Micrazim instructions for use. Micrazim instructions for use, contraindications, side effects, reviews

- This is a modern drug containing pancreatine micrographs of animal origin. High-active enzymes - lipase, protease and amylase - cleave carbohydrates, proteins and fats, helping to get rid of unpleasant sensations of gravity after eating. The small size of the granules (less than 2 mm) allows them to be evenly mixed with food, it is easy to move to the place of action and instantly activated, contributing to rapid digestion.

Description of the drug

The micrazim is represented by solid gelatin capsules No. 2 in a transparent housing with a brown lid (with a dosage of 10,000 units) and No. 0 in a transparent case with a dark orange lid (in a dosage of 25,000 units). Capsules contain pellets of a spherical or cylindrical shape. The granules have a light brown or brown and the smell characteristic of pancreatin.

Excipients

Sheath capsules Contains gelatin, water and dyes (Punchy, yellow quinoline, patented blue and titanium dioxide).

Micrographer Shell (Pellet) Formed by methacrylic acid, ethyl acrylate by copolymer, triethyl citrate, simethicone emulsion, dimethicone, methylcellulose, colloidal silicon (precipitated and suspended), sorbic acid, talc and water.

Pharmacological properties of micrazim

The medication includes natural digestive enzymes obtained from the pancreas of animals. This amylase, lipase and protease are highly active substances that ensure the splitting and further processes of digestion of proteins, fats and carbohydrates entering the gastrointestinal tract together with food.

After applying, the gelatin capsule is quickly dissolved under the influence of the acids of the gastric juice, which makes it possible to be released by the micrographs of pancreatine with a coated with intestinal-soluble shell.

The small size of these granules gives them an opportunity evenly and quickly mixed with food present in the stomach to move with the food lump at the right time, and from there to the small intestine. Here, pancreatic enzymes are exempt from the shell, protected them from the effects of gastric acids, and are included in the process of digestion of food. The highest enzymatic activity of the drug is manifested after 30 minutes after the use of the capsules, which achieves a quick effect effect.

After lipase, amylase and protease entered into interaction with the food casket in the small intestine, they lose their enzymatic activity and simultaneously with the bowel contents move to the lower gastrointestinal departments to leave the body naturally. Micrazima has its action only in the lumen of the small intestine and does not penetrate it into the bloodstream.

Indications for use

Indications to the use of micrazim are the following diseases and conditions.

Rope enzyme therapy of pancreatic excessive insufficiency(deficiency or absence of own pancreatic enzymes), which is due to chronic pancreatitis, pancreathetomy (pancreatic removal), complications after irradiation, cystic fibrosis, excess gas formation (meteorism), diarrhea that is not associated with intestinal infections.

Disorders of splitting and suction processes of nutrientsresulting from resection of the stomach and / or small intestines. The tool is used to normalize and improve digestive processes in people who do not suffer from violation of the gastrointestinal functions, in the event of merors in nutrition (regular presence in fatty food diet, frequent episodes of overeating, no power mode). Also, the testimony for the use of micrazim is a violation of the chewing function, in which food does not pass sufficient processing with digestive enzymes of saliva. The drug is suitable for patients with gastrokardial syndrome (Remergeld), persons with a sedentary lifestyle and people who have suffered a long period of immobilization (for example, bedding for any diseases).

Preparatory stage for examination of the abdominal organs with ultrasound or radiography.

Contraindications for use

• individual intolerance to at least one of the components contained in the medicine;
• acute form of pancreatitis;
• the aggravation of chronic form of pancreatitis.

Application by micrazim pregnant and nursing

Data on the effects of the drug on the body of women during pregnancy and lactation are absent. In connection with this, micrazima may be assigned after a thorough evaluation of indications, risks and possible advantages of its use and only if the expected positive effects of enzyme therapy for the mother are superior to the potential damage to the fetus.

Impact on the ability to control the vehicle

Information about the decrease in the concentration of attention during the reception is absent.

Features of interaction with other medicines

With simultaneous reception of pancreatin with iron preparations, a decrease in the latter suction may be observed.

The form of the drug

Micrazim is produced in capsules of 10,000 and 25,000 units.

The drug is fascia:

• in the contour cellular package created from the polyvinyl chloride film and aluminum printed lacquered foil of 3 or 10 capsules;
• in the cans from dark glass, which are harvested with dense traffic jams from high pressure polyethylene at 20, 30, 40 or 50 capsules. To fill out free space, medical hygroscopic wool is used;
• in polymeric banks with screwed lids, either bottles made of plastic, with screwdrived covers of 20, 30, 40 or 50 capsules.

Banks, vials and contour cellular packages are placed in a pack of cardboard.

For more detailed acquaintance with properties, composition, indications and contraindications, it is necessary to explore the instructions for use of micrazim.

Micrazim refers to a group of enzymes. The drug is used inside and its release begins only at the level of the small intestine, where the need for pancreatic enzymes is manifested.

Composition

As the main active substance to micrazim, the presence of pancreatin is distinguished.
From the auxiliary it is the emulsion of copolymers, gelatin, Talc Laurilsulfate and other means.

Form release

• The only presented form are capsules. The capsule capsule lid has a brown color, the case is transparent.
• The content is represented by the presence of spherical or cylindrical pallets having a brown or light brown color.
• They differ from other means of such a composition of the presence of a characteristic smell.
• For sale micrazim in cardboard packages containing plastic blarses. Micrazim is presented in the dosages of 10,000 units and 25,000 units. The amount may be equal to 10 to 30 pieces.

pharmachologic effect

Micrazim refers to the latest generation preparations, which has enzyme properties. This is due to the main operating component - pancreatine.

Pharmacodinamka

Pharmacokinetics

1. Due to the characteristics of the structure of the capsule, the initial processes of its dissolution can be noted in the cavity of the stomach.
2. In the small intestine there is a yield of finite products microzima microzim.
3. The suction of the substance in the mucous membrane does not begin, as the action must be shown in the cavity.
4. The manifestation of the effect can be noted after half an hour from the moment of reception.
5. Through Cal, the release of metabolic products by micrazim in the environment.

Indications for use

Among the testimony, the microzima should be selected such as:

Instructions for use

• The average therapeutic dose according to the instructions should be considered 1000 mg of micrazim.
• It is necessary to use it simultaneously with meals, and it is also possible after its use. For feeding the capsule requires a large amount of water.
• It is not recommended to drink by micrazim any other liquid.
• The capsule is necessary to swallow the entirely, it is forbidden to chew due to it is possible to reduce the effect.

Application for fibrosis

The greatest daily allowable dose is counted in childhood not older than 1.5 years 5000 units daily. For more than 1.5 years, the dosage can be increased to 100,000 units.

Pregnancy and breastfeeding

Since there is no information about the possible effect of the drug on the body of the fetus, the reception with caution is permitted. The danger to the course of pregnancy, micrazima may cause due to the possible increase in the tone of the uterine wall.

Micrazim does not penetrate the child through breast milk, but during lactation, the reception should be carried out on strict indications.

Childcare

After the reception is appointed by a specialist, it is possible to use micrazim for children. In this case, care and accurate selection of the recommended dosage should be taken.

Side effects

Against the background of the increased sensitivity of the body to components, as well as in the case of relative contraindications, may appear:

In case of manifestations of any side effect, it is necessary to stop receiving micrazim and it is possible to apply the means of symptomatic therapy. With a pronounced violation of well-being, it is necessary to refer to a specialist.

Contraindications

Before applying, micrazim must be familiar with the instruction, as it is required to take into account possible contraindications, including:

• The presence of individual intolerance or cases of allergic manifestations on any component, as well as funds with a similar composition.
• Development of acute pancreatitis.
• The condition associated with the exacerbation of chronic inflammatory processes in the pancreas area.

Overdose

This state may occur with a significant exceedable concentrations of the use of micrazim or non-compliance with dosage of childhood persons.

One of the main ways to eliminate these states is the abolition of micrazim, using sufficient liquid and the purpose of symptomatic treatment.

Medicinal interaction

• Against the background of simultaneous use of micrazim and agents that contain folic acid, it is possible to break its suction. As well as when using micrazim, the degree of absorption decreases.
• With regular use of micrazim, the development of a anemic state is possible due to reduced absorption of drugs containing iron.
• The decrease in bioavailability is manifested while simultaneously use with antacid agents, as well as drugs containing in its composition various dosages of calcium carbonate or magnesium hydroxide.

Conditions of vacation from pharmacies

Micrazima can be purchased independently, this does not require a specialist recipe.

Storage conditions

Micrazima before use should not be stored in an open form, each capsule should be in the intact package until the moment of use.
Temperature mode should be equal to 18-25 degrees.

Shelf life

The storage duration of micrazes should not be more than 2 years.

Cost of micrazima

• The average cost for micrazim dosage of which is 100,000 units on average is within 150 rubles .
• Micrazim dosage 250,000 units costs 300-400 rubles.

In both cases, the price for packages containing 20 tablets is presented.

Analogs

• Creon It is a similar preparation with fermentation activity. As the main active component, the presence of pancreatin is determined. The agent can also be used in childhood, as well as in case of insufficient enzymatic activity against the background of a malignant process. Due to the features of the shell, it is necessary to exclude simultaneous reception with acidic products. The average cost is about 280-320 rubles.
• Pancreatin. This agent with the same-name substance, which can be used in the development of lack of pancreatic enzyme or improvement of the digestive function. The disadvantage of this drug is low bioavailability. It is associated with partial destruction of hydrochloric acid. Due to the absence of a protective capsule, the main operating component is not protected against aggressive internal environmental factors. Price is within 20-40 rubles.
• Mezim. It acts its activity due to the fact that it contains such components as lipase, amylase and protease. It has high bioavailability and a rapid mechanism of action. The average cost is 75-100 rubles.
• Festal. In addition to Pancreatin, bile acids are also included in the operating component. They contribute to the relief of digestion, especially against the background of consuming oily food. Price averages 120-140 rubles.
• Ermal. At the expense of highly active pancreatin, insufficiency of the enzymatic function of the pancreas is compensated. As part, it is possible to detect the content of alpha-amylase, chymotrypsit, trypsin and lipases. These substances in use enhance digestion in most parts of fat and protein food. It also includes suppression of hydrochloric acid and the removal of pain syndrome. The effect is manifested in 30 minutes from the moment of use. Price is within 160-200 rubles.
• Enzystal-P.. The drug when applied has enzymatic activity. Like many other means of this group, it is applied to treat manifestations of fibrosis, but it should be noted that, in contrast to others, it is more often able to cause the development of a colonservon. Price varies within 120-150 rubles.
• Panzinorm. Despite the similar active ingredient for this and other means a distinctive feature is the recommended reception mode. The optimal time is considered to be used until the use of food. The average cost is 90-120 rubles.
• Pankrenorm. Pancreatine-based preparation is widely used in the above states, as well as disorders in the work of the pancreas during alcohol exposure. Due to the presence of a protective shell, the early exit of the active component does not occur before entering the subtle intestine. Special attention should be paid to patients who have been diagnosed with fibrosis, as it is impossible to increase the dosage of Pankrenorm during pathology. Price from 70 to 130 rubles.

Micrazim (10,000 \\ 25 000) is an enzyme tool based on pancreatin, is used as substitution therapy to improve the process of digestion. The active ingredient is Pancreatin.

The active ingredient of the capsules contains enzymes that contribute to the digestion process of proteins (protease), fats (lipases) and carbohydrates (amylases) in the intestinal lumen.

The capsules of micrazim 10000 or micrazima 25000 dissolve in the stomach under the action of gastric juice, and the microgranules of pancreatine together with food first in the duodenum, and then in the delicate intestine. Enzymes are released in it and food digestion is ensured.

Pancreatins in the form of microgranules ensures a uniform distribution of the digestive enzymes by intestines and faster mixing them with the bowel content. This explains the higher enzymatic activity of the micrazima compared with the analogues in the form of tablets.

The drug is produced in the form of capsules for intake (oral administration). They have an oblong shape and a smooth surface. The main active substance of the drug is pancreatin. Its content in one capsule is 10,000 and 25000 units (units of action).

Indications for use

What does micrazim help? According to the instructions, the drug is prescribed in the following cases:

• Chronic pancreatitis (inflammation of the pancreas).
• Pancatorectomy - Surgical removal of part of the pancreas.
• Mukobovysidosis - congenital disease, is associated with a violation of the functional activity of almost all organism glands, including the pancreas.
• The state after irradiation, accompanied by the lack of pancreatic gland.
• Meteorism is a scrawl, associated with disruption of food digestion.
• Diarrhea (diarrhea) noncommunicable nature.
• Disruption of digestion or suction of food after surgical resection (partial removal) of the stomach or small intestine.
• The use of a significant amount of fatty food, irregular nutrition, which lead to an increase in the functional load on the pancreas.
• Violation of the process of chewing food, which leads to the difficulty of its subsequent digestion.
• Lifeline lifestyle or long-term immobilization due to severe injury or pathology.
• Remcheldy syndrome.

Additionally, it is used in the process of preparing the digestive tract to a radiographic or ultrasound study.

It can be assigned to improve the process of digestion in adults and children with the normal function of the gastrointestinal tract (gastrointestinal tract): with errors in the diet (including overeating, use of rough and oily food, irregular nutrition), with a low-fat lifestyle, violation of chewing function, long-term immobilization .

Mikrazim, dosage instructions

Capsules are taken inside with food or immediately after eating, drinking clean water (not alkaline!) Or juice. If you have been scheduled to take more than 2 capsules - it is recommended to take half to take immediately before meals, the rest during meals.

The exact dosage depends on the age and the degree of lack of pancreatic gland, is selected by the doctor individually. Standard dosages recommended by the instructions for use of micrazim - 2 capsules 10 000 or 1 capsule 25 000 \\ 3 times a day, with basic meals.

Maximum daily dose - 15-20,000 units per 1 kg of body weight.

The average dose for adults is 150,000 units per day. With the complete deficiency of the excessive function of the pancreas - 400,000 units per day (corresponds to the daily need of an adult in Lipaz).

With steamer and diarrhea, on the background of weight reduction, 25,000 units are prescribed standard for each meal. In the case of good tolerability of enzymes, a one-time dose of the drug can be increased to 35,000 units.

With an unselected steamer and the absence of diarrhea, as a rule, take 1 capsule microzim 10000 for each meal.

To prevent the development of constipation throughout the course of the drug intake, a large amount of liquid should be consumed.

special instructions

Children and adults, for a long time receiving pancreatine therapy in significant doses, should be regularly observed at a specialist.

The main reasons for the ineffectiveness of enzyme therapy are the inactivation of enzymes in the duodenum intestine as a result of the acidification of its contents related to the small intestine diseases (melted invasions, domestic duodenostasis, failure to comply with the patients of the recommended treatment regimen, the use of enzymes that have lost their activity.

Replacement therapy in the enzyme deficiency of the pancreas cannot replace the treatment of the underlying disease.

Side effects

The instruction warns the possibility of developing the following side effects when prescribing micrazim:

• Allergic reactions (rash, urticaria);
• Constipation;
• Diarrhea;
• Discomfort in epigastrics;
• Nausea and vomiting;
• Increased uric acid level in urine and blood.

There are rare cases of narrowing the intestinal lumen in people with cystic fibrosis.

Contraindications

Contraindicated to micrazim in the following cases:

• Acute pancreatitis;
• Aggravation of chronic pancreatitis;
• Increased sensitivity to the components of the drug.

There are no data on the use of pregnancy and during lactation (breastfeeding), therefore the purpose of the drug is possible only in cases where the intended benefit for the mother exceeds the potential risk to the fetus or child.

Micrazim - a drug that belongs to the enzyme clinical and drug group. Such remedies are used as part of complex therapy in various pathologies of the digestive system, accompanied by a decrease in its functional activity. Such a means can also be used as a component of monotherapy for diseases of the gastrointestinal tract associated with the lack of enzymes in the body.

Dosage form

The drug is made in the form of capsules intended for oral administration.

Description and composition

The drug micrazim is represented in the form of solid, gelatin capsules having a dark orange lid and a transparent case. The capsule contains elements of a cylindrical and spherical shape having a characteristic smell.

The capsule contains - 25000 units, which corresponds to 25,000 lipases, 19,000 amylases and proteases of at least 1300 units.

The list of excipients is presented in the following form:

• eudragit;
• triethyl citrate;
• talc;
• symmetics emulsion.

The composition of the shell:

• gelatin;
• water;
• lauril sulfate sodium;
• methyl apograproxybenzoate;
• propyl PyroquinSibenzoate;
• dye;
• titanium dioxide.

Pharmacological group

The active ingredient of the capsule contains in its composition enzymes that can significantly accelerate the process of digestion and digesting proteins, fats and carbohydrates in the intestinal lumen. Due to the presence of a fat-soluble capsule is released in the lumen of the small intestine, and its enzymes are mixed with food content. Against the background of such actions and achieves digestive activity.

After receiving the capsules, the active ingredient is not absorbed into the systemic blood flow. Therapeutic effect is traced after half an hour. Enzymes exhibit their activity in the intestines and are derived from the patient's body along with a challenge content.

Indications for use

The reception of the capsule is shown as substitution therapy in the insufficiency of the functional activity of the pancreas.

for adults

The list of readings to the use of the drug can be represented as follows:

• chronic pancreatitis;
• period after removal of part of the pancreas;
• fibergation;
• period after irradiation;
• elevated meteorism;
• diarrhea, various digestive disorders;
• taking fatty food in significant quantities;
• disorders of digestion;
• sedentary lifestyle;
• gastroindial pathology.

Reception of this agent can also be shown during the preparation of the patient's body to carry out x-ray or ultrasound examination.

for children

The drug is often used in pediatric practice in the presence of testimony against children over the age of 1 year. Dosages are defined individually, after considering the age of the child. When manifesting any disturbing symptoms, the reception stops.

The drug can be used during pregnancy in case the expected benefit for the mother prevails significantly over possible harm to the child. Studies regarding the influence of the child's body were carried out, teratogenic impact is not expressed.

Use the composition during the breastfeeding period is not recommended. The active ingredients in sufficient quantities penetrate breast milk. Often, on this background, various allergic reactions are developing in the newborn, the development is not excluded.

Contraindications

The list of contraindications prohibiting the reception of the means is unsubsioned. The list of possible states belong:

• acute pancreatitis;
• inflammation of the pancreas during the period of exacerbation;
• increased sensitivity to or its auxiliary components;
• bad tolerability means.

Before using the droplets, it is necessary to eliminate the likelihood of contraindications.

Applications and doses

Medicinal microzim in the form of capsules is intended solely for oral administration. Experts recommend taking a means before meals or during meals. Capsules are forbidden to chew, the element should be made with sufficient water. If the process of swallowing such elements is hampered by the capsule can be opened, and the powder contained in it is permissible to apply such a method in children.

The means of receiving the means and the dosing mode of the drug is determined individually. Recommended doses can vary significantly. When determining the optimal dosage, the severity of the pathological process and the patient's age is taken into account. The reception time may also be different.

for adults

The dosage of the drug is determined individually depending on the age and degree of lability of the pancreas. The permissible daily dosage for adults is about 150,000 units per day. With the complete deficiency of the outer-generating function, the dose is 400,000 units / day. This volume corresponds to the daily need of the body in enzymes.

The maximum permissible daily dose for the patient is 15,000 units / kg.

for children

The maximum daily dosage for children under the age of 1.5 years is 50,000 units / day. For children older than 100,000 units. The dose for children over the age of 12 is determined individually.

for pregnant women and during lactation

The drug can be used during pregnancy in the presence of indications for use. Assigning a means, the doctor should evaluate the state of the woman, if the insufficiency of the enzymes is expressed strongly, proceed to the reception, but the pattern of therapy, and its duration is determined individually. It is not recommended to undergo such treatment for women in the last period of pregnancy. In the period of breastfeeding, the composition is not recommended, not excluded in the development of infants.

Side effects

When applied in regulated dosages, side effects are extremely rare.

The list is possible:

• diarrhea;
• a sense of discomfort in the area of \u200b\u200bthe stomach;
• nausea;
• vomit urge;
• skin reactions.

Interaction with other medicines

Probably a decrease in activity when admission in a complex with antacids, which contains calcium. Uncommitted with iron preparations are not recommended, a decrease in therapeutic efficacy is possible.

special instructions

It is forbidden to use the agent in the aggravation phase of chronic pancreatitis. Patients with violations in the work of the digestive system are possible a high sensitivity to.

Overdose

When receiving funds in the dosage instructions, an overdose is excluded. Against the background of consumption of composition in doses exceeding the norm, a strong manifestation of adverse reactions is possible. The manifestation is characteristic of children. In such cases, symptomatic treatment is carried out. Reception of drugs to micrazim stop.

Storage conditions

The drug should be stored in the original packaging, in a dry, protected from the access of children. The optimal storage temperature is 25 degrees. Maximum duration of storage - 2 years from the date of production. Apply an overdue tool is prohibited.

Analogs

Medicinal medicine is distinguished by a unique composition. The tool has good tolerance among patients. The effect of receiving the means is manifested after 1-2 weeks after the start of the course of use. Modern Pharmacology presents the patient to the patient many enzymes, distinguished by high efficiency, but to replace the analog appointed by the micrazim can only after consultation with a specialist.

- an enzyme preparation intended to optimize the flow of digestive processes. The equipment includes digestive enzymes that ensure the splitting of proteins, fats and carbohydrates, resulting in complete absorption of the drug in the intestine. The main substance means is. The shell capsule dissolves well into the gastrointestinal tract. Reception during pregnancy and breastfeeding is allowed. The tool is used in pediatrics.

Digestin

Digestine is a balanced combination of digestive enzymes that ensure complete splitting of proteins, fats and carbohydrates entering the body. The drug is not used for children under the age of 3 months. The drug can be appointed during pregnancy. Side effects Against the background of using the funds are extremely rare.

Pancitrath

Panecitrate is often used to compensate for the pancreatic functions against the background of disorders provoked by the insufficient combination of the secret. As a result of exposure, protein cleavage process is ensured to amino acids. Pancutrate provides normalization of all digestive processes, ensures restoration of the functions of the gastrointestinal tract.

Price

The cost of the micrahis is an average of 401 rubles. Prices fluctuate from 190 to 1301 rubles.

Enzyme. Contains pancreatic enzymes - amylase, lipase and proteases that facilitate digestion of carbohydrates, fats and proteins, which contributes to their more complete suction in the small intestine. In case of diseases of the pancreas compensates for the insufficiency of its excessive function and contributes to the improvement of the digestion process.

Pharmacokinetics

Pharmacokinetics of pancreatin has not been studied.

Form release

Capsules solid gelatin, size number 2, with a brown lid and a transparent case; The contents of the capsules are cylindrical pellets or a spherical shape from light brown to brownish color, with a characteristic smell.

Auxiliary substances: EDRAGIT E-100 (methyl methacrylate, dimethylaminoethyl methacrylate and butyl methacrylate copolymer), triethyl citrate, talc, etitone Emulsion.

The composition of the capsule shell: gelatin, water, sodium lauryl sulfate, methylparaben, propylparaben, dyes (punching 4R, quinoline yellow, patented blue V, titanium dioxide).

10 pieces. - Packaging cell contour (1) - packs cardboard.
10 pieces. - Packaging cell contour (2) - packs cardboard.
10 pieces. - Packaging cell contour (3) - packs cardboard.
10 pieces. - Packaging cell contour (4) - packs cardboard.
10 pieces. - Packaging cell contour (5) - packs cardboard.
20 pcs. - Polymer bottles (1) - packs cardboard.
30 pcs. - Polymer bottles (1) - packs cardboard.
40 pcs. - Polymer bottles (1) - packs cardboard.
50 pcs. - Polymer bottles (1) - packs cardboard.
20 pcs. - Dark glass banks (1) - Cardboard packs.
30 pcs. - Dark glass banks (1) - Cardboard packs.
40 pcs. - Dark glass banks (1) - Cardboard packs.
50 pcs. - Dark glass banks (1) - Cardboard packs.
300 pcs. - Packaging cell contour (1) - cardboard boxes.
500 pcs. - Packaging cell contour (1) - cardboard boxes.
1000 pcs. - Packaging cell contour (1) - cardboard boxes.

Dosage

Dose (in terms of lipase) depends on the age and degree of failure of the pancreas function. The average dose for adults is 150,000 units / day. With the complete failure of the exhaustory function of the pancreas - 400,000 units / day, which corresponds to the daily need of an adult in Lipaz.

The maximum daily dose is 15,000 units / kg.

Children under the age of 1.5 years - 50,000 units / Couth; Older 1.5 years - 100,000 U / day.

The duration of treatment may vary from several days (when the digestive process is violated due to errors in the diet) to several months and even years (if necessary, constant replacement therapy).

Interaction

With simultaneous use with antacids containing calcium carbonate and / or magnesium hydroxide, it is possible to reduce the effectiveness of pancreatin.

With simultaneous use, it is theoretically a decrease in the clinical efficacy of acarbosis.

With the simultaneous use of iron preparations, it is possible to reduce iron absorption.

Side effects

When used in medium therapeutic doses, the side effect is observed in less than 1%.

From the digestive system: in some cases, diarrhea, constipation, discomfort in the area of \u200b\u200bthe stomach, nausea. The causal relationship of the development of these reactions with the action of pancreatin is not established, since These phenomena refer to the symptoms of the excess of the pancreas.

Allergic reactions: In some cases, skin manifestations.

From the metabolism: with long-term use in high doses, hyperurickozuria is possible, in excessively high doses - an increase in the level of uric acid in the blood plasma.

Others: When using pancreatin in high doses in children, the occurrence of perianal irritation may occur.

Indications

Insufficiency of the outer-generating function of the pancreas (including in chronic pancreatitis, fibrosis).

Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder; States after resection or irradiation of these organs, accompanied by disorders of digestion, meteorism, diarrhea (as part of combination therapy).

To improve food digestion in patients with a normal gastrointestinal function in the event of errors in nutrition, as well as with violations of chewing function, forced long-term immobilization, a sedentary lifestyle.

Preparation for X-ray and ultrasound examination of the abdominal bodies.

Contraindications

Acute pancreatitis. Increased sensitivity to pancreatic.

Features of application

Application in pregnancy and breastfeeding

The safety of the use of pancreatin during pregnancy is not sufficiently studied. Application is possible in cases where the expected benefit for the mother exceeds the potential risk to the fetus.

In experimental studies, it was found that Pancreatin does not have teratogenic action.

Application in children

Application is possible according to the dosing mode. With high activity of the lipase contained in Pancreatin, the likelihood of the development of constipation in children increases.

special instructions

In case of cystic dose should be adequate to the number of enzymes, which is necessary for suction of fats, taking into account the quality and quantity of food consumed.

Under the fibergation, the use of pancreatin in doses of more than 10,000 units / kg / day (in terms of lipase) is not recommended due to the risk of risk of strictures (fibrous colonservation) in the Ileocecal Department and in the ascending colon.

With high activity of the lipase contained in Pancreatin, the likelihood of the development of constipation in children increases. Increasing the dose of Pancreatine in this category of patients should be carried out gradually.

Disorders on the part of the digestive system may occur in patients with increased sensitivity to pancreaticine, or in patients with MECONIC ILEUS or resection of the intestine in history.