Cortexin is a nootropic preparation of cerebroprotective, anticonvulsant and antioxidant action. The active substance is Cortexin, auxiliary - glycine.
Contains a complex of low molecular weight water-soluble polypeptide fractions penetrating through the BCB directly to nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect.
- Nootropic - improves the functions of the cerebral cortex, the processes of training and memory, the concentration of attention, stability at various stressful effects.
- Neuroprotective - protects neurons from the damage to various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
- Antioxidant - inhibits peroxidation oxidation of lipids in neurons, increases the survival rate of neurons in conditions of oxidative stress and hypoxia.
- Tissue-specific - activates the metabolism of the TNS neurons and the peripheral nervous system, reparative processes, contributes to improving the functions of the cerebral cortex and the total tone of the nervous system.
The use of Cortexin helps to improve the highest functions of the brain, memory. With it, it is easier to study, carefulness increases, patients are becoming more resistant to stressful situations.
The drug protects neurons from the effects of neurotoxins, increases their survival in oxygen starvation and oxidant stress, reduces the toxicity of psychotropic substances.
Reparative processes are activated, the function of the cerebral cortex is improved, the tone of the nervous system increases. Cortexin contributes to the stimulation of the metabolism of neurons of the central and peripheral nervous system.
1 ampoule context 5 mg for the preparation of the solution for a V / M injection in the form of a powder or porous mass contains:
- the active ingredient: a complex of water-soluble polypeptide fractions with a molecular weight of not more than 10,000 yes (cortexin) - 5 mg;
- auxiliary substance: Glycine - 6 mg.
Indications for use
Why do you need Cortexin? According to the instructions for use, the drug is prescribed in the following cases:
- in the complex therapy of the cranial and brain injury;
- brain circulation disorders;
- with viral and bacterial neuroinfections;
- encephalopathy;
- asthenic states;
- acute and chronic encephalitis and encephalomyelitis;
- memory violations;
- epilepsy;
- in case of violation of memory and thinking;
- with different forms of children's cerebral paralysis;
- with a decrease in learning abilities;
- with a delay in psychomotor and speech development in children.
Instructions for applying Cortexin, dosage
The drug is intended for per / m administration.
Before the priority, the contents of the Cortexin ampouxin are dissolved in 1 to 2 ml of 0.5% solution (novocaine), 0.9% solution of sodium chloride or water for injection, directing the needle to the wall of the bottle in order to avoid foaming.
The drug is introduced every day once for 10 days:
- children with body weight up to 20 kg at a dose of 0.5 mg / kg;
- with body weight more than 20 kg;
- adults - at a dose of 10 mg.
If necessary, re-conducted after 3 - 6 months. Patients with ischemic stroke The repeated course of therapy is carried out in 10 days after the end of the previous one.
Side effects
The instruction warns the possibility of developing the following side effects when appointing Cortexin:
- the reactions of individual sensitivity to the components of the drug are possible.
The most frequent side reactions are pain and burning in place of injection, less often arise allergic rashes or urticaria.
Drug interaction of the drug is not described.
Contraindications
Contraindicated to appoint Cortexin in the following cases:
- individual intolerance to the drug;
- pregnancy.
An ampoule with a dissolved drug cannot be stored and used after storage.
Overdose
Cases of overdose by the drug are not registered.
Cortexin analogs, price in pharmacies
If necessary, replaced the cortexin on an analogue by ATX code - these are drugs:
- Amilosar,
- Vipotropyl,
Similar by action:
- Neuroksimet;
- Gingko Biloba;
- Central-b.
Choosing analogues It is important to understand that the instructions for applying Cortexin, the price and reviews of similar drugs do not apply. It is important to obtain a doctor's advice and not to produce an independent replacement of the drug.
Price in the pharmacies of Russia: Ampoules Cortexin 10mg., 10pcs - from 786 to 1194 rubles, lyophilisate 10 mg 5 ml 10 pcs. - 1207 rubles, Cortexin for children lyophilisate 5 mg 10 pcs. - from 754 to 786 rubles.
Store in an inaccessible for children protected from light at a temperature not higher than 25 ° C. Shelf life - 3 years. The pharmacies are sold on the recipe.
In neurological diseases, doctors prescribe nootropic medicine "Cortexin". Instructions for use and reviews about the preparation indicate that this tool improves cerebral blood circulation and brain function. The medicine protects the central nervous system from the effects of adverse factors. The drug is also used to treat children with mental delays and this tool consists of components of natural origin, it is well tolerated and has few contraindications.
The composition and effect of the drug
The "Cortexin" includes proteins obtained from animal brain cortex (pigs and cattle). These peptide compounds are an active substance of the drug. The medication is performed only in the form of powder (lyophilisate) for injection administration. In addition to the active ingredient, the "Cortexin" includes the amino acid glycine. This excipient improves metabolic processes in the central nervous system and complements the effect of proteins.
The lyophilisate looks like a white powder or porous mass. It is packaged in 5 ml bottles. Adult preparation contains 10 mg of active substance. Also produced "Cortexin" for children with a reduced dosage of the drug component - 5 mg.
Consider the pharmacological effect of this medication. First of all, it affects the brain as nootrop. This means that under the influence of the active component of the drug in the patient, mental activity is improved. A person becomes easier to memorize information, concentrate attention, and also fight stress.
In addition, the drug protects the cells of the nervous system from adverse factors. In humans, harmful substances are accumulated in the human body, which adversely affect the state of neurons. The drug eliminates their negative impact. The instruction for "Cortexin" and the drug reviews report that this means can stop the toxic effect on the brain of psychotropic medicines and ethanol.
The medicine can be applied both as an anticonvulsant. It effectively suppresses the foci of pathological activity in the brain. Also, the drug acts as an antioxidant. This means that it is inhibits fat oxidation processes and prevents the negative impact of free radicals on the nerve cells.
Patients are often interested in: Does "Cortexin" produced in tablets? Currently, there is only an injection form of release. However, you can choose similar preparations in a tablet form. Medicines similar to action will be discussed below.
Indications
This medicine is used in the complex therapy of the diseases of the central nervous system in adults. Children's psychiatrists when mental development delays in small patients also apply "Cortexin". Indications for the purpose of medication are as follows:
- cerebral circulation disorders;
- all types of encephalopathy;
- injuries of the skull and brain, as well as their consequences;
- memory disorders;
- reducing the concentration of attention;
- violation of thinking;
- encephalitis;
- epileptic attacks;
- asthenic states;
- autic spectrum disorders in children;
- delay in speech development and psychomotor functions;
- cardiopsychoneurosis;
- cerebral palsy.
The drug is also used to treat children experiencing serious difficulties in school. It is noted that the small patients significantly improves the memory and the ability to absorb new information after the course of therapy "Cortexin". An indication of the prescription of the drug are congenital diseases of the central nervous system in babies. In this case, the drug is used in comprehensive treatment.
Contraindications
This natural remedy has few contraindications. It is not recommended to apply under the individual intolerance to the active component and allergies to the drug. This medicine is also contraindicated by pregnant women and nursing mothers. Currently, the effect of the drug on the fruit is not studied. Therefore, future mothers are better to abandon the use of such a medicine. The active ingredient can penetrate milk. If there is a need to pass the course of treatment with lactation, then breastfeeding must be interrupted.
Unwanted effects
The instruction for "Cortexin" and the reviews about the preparation indicate that injections are usually well tolerated. In rare cases, patients had manifestations of allergies: itching and skin rash by type of urticaria. To prevent such unwanted effects, it is recommended to use water for injection or saline as a solvent for lyophilisate. Allergies were most often noted in cases where novocaine was used for breeding powder.
How to make drug injections
Before applying "Cortexin" in ampoules, powder must be dissolved. For this, the following solvents can be used:
- Novocaine.
- Saline.
- Water for injection.
Each solvent has its pros and cons. Novocaine has anesthetic effect and reduces the painfulness of the injection. However, it increases the likelihood of allergies. When using saline or water for injection, side effects are noted less often, but injections can cause discomfort. These solutions are not contained in the package with the medicine, they must be purchased separately.
To prepare the composition for crustixin injections, you will need 1-2 ml of solvent. It is necessary to follow the following algorithm of actions:
- Prepare a sterile syringe and put a needle on it.
- Open the ampoule with the solvent.
- Place the needle into the solvent and type the liquid.
- Remove the foil layer and pierce the tube tube with powder.
- Release the solvent into the bottle.
- To achieve complete dissolution of powder. To do this, you can slightly swing the bottle from side to the side.
- Dial a solution into a syringe.
The prepared composition must be used immediately for injections. Instructions for the use of "Cortexin" prohibits storing the solution. After 20 minutes, it becomes unsuitable for use. It is also impossible to mix it with other medicines in one syringe.
Pricks "Cortexin" make intramuscularly to the following parts of the body:
- upper third of the hip;
- top one third of the shoulder;
- in the front of the abdomen (if the patient is not too complete a set).
It is important to remember that this drug is not introduced into the buttocks. In this area of \u200b\u200bthe body, too much fat is contained, and the medicine will be badly absorbed.
In the instructions and reviews of "Cortexin" it is reported that the injection of the drug can be rather painful. Therefore, with a new introduction, the medication needs to retreat from the previous place of the injection at least 1 cm. Otherwise, the formation of hematomas and subcutaneous hardening is possible.
Dosage for adult patients
"Cortexin" for adults are prescribed 1 bottle (10 mg) daily. The course of treatment is 10 days. If you need to repeat therapy, then take a break for 3-6 months, and then renew the ten-day course.
If the treatment of stroke and post-stroke state is carried out, then injections are made twice a day at 10 mg. The course of therapy also takes 10 days. Then take a break for 10 days, after which the treatment is repeated. Usually two therapy courses are enough to improve the state.
Pricks of the drug is better to do in the morning or day. The use of medication in the evening can lead to insomnia, as this tool stimulates the nervous system.
Application of the drug for the treatment of children
"Cortexin" for children weighing more than 20 kg is prescribed in the same dosage as adult patients. If the baby's body is less than 20 kg, the amount of the drug doctor counts individually for each small patient. The dosage is recommended - 0.5 mg of medication per kilogram of weight.
This drug can be prescribed even a newborn. Instructions for use and reviews about "Cortexe" indicate that children have a well tolerate this means. You only need to follow the correct injection technique. It is better to take thin needles for the syringe and enter the solution very slowly. Then the child will not feel pain from the injection.
special instructions
Instructions for the use of "Cortexin" does not report the interaction of this medication with other drugs. This nootropic agent is often used in comprehensive treatment. It is well combined with other drugs and does not weaken their effect.
Also, the instructions for "Cortexin" and the reviews about the preparation indicate that its use does not reduce the concentration of attention. Therefore, driving a car and the fulfillment of complex works against the background of treatment is not contraindicated. On the contrary, this medicine increases attentiveness and improves human performance.
Storage, price and analogues
The cost of the drug in pharmacy chains is from 700 to 1300 rubles. Patients are often interested in the counterpart "Cortexin". It is impossible to choose a drug with a fully identical composition. However, there are nootropic drugs similar torapeutic action.
Some patients seem uncomfortable injection form "Cortexin". The tablets produce the following analogues of the drug:
- "Mexidol". This is a synthetic antioxidant drug. It has similar indications for use. However, the medicine is contraindicated to children and can adversely affect the concentration of attention. The price of the medication is from 243 to 580 rubles.
- "Armadin". The drug is a structural analogue of "Mexidol". However, it can be used in the treatment of children.
- "Citooflavin". The medication includes amber acid, inosine and vitamins. The purpose of the drug is shown in encephalopathy, post-ply and post-traumatic states, as well as with acute violations of cerebral blood circulation. This is a fairly safe tool that is allowed to be taken even during pregnancy and lactation.
- Natural preparation, its active component is a protein from the blood of calves. It is prescribed with VDC, encephalopathy and other lesions of the nervous system. However, it is less effective in the treatment of speech development delay in children. This drug according to indications can be applied during pregnancy and lactation. The price of drugs ranges from 500 to 1700 rubles.
All of the above preparations are released not only in tablets, but also in the form of solutions for injections.
Injection form also produce a cure for cerebrolysis. This drug has a similar composition, it is also made of pig brain proteins. This tool can be prescribed even to newborn children. Indications for use are the same as the "Cortexin", however, with epilepsy, the drug is contraindicated. Its price in pharmacy networks ranges from 650 to 1000 rubles.
Cortexin - instructions for use (how to breed, how to make injections), analogues, reviews
thank
The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!
Cortexin represents nootropic medicinal preparationAlso peptide (protein) bioregulator. Cortexin improves the metabolism process in brain structures, and due to this cerebroprotective, nootropic, anticonvulsant and antioxidant effect on the CNS.The drug is used in the complex therapy of cranopy and brain injuries, violations of cerebral circulation, neuroinfection, encephalopathy, encephalitis, encephalomyelitis, epilepsy, vegetative-vascular dystonia, cerebral paralysis, psychomotor and speech development delays in children, as well as memory disorders, thinking and ability to learning.
Composition and form of release
Currently, Cortexin is produced in a single dosage form - this is a lyophilisate for the preparation of a solution for intramuscular injections. The lyophilisate is placed in 5 ml glass bottles, which are packed in cardboard boxes of 2, 5 or 10 pieces.Lyophilisate is a special way dried protein fractions extract derived from cattle and pig brain cortex. It is this peptide extract that is the active component of the drug Cortexin. Each glass bottle contains 10 mg of protein fractions of the cerebral cortex of cattle and pigs.
In addition, in the pharmaceutical market of the CIS countries, there was a children's cortexin, the vials of which contain only 5 mg of the lyophilisate protein fractions of the cortex of corts and pigs. In addition to dosage, children's and adult cortexes are no different.
As an auxiliary component, only the amino acid glycine is included in the composition of the lyophilisate. Externally, the lyophilisate is a powder or a homogeneous porous mass of white or white-yellowish color.
Therapeutic action
Cortexin contains low molecular weight (small and length of the molecule) proteins of the cortex of the brain of pigs and cows, which, with intramuscular administration, can penetrate through the hematopalic barrier and fall into the human brain, providing its positive therapeutic effect. Cortexin has the following therapeutic effects:
- Neuroprotective (cerebroprotective);
- Nootropic;
- Anticonvulsant;
- Antioxidant.
Nootropic action Cortexin consists in improving the cognitive function of the brain. That is, it becomes easier for a person to learn, work, absorb new, etc., since the memory is improved, the concentration of attention and stress resistance.
Anticonvulsant action It is the ability to suppress the activity of the pathological focus in the brain and, thereby, to prevent the development of convulsion.
Antioxidant action It consists in slowing the process of lipid peroxidation and, thereby preventing damage to the cells of various brain structures with free radicals. In addition, Cortexin increases the survival rate of brain cells in hypoxia.
In addition to the above effects, Cortexin has tissue-specific actionwhich is the activation of the exchange of substance and repair processes in the structures of the brain, thereby improving the functional state and the total tone of the central nervous system.
The mechanism of the Cortexin action is ensured by the activation of neurons and neurotrophic brain factors, due to which the transmission of information between brain structures occurs much faster and more efficient. In addition, Cortexin optimizes the balance of brake and exciting amino acids, dopamine and serotonin in the brain, which reduces convulsive activity and improves bioelectric potential.
Indications for use
Cortexin is shown to use as part of the complex therapy of the following states and diseases:- Brain circulation disorders;
- Heart injuries and their consequences;
- Encephalopathy of any origin;
- Cognitive violations (memory disorders, attention, thinking);
- Acute or chronic encephalitis or encephalomyelitis;
- Vegeta dystonia;
- Reduced ability to learn and master the new;
- Delay of psychomotor development of children;
- Delay of the speech development of children;
- Critical conditions of newborn children with perinatal lesion of the central nervous system.
Cortexin - instructions for use
How to breed Cortexin
Since the rules for the use and breeding of children's and adult cortexin are the same, consider them together.The bottle with lyophilisate (and childish, and adults) contains one dose of Cortexin, which is directly dissolved in front of the injection, and the obtained finished solution is injected intramuscularly. The contents of the bottle can be brewed by the following solvents:
- 0.5% novocaine solution;
- Water for injection sterile;
- The saline solution is sterile for injection.
For breeding of lyophilisate, it is recommended to acquire novocaine solutions, physiological or water for injections, spilled in a small capacity container, for example, a bottle or ampoule. Optimally acquire ampoules or bottles of 2 ml or 5 ml in order to use the entire existing solution at once. Such a requirement is due to the fact that the solutions for breeding the lyophilisate Cortexin should be sterile, and the sterility once opened an ampoule or a bottle of relatively large volume at home is impossible. Therefore, it is better for each dilution to use a sterile solution, before that stored in hermetically blocked dishes.
For breeding adult or child lyophilisate, 1 is 2 ml of any specified solution. Dilution is made as follows:
1.
Take the sterile syringe of the desired volume and put the needle to the needle holder.
2.
Open the ampoule with the solvent.
3.
Lower the needle into the vial or ampoule and typing the desired amount of solution (1 - 2 ml).
4.
Remove the aluminum foil from the tube on the bottle with the lyophilisate cortexin (if any).
5.
Purify the rubber plug on the bottle with the lyophilisate syringe, in which the solvent is located.
6.
Lower the needle to about the middle of the bottle with lyophilisate.
7.
Slowly pressing the syringe piston, release the solvent in the lyophilisate. To prevent the foaming of lyophilisate, it is recommended to direct the needle from the syringe to the wall of the bottle, because in this case the liquid will be evenly drained along the glass and fall on the powder without inflating it.
8.
When the entire volume of the solvent will be released into lyophilisate, it is necessary, without removing the needles of the syringe, gently shake the bottle from side to side to achieve complete dissolution of the powder. When there is a homogeneous solution without flakes in the vial, this means that the lyophilisate completely dissolved and can be used for injection.
After complete dissolution of the lyophilisate, it is gained in the syringe. You can recruit lyophilisate with the same needle that was used to dissolve the preparation provided that it was not taken out of the tube for the period of mixing the solution. If the needle was removed from the tube tube with lyophilisate, then another sterile needle should be taken to set the finished solution in the syringe, since it will be used for subsequent injection.
Protexin lyophilisate should be breeding immediately before the injection and use immediately after obtaining the solution, since the latter cannot be stored. If for some reason the Cortexin solution was not introduced immediately after cooking and stood over 20 minutes, it should be thrown out and used anew diluted lyophilisate from another bottle.
The finished solution of Cortexin can not be mixed with other drugs, it should be administered separately.
Dosage preparation
Adults and children having a body weight of more than 20 kg , Cortexes are injected at 10 mg (one lyophilisate bottle) one time per day, within 10 days. Dosage data and treatment is the same for various states and diseases, with the exception of ischemic stroke. If necessary, Cortexin therapy courses can be renob, withstanding intervals between them at least 3 to 6 months.In stroke and in the rehabilitation period after such It is recommended to intramuscularly enter 10 mg of Cortexin (1 vial) twice a day, within 10 days. Then they take a break for 10 days, and again introduced one bottle of Cortexin 2 times a day for 10 days. Two such courses of treatment with a 10-day break between them are sufficient and complete for the treatment of ischemic stroke and improve rehabilitation after its end. Making an injection preferably in the morning and during the day, since the introduction of the drug in the evening clock can provoke excessive excitement and difficulty with falling asleep. If necessary, the course of applying Cortexin can be re-carried out, withstanding between two subsequent courses of the interval with a duration of 3 to 6 months.
Children having a body weight less than 20 kg , Cortexin dosage is calculated individually, based on the ratio of 0.5 mg per 1 kg of weight. The calculated dose is introduced to the child one time per day for 10 days. If necessary, therapy courses are repeated every 3 to 6 months, until the desired result is obtained.
If for any reason the injection of Cortexin was missed, then the next day should not be administered a double dose. It is necessary to introduce a conventional single dosage of the drug and lengthen the course of therapy so that it consists of 10 injections.
Crustixin rules
Injections of Cortexin (injections) make only intramuscularly. Before injection, you should choose the optimal place on the body to which the areas include where the muscles are suitable for the skin surface closest, such as: - The front-side surface of the hip in the upper third;
- Outer top one third of the shoulder;
- The front wall of the abdomen (not fat people).
Choosing an injection area, it is necessary to treat it with a cotton swab dipped in an antiseptic, for example, 70% alcohol, chlorhexidine, Belarus, etc. Then you should enter the needle into the thickness of the tissue, while holding it perpendicular to the surface of the skin. The needle is entered so that about 3 - 4 mm of free space remain between the skin and the needle holder. After that, slowly pressing on the piston, produce a solution in tissue and remove the syringe. After the injection is performed, the area of \u200b\u200bthe injection is again wiped with a cotton swab, moistened with an antiseptic.
For each subsequent injection from the trail from the past, 1 cm. That is, there must be a distance of at least 1 cm. All injections needed to the course of therapy can be made in the same body of the body, but withsting them between them Distance in 1 cm.
Application during pregnancy and breastfeeding
During pregnancy, Cortexes are contraindicated, because there are no genuine and convincing data on its safety for the fetus and mother.In breastfeeding, do not apply Cortexin. If a nursing woman for some reason is necessary to undergo a course of treatment with Cortexin, then it follows the period of therapy to stop feeding the child and translate it into artificial milk mixtures. A day after the last injection, you can continue breastfeeding, if you managed to maintain lactation.
Impact on the ability to manage mechanisms
Cortexin does not impair the ability to control the mechanisms, but, on the contrary, improves it, therefore, against the background of the use of the drug, you can engage in any kind of activities that require high reaction speeds and concentrations.Overdose
The overdose of Cortexin was not fixed for the entire period of observation of the drug.Interaction with other drugs
Cortexin does not significantly interact with other drugs, so it can be included in the complex therapy with any other drugs.Cortexin for children
Cortexin in practical healthcare is used for children of any age, including more than 1 year older. For young kids, the drug is most often prescribed to eliminate the delay of motor, mental or speech development, with PPTSNS (perinatal damage to the central nervous system), as well as for correction of behavior, namely, eliminating hysterical, nervousness, etc. This drug is even called "talkers", because after the course of injection of Cortexin, children quickly begin to speak, quickly and well remember new material, the texts and poems are retelling easily, it becomes clean and diverse. Also, Cortexin contributes to the acceleration of motor development of children, as a result of which, after the course of its use, the kids begin to sit, crawl, get up on legs, etc. Cortexin school children are most often prescribed to improve cognitive functions, that is, memory, thinking and attention. As a rule, schoolchildren are given by severe learning material, low ability to teach, inadvertent and monotonous speech, etc. Also, the drug is prescribed to children of any age to eliminate the consequences of various adverse effects on the brain, such as injuries, hypoxia, stress, etc.
Cortexin - Instructions for use in children
Children with a mass of body 20 kg and more cortecs are prescribed in an adult dosage, that is, 10 mg one time per day for 10 days. And for children with a body weight, less than 20 kg dosage of the drug is calculated individually, based on the ratio of 0.5 mg per 1 kg of weight. The calculated dosage is one-time, that is, such a quantity of the drug is introduced to a child one time per day for 10 days. A child can enter any cortexin - both children's, and adult, it is only important to correctly calculate the amount of solution required by the dose.Consider on the example, how to correctly calculate the dosage of cortexin for a child and translate milligrants of lyophilisate into milliliters of the finished solution.
For example, a child has a body weight of 15 kg, which means it is necessary 0.5 * 15 \u003d 7.5 mg of the cortexin lyophilisate for one injection. Next, it is necessary to decide how many milliliters of the solution you will use to breed the cortexin lyophilisate, as it is important for further computing. We put 1 ml of solution to breed the lyophilisate will be used. Then in 1 ml of the finished solution of adult cortexin will contain 10 mg of lyophilisate. But the child for injection requires not all 10 mg of lyophilisate, but only 7.5 mg. It means that it is necessary to calculate, in many milliliters of the finished cortexin solution obtained by mixing the entire volume of lyophilisate with 1 ml of solvent, contains only 7.5 mg of the active component. To do this, make up the proportion:
1 ml of solution - 10 mg of lyophilisate;
X ml of solution - 7.5 mg of lyophilisate;
According to the proportion, the equation is: x \u003d 7.5 mg * 1 ml / 10 mg; X \u003d 0.75 ml.
It means that 7.5 mg of lyophilisate is contained in 0.75 ml of a solution obtained by mixing the entire volume of the cortexin powder existing in the vial with 1 ml of solvent. Thus, for the production of injection, the child will have to dilute all the lyophilisate in the bottle and dial only 0.75 ml into the syringe. The residues of the solution should be thrown away, and for the next injection, it is possible to breed the lyophilisate from the new bottle.
In a similar way, the dosage and volume of the finished solution for injection for a child with any body weight is calculated. You can use the diagram, substituting your own numbers into it. When using children's dosage cortexin, only given the fact that one lyophilisate bottle contains not 10 mg of the active substance, but 5 mg.
Parents must remember that it is impossible to separate the lyophilisate in the bottle on the part, It is necessary to breed it all. And only then from the whole solution to select the volume necessary for a single introduction to the child. The residues of the solution should be thrown away, and not to store, and for each next injection, all the lyophilisate from one bottle is again selected, to select the desired volume, enter the child, etc.
The duration of Cortexin therapy is 10 days, and the injection is recommended in the first half of the day (up to 14.00 - 15.00), since the drug has an exciting effect, as a result of which, when introduced in the evening, it can provoke difficulties with falling asleep. Curriculum of therapy can be repeated, withsting intervals between them with a duration of 3 - 6 months, and every time re-calculating the dosage on the actual mass of the child's body.
To breed the lyophilisate for the production of cortexin injections, children are recommended to use saline or sterile water for injection, and not novocaine. The fact is that novocaine can provoke allergic reactions and reduce the severity of the therapeutic effect of Cortexin. For children, it is optimally breeding an adult cortexin (10 mg) 1 ml of solvent, and a children's 2 ml.
Injections of Cortexin Children should be carried out strictly intramuscularly according to the same rules as for adults. In addition, to reduce the pain of the injection, it is necessary to take thin needles and enter the solution very slowly, and then, according to children, they practically do not feel pain.
Side effects
Cortexin, as a rule, is well tolerated and does not provoke any side effects. However, in rare cases, the drug is capable of causing various allergic reactions as a side effect (Photo of drug
Latin name: Cortexin.
ATX code: N06BX
Active substance: Polypeptides of the cerebral cortex
Manufacturer: LLC "Gerofarm", Russia
Description Actual on: 23.10.17
Cortexin is a nootropic drug that has a tissue-specific effect on the bark of the brain due to its optimally balanced composition of neurotransmitters and polypeptides.
Active substance
Polypeptides of the Cerebral Cortex of Cattle (Polypeptides of Cattle).
Release form and composition
Produced in the form of lyophilisate for the preparation of the solution for the I / M administration. The drug is implemented in bottles (3 ml) placed in contour cellular packs of 5 pcs.
Indications for use
It is used for the following diseases and states:
- Neuroinfection of viral and bacterial character.
- Cereal brain injuries.
- Brain circulation disorders.
- Asthenic syndrome.
- Complex epilepsy therapy.
- Encephalopathy of various nature of origin.
- Complex therapy of encephalitis and encephalomyelitis.
- Child cerebral paralysis.
- Over-segmental vegetative disorders.
- Delay of speech and psychomotor development.
- Reduced learning ability.
- Violation of memory and thinking.
Contraindications
Contraindications to the use of this drug are: allergic reactions to cortexin in history, intolerance to the patient of other components of the drug, pregnancy and lactation period.
Instructions for applying Cortexin (method and dosage)
The drug is intended for per / m administration.
Before injection, the contents of the vial are dissolved in 1 - 2 ml of 0.5% plosen solution (novocaine), 0.9% sodium solution of chloride or water for injection, directing the needle to the wall of the bottle to avoid foaming. The drug is introduced every day once: children with body weight up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg and adults - at a dose of 10 mg for 10 days.
If necessary, re-conducted after 3 - 6 months.
Side effects
The use of the drug may cause side effects in the form of a reaction of hypersensitivity.
Overdose
There are no data on overdose cases.
Analogs
Analogs in the ATX code: Amilosar, Vinopotropyl, Glycine, Divaja, Oaron.
Do not make a decision on replacing the drug yourself, consult your doctor.
pharmachologic effect
Cortexin has nootropic, neuroprotective, tissue-specific and anti-coating effect.
- The nootropic effect of the drug lies in its ability to improve the highest functions of the brain, the concentration of attention, memory, facilitate learning processes, develop resistance to various stressful effects.
- The tissue-specific effect of the drug lies in its ability to activate the metabolism of neurons of the peripheral and central nervous system. In this regard, against the background of the use of Kotrexin, patients have an improvement in the functions of the cerebral cortex and the state of the nervous system as a whole.
- The neuroprotective effect of the drug is aimed at protecting neurons from the effects of various neurotoxic and endogenous factors. Thus, this tool reduces the toxic effect on the use of various psychotropic substances.
- As for the antioxidant effect of the drug, it comes down to preventing or slowing the lipid peroxidation in neurons. Thus, the use of cortexin contributes to the survival of neurons in hypoxia and oxidative stress.
special instructions
When using a 0.5% solution, the procaine should adhere to information about age limitations, precautions, contraindications set forth in the application instructions.
The bottle with a dissolved powder cannot be stored and used after storage. It is also not recommended to mix with other solutions.
In the case of passing an injection, you should not enter a double dose, and to carry out the following injection as usual in the planned day.
During pregnancy and breastfeeding
Contraindicated to use during pregnancy.
If necessary, it is necessary to stop breastfeeding during lactation.
In childhood
Application is possible according to the dosing mode.
Medicinal interaction
Medicinal interaction is not described.
Conditions of vacation from pharmacies
Recommended by recipe.
Terms and Storage Terms
Store in an inaccessible for children protected from light at a temperature not higher than 25 ° C. Shelf life - 3 years.
Price in Pharmacies
Price Cortexin for 1 package from 729 rubles.
P N003862 / 02Trade name:
Cortexin®
Grouping Name:
polypeptides of the cortex of the brain of livestock.
Dosage form:
lyophilisate for the preparation of a solution for intramuscular administration.
Composition
One bottle contains:
active substance- Cortexin 10 mg (complex of water-soluble polypeptide fractions),
auxiliary - glycine 12 mg (stabilizer).Description
Lyophilized powder or porous weight of white or white with yellowish color tinge.
Pharmacotherapeutic Group:
nootropic.
ATX code:
Characteristic
Cortexin is a complex of water-soluble polypeptide fractions with a molecular weight of no more than 10,000 yes.
pharmachologic effect
Pharmacodynamics
Cortexin® contains a complex of low molecular weight water-soluble polypeptide fractions penetrating through the hematorecephalic barrier directly to nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect.Nootropic - improves the highest functions of the brain, the processes of learning and memory, the concentration of attention, stability at various stressful effects.
Neuroprotective - protects neurons from the damage to various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
Antioxidant - inhibits peroxidation oxidation of lipids in neurons, increases the survival rate of neurons in conditions of oxidative stress and hypoxia.
Tissue-specific - activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, contributes to improving the functions of the cerebral cortex and the total tone of the nervous system.
The mechanism of action of the drug Cortexin® is due to the activation of neuron peptides and neurotrophic brain factors; optimization of the balance of metabolism of exciting and brake amino acids, dopamine, serotonin; Hamkergic effects; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).
Pharmacokinetics
The composition of the drug Cortexin®, the active substance of which is a complex of polypeptide fractions, does not allow us to hold an ordinary pharmacokinetic analysis of individual components.Indications for use
In the complex therapy of violations of the brain circulation, the cranial and brain injury and its consequences, encephalopalopathy of various genesis, cognitive violations (disorders of memory and thinking), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic states (needless vegetative disorders), reduced learning ability, Delays in psychomotor and speech development in children, various forms of children's cerebral paralysis.
Contraindications
Individual intolerance to the drug.
Application during pregnancy and in breastfeeding period
The drug is contraindicated in pregnancy (due to the lack of data of clinical studies). If necessary, prescribing the drug during the lactation period should be stopped breastfeeding (due to the lack of data of clinical studies).
Method of application and dose
The drug is injected intramuscularly.
The contents of the vial before injection are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), injection water or 0.9% sodium solution chloride (directing the needle to the vane of the bottle in order to avoid foaming) and are administered once every day: adults in a dose of 10 mg for 10 days; Children with body weight up to 20 kg at a dose of 0.5 mg / kg, with a mass mass of more than 20 kg at a dose of 10 mg for 10 days.
If necessary, conduct a re-course after 3-6 months.
With a coarse ischemic stroke in acute and early restorative periods, adults at a dose of 10 mg 2 times a day (in the morning and day) within 10 days, with a re-course after 10 days.
Possible unwanted reactions
The following undesirable reactions observed during clinical use are listed below in accordance with system-organ classification, in descending order of the occurrence: very often (≥1 / 10), often (≥1 / 100, but<1/10), нечасто (≥1/1 000, но <1/100), редко (≥1/10 000, но <1/1 000), очень редко (<1/10 000).
Overdose
Currently, the cases of overdose of the drug did not report.
Interaction with other drugs
The use of local Lidocaine anesthetic as a solvent for the preparation of a solution in children is associated with an increase in the severity of manifestations of unwanted reactions, and therefore its application is not recommended. (See "Special Instructions").
special instructions
Use Cortexin® only by appointment of a doctor!
When using a 0.5% removal solution (novocaine) as a solvent for the drug Cortexin®, information about contraindications, precautions and age limitations set forth in the application instructions (Novocaine) should be adhere to information about contraindications.
The use of local lidocaine anesthetic as a solvent for the preparation of a solution of the drug Cortexin ® is not recommended.
The bottle with a dissolved drug can not be stored and used after storage. The Cortexin® preparation solution is not recommended to be mixed with other solutions.
Features of the action of the drug at the first reception or there is no cancellation.
Special precautions during the destruction of unused drugs are not required.
Impact on the ability to control vehicles, mechanisms
In the event of symptoms of the exciting action (see the section "Sidey action"), the drug may influence the performance of potentially hazardous activities that require special attention and rapid reactions (automotive management, work with moving mechanisms).
Form release
Lyophilisate for the preparation of a solution for intramuscular administration, 10 mg. On 22 mg of lyophilisate into the vials of colorless glass with a capacity of 5 ml, covered with corks rubber and rolled aluminum caps with a tear-off plastic lining of orange. 5 bottles in the contour cellular package from the film of polyvinyl chloride or polyethylene terephthalate and aluminum foil. 2 contour cellular packages with instructions for use in a pack of cardboard.
Shelf life
3 years.
Do not use after the expiration date indicated on the package.Storage conditions
In the place protected from light at a temperature not higher than 25 ° C.
Keep out of the reach of children.Conditions of vacation
Released on the recipe.
Manufacturer
1. LLC "Gerofarm", Russia
2. FIRM FIRMENT LLC, RussiaAddress of the manufacturer / production site
1. Russia, 196158, St. Petersburg, Moscow Highway, d. 13, lit. Vi, lit. Ll; Russia, 142279, Moscow region, Serpukhovsky Municipal district, urban settlement Obolensk, district R.P. Obolensk, p. No. 5
2. Russia, 143422, Moscow region, Krasnogorsk district, p. Petrovo-Far, "Biomed" them. Mechnikov.Complaintory
LLC "Gerofarm",
Russian Federation, 191144, St. Petersburg, Degtyar Lane, D.11, Lit. B.
Cystitis during pregnancy: to cure and prevent repeated development can be pregnant during cystitis
Is it possible to make a pregnant cherry?
Cesarean without indications possible operation?
Cesarean section: from preparation for surgery before extracting from the maternity hospital What you need to make caesarean section
Menstrual-like bleeding in the middle of the cycle