Nicotine tablets Purpose and contraindications. Nicotinic acid injections at osteochondrosis

Nicotine Acid, or Vitamin B3, plays an important role in metabolism. This substance is contained in many foods, so the clinical deficiency of this vitamin in medical practice is diagnosed quite rarely. But in order to prevent and treat some diseases, Nicotinic acid in tablets should be applied to the appointment of a doctor.

And its derivatives as auxiliary can be used in the treatment of excess cholesterol in the body. It is not recommended to take the drug - when choosing an incorrect number and mode of use of this drug, as well as in improper nutrition, liver damage is possible.

Acid "in tablets: testimony for use

As already mentioned, in the deficiency of vitamin B3 in the body, the disease begins to develop a disease called Pellagra. Nicotinic acid has a positive effect on carbohydrate exchange and expands the vessels. In addition, under the influence of this substance, healing of ulcers and wounds is accelerated, cholesterol level decreases, the operation of the cardiovascular system is improved.

Nicotinic acid in tablets is most often used as a prophylactic measure in the threat of the development of Pellagra. It is used for diseases of the liver, including cirrhosis and hepatitis. In some cases, the drug has a positive impact at neuritis. With the help of this vitamin removed the kidneys, limbs and brain. Along with special diets and exercise, nicotinic acid is used to eliminate cholesterol.

Preparation "Nicotinic acid" (tablets): instructions for use

The daily dose, the duration of treatment and the reception mode must appoint a doctor. These characteristics depend on the patient's disease, the state of its organism, other preparations and still many factors. In no case cannot be taken tool independently - it is better to correct the daily amount of vitamin that comes with food.

Take pills must be necessary after eating. If you use a drug on an empty stomach, the likelihood of side effects is significantly increased.

Drug "Nicotinic Acid" in tablets: Contraindications

This drug can be taken not to all patients. Means is contraindicated to persons with increased susceptibility of the body to active substances. In addition, its use is not recommended in the presence of peptic formations in the stomach or duodenum, when the disease is at the aggravation stage.

Gout and hyperuricemia are also considered to be contraindications to the reception of this fund. In any case, the drug can only be prescribed.

Possible side effects

In most cases, the medicine is quite well perceived by the body. All side reactions are caused by the release of histamine during the exchange. Patients sometimes complain about dizziness and weakness. Sometimes the skin is blushing on the face and the upper half of the body - it can be felt a weak burning and tingling. As long as you do not know how the drug works on you, you should not get behind the wheel or deal with complex, requiring a rapid reaction, mechanisms.

With prolonged and uncontrolled medication, more serious consequences are possible. Overdose is manifested by vomiting, diarrhea. In some cases, anorexia is developing. It is also possible to gradually and damage to the mucous membrane of the digestive tract.

Drug "Nicotine Acid" in tablets: reviews

As a means for preventing neurological diseases, this drug has proven itself very well. According to the reviews of doctors and patients, they pass quite quickly, while the adverse reactions are rarely recorded.

And Nicotinamide is contained in animal organs (liver, kidneys, muscles, etc.), in milk, fish, yeast, vegetables, fruits, buckwheat and other products. Nicotinic acid and its amide play a significant role in the life of the body: they are promotional groups of enzymes - code-edges I (difosphoridinnucleotide - above) and code-strap (Tryphosphopyridinnucleotide - NADF), which are carriers of hydrogen and carrying out redox processes. Codecidase II also participates in the transfer of phosphate. The insufficiency of vitamin RR in humans leads to the development of Pellagra (disease caused by deficiency of nicotine acid / vitamin RR /, tryptophan and riboflavin / vitamin B2 /).

Indications for use

A nicotinic acid And its amide is specific anti-flagrand means (means for the treatment of Pellagra), in connection with which they are designated as vitamin RR. Their use, especially in the early stages of the disease, leads to the disappearance of pellang phenomena.
A nicotinic acid It possesses not only with anti-inflammatory properties; It improves carbohydrate exchanges, acts positively with light shapes of diabetes, diseases of the liver, heart, ulcerative disease of the stomach and duodenal and enterocolites (inflammation of thin and colon), sluggishly healing wounds and ulcers. It also has a vasodilatory action.
A nicotinic acid It has lipoproteide activity (reduces blood lipoprotein levels). In large doses (3-4 g per day) reduces the content of triglikerides and beta lipoproteids in the blood. In patients with hypercholesterolemia (with an elevated cholesterol content of blood), the ratio of cholesterol / phospholipids in low density lipoproteins is reduced.
Assign as a specific means for the prevention and treatment of Pellagra. In addition, it is used in gastrointestinal diseases (especially in gastritis / inflammation of the stomach / with reduced acidity), diseases of the liver (acute and chronic hepatitis, cirrhosis), spasms (sharp narrowing of the lumen) of vessels of limbs, kidneys, brain (see Nikrine , NicoShpan, xanthinol nicotine, 177), with neurites of the facial nerve (inflammation of the face nerve), atherosclerosis, long-lasting wounds and ulcers, infectious and other diseases.

Mode of application

Apply nicotine acid inside (after meals) and parenterally (bypassing the gastrointestinal tract). For prophylactic purposes, they are prescribed inside by an adult at 0.015-0.025 g; Children - 0.005-0.02 g per day.
At Pellagra, they give adults inside 0.1 g 2-3-4 times a day for 15-20 days; Parenterally introduces 1% solution of 1 ml 1-2 times a day for 10-15 days. Children are prescribed inside from 0.005 to 0.05 g 2-3 times a day.
With other diseases, nicotinic acid is prescribed by an adult at 0.02-0.05 g (up to 0.1 g); Children - 0.005-0.03 g 2-3 times a day.
As a vasodilator with ischemic stroke (insufficient supply of brain tissue with oxygen due to an acute brainwatching disorder) administered intravenously 1 ml of 1% solution.
Intravenously introduced slowly. The subcutaneous and intramuscular administration of nicotinic acid is painful. In order to avoid irritation, it is possible to use sodium nicotinal (sodium salt of nicotinic acid) or nicotinomide.
Higher doses for adults inside: one-time - 0.1 g, daily - 0.5 g; in Vienna (in the form of sodium salt): one-time - 0.1 g, daily -0.3 g. When taking inside, one-time dose can be gradually increased (in the absence of side effects) to 0.5-1 g, and the daily dose - up to 3-5 g (mainly in the treatment of atherosclerosis and other violations of lipid metabolism).
The daily need for nicotine acid (and in nicotinamide) is for an adult about 20 mg, with severe physical work - about 25 mg, for children from 6 months. Up to 1 year - 6 mg, from 1 year to 1.5 years - 9 mg, from 1.5 to 2 years - 10 mg, from 3 to 4 years - 12 mg, from 5 to 6 years - 13 mg, from 7 Up to 10 years - 15 mg, from 11 to 13 years old - 19 mg, for young men, 14-17 years old - 21 mg, for girls 14-17 years - 18 mg.

Side effects

A nicotinic acid (Especially when taking inside an empty stomach and in persons with increased sensitivity) can cause redness of the face and the upper half of the tovor, dizziness, a feeling of blood tide to the head, a rattured rash, paresthesia (feeling of numbness in the limbs). These phenomena pass on their own. With a rapid intravenous administration of a solution of nicotine acid, a strong decrease in blood pressure may occur.

Contraindications

Intravenous injections are contraindicated in severe forms of hypertension (perfection raising blood pressure) and atherosclerosis.
Persons with increased sensitivity to nicotinic acid should be prescribed Nicotinamide, except in cases where a nicotinic acid Used as a vasodilator.
It should be borne in mind that the long-term use of large doses of nicotine acid can lead to the development of liver dystrophy. To prevent this complication, it is recommended to include in diet products rich in methionine - indispensable / uninteresting in the body / amino acids, or prescribe methionine and other lipotropic (selectively interacting with fats).

Form release

Powder; Tablets at 0.05 g (for therapeutic purposes); 1.7% solution of nicotine sodium (corresponds to a 0.1% solution of nicotinic acid) in 1 ml ampoules; pH solution for injection 5.0-7.0.

Storage conditions

List B. Powder - in a well-closed container protecting from light; Tablets and ampoules - in light-protected place.

Synonyms

Vitamin PP, Vitamin Vz, Apalagrin, Indushancin, Libit, Niacin, Nikolai, Nikhodon, Niconacid, Nikoten, Nikitite, Pellagramin, Pelonin, Peviton, Vitaplex N.

Composition

Pyridicarbonic-3 acid.
White crystalline powder. It is badly soluble in cold water (1:70), better in hot (1:15), it is difficult to soluble in alcohol.

Additionally

Nicotinic acid is included in the preparations of Vitaiodurol, Vicein, Ksantinol Nikotinath, Lipostabil, Nikoverin, Nicochap, Spruce, etc.

Main settings

Name:	A NICOTINIC ACID
ATH code:	C04AC01 -

Medical Instructions

drug

A nicotinic acid

Tradename

A nicotinic acid

International non-proprietary title

A nicotinic acid

Dosage form

Solution for injection 1%, 1 ml

Composition

1 ml of solution contains

active substance - nicotine Acid 10 mg,

excipients:sodium bicarbonate, water for injection.

Description

Transparent, colorless liquid.

Pharmacotherapeutic group

Himolypidemic drugs. Hypocholesteromemic and hypotrigliserineic drugs. Nicotinic acid and its derivatives . A nicotinic acid.

Code ATX C10AD02.

pharmachologic effect

Pharmacokinetics

Nicotinic acid is quickly absorbed in parenteral administration. Equally distributed by organs and tissues. Is inactivated mainly by methylation and less by conjugation. Partially biotransformed in the liver with the formation of N-methylnicotamide, methylpyridoncarboxamides, glucuronide and a complex with glycine. Half-life (T 1/2) -45 minutes. Examined from the body kidneys in unchanged form and in the form of metabolites. The kidney clearance depends on the concentration of nicotine acid in the blood plasma and can decrease with a high concentration of its plasma.
Pharmacodynamics

In the structure of nicotinic acid is close to nicotine.
Nicotinic acid and its amide play a significant role in the life of the body: they are promotional groups of enzymes - code-edges I (difosphoridinnucleotide - above) and code-strap (Tryphosphopyridinnucleotide - NADF), which are carriers of hydrogen and carrying out redox processes. Codecidase II also participates in the transfer of phosphate.

Nicotinic acid replenishes the deficiency of vitamin PP, has a vasodilatory action. Participates in the regulation of tissue respiration, fat metabolism, reduces the overall level of cholesterol, low density lipoproteins (especially triglycerides).

Indications for use

• prevention and treatment of Pellagra (Avitaminosis PP)

As part of comprehensive therapy: the spasm of the vessels of the extremities (obliterating endarterite, Reino disease), neuritis of the face nerve, ischemic brain circulation disorders

Method of application and dose

Nicotinic acid is administered by adult subcutaneously, intramuscularly or intravenously slowly.

For intravenous inkjet administration A single dose of the drug is bred in 10 ml of 0.9% solution of sodium chloride, administered by no less than 5 minutes (no faster 2 mg of nicotinic acid per 1 minute).

For intravenous drip administration An once dose of the drug is divorced at 100-200 ml of 0.9% sodium chloride solution, the rate of administration is 30-40 drops per minute.

Subcutaneous and intramuscular administration is painful.

With Pellagra, 1% solution of 1 ml is administered intravenously or intramuscularly 1-2 times a day for 10-15 days.

With ischemic violation of the cerebral circulation, intravenously (slow) 1 ml of 1% solution is introduced.

With other testimony Prescribed subcutaneously or intramuscularly at 10 mg (1 ml) 1 time per day for 10-15 days. It is possible to add to the infusion solution: 10 mg (1 ml) of nicotinic acid per 100-200 ml of infusion solution.

Higher doses With intravenous administration: a single one - 100 mg (10 ml), daily - 300 mg (30 ml).

Side effects

Hyperemia of the face and upper half of the body with a feeling

tingling and burning (in persons with increased sensitivity)

Urticaria, skin rash, itching

Dizziness, blood tide feeling to the head, headache

Ortostatic hypotension, collapse (with rapid intravenous administration)

With long-term use of large doses

- dry skin, exfoliative dermatitis

• anorexia, vomiting, diarrhea
• violation of the liver function, incl. fatty liver dystrophy, jaundice
• arrhythmia

• presthesia
  • hyperuricemia
  • hyperpigmentation, hyperkeratosis
  • reduction of glucose tolerance
  • hyperglycemia
  • transient increase in the activity of aspartaminotransferase,

lactatadehydrogenase, alkaline phosphatase

• irritation of the mucous membrane of the gastrointestinal tract.

- asthenia

- soreness at the site of subcutaneous and intramuscular injections.

Contraindications

Increased sensitivity to nicotine acid

Heavy forms of arterial hypertension

Atherosclerosis (for intravenous injections)

Ulcery disease of the stomach and duodenum (in the stage

exacerbations)

Pronounced liver function disorders: hepatitis, liver cirrhosis

Recently suffered myocardial infarction

Decompensated sugar diabetes

Gout and hyperuricemia

Pregnancy, lactation period

Children's age up to 18 years

Medicinal interactions

Oral contraceptives and isoniazid Reduce the conversion of tryptophan into nicotine acid and, thus, can increase the need for nicotine acid.

Nicotinic acid reduces efficiency and toxicity Barbiturates, anti-tuberculosis, sulfonamides. With joint use with sulfonylurea drugs, blood glucose can increase blood glucose. Nicotinic acid also reduces neomycine toxicity and prevents the decrease in cholesterol concentration and high density lipoproteins.

Antibioticsmay increase redness of the skin caused by nicotine acid.

Acetylsalicylic acid Reduces the effect of skin redness arising from nicotinic acid.

Lovastatin, Handustatin Due to the increase in the risk of developing adverse reactions, it is not recommended to combine with nicotine acid.

Care must be taken when combination with hypotensive means (It is possible to strengthen the hypotensive action), anticoagulants, acetylsalicylic acid (due to the risk of developing hemorrhage).

The drug potentiate action fibrinolytic products, spasmolitics and heart glycosides, toxic effect of alcohol on the liver.

It should not be mixed with a thiamine chloride solution (thiamine destruction occurs).

special instructions

Before applying the drug, you must consult with your doctor.

Since long-term use can lead to liver dystrophy, for the prevention of the latter in the patient diet, they include rich with methionine products or prescribe methionine, lipoic acid. In the process of treatment, it is necessary to control the function of the liver. When an increased sensitivity appears to the drug (except for applications of as a vasodilator), it is possible to replace nicotinamide.

Carefully The drug is used for hyperacid gastritis, ulcerative disease of the stomach and duodenum (out of the aggravation stage).

The use of the drug may lead to an increase in insulin need in patients with diabetes mellitus. It is impractical to apply to the correction of dyslipidemia in patients with diabetes.

It is necessary to regularly monitor glucose due to a possible decrease in glucose tolerance, as well as serum uric acid level due to a possible increase as a result of long-term therapy.

Carefully prescribed under glaucoma, bleeding, arterial hypotension, violation of the liver and kidney function, diseases of the liver and impaired its function in history, diabetes, violation of heart rate, migraine, alcohol abuse.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

Given the side effects of the drug, caution should be taken when driving motor transport and moving mechanisms.

Overdose

Symptoms:strengthening side effects from the cardiovascular system - arterial hypotension, headache, is possible loss of consciousness, dizziness, feeling of blood tide to the head.

Treatment:cancellation of the drug, disintellation therapy, symptomatic treatment. Specific antidote is absent.

Release form and packaging

1 ml into a neutral glass ampoules for syringe filling or imported, or sterile sterile ampoules for syringe filling imported, with a break point or a ring of a break.

The label or script paper label is glued to each ampoule.

5 or 10 ampoules are packaged into the contour cellular packaging of polyvinyl chloride and aluminum or imported foil.

The contour packages are placed in cardboard boxes or corrugated cardboard.

In group packaging with contour packages invest approved medical instructions in state and Russian languages. The number of instructions is embedded by the number of boxes or packages.

Storage conditions

Store in the place protected from light, at a temperature not higher than 30 o C.

Keep out of the reach of children!

Storage term

Do not use after the expiration date.

Conditions of vacation from pharmacies

On prescription

Manufacturer

Owner of the registration certificate

JSC "Himfarm", Republic of Kazakhstan

The address of the organization hosting on the territory of the Republic of Kazakhstan complaints from consumers for product quality (product)

JSC "Himfarm", Republic of Kazakhstan

g.Symkent, ul. Rashidova, 81.

Telephone number 7252 (561342)

Fax number 7252 (561342)

E-mail address [Email Protected]

Peripheral vasodilators. Nicotine Acid and its derivatives.

Code ATX C04A C01.

Pharmacological properties

Pharmacodynamics.

Nicotinic acid (vitamin PR) independently or as an amide is a prosthetic group of code-strain enzymes I nicotinindaenindinucleotide - over) and code-strap (nic- NADF), which carry out the transfer of hydrogen in oxidation reactions, as well as the transfer of phosphate.

By participating in metabolism, tissue breathing, synthesis processes, nicotinic acid normalizes the content of lipoproteins and triglycerides in the blood.

It has a vasodilant influence at the level of preventive and arterioles (including brain), which improves microcirculation.

It has a weak anticoagulant effect (increases the fibrinolytic blood activity), has disintellation properties due to the enhancement of the disinfective function of the liver and kidneys.

Eliminates the deficiency of vitamin RR, is a specific anti-flag agriculture.

Pharmacokinetics.

Nicotinic acid is quickly absorbed from the place of administration during parenteral use. Equally distributed over all organs and tissues. Is inactivated mainly by methylation and at least - by conjugation. Biotransformation products are excreted with urine. Nicotinic acid can appear in the urine in an active form if the organism comes in an increased amount.

Indications

Treatment of Pellagra (Vitamin RR Avitamint).

Ischemic violations of cerebral circulation.

Obtaining limb vessel diseases (refriring endarteritic, Reino disease).

Spasm of kidney vessels.

Contraindications

Increased sensitivity to the components of the drug. Ulcery disease of the stomach and duodenum (in the stage of exacerbation), gout, hyperuricemia, severe liver failure (including cirrhosis), heavy forms of arterial hypertension and atherosclerosis (intravenous administration), decompensated diabetes, recent myocardial infarction, sudden decrease in peripheral Vascular resistance in history. Liver diseases in the active stage and resistant increase in the activity of transaminase in serum (non-refined etiology). Pregnancy, breastfeeding period. Children's age up to 18 years.

Interaction with other medicines and other types of interactions

Oral contraceptives and isoniazid Reduce the conversion of tryptophan into nicotine acid and thus can increase the need for nicotine acid.

Nicotinic acid reduces efficiency and toxicity probenecide, neomycin, barbiturates, anti-tuberculosis, sulfonamides.

Antibiotics May increase redness of the skin caused by nicotine acid. Acetylsalicylic acid Reduces the effect of skin redness arising from nicotinic acid.

Lovastatin,rTustatin Due to the increase in the risk of developing adverse reactions, it is not recommended to combine with nicotine acid. There are reports on cases of rabbomyolysis when using nicotine acid with lovastatan.

Care must be taken when combination with hypotensive means(It is possible to strengthen the hypotensive action), anticoagulants, acetylsalicylic acid (due to the risk of developing hemorrhage).

The drug potentiate action fibrinolytic means, spasmolitics and heart glycosides, Toxic action alcohol on the liver.

Precautions

Since long-term use can lead to liver dystrophy, to prevent the latter in the patient diet, it should be included with methionine products or prescribe methionine, lipoic acid. In the process of treatment, it is necessary to control the function of the liver. With the emergence of increased sensitivity to the drug (except for cases of applications as a vasodilator), it can be replaced with nicotinemide.

With caution, the drug is used with hyperacid gastritis, heart rate disorders, ulcer of the stomach and duodenum (out of the aggravation stage), hemorrhages, glaucoma, renal failure, arterial hypotension of moderate degree, abuse of alcohol, unstable angina (patients who take nitrates, calcium antagonists Channels, β-blockers).

The use of the drug may lead to an increase in insulin need in patients with diabetes mellitus. It is inappropriate to apply to the correction of dyslipidemia with patients with diabetes.

It is necessary to regularly monitor the level of glucose due to a possible decrease in glucose tolerance, as well as the level of uric acid in serum due to the possible increase as a result of long therapy.

Application during pregnancy or feedingrudew

The drug is contraindicated during pregnancy. If necessary, applying the drug should stop breastfeeding.

The ability to influence the reaction rate when managing motor vehicles or other mechanisms

Studies regarding the influence of the reaction rate were not carried out, but if during treatment with drugs, dizziness and drowsiness are observed, it should be refracted from working with complex mechanisms.

Method of application and dose

Prescribe adults intravenously (slow), intramuscularly and subcutaneously (intramuscular and subcutaneous injections of painful).

For intravenous inkjet administration, a one-time dose of the drug is dissolved in a 10 ml of 0.9% solution of sodium chloride, to introduce at least 5 minutes (no faster than 2 mg of nicotinic acid per 1 minute).

For intravenous drip administration, a single dose of the drug is divorced in 100-200 ml of 0.9% sodium chloride solution, the rate of administration is 30-40 drops per minute.

Pellagra. Assign intravenously or intramuscularly at 10 mg (1 ml) 1-2 times a day. The course of treatment is 10-15 days.

Ischemic violations of cerebral circulation. Intravenously (slow) administer 10 mg (1 ml).

Other readings. Appoint subcutaneously or intramuscularly at 10 mg (1 ml) 1 time per day for 10-15 days. It is possible to add to the infusion solution: 10 mg (1 ml) of nicotinic acid per 100-200 ml of infusion solution.

Higher doses With intravenous administration: a single one - 100 mg (10 ml), daily - 300 mg (30 ml).

Children

The use of the drug in children under 18 is contraindicated.

Overdose

Symptoms: Strengthening side effects from the cardiovascular system - arterial hypotension, headache, is possible loss of consciousness, dizziness, sensation of the tide. Nausea, vomiting, diarrhea, hyperemia, itching skin.

Treatment: Cancellation of the drug, disintellation therapy, symptomatic treatment. Specific antidote is absent.

Adverse reactions

From the side of the cardiovascular system: The feeling of the tide, which can be accompanied by shortness of breath, tachycardia, heartbeat, increased sweating, chills, edema, feeling of tingling and burning; arrhythmias; With rapid administration - a significant decrease in blood pressure, orthostatic hypotension, collapse.

From the central andperipheral nervous Systems: Dizziness, paresthesia, headache.

From the immune system, leather and subcutaneous fiber: Hyperemia of the skin of the face and the upper half of the body with a feeling of tingling and burning, dry skin and mucous membranes of the eye, rarely - the swelling of the eye, very rare in patients with coronary heart disease - acantosis. These symptoms are unstable and disappeared after canceling the drug. The reactions of hypersensitivity, including from the respiratory organs, urticaria, itching, rash.

From the gastrointestinal tract: nausea, vomiting, anorexia, aggravation of the stomach.

Local reactions: Painness, swelling at the site of subcutaneous and intramuscular injections.

With prolonged use in large doses - hyperuricemia, reduction of glucose tolerance, liver function, liver dystrophy, jaundice, increase aspartataminotransferase levels, lactate dehydrogenase, alkaline phosphatase, uric acid, hypophosphatemia, reduction of platelets, lengthening prothrombin time, hyperpigmentation, hyperkeratosis, Clear, diarrhea, nausea, vomiting, anorexia, aggravation of stomach ulcers, amblyopia, insomnia, mealgia, decrease in blood pressure, rhinitis, binding vision, edema, myopathy, exfoliative dermatitis.

When listed adverse reactions, as well as adverse reactions not specified in this manual, it is necessary to stop taking the drug and consult a doctor.

An indispensable organic compound, which is involved in the bloodstream and exchange processes of our body. Opened this element relatively recently, but there is already data on its benefits and states related to a lack. A tablet forms or a solution for injection is sold in pharmacies, but many people simply do not know about its use. What is nicotinic acid, instructions for use, testimony and contraindications - our article will give all the necessary information.

Vitamin RR refers to the group of important vitamins. Its lack leads to the occurrence of Pellagra - diseases associated with insufficient absorption of nutrients (proteins, amino acids and carbohydrates). With a deficiency of nicotine acid, a deterioration of the condition of the skin, disorder of digestion and the instability of the hormonal background is observed. For children, the lack of this vitamin is fraught with a lag in development, weak immunity and predisposition to chronic stomach diseases.

Functions of nicotine acid in the body:

1. Participates in blood circulation processes.
2. Helps reduce blood cholesterol.
3. It is a prophylactic agent of cardiovascular diseases.
4. Improves metabolic processes.
5. Promotes the splitting of fats.
6. Improves brain circulation.
7. Normalizes high blood pressure.
8. Positive affects vessels.
9. Stimulates the work of the gastrointestinal tract.
10. Beneficially affects the work of cookies and kidneys.

Most often, vegetarians suffer from lack of vitamin RR, as well as people who adhere to strict shipless. To eliminate the likelihood, it is necessary to supplement its diet with complex vitamins or special nicotinic acid preparations.

Indications for use

Nicotinic acid is used in the treatment and prevention of various diseases. There are studies that sufficient reception of vitamin PP allows to strengthen the protective forces of the body, and also slows down the aging processes.

In complex therapy, nicotinic acid preparations are used in the following cases:

• Treatment and prevention of Pellagra.
• Prevention of heart disease and arteriosclerosis.
• With diabetes mellitus.
• To remove vessel spasms.
• Treatment of skin diseases and problems with hair.
• Treatment of neurites facial nerve.
• To improve the work of the gastrointestinal tract.
• In therapy of gastritis and ulcers of the stomach.
• With enterocolitis and liver diseases.
• With long non-healing wounds and trophic ulcers.

Nicotinic Acid

In pharmacy chains, many drugs containing nicotine acid or its derivatives can be found. It is produced in the form of tablets and solutions for injection. Due to the wide range of applications, can be used orally, intramuscularly and intravenously. Most multivitamin complexes also include this component. The course of treatment depends on the characteristics of the body, therefore it should be calculated individually.

Prices and manufacturers of nicotinic acid:

1. Nicotine Acid "Pharmstandard" (Ufa Vitamin Plant, Russia). Tablets (50 pieces) - the price of 39 rubles. Ampoules (10 pieces) - 137 rubles.
2. Nicotine Acid Biosynthesis (Russia). Tablets (50 pieces) - 18.70 rubles. Ampoules (10 pieces) - 140 rubles.
3. Vitamin RR "MoschimfarmPreatparat" (Russia). Tablets (50 pieces) - 20 rubles. Ampoules (10 pieces) - 125 rubles.
4. Nicotinic acid "Vial" (China). Tablets (50 pieces) - 23 rubles. Ampoules (10 pieces) - 111 rubles.

The tablet form contains 0.05 grams of the active ingredient. The injection solution (0.1%) includes 10 mg of the active substance of nicotinic acid.

What is better to choose: ampoules or pills?

The absorption of the active substance of drugs occurs very quickly. The maximum concentration is achieved already in 45 minutes after receiving tablets, and with intramuscular or intravenous injection - 10-15 minutes later.

For the treatment of vascular pathologies, the tablets are most often prescribed, because intravenous administration of the drug can create additional problems. In addition, it should be borne in mind that injections of nicotinic acid are quite painful, so the medicine is best combined with anesthetics.

For the treatment of Pellagra, tablets and intravenous administration are used, it is permissible to use drugs intramuscularly. To quickly fill the lack of vitamin RR, the subcutaneous method of administration of the drug is used. It feels the heat and local redness of the skin. These symptoms are not dangerous and pass on their own.

Features of reception tablets

How to take vitamin RR in tablets? Nicotinic acid is able to increase the secretion of gastric juice, which in some cases it may be undesirable. Usually pills are accepted immediately after eating, the daily dosage is shaken by two - three receptions.

It is impossible to combine the reception of tablets with products that increase the acidity of the stomach, as well as alcohol. Preparations of this group accelerate the metabolism, therefore are often used to reduce weight. For this, it is necessary to use at least 1 grams of the active substance per day for a month.

Important! The dosage of nicotinic acid tablets is strictly individual and is appointed by the attending physician.

How to use in the form of injections

What are the nicotine acid injections prescribe? "Ambulance" with ischemic stroke is to introduce one ampoule vitamin PP intravenously. To reduce the level of cholesterol in the blood, a standard diagram is used, at which the initial dosage is from 0.1 to 0.3 g of the drug three times a day. The course of treatment must be carried out in stationary conditions under the supervision of the doctor. It is also desirable to also carry out laboratory control of blood indicators and monitor the increase in concentration in the urine.

Important! Nicotinic acid injection course is also strictly individual. Consultation of the attending physician is obligatory.

Features of receiving nicotine acid for children

Reception of nicotinic acid in any forms contraindicated to two years. In the future, the recommended dosage depends on the age and weight of the patient. For the prevention of avitaminosis and improving metabolic processes in the body, children are prescribed 5-20 mg of the active substance per day. In the treatment, an increase in volume up to 45 mg, divided into three receptions, is allowed. Consultation doctor is obligatory.

Is it possible to take during pregnancy and lactation

Nicotinic acid preparations are allowed during pregnancy and breastfeeding, but only after consulting the attending physician. Dosage and duration of treatment depends on the specific disease, age and individual characteristics of the patient.

Nicotine Acid in Cosmetology

A very good result showed the use of nicotine acid for hair and skin health. For this, the solution in its pure form (1 ampule) is applied to the scalp, rubbing it with massage movements. Head must be wrapped and waited at least half an hour. Such procedures must be repeated daily by a course of two weeks, and then take a break. After a short time, the hair growth can be accelerated, an increase in their density, as well as the deliverance from dandruff and other skin diseases.

If you are interested in the use of vitamin PP for hair, we suggest familiarizing yourself with other vitamins in hair ampoules in the article.

Contraindications and possible harm

Among the side effects of the reception of drugs containing nicotine acid, the following states can be distinguished: heat, dizziness, numbness of limbs, redness and rash on the skin, digestive disorders, as well as a sharp decrease in pressure. Especially often such symptoms are manifested with prolonged and uncontrollable treatment, as well as the excess of the necessary dosage.

Nicotinic acid has the following contraindications:

1. Individual intolerance.
2. Panish stomach and duodenal diseases.
3. Liver failure.
4. Children's age up to two years.
5. Uncontrollable "jumps" of pressure.
6. Gout.
7. Hemorrhages in the brain and internal organs.

Important! It is impossible to combine the reception of drugs containing vitamin RR, with alcohol (increases the toxic effect on the liver), antibiotics, as well as anti-tuberculosis means (reduces efficiency). Caution is used with spasmolitics, cardiac glycosides, acetylsalicylic acid and anticoagulants.

Nicotine Acid is an important element for the work of the body. Vitamin RR is necessary for the work of the heart, the gastrointestinal tract, internal organs and the production of hormones. You can fill the lack of this element when taking pharmacy preparations, but the dosage and duration of treatment must be coordinated with your doctor.