Nimesil from what. Nimesil ® (Nimesil ®)

The date: 09.10.2021

In this article, you can read the instructions for using the drug Nimesil. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Nimesil in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Nimesil in the presence of existing structural analogues. Use for the treatment and relief of pain in various diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Nimesil- non-steroidal anti-inflammatory drug from the class of sulfonamides. It has anti-inflammatory, analgesic and antipyretic effects. Nimesulide acts as an inhibitor of the cyclooxygenase enzyme responsible for the synthesis of prostaglandins and inhibits mainly cyclooxygenase 2.

Compound

Nimesulide + excipients.

Pharmacokinetics

After oral administration, the drug is well absorbed from the gastrointestinal tract. Easily penetrates through histohematic barriers. Nimesulide (the active substance of the drug Nimesil) is excreted from the body, mainly by the kidneys (about 50% of the dose taken). With repeated administration of the drug, cumulation is not observed.

Indications

treatment of acute pain (pain in the back, lower back; pain in the musculoskeletal system, including injuries, sprains and dislocations of the joints, tendonitis, bursitis; toothache);
symptomatic treatment of osteoarthritis with pain syndrome;
algomenorrhea.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use.

Release form

Powder or granules for oral suspension 100 mg.

Forms in the form of tablets at the time of the description of the drug in the directory did not exist.

Instructions for use and regimen

Nimesil is taken orally, 1 sachet (100 mg of nimesulide) 2 times a day. The drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in about 100 ml of water. The prepared solution cannot be stored.

Nimesil is used only for the treatment of patients older than 12 years.

Adolescents (aged 12 to 18 years): based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents.

Elderly patients: in the treatment of elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs.

The maximum duration of treatment with nimesulide is 15 days.

To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course.

Side effect

anemia;
eosinophilia;
hemorrhagic syndrome;
thrombocytopenia;
pancytopenia;
thrombocytopenic purpura;
rash;
increased sweating;
dermatitis;
anaphylactoid reactions;
hives;
angioedema;
dizziness;
nervousness;
headache;
drowsiness;
blurry vision;
arterial hypertension;
tachycardia;
dyspnea;
exacerbation of bronchial asthma;
bronchospasm;
diarrhea, constipation;
nausea, vomiting;
stomach ache;
dyspepsia;
stomatitis;
tarry stool;
gastrointestinal bleeding;
ulcer and / or perforation of the stomach or duodenum;
jaundice;
hematuria (blood in the urine);
urinary retention;
hyperkalemia.

Contraindications

history of hyperergic reactions, for example, bronchospasm, rhinitis, urticaria, associated with the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs), incl. nimesulide;
hepatotoxic reactions to nimesulide in history;
concomitant (simultaneous) use of drugs with potential hepatotoxicity, for example, paracetamol or other analgesic or non-steroidal anti-inflammatory drugs;
inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
the period after coronary artery bypass grafting;
fever in infectious and inflammatory diseases;
complete or partial combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses with intolerance to acetylsalicylic acid and other NSAIDs (including history);
peptic ulcer of the stomach and duodenum in the acute phase, the presence of a history of ulcers, perforation or bleeding in the gastrointestinal tract;
a history of cerebrovascular bleeding or other bleeding, as well as diseases accompanied by bleeding;
severe blood clotting disorders;
severe heart failure;
severe renal failure (CC less than 30 ml / min), confirmed hyperkalemia;
liver failure or any active liver disease;
children's age up to 12 years;
pregnancy and breastfeeding period;
alcoholism (simultaneous intake with alcohol is prohibited due to the risk of bleeding from the gastrointestinal tract), drug addiction;
hypersensitivity to the components of the drug.

Use during pregnancy and lactation

Like other drugs of the NSAID class that inhibit the synthesis of prostaglandins, Nimesil can adversely affect the course of pregnancy and / or the development of the embryo and may lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which may progress to renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and during breastfeeding.

special instructions

Unwanted side effects can be minimized by using the lowest effective dose of the drug for the shortest possible course.

Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.

The risk of gastrointestinal bleeding, ulceration or perforation of the ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially complicated by bleeding or perforation, as well as in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also increase the risk of gastrointestinal bleeding. In the event of gastrointestinal bleeding or ulcers in patients taking Nimesil, treatment with the drug should be discontinued.

Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.

There is evidence of the occurrence of rare cases of reactions from the liver. If there are signs of liver damage (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of "liver" transaminases), you should stop taking the drug and consult your doctor.

Despite the rare occurrence of visual impairment in patients taking nimesulide simultaneously with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.

The drug can cause fluid retention in the tissues, so patients with high blood pressure and cardiac disorders should use Nimesil with extreme caution.

In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be discontinued.

Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There are not enough data to exclude the risk of such events when using nimesulide.

The composition of the drug includes sucrose, this should be taken into account for patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and people on a low-calorie diet. Nimesil is not recommended for patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.

Nimesil should not be used simultaneously with other NSAIDs.

Nimesulide can change the properties of platelets, so care must be taken when using the drug in people with hemorrhagic diathesis, but the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforations, deterioration of kidney, liver and heart function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.

Like other NSAIDs that inhibit prostaglandin synthesis, nimesulide may adversely affect pregnancy and/or fetal development and may lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which may progress to renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can adversely affect female fertility and is not recommended for women planning a pregnancy. When planning pregnancy, consultation with your doctor is necessary.

Simultaneous administration of the drug Nimesil with alcohol is prohibited due to the risk of bleeding from the gastrointestinal tract.

There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first sign of a skin rash, mucosal lesions or other signs of an allergic reaction, Nimesil should be discontinued.

The effect of the drug on the ability to drive vehicles and control mechanisms

The effect of Nimesil on the ability to drive vehicles and control mechanisms has not been studied, therefore, during the period of treatment with Nimesil, care should be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

drug interaction

Pharmacodynamic Interactions

When combined with glucocorticosteroids, the risk of gastrointestinal ulcers or bleeding increases.

When combined with antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, the risk of gastrointestinal bleeding increases.

NSAIDs may increase the effect of anticoagulants such as warfarin. Due to the increased risk of bleeding, this combination is not recommended and contraindicated in patients with severe coagulation disorders. If combination therapy still cannot be avoided, careful monitoring of blood coagulation parameters should be carried out.

Diuretics

NSAIDs can weaken the effect of diuretics.

In healthy volunteers, nimesulide temporarily reduces the excretion of sodium under the action of furosemide, to a lesser extent - the excretion of potassium, and reduces the actual diuretic effect.

Co-administration of Nimesil and furosemide leads to a decrease (approximately 20%) in the area under the concentration-time curve (AUC) and a decrease in the cumulative excretion of furosemide without changing the renal clearance of furosemide.

The co-administration of furosemide and nimesulide requires caution in patients with impaired renal and cardiac function.

ACE inhibitors and angiotensin II receptor antagonists

NSAIDs may reduce the effect of antihypertensive drugs. In patients with mild to moderate renal insufficiency (CC 30-80 ml / min) with the joint appointment of ACE inhibitors, angiotensin 2 receptor antagonists or substances that suppress the cyclooxygenase system (NSAIDs, antiplatelet agents), further deterioration of renal function and the occurrence of acute renal failure are possible. which is usually reversible. These interactions should be considered in patients taking Nimesil in combination with ACE inhibitors or angiotensin 2 receptor antagonists. Therefore, the combined use of these drugs should be prescribed with caution, especially for elderly patients. Patients should be adequately hydrated and renal function should be closely monitored after initiation of concomitant therapy.

Pharmacokinetic interactions with other drugs

There is evidence that NSAIDs reduce the clearance of lithium, which leads to an increase in the concentration of lithium in the blood plasma and its toxicity. When prescribing nimesulide to patients receiving lithium therapy, regular monitoring of plasma lithium concentrations should be carried out.

No clinically significant interactions have been observed with glibenclamide, theophylline, digoxin, cimetidine, and antacids (eg, a combination of aluminum and magnesium hydroxides).

When prescribing nimesulide less than 24 hours before or after taking methotrexate, caution is required, since in such cases the plasma level of methotrexate and, accordingly, the toxic effects of this drug may increase.

In connection with the action on renal prostaglandins, prostaglandin synthetase inhibitors, which include nimesulide, can increase the nephrotoxicity of cyclosporins.

Interaction of other drugs with nimesulide

Studies have shown that nimesulide is displaced from the binding sites by tolbutamide, salicylic acid and valproic acid. Despite the fact that these interactions were determined in blood plasma, these effects were not observed during the clinical use of the drug.

Analogues of the drug Nimesil

Structural analogues for the active substance:

Actasulide;
Ameolin;
Aponil;
Aulin;
Cockstral;
Mesulide;
Nise;
Nemulex;
Nimegesik;
Nimesulide;
Nimika;
Nimulid;
Novolid;
Prolid;
Sulaidin;
Florida.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Modern pharmacological firms are full of a variety of painkillers and antipyretics. Such drugs are probably in every home first aid kit. They help the patient quickly get rid of pain and fever, which can appear suddenly. Practice shows that one of the most effective and sought-after medicines is Nimesil. Instructions, reviews and description of the drug will be given for your attention in today's article. You will also find out how you can replace this tool.

What is Nimesil?

"Nimesil" is a powder that is produced by a German pharmacological company. It contains the medicinal substance nimesulide. The drug is packaged in sachets, each containing 100 mg of the main component and 2 grams in total. The manufacturer here uses additional components: sucrose, citric acid, ketomacrogol, maltodextrin and orange flavor.

"Nimesil" - has analgesic and antipyretic effects. It is also able to eliminate the inflammatory process that occurs in the body. The drug is included in the list of non-steroidal anti-inflammatory drugs that are sold without a prescription. The cost of 30 bags is about 700-800 rubles. Some pharmacies sell sachets by the piece.

The manufacturer about the drug

The annotation says that Nimesil is a great way to get rid of pain caused by various reasons. The medication is used when:

I have a toothache;
pain occurs after surgery or minimally invasive interventions;
the patient is diagnosed with arthritis or other pathologies of the musculoskeletal system, accompanied by pain.

The medicine effectively eliminates fever, which may occur with infectious diseases or for other reasons. The use of Nimesil powder is a way to eliminate the inflammatory process occurring in the joints and soft tissues. Also, the medication is used for vascular, gynecological and urological pathologies.

Contraindications for use

Before using the drug "Nimesil", instructions for use (reviews say this) should be carefully read. Particular attention should be paid to the point where contraindications are stipulated. If you have the same at least one, then the use of the medication should be abandoned. Powder "Nimesil" is contraindicated:

with high sensitivity of the patient's body to the active substance or other components;
ulcerative lesions of the intestine or stomach;
bleeding in the digestive tract;
pregnancy, as it can have a negative effect on its course and the formation of the fetus;
breastfeeding due to unhindered penetration into milk;
increased pressure;
kidney failure.

It is forbidden to use the medicine in pediatrics, unless otherwise specified by the doctor individually.

"Nimesil": application

Reviews about the drug say that it is quite pleasant to take it. The drug is taken orally in liquid form, it has a sweet taste and does not cause disgust. The instruction recommends using the medicine only after eating, since the active substance can adversely affect the gastric mucosa.

A single dose of the drug is 100 mg of nimesulide, which is equal to one sachet. In case of urgent need, the portion of the medicine can be doubled. The daily norm of the drug is 200 mg, it should not be exceeded on its own.

Before taking it is necessary to prepare the medication. How to breed "Nimesil", the instruction tells in detail. To do this, you will need 250 ml of clean drinking water. Pour the powder into a container and mix thoroughly. Drink the solution when the granules are completely dissolved. Do not store finished medicine. Dilute a new dose before each dose.

Consequences of therapy

It is expected that the drug will have a positive effect on the human body in the form of lowering fever and eliminating pain. The drug blocks the synthesis of prostaglandins in the focus of inflammation. The tool works for at least 6 hours. But for some people, the medication works differently. It causes side reactions, which can be expressed as follows:

disorders of the digestive system (heartburn, abdominal pain, diarrhea or constipation, nausea);
effects on the central nervous system (dizziness, headache, fatigue and drowsiness);
allergies (skin rash and itching,;
violations of the outflow of fluid (edema, malfunction of the kidneys).

If one or more of the described symptoms appear, you should immediately stop treatment and seek help from a medical institution.

Additional information about the medication

The manufacturer tells a lot of important information about the drug, which must be taken into account if you are going to take the claimed remedy:

"Nimesil" for young children is not prescribed under any circumstances. Adolescents can be treated, but only if prescribed by a doctor, taking into account the benefits and risks. In each situation, an individual dose of the drug is selected.
Patients with a history of gastrointestinal diseases should use the medicine with extreme caution, as pathologies may worsen. To reduce the risk, it is necessary to take the minimum dose of the drug in a short course.
The drug contains sucrose. This should be noted in patients with diabetes, fructose intolerance, or those on a low-calorie diet.
Nimesil should not be combined with other drugs of the NSAID group.
Medicines that reduce blood clotting, taken together with Nimesil, enhance their effect.

Analogues

You can replace the drug with similar means based on nimesulide. You can choose from the following medications:

"Nimulid" - a syrup approved for use in children from the age of one;
"Nise" - tablets containing 100 mg of active ingredient in each pill;
"Nimesulide" - granules for the preparation of a solution;
"Nemulex" - granules acceptable for use in children from 12 years old;
"Aponil" - tablets of 100 mg;
"Nimika" - dispersible tablets.

If for some reason Nimesil is not suitable for you, you can choose tablets based on another active ingredient. Safer means are drugs based on ibuprofen and paracetamol. Trade names of such drugs: "Kalpol", "Panadol", "Nurofen", "Ibuklin" and so on. You can buy them without a prescription in almost every pharmacy chain. You can replace the drug "Nimesil" with the help of "Diklovit", "Ketorol", "Ketonal" and many others. If the claimed medicine does not suit you, then contact a specialist to select an alternative remedy.

Nimesil is a medical drug that belongs to the group of anti-inflammatory non-hormonal drugs.

The active ingredient is nimesulide, a substance that relieves pain, reduces temperature, and fights the inflammatory process. The tablets act as an inhibitor of cyclooxygenase extracts, which is responsible for the formation of prostaglandins and inhibits mainly cyclooxygenase-2.

Nimesil is prescribed for the treatment of infectious diseases, the fight against degenerative inflammatory pathologies of the musculoskeletal system (osteochondrosis, arthritis, rheumatism, bursitis, osteoarthritis, radiculitis), the elimination of fever of various origins, the treatment of vascular, gynecological and urological diseases.

Clinical and pharmacological group

NSAIDs. Selective COX-2 inhibitor.

Terms of dispensing from pharmacies

Released without a doctor's prescription.

Prices

How much does Nimesil cost in pharmacies? The average price is at the level of 900 rubles for a pack of 30 bags. For comparison, the price for 1 sachet of Nimesil is 25-32 rubles.

Release form and composition

The drug Nimesil is available in the dosage form of a powder for the preparation of a suspension, which is intended for oral administration. It has a light green color, coarse grain and an orange smell. The main active ingredient of the drug is nimesulide, its content in 1 sachet of powder is 100 mg.

The drug also contains additional compounds, which include:

Ketomacrogol.
Anhydrous citric acid.
Sucrose.
Orange flavor.
Maltodextrin.

Nimesil powder is packaged in aluminum foil bags of 2 g each. A cardboard pack contains 9, 15 or 30 bags.

Pharmacological effect

The therapeutic effect of the drug Nimesil, the instruction indicates this, is due to the fact that it affects the metabolism of arachidonic acid by inhibiting cyclooxygenase (COX), which reduces the biosynthesis of prostaglandins.

The drug has a selective (selective) effect on COX-2, due to which the formation of prostaglandins with cytoprotective properties in the gastric mucosa is not disturbed. In this case, the risk of adverse reactions is reduced. The drug reduces the production of superoxide anions by neutrophils, and also inhibits the formation of free radicals that appear during the inflammatory process.

Indications for use

What is Nimesil for? This drug is prescribed for the diagnosis of the following diseases:

Gynecological and urological diseases;
Pain syndrome - menstrual, traumatic, rheumatic, postoperative origin;
Inflammatory and infectious diseases, including postoperative and traumatic inflammations;
Inflammatory and degenerative diseases affecting the musculoskeletal system - bursitis;
Diseases that are accompanied by high fever.

The drug is relevant as a means for long-term therapy and can be used to dull the pain syndrome.

Contraindications

Nimesil powder should not be taken if a person has certain pathological processes or physiological conditions, which include:

The patient's age is less than 12 years.
Individual intolerance to any of the components of the drug.
Recovery period after coronary artery bypass surgery.
A history of diseases accompanied by increased bleeding, hemorrhagic stroke of the brain.
Severe disorders, accompanied by a violation of blood coagulation (decrease in the functional activity of the hemostasis system).
A pronounced decrease in the functional activity of the heart (severe heart failure).
The combined use of drugs that have a negative effect on the state of the liver (hepatotoxic drugs).
Past gastrointestinal bleeding, including on the background of peptic ulcer.
Hypersensitivity (hypersensitization) of the body to acetylsalicylic acid, including those suffered in the past and accompanied by bronchospasm (allergic bronchitis), inflammation of the nasal mucosa, urticaria.
Severe renal or hepatic failure.
Chronic alcoholism or drug addiction.
Pregnancy or the period of breastfeeding (lactation) in a woman.
Non-infectious inflammatory chronic bowel diseases in the acute stage (ulcerative colitis).
Feverish conditions, accompanied by an increase in body temperature, in particular in acute respiratory viral pathology, bacterial infections.
The presence of allergic diseases, including a combination of polynosis, bronchial asthma, as well as intolerance to acetylsalicylic acid, which is non-steroidal anti-inflammatory drugs.
A peptic ulcer characterized by a violation of the integrity of the mucous membrane of the stomach or duodenum. This is due to the fact that the drug Nimesil partially reduces the level of prostaglandins, which are responsible for protecting the mucous membrane of the upper gastrointestinal tract from aggressive factors (hydrochloric acid of gastric juice).

With caution, Nimesil powder is used for concomitant type 2 diabetes mellitus, high blood pressure (arterial hypertension), coronary heart disease, clopidogrel, heparin and its analogues), as well as hormonal anti-inflammatory drugs (glucocorticosteroids), peripheral arterial pathology, smoking, concomitant use of drugs that reduce blood clotting (non-steroidal anti-inflammatory drugs.

Dosage and method of application

The instructions for use indicate that Nimesil is taken orally, 1 sachet (100 mg of nimesulide) 2 times / day. The drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in about 100 ml of water. The prepared solution cannot be stored.

Nimesil is used only for the treatment of patients older than 12 years.

Adolescents (aged 12 to 18 years): based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents.
Patients with impaired renal function: based on pharmacokinetic data, there is no need to adjust the dose in patients with mild to moderate renal insufficiency (CC 30-80 ml / min).
Elderly patients: in the treatment of elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs.

The maximum duration of treatment with nimesulide is 15 days.

To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course.

How to breed Nimesil?

To prepare the solution, take 1 sachet and pour the contents into a glass. Then pour it with 100 ml of water. Stir thoroughly so that the mixture acquires a more pronounced color. The dosage of the drug can be adjusted by the doctor, focusing on the severity of the pathology and the general condition of the patient.

Side effects

The use of the drug Nimesil can cause the following side effects:

Sense organs: blurred vision.
Respiratory system: bronchospasm, exacerbation of asthma, shortness of breath.
Bile system and liver: fulminant hepatitis, hepatitis, cholestasis, jaundice.
Cardiovascular system: tachycardia, hypertension, hot flashes, pressure lability.
CSC: feeling of fear, dizziness, nightmares, nervousness, drowsiness, headache, encephalopathy.
Lymphatic and circulatory system: eosinophilia, anemia, thrombocytopenia, hemorrhages, thrombocytopenic purpura, pancytopenia.
Allergic reactions: rash, itching, hypersensitivity reactions, increased sweating, dermatitis, erythema, urticaria, anaphylactoid reactions, erythema multiforme, angioedema, Lyell's syndrome, Stevens-Johnson syndrome.
Gastrointestinal tract: nausea, diarrhea, constipation, vomiting, gastritis, flatulence, stomach pain, stomatitis, dyspepsia, bleeding in the stomach, tarry stools, ulcer.
Urinary system and kidneys: hematuria, dysuria, renal failure, urinary retention, interstitial nephritis, oliguria.

Overdose

Nimesil quickly relieves pain and its effect lasts up to six to eight hours. With severe inflammation and unbearable pain, more frequent use is allowed - up to 3-4 times a day. But such use of it cannot last more than one day. If an overdose occurs, and the body reacts with bloating, vomiting or hives, it is necessary to wash the stomach and drink activated charcoal.

With severe symptoms of poisoning, when home methods do not help, you should consult a doctor.

special instructions

Before you start using the drug, read the special instructions:

Nimesil should not be used simultaneously with other NSAIDs.
If there are signs of a “cold” or an acute respiratory viral infection during treatment with Nimesil, the drug should be discontinued.
Unwanted side effects can be minimized by using the lowest effective dose of the drug for the shortest possible course.
Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.
Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.
The risk of gastrointestinal bleeding, ulceration or perforation of the ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially complicated by bleeding or perforation, as well as in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also increase the risk of gastrointestinal bleeding. In the event of gastrointestinal bleeding or ulcers in patients taking Nimesil, treatment with the drug should be discontinued.
Despite the rare occurrence of visual impairment in patients taking nimesulide simultaneously with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.
There is evidence of the occurrence of rare cases of reactions from the liver. If signs of liver damage appear (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of “liver” transaminases), you should stop taking the drug and consult your doctor.
In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be discontinued.
The drug can cause fluid retention in the tissues, so patients with high blood pressure and cardiac disorders should use Nimesil with extreme caution.
The composition of the drug includes sucrose, this should be taken into account for patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and people on a low-calorie diet. Nimesil is not recommended for patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.
Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There are not enough data to exclude the risk of such events when using nimesulide.
Nimesulide can change the properties of platelets, so care must be taken when using the drug in people with hemorrhagic diathesis, but the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.
Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforations, deterioration of kidney, liver and heart function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.
There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first sign of a skin rash, mucosal lesions or other signs of an allergic reaction, Nimesil should be discontinued.
Like other NSAIDs that inhibit prostaglandin synthesis, nimesulide may adversely affect pregnancy and/or fetal development and may lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which may progress to renal failure. with oligodyramnia, to an increased risk of bleeding, a decrease in uterine contractility, the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can adversely affect female fertility and is not recommended for women planning a pregnancy. When planning pregnancy, consultation with your doctor is necessary.

drug interaction

When using the drug, it is necessary to take into account the interaction with other drugs:

Nimesulide is able to stimulate the nephrotoxicity of cyclosporins.
Anti-inflammatory non-steroidal drugs can weaken the effects of diuretics.
With simultaneous use with glucocorticosteroids, the risk of ulcers or bleeding from the stomach and intestines increases.
Anti-inflammatory non-steroidal drugs can enhance the effects of anticoagulants, so this combination is not recommended for people with severe coagulation disorders. If this combination still can not be avoided, it is necessary to carefully monitor the parameters of blood clotting.
When used with antiplatelet agents and selective serotonin reuptake inhibitors, the likelihood of bleeding from the stomach or intestines is also increased.
Nimesulide is able to temporarily reduce the evacuation of sodium and potassium under the influence of Furosemide and thereby weaken the diuretic effect of the latter. It must also be remembered that such co-administration of drugs requires caution in individuals with impaired renal and cardiac function.
Anti-inflammatory non-steroidal drugs reduce the clearance of lithium, which causes an increase in the level of the latter in the blood.
When prescribing Nimesil less than a day before or after the use of Methotrexate, care must be taken, since in such cases the content of Methotrexate in the blood and its toxic effects may increase.
Anti-inflammatory non-steroidal agents may weaken the effect of antihypertensive agents. In persons with compensated renal insufficiency, while prescribing ACE blockers, angiotensin receptor antagonists of the second type, or agents that suppress cyclooxygenase, progression of deterioration in kidney function and the development of reversible acute renal failure is possible.

One of the means of choice for eliminating acute pain is "Nimesil" powder. This drug has a good short-term effect, but it is dangerous with the potential occurrence of many side effects. The best recommendation in this case would be to refuse the self-administration of potent drugs.

The sachet contains small granules for the preparation of a suspension. The taste of the drink is improved by orange flavor, sweetener and citric acid. Macrogol polymer and maltodextrin are added to the powder to maintain the structure of the suspension.

The main active ingredient is the substance nimesulide. A serving prepared from one sachet contains 0.1 g of this component.

Pharmacological properties and indications for use

Answering the question of what Nimesil helps with, you should immediately say that it does not have a therapeutic effect - they drink the suspension as an anesthetic.

It relieves sensations in the following conditions:

joint pain;
pain during the menstrual cycle;
acute muscle pain, including after injuries and sprains;
pain syndrome due to inflammation of the teeth and gums.

The active ingredient blocks receptors that are sensitive to pain mediators.

As a result, when inflammatory agents are thrown into the intercellular space, the nerve endings simply cease to perceive them. Acute sensations are suppressed, the pain gradually subsides.

In addition, the same component acts in another direction - it reduces the production of substances formed during inflammation. Thus, not only the pain syndrome subsides, but also redness, swelling, and swelling of tissues disappear.

Age restrictions for admission

Powder for oral administration is prohibited for children under twelve years of age due to its high toxicity.

Powder Nimesil: instructions for use

This substance is potent. Its improper dosing can have far-reaching negative consequences. It is possible to reduce the likelihood of adverse reactions by reducing the duration of administration.

How to dilute Nimesil powder

The granules dissolve best in warm water. They are placed in a glass and filled with one hundred milliliters of liquid. The prepared product is not stored, but consumed immediately.

Dosing regimen

The contents of one package are used once. This is a standard one-time rate. Everyone from the age of twelve is prescribed the same dosage.

Maximum per day you can take "Nimesil" in the amount of no more than two sachets. The course of treatment should not exceed twelve days.

In order to avoid the occurrence of side effects, you should try to minimize the daily intake of the drug and the duration of the entire treatment.

Special instructions for use

During long-term use of the drug, it is necessary to monitor the condition of the kidneys and the blood picture.
In persons with gastrointestinal diseases, an exacerbation of problems against the background of admission is possible. At the first appearance of signs of intoxication and digestive upset, further treatment should be abandoned.
In patients with impaired renal and hepatic function, individual correction of the intake rate is required. There are no such measures for the elderly.

Eating does not affect the degree of absorption of the active substance. But in order to avoid complications from the digestive tract, the prepared suspension must be drunk after meals.

In practice, cases of a sharp deterioration in vision during treatment have been recorded. For any problems with the eyes, the powder should be discontinued.

If during the treatment period the body temperature rises or respiratory infections occur, further use of the drug should be abandoned.

Drug interactions with other drugs

The active substance partially suppresses the production of platelets and promotes blood thinning. Its use is contraindicated with the simultaneous administration of drugs that perform the same function. Violation of these requirements is fraught with the discovery of internal bleeding.
The powder is able to reduce the effectiveness of diuretics and prevent the removal of salts from the body.
The drug enhances the toxicity of antibiotics and anticancer drugs. Their simultaneous reception has a devastating effect on the liver. For the same reason, the suspension is not compatible with alcohol.
With the simultaneous use of powder and vasodilators that lower blood pressure, enzymes that inhibit kidney activity can accumulate. As a result, kidney failure develops as a side effect.
The active substance argues with drugs against diabetes. For this reason, their joint reception is unacceptable.

Contraindications, side effects

The drug in question has an impressive list of contraindications.

Its use is canceled if in the past and present the patient had or still has:

inflammatory diseases of any parts of the digestive tract, complicated by ulcers, erosions, perforation of the wall, bleeding;
serious violations in the excretory system;
pathological conditions of the liver;
poor susceptibility to non-steroidal analgesics;
aspirin poisoning;
allergy to other anti-inflammatory drugs;
pathology of the hematopoietic system with impaired coagulability;
any hay fever, sinusitis, respiratory diseases;
fever;
body temperature that is different from normal;
surgical intervention in the work of the heart and blood vessels;
hypertension, type 2 diabetes mellitus;
pregnancy and lactation.

Alcoholism and smoking should be singled out as a separate line of contraindications. The drug has a strong effect on the liver. It should not be given to those who have ever experienced chemical destruction of this organ in the past.

Among the reactions to the substance are observed:

allergies, dermatitis of varying severity up to tissue rejection;
disorders of the blood picture with a sharp decrease in the number of red blood cells and an increase in inflammation and allergic reactions;
decreased visual acuity;
changes in the work of the heart with rhythm disturbance, changes in blood pressure;
nervous seizures, dizziness, decreased efficiency, disruption of the brain, a feeling of fear at night;
breathing disorder;
general malaise;
exacerbation of intestinal diseases;
urinary retention;
weakening of liver and kidney function;

This list does not include individual reactions to the drug.

Suspension analogs include drugs:

"Aponil";
"Nise";
"Nimegesic";
"Nimesulide";
"Nimide";
"Nimulid".

Basically, analogues are preparations of Indian origin, which, in terms of price, win against the powder in question. All drugs from the list have the same active ingredient, so they have similar instructions for use. Medicines are dosed according to the same principle.

Aponil is produced in Cyprus. It has the dosage form of tablets. In the unit of the drug 100 mg of the active substance. Like all drugs of this series, it is dispensed by prescription.
"Nise" is produced in the form of tablets of a half and a whole dose. Also available as a topical 1% gel. In the case of the gel, it is necessary not to exceed the permissible ten-day course of treatment. In this form, the drug can only be applied to undamaged skin.
Nimegezik is a ready-made suspension with the aroma of ripe melon. Used in adults. One-time rate - two caps. The bottle contains 60 ml of medication.
"Nimesulide" - tablets 100 mg. Rarely sold in pharmacies in the form of a gel. It is used similarly with "Nise".
Nimid is a remedy of Indian origin in the form of sachets and an external gel. Dosages and method of use are exactly the same as for similar drugs.
"Nimulid" is an Indian counterpart. It is found in tablets, in the form of an external gel and a ready-made suspension. Previously recommended for children as the most powerful antipyretic. Later it turned out that the reception is not compatible with the high temperature.

Now all drugs based on such an active substance are prohibited for prescribing to children under 12 years of age.

The powder in question has a pronounced analgesic property. Feedback on its use is mostly positive. But do not forget that this remedy greatly complicates the work of the liver. Therefore, if possible, long-term treatment should be avoided.

Powder Nimesil is an antipyretic, anti-inflammatory drug. As for dentistry specifically, the powder used for stomatitis, periodontitis, toothache, inflammation of the gums, with infection and for general prevention of the oral cavity.

Powder Nimesil - a brief description, composition, release form

Nimesil powder was developed by American pharmacists. It has not such a large number of analogues - only two. May have allergic reactions and other side effects. It can be produced without a doctor's prescription, but with severe indications - only with a prescription. The company that produces Nimesil is Burling Chemie. The composition of nimesil includes one active substance: nimesulide in a mass of 100 g.

As well as excipients:

Ketomacrogol
sucrose
Maltodextrin
Lemon acid
orange flavor

The active substance is in an amount of more than 1%, the auxiliary is less than 1%.

Produced in a cardboard box in a laminated bag, which contains granules for the preparation of the procedure. Total bags with granules in a carton box 30.

Store in a dark, cool place where the temperature does not exceed 20 degrees Celsius. Best stored in the refrigerator. Shelf life 2 years.

In appearance, the powder in the capsule has a yellow color with an orange smell.

Pharmacological properties

The pharmacological properties are antipyretic, anti-inflammatory effect. Nimesil acts quickly, thanks to its active substance nimesulide, which just plays the role of an antipyretic substance. The effect of the drug is average, about 6 hours.

Indications for use in dentistry

In general, nimesil is used for various indications, but specifically in dentistry it is used for:

Toothache (reduces pain).
Mouth infections
Inflammation of the holes after tooth extraction
Inflammation of the gums
Periodontitis
stomatitis

The drug can be taken both for a long time and for a short time, with a sharp need. Usually, with prolonged use, it is taken within two weeks, with a short one - 2-3 days.

Contraindications

The drug should not be taken with the following contraindications:

Pregnancy (it is not known how the body will react to the drug).
Lactation period (during lactation it is forbidden to consume any medications)
Physical intolerance to any component from the composition of nimesil (nimesulide, excipients)
Bleeding from the gastrointestinal tract
stone disease
Diabetes
Hypersensitivity to a substance in the formulation
Heart failure
Heartburn (the action of the powder will only increase heartburn)
Vomit
Sharp abdominal pain
Contraindicated in children under 14 years of age.

Instructions for use

The drug is used only by adults, it is strictly prohibited for children. The usual dose is 200 mg per day. Should be taken after meals twice a day: morning and evening. 100 mg in the morning, 100 mg in the evening.

In order to make a solution, you need to remove one package from the box, pull out the granule and dissolve it in warm boiled water. For severe indications, the dose can be increased. For use by the elderly, the dose must be changed, depending on the indication. Also, with severe indications, it is necessary that the doctor strictly controls the doses and the use of the drug itself.

Interactions with other drugs

If, in addition to nimesil, they consume drugs to improve blood clotting, the effect of Nimesil will be high. If Nimesil is consumed together with lithium preparations, the concentration of lithium in the blood will be increased.

In addition, Nimesil easily enters into preparations with a protein composition.

While taking the drug doses must be strictly controlled. otherwise side effects may occur. Carefully use the drug together with diuretic drugs. You should not combine the powder with drugs to lower pressure, with drugs of any cardiac nature.

Side effects

Nimesil has quite a lot of side effects, this is again due to nimesulide and its action:

Dizziness
Nausea
Vomit
Drowsiness
hypertension
Tachycardia (rare)
Hemorrhage
Diarrhea
Visual impairment (rare)
Dyspnea
Hepatitis (rare)
Jaundice (rare)
Hematuria (rare)
Kidney failure (rare)
Anemia (rare)
Purpura (rare)
Constipation (rare)
Heavy sweating

The price of the drug and analogues

On average, the price of Nimesl in Russia for 30 bags of 100 mg granules is from 600 to 900 rubles. Online pharmacies from 500 to 850 rubles.

Nimesil's analogs:

Aponil. Aponil has the same active substance as nimesil - nimesulide. The drug itself is available in small tablets of 100 mg. There are usually 20 tablets in a carton. As far as dose is concerned, for an adult 100 mg per day is enough children under 12 years old, should be calculated: 1.5 mg per 1 kg of weight. The average price of Aponil for 20 tablets of 100 mg in Russia is from 150 to 370 rubles, for 30 tablets of 100 mg from 220 to 400 rubles. Application of Aponil pregnant women are strictly prohibited. Produced without a doctor's prescription.
Nise. Nise has the same active substance as nimesil - nimesulide. Nise is available in 100 mg tablets. There are usually 20 tablets in a carton. Adults you need to take 100 mg per day, twice a day. children should be taken twice a day, counting 3 mg per 1 kg of weight. Also available in gel, which is used externally. To apply the gel, you need to wash and dry the skin, then apply to the affected area of the body. The average price of Nise in tablets from 200 to 350 rubles, in gel from 150 to 250 rubles. Nise consumption pregnant women in pills is strictly prohibited. Produced without a doctor's prescription. Here you can read in detail.