory effect in a short time. In addition, the use of Diprospan reduces the likelihood of complications. These qualities of the drug are due to its unique microcrystalline structure.

The administration of Diprospan leads to blocking of the inflammatory process that occurs during osteochondrosis at the cellular biochemical level. The drug has an inhibitory effect on substances that provoke an inflammatory reaction.

It should be noted that in the treatment of osteochondrosis and other diseases of a degenerative-dystrophic nature, Diprospan cannot be considered a panacea. It only helps eliminate pain and inflammation.

Since long-term use of Diprospan can lead to the destruction of cartilage tissue, for osteochondrosis it is advisable to combine a corticosteroid with chondroprotectors. They protect cartilage from the aggressive effects of Diprospan and accelerate their regeneration.

Administration of the drug

The injection solution is administered intramuscularly, intradermally, peri- or intra-articularly (into the periarticular area or joint).

Intra-articular administration of the drug

For intramuscular injections, 1-2 ml of the drug is prescribed.
Periarticular administration: 0.2 ml per 1 sq. cm of the skin of the joint.
Intra-articular administration: maximum 2 ml per 1 injection once a week.

Before administration, the drug is slightly warmed up (to body temperature). Intramuscular administration of Diprospan is carried out in the outer upper quadrant of the buttock.

If a blockade with Diprospan is performed for osteochondrosis, it is diluted with lidocaine or novocaine - the choice depends on the individual tolerance of the particular patient. If pain occurs, preliminary local anesthesia is recommended.

Diprospan is a long-acting drug: the active components will remain in the body for about 10 days. Therefore, its use should be limited: the drug can be prescribed a maximum of once every 14-30 days.

Side effects

According to expert reviews, in some cases, the use of Diprospan for osteochondrosis can provoke the development of undesirable reactions. The main ones:

Setting up an injection of diprospan

Metabolic disorders: increased potassium secretion, increased amount of excreted calcium, hypernatremia, negative nitrogen balance, retention of excess fluid in the body, lipomatosis with possible neurological complications, weight gain.
Cardiovascular system: increased blood pressure, development of chronic heart failure.
Musculoskeletal system: steroid myopathy, muscle weakness, loss of muscle mass, increased severity of myasthenic symptoms in myasthenia gravis, osteoporosis, pathological fractures of long bones, joint instability, tendon ruptures, necrosis of the head of the humerus or femur, compression fracture of the spine.
Digestive system: hiccups, flatulence, pancreatitis, damage to the gastrointestinal tract of an erosive-ulcerative nature. Perforation and bleeding are possible.
Dermatological reactions: thinning and atrophy of the skin, impaired wound healing, ecchymoses, petechiae, dermatitis, stretch marks, acne, a tendency to develop candidiasis and pyoderma, worsening reaction to skin tests, increased sweating.
Central and peripheral nervous system: increased intracranial pressure (may be accompanied by papilledema), convulsions, dizziness, headaches, frequent mood changes, insomnia, irritability, tendency to depression, psychotic reactions, euphoria.
Endocrine system: secondary adrenal insufficiency, menstrual irregularities, development of steroid diabetes mellitus, Itsenko-Cushing syndrome, increased need for insulin, decreased carbohydrate tolerance, in children - delayed growth and puberty.
Vision: increased intraocular pressure, exophthalmos, glaucoma, cataracts, rarely - loss of vision.
Allergic reactions: anaphylactic shock, angioedema, arterial hypotension.
Local reactions: skin and subcutaneous atrophy, hyperpigmentation, hypopigmentation, aseptic abscesses.
Other reactions: flushing of the face after injection.

Diprospan is a drug that can be used to quickly relieve inflammation or prevent the proliferation of connective tissue. It effectively suppresses immunological and allergic reactions. It works even when other drugs are powerless, but, being a glucocorticosteroid drug, Diprospan has serious side effects.

Side effects of Diprospan on the central nervous system

Most often, after Diprospan injections are prescribed, side effects occur in the human central nervous system and sensory organs. With long-term use, this medicine may cause:

dizziness;
headache;
convulsions;
insomnia;
increase in intracranial pressure.

If treatment with Diprospan is not stopped, some patients experience damage to the optic nerve. Very often, when using it, sudden mood swings are possible. For example, it can change from joyfully elevated to depressed, while being combined with increased irritability or anxiety. In rare cases, even acute psychoses develop, which are accompanied by a disturbance in the patient’s orientation and the appearance of hallucinations.

The consequences of administering Diprospan in the head or neck area are an increase in intraocular pressure and the formation of cataracts. This can even cause sudden loss of vision. And with long-term use of this medicine, the risk of developing viral, fungal and bacterial eye infections increases.

Side effects of Diprospan on the cardiovascular system

Despite the obvious benefits, Diprospan can also harm the patient’s cardiovascular system, since it promotes the retention of water and sodium in the body, and also removes potassium and calcium, because this provokes a load on the human heart and leads to weakness of the heart muscle. As a result, a person may develop:

cardiovascular failure;
vascular thrombosis;
increased blood pressure.

In case of myocardial infarction, the harm of Diprospan is that the patient slowly forms a scar in the area of necrosis of myocardial tissue, and this leads to myocardial rupture.

Metabolic side effects of Diprospan

According to the instructions, the side effects of Diprospan are also changes in all types of metabolism. Protein metabolism changes as protein breakdown increases, and carbohydrate metabolism changes due to the fact that the amount of glucose in the blood increases significantly and the process of its deposition accelerates. All this leads to fat being accumulated and deposited, mainly in the upper part of the body.

All metabolic changes affect the state of the endocrine system and the consequences of Diprospan injections can be:

development of Itsenko-Cushing syndrome;
exacerbation of diabetes mellitus;

Other side effects of Diprospan

In some cases, under the influence of Diprospan, muscle weakness occurs, and bone tissue loses calcium. It leads to decreased muscle mass and increased bone fragility. After using this drug, aseptic necrosis of the humerus and femur, as well as tendon ruptures, may occur. If Diprospan was used to treat children, then they may experience premature complete closure of growth zones in the bones.

Often, intramuscular administration of this type of drug causes erosive and ulcerative lesions of even a healthy stomach, inflammation of the pancreas, and thinning of the skin. At the injection site of Diprostan, areas of decreased or increased pigmentation and purulent abscesses may appear.

Diprospan is a glucocorticoid drug. This drug has pronounced immunosuppressive, antiallergic and anti-inflammatory effects.

The effect of the drug is provided by two biologically active components: betamesone dipropianate and betamethasone sodium phosphate. The combination of these substances ensures a quick effect and long-lasting action of Diprospan.

Let's consider reviews from doctors about the use of the drug Diprospan in the treatment of patients with pathologies of the musculoskeletal system.

Reviews from doctors about the drug Diprospan

“It is important to convey to the patient that diprospan is still a hormonal drug. This means that there should be no thoughtless and uncontrolled use of the drug. Only strict medical supervision can be the key to effective treatment using diprospan.

As a rule, the course of treatment is limited to three blockades. It is important to maintain an interval of at least 7 days between injections.

Course treatment with this remedy should not be repeated more than 3 times throughout the year. It is important to remember that glucocorticoids can only have beneficial effects when used correctly.

If they are used irrationally, serious complications may develop in various organs, as well as necrotic changes in their tissues.”

Ruslan

“I have been working in traumatology for many years. I am familiar with diprospan firsthand. The most important thing, of course, is for both the doctor and the patient to understand that this remedy is hormonal. These types of drugs require some caution in use.

I most often use diprospan in the form of periarticular (periarticular) injections. I know that many people use it for intra-articular injection, but I believe that such actions are accompanied by too high a risk of infection in the joint cavity.

The best effects from the use of diprospan, in my practice, were achieved in the treatment of enthesopathies (periarthritis), bursitis, periarthrosis, fasciitis, tendonitis and when performing paravertebral blockades in the lumbar region. I believe that diprospan is a fairly affordable, effective and safe remedy in the treatment of pathologies of the musculoskeletal system.”

Alexander

“Diprospan is an effective remedy for eliminating local pain. With adequate use in compliance with doses and frequency of administration, excellent results are achieved with minimal side effects.

The drug is good for muscle and joint pain, as well as for skin pathologies. However, there are patients who, without consulting a doctor, voluntarily begin a course of treatment with inadequate doses of the drug.

Such cases, unfortunately, lead to the development of serious multiple organ complications while taking diprospan. Most often, pathological processes begin to manifest themselves in disturbances in the functionality of the endocrine system, and then in other organs.”

Marina

“I often prescribe this drug to my patients. I believe that diprospan has an optimal price-quality ratio and high efficiency.

Unlike its analogues in terms of the mechanism of action, diprospan rarely causes the development of side effects in the form of local atrophy of soft tissues in the area of drug administration. “Excellent tolerability and high efficiency make the drug an ideal solution for eliminating pain of various etiologies.”

Veronica

“Diprospan has clear indications for use. When used correctly, this product always achieves sufficient effectiveness. I use the drug both intramuscularly and intra-articularly or periarticularly by administering the drug.

Like any glucocorticoid, diprospan can, with long-term use, cause the development of various complications. However, with caution this can be avoided.”

Svetlana

« I actively use diprospan in the practice of a chiropractor. If it is necessary to carry out a drug blockade, I most often use diprospan. This method of treatment is most effective for inflammatory pathologies with a protracted course: lumbodynia, thoracalgia, cervicalgia.

However, the remedy is not ideal. In cases where a non-inflammatory component plays a leading role in the pathogenesis of pain, diprospan is ineffective. However, in such situations, the differential diagnosis of pathology becomes easier.”

Margarita

“Diprospan is a good drug. However, its use is most effective when the solution is locally introduced into the affected area.

With inadequate administration of diprospan into the body, the effectiveness of the drug is insufficient. That is why I recommend using diprospan only as one of the components of anti-inflammatory therapy.”

Svetlana

“Diprospan, like any glucocorticoid drug, has a number of positive effects. However, despite this, it is worth considering that this medication has a number of contraindications.

Thus, the doctor should know that diprospan should not be prescribed for diabetes mellitus, Cushing's syndrome, tuberculosis, skin mycoses, mental disorders, during the period of vaccination, gastric ulcers or infectious diseases. The contraindications already listed make it impossible to use the drug in a large percentage of patients.

It is also important to distinguish the side effects of the drug from other conditions in the body. While taking the drug, side effects may develop such as: surges in blood pressure, Cushing's syndrome, mental disorders, individual intolerance to the drug."

Alexander

“I would like to note the high effectiveness of the drug for rheumatoid arthritis and other pathologies of the musculoskeletal system, since many people know this drug as an antiallergic. As a rule, patients are reluctant to undergo treatment with glucocorticoids, as they associate hormonal drugs with a large number of side effects and lifelong medication use.

However, it is worth explaining to patients that there are a number of pathologies that require the prescription of drugs from this pharmacological group. In addition, treatment with glucocorticoids is a course and, with a properly selected regimen, provides a long-lasting therapeutic effect.”

Hope

“The prescription of diprospan requires high competence and caution from the doctor. Despite the good effectiveness of the drug, diprospan should not be used as a first-line remedy.

This drug should be prescribed strictly according to indications and according to an individually selected dosage regimen and dosage. Careless administration of the drug can lead to the development of serious disorders in the patient’s body.”

Vladimir

“I prescribe diprospan to my patients quite rarely, only in cases of ineffectiveness of other drugs. I believe that such a drug should not be prescribed to everyone, as there are a number of contraindications and side effects.”

Irina

« In my medical practice, I try to use glucocorticoids as little as possible. However, you should not abuse drugs of this series.

When using diprospan, as well as its analogues, it is important to ensure precise delivery of the drug to the site of localization of the pathological process (for diseases of the musculoskeletal system). As a rule, the injection is given deep into the muscle or into the cavity of the diseased joint.

If this drug is administered incorrectly, the effect may be noticeably lower or absent altogether. Glucocorticoids have a pronounced anti-inflammatory effect, but in some cases this is not enough. For pathologies of the musculoskeletal system, an integrated approach to treatment is important.”

Zhanna

“Diprospan is one of the injectable drugs of the glucocoticoid series. The main advantage of this product is that it contains a fast-acting and long-acting form of betamethasone.

Thanks to these components, the effect of using this drug occurs quickly and lasts for some time (the prolonged form of betamethasone is eliminated from the body no earlier than after 10 days). Thus, diprospan can be effectively used both as emergency care for a patient and for planned treatment.”

Anastasia

“I believe that diprospan acts in the same way as other drugs of this pharmacological group. You can use any other glucocorticoid drug with the same success at a more reasonable price.”

Michael

“In my medical practice, I came across a patient who unauthorizedly used Diprospan for joint pain. He started treatment on his own after learning that it helped a neighbor. As a result, Cushing's syndrome, muscle atrophy (at the injection site) and damage to the liver, kidneys, and cardiovascular system developed.

I would like to draw the reader’s attention to the fact that diprospan, like any drug in this group, should be prescribed exclusively by a doctor. In addition to excluding contraindications to the use of the drug, it is necessary to select the dose of the drug and the regimen for its use.”

Stanislav

“I prescribed diprospan to my patients only a few times. In most of these cases, patients noted the development of side effects, such as nausea, weakness, dizziness, increased blood pressure, and weight gain. Perhaps this is just a coincidence, but I decided to use other drugs in this series for myself.”

Diprospan is a drug from the glucocorticosteroid group.

It is characterized by increased glucocorticoid activity and insignificant mineralocorticoid activity. The drug has an immunosuppressive and antiallergic effect, has a pronounced and varied effect on all types of metabolic processes in the human body.

The main active ingredient of Diprospan is betamethasone sodium phosphate. It is highly soluble in liquid and, after intramuscular administration, is quickly absorbed from the injection site and undergoes hydrolysis.

On this page you will find all the information about Diprospan: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Diprospan injections. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

GCS for injection is a combination of a depot form and a fast-acting form.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much do Diprospan injections cost? The average price in pharmacies is:

220 rubles – per package with 1 ampoule;

800 rubles – for a package of 5 ampoules.

Release form and composition

The drug Diprospan is presented on the pharmacological market in the form of a suspension for injection use (intramuscular, intra-articular, periarticular injections). Ampoules with suspension (volume 1 ml) are placed in cardboard packages of 1 or 5 ampoules.

The main active ingredient of Diprospan is betamethasone. As part of the medicine, it is presented in two forms:

betamethasone sodium phosphate (2 mg per 1 ml) – provides a rapid onset of therapeutic effect;

betamethasone dipropionate (5 mg per 1 ml) – prolongs the therapeutic effect, promotes prolonged action of the drug.

The substance is completely eliminated from the body in the form of inactive metabolites by the kidneys. It is for this reason that for people with diseases or partial kidney dysfunction, the use of Diprospan is indicated only in extreme cases.

Pharmacological effect

The drug belongs to the group of glucocorticosteroids. The main effect of Diprospan is associated with pronounced glucocorticoid activity; the mineralocorticoid effect is practically not expressed. The action of Diprospan is aimed at suppressing inflammation, allergic reactions, and immunosuppression. Inhibits the function of the pituitary gland.

Diprospan is a medicine that consists of two active components with different rates of action.

One of them, betamethasone sodium phosphate, easily dissolves, hydrolyzes and is absorbed after administration, providing a rapid therapeutic effect. Discharged within 24 hours. The other, betamethasone dipropionate, creates a depot after administration, from which it is released gradually. As a result, a long-lasting effect of the drug is ensured. The time for complete elimination is 10 days or more.

Diprospan crystals are very small, which allows it to be inserted into small joints through a very thin needle.

Indications for use

What does it help with? Diprospan is prescribed in the following cases:

Adrenal cortex insufficiency.

Hemoblastoses: tumor pathologies of hematopoietic and lymphatic tissue.

Allergic diseases: hay fever, drug allergies, allergic bronchitis, insect bite allergy, serum sickness.

Diseases of the soft tissues and musculoskeletal system: bursitis, osteoarthritis, epicondylitis, lumbago, radiculitis, torticollis, foot diseases, fasciitis.

Systemic connective tissue diseases: dermatomyositis, periarteritis nodosa, scleroderma,.

Other pathological conditions and diseases: nephrotic syndrome, nephritis, ulcerative colitis, malabsorption syndrome, adrenogenital syndrome, regional ileitis.

Dermatological diseases: monetoid, severe photodermatitis, pemphigus vulgaris, herpetic dermatitis and cystic acne.

Contraindications

Diprospan injections can be used for treatment only as prescribed by a doctor. Before starting therapy, the patient should carefully read the accompanying instructions, since the medicine has a number of the following contraindications:

Intravenous and subcutaneous administration;

Fungal skin infections;

Children under 3 years of age (due to benzyl alcohol included in the composition);

Individual intolerance to the components of the drug;

Administration of the drug into the intervertebral spaces affected by the infectious process;

Infectious arthritis - for intra-articular administration.

Diprospan injections are prescribed with caution to patients with the following conditions:
Use during pregnancy is possible only in case of urgent need, since the substances included in the solution and suspension penetrate the placental barrier to the fetus. If pregnancy occurs during Diprospan therapy, you should not abruptly discontinue the medicine - a drug withdrawal plan should be drawn up by a doctor, taking into account the underlying disease, as well as concomitant pathologies and problems.

During lactation, one should also take into account the fact that glucocorticoids are excreted in small quantities into breast milk.

Instructions for use

The instructions for use indicate that the dose of Diprospan and the method of administration depend on the clinical picture and severity of the disease.

For intramuscular administration, a dose of 1-2 ml is used. The drug is injected deep into the gluteal muscle.

When administered intradermally into the lesion, one dose should contain no more than 0.2 ml/cm2, and the total dosage per week should not exceed 1 ml.

If periarticular and intraarticular administration is necessary, the dosage can vary from 0.25 to 2 ml. Here you need to take into account the size of the joint.

If local infiltration is used, then diprospan is dosed as follows: for tenosynovitis and synovial cyst - 0.25-0.5 ml, for bursitis - from 0.25 to 1-2 ml, for fibrositis and myositis - from 0.5 to 1 ml, for tendonitis – 0.5 ml.

The injection of this drug is not painful, but in exceptional cases diprospan can be combined with an anesthetic. For pain relief, a local anesthetic is used - a one percent solution of lidocaine or procaine, which is mixed with the drug in one syringe.

Side effects

When using the drug Diprospan, the following undesirable side reactions may develop:

Allergic reactions.

Menstrual irregularities.

In diabetes mellitus there is an increased need for the use of hypoglycemic drugs.

Headache, dizziness, development of depression, convulsions.

Nitrogen imbalance, weight gain.

With parenteral administration: development of aseptic abscesses, skin hyperemia, flushing.

Increased blood pressure, development of chronic heart failure.

Development of erosive and ulcerative lesions of the gastrointestinal tract, risk of bleeding.
Development of muscle weakness, joint instability, tendon ruptures, osteoporosis, aseptic necrosis of the head of the humerus or femur.

Intra-articular administration of the drug may cause the following side effects:

blood poisoning (sepsis);

damage to nerve endings, cartilage tissue and tendons;

bone necrosis (aseptic);

microcrystalline arthritis;

hemorrhages into the joint cavity.

With a single use or small doses, Diprospan is well tolerated by all age categories of patients.

Overdose

Symptoms of overdose include nausea, sleep disturbance, euphoria, agitation or depression. When using high doses, manifestations of systemic osteoporosis, fluid retention in the body, and increased blood pressure are possible.

Treatment is gradual withdrawal of the drug, supporting the body by correcting the electrolyte balance, taking antacids, phenothiazines, and lithium preparations. According to the instructions, when Cushing's syndrome develops, aminoglutethimide is taken.

special instructions

Glucocorticoids increase tolerance to ethyl alcohol, reducing its toxic effect on the body. At the same time, the concentration of alcohol in the blood remains the same. This allows the use of these hormonal drugs in the treatment of ethyl alcohol poisoning.

Diprospan can be mixed with solutions of local anesthetics in equal volumes. It is unacceptable to use the medication in the treatment of hyaline membrane disease in newborns. The drug should not be injected into the intervertebral spaces, into infected areas and unstable joints. Before starting treatment, it is necessary to conduct an examination: a general blood test, blood glucose levels, electrolytes. For concomitant tuberculosis, sepsis, and intercurrent infections, antibiotics are administered simultaneously.

Drug interactions

Diprospan may enhance potassium excretion caused by amphotericin B.

When using corticosteroids and estrogens simultaneously, it may be necessary to adjust the dose of the drugs (due to the risk of overdose).

When used together, GCS can reduce the concentration of salicylates in the blood plasma.

The simultaneous use of corticosteroids and cardiac glycosides increases the risk of arrhythmia or digitalis intoxication (due to hypokalemia).

Simultaneous administration of GCS and somatotropin may slow down the absorption of the latter (administration of betamethasone in doses exceeding 0.3-0.45 mg/m2 of body surface area/day should be avoided).

With the combined use of GCS with NSAIDs, with ethanol or ethanol-containing drugs, it is possible to increase the frequency or intensity of erosive and ulcerative lesions of the gastrointestinal tract.

When using the drug Diprospan and indirect anticoagulants together, changes in blood clotting are possible, requiring dose adjustment.
When using the drug Diprospan and potassium-sparing diuretics together, the likelihood of developing hypokalemia increases.

GCS may interfere with the nitrogen blue tetrazole test for bacterial infection and cause a false negative result.

When the drug Diprospan is prescribed simultaneously with phenobarbital, rifampin, phenytoin or ephedrine, it is possible to accelerate the metabolism of betamethasone while reducing its therapeutic activity.

"Diprospan" refers to proven long-acting drugs for the treatment of diseases of the musculoskeletal system. The contraindications and side effects of Diprospan are quite impressive, so before using the product you need to make sure that the benefits of treatment will be higher than the possible harm.

"Diprospan" is available in the form of injection solutions, which are made subcutaneously or intramuscularly, and are also used for administration through a dropper. The high speed of exposure speaks in favor of the use of the drug "Diprospan", and the contraindications are discussed in detail below.

The therapeutic effect of the composition is very diverse. "Diprospan" has an anti-inflammatory effect that lasts for 72 hours after administration. Other advantages of the drug include:

antiallergic effect,

anti-shock effect,

immunomodulatory property,

desensitizing effect.

The drug is used to treat acute diseases and relieve symptoms of shock. "Diprospan" has established itself as a reliable product with high efficiency.

Diprospan: scope

The drug is a glucocorticoid drug and has an impressive list of side effects, however, the contraindications are not so great, because the drug is often administered in emergency cases when other treatment methods are ineffective. The drug begins to act within 10 minutes. Direct indications for the use of Diprospan are:

acute pain accompanying injury;

inflammatory diseases of the musculoskeletal system;

specific polyarthritis;

extra-articular rheumatism;

all types of pain shock: burn, traumatic, postoperative, etc.;

acute hepatitis;

connective tissue diseases;

neoplasms, including malignant ones.

For intramuscular administration, a dosage of 2 ml is sufficient. The injection is not painful, but under certain conditions the product may be recommended for use simultaneously with the anesthetic.

The drug must not be administered intravenously. "Diprospan" has a pronounced analgesic effect and can be recommended for any acute pain. During treatment you should not drink alcohol in any form. Vaccinations should also not be done during treatment with Diprospan.

The drug can be recommended for hepatic coma, cerebral edema, and nonspecific ulcerative colitis. If an anaphylactoid reaction occurs, a single dose of the drug should be immediately administered intramuscularly. For the treatment of joint diseases, the dosage is determined individually. When carrying out local infiltration, a single dosage of the drug can range from 0.25 to 2 ml, depending on the severity of the disease and its location.

Side effects and contraindications

"Diprospan" is often used in emergency cases, so the only serious contraindication to its use is individual intolerance. If we are talking about long-term therapy, then direct contraindications are:

tuberculosis,

HIV infection,

renal dysfunction,

bleeding disorder,

pregnancy and lactation,

mental disorders,

diabetes.

The list of contraindications is very wide. Local injections should be used with caution if you have skin problems. Dermatoses and eczema are direct contraindications to local therapy. In this case, the drug can be used only intramuscularly.

The side effects of Diprospan are also quite extensive. Most often they occur as a result of a drug overdose. Therefore, when carrying out complex therapy, possible side effects should be taken into account, including:

muscle weakness – observed when treating joints using local infiltration;

Mood swings – emotional instability caused by anxiety. A number of patients experience increased intracranial pressure, which also has a negative effect on the psycho-emotional state.

edema – fluid retention in tissues is caused by deterioration of the urinary system. Along with this, there is an increase in sodium levels in the blood and a sharp decrease in calcium and potassium;

metabolic disorders – leads to weight gain;

Digestive problems – common side effects include nausea, diarrhea, bloating. Less common are ulcerative lesions of the gastric mucosa, which can develop with prolonged use of the drug.