Active substances: calcium (calcium citrate tetrahydrate and calcium carbonate) 250 mg; vitamin D3 (colecalciferol) 50 IU; zinc (zinc oxide) 2 mg; copper (copper oxide) 0.5 mg; manganese (manganese sulfate) 0.5 mg; boron (sodium borate decahydrate) 50 mcg;
Excipients: soy polysaccharide - 10 mg; sodium lauryl sulfate - 5 mg; colloidal silicon dioxide - 3.9 mg; croscarmellose sodium 28 mg; MCC - 199.45 mg; stearic acid - 35 mg; magnesium stearate - 10 mg;
Film shell: hypromellose - 11.71 mg; triacetin - 2.53 mg; mineral oil - 1.27 mg; sodium lauryl sulfate - 0.004 mg; titanium dioxide - 7.03 mg; magnesium silicate – 5 mg
Indications for use Kalcemin
Prevention and complex treatment of osteoporosis of various origins; replenishment of calcium and microelements deficiency in adolescents, women during pregnancy and breastfeeding.
Contraindications to the use of Calcemin
- increased individual sensitivity to any of the components of the drug;
- hypercalcemia and hypercalciuria;
- nephrolithiasis;
- hypervitaminosis D3;
- severe renal failure;
- active form of tuberculosis;
- decalcifying tumors (myeloma, bone metastases, sarcoidosis);
- children under 5 years of age.
Carefully: benign granulomatosis; taking cardiac glycosides and thiazide diuretics; pregnancy; lactation period.
Children from 5 to 12 years old - 1 tablet 1 time per day with meals.
Adults and children over 12 years old - 1 tablet 2 times a day with meals.
During pregnancy and breastfeeding: from the 20th week of pregnancy and the entire period of breastfeeding - 1 tablet. 2 times a day.
The minimum course of taking the drug for the treatment of osteoporosis as part of complex therapy for adults is 3 months, a longer course is after consultation with a doctor.
The minimum course of taking the drug for the prevention of osteoporosis for adults is 1 month, a longer course is after consultation with a doctor.
The minimum course of taking the drug for children and adults with a deficiency of calcium and microelements is 2-3 months, a longer course is after consultation with a doctor.
A second course of taking the drug is possible 1 month after the end of treatment.
Use of Calcemin during pregnancy and breastfeeding
During pregnancy and breastfeeding, taking the drug should be agreed with your doctor. The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3; hypercalcemia that develops against the background of an overdose during pregnancy can cause defects in mental and physical development in the fetus. In nursing women, it should be taken into account that colecalciferol and its metabolites pass into breast milk, so it is necessary to control the intake of calcium and vitamin D3.
pharmachologic effect
Replenishing calcium deficiency, regulating calcium-phosphorus metabolism, replenishing the deficiency of macro- and microelements, replenishing the deficiency of vitamin D.
Pharmacodynamics
A combined preparation containing calcium, vitamin D3, osteotropic minerals that regulate calcium metabolism.
The pharmacological effect of the drug is determined by the properties of its constituent ingredients.
Calcium is involved in the formation of bone tissue, reduces resorption (resorption) and increases bone density, prevents diseases of the musculoskeletal system, and helps strengthen the skeletal system and joints.
Calcium citrate ensures the absorption of calcium regardless of the functional state of the gastrointestinal tract, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as during treatment with drugs to reduce secretion; reduces the level of bone resorption markers, which indicates a slowdown in the processes of bone tissue destruction; regulates the level of parathyroid hormone, which leads to improved regulation of calcium homeostasis; does not increase the content of oxalates and calcium in the urine, therefore, does not cause the risk of kidney stones; does not block the absorption of iron, which reduces the risk of developing iron deficiency anemia.
Colecalciferol (vitamin D3) regulates the exchange of calcium and phosphorus in the body, participates in the formation of the bone skeleton, helps maintain bone structure, enhances the absorption of calcium in the intestine and the reabsorption of phosphorus in the renal tubules.
Zinc promotes the synthesis of sex hormones, which prevents the destruction of bone tissue.
Manganese is involved in the formation of proteoglycans, which improves the quality of bone tissue and forms the protein matrix of bone tissue.
Copper is involved in the synthesis of collagen and elastin, which is part of bone and connective tissue, which affects the formation of bone mass.
Boron reduces excessive activity of parathyroid hormone, improves calcium absorption, reduces the risk of developing colecalciferol deficiency, and helps prevent osteoporosis.
Side effects of Calcemin
Nausea, vomiting, flatulence, diarrhea, constipation, hypercalcemia and hypercalciuria, allergic reactions (itching, rash, urticaria).
special instructions
The dose should not exceed that specified in the instructions, because Increased calcium intake may inhibit intestinal absorption of iron, zinc and other essential minerals.
Overdose
Symptoms: decreased appetite, thirst, polyuria, dizziness, fainting, constipation, nausea and vomiting. With long-term use of excessive doses, calcification of blood vessels and tissues occurs.
Treatment: it is necessary to reduce the dose or stop using the drug. You should induce vomiting and rinse the stomach. Therapy is symptomatic.
Drug interactions
With simultaneous use of the drug Calcemin® with vitamin A, the toxicity of vitamin D3 is reduced.
Phenytoin, barbiturates, corticosteroids reduce the effectiveness of vitamin D3.
Laxatives reduce the absorption of vitamin D3.
GCS, hormonal contraceptives for systemic use, levothyroxine impair the absorption of calcium ions.
When using tetracyclines simultaneously, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) - at least 2 hours.
When using the drug Calcemin® together with cardiac glycosides, their toxicity increases (monitoring of the ECG and clinical condition is necessary), with thiazide diuretics - the risk of hypercalcemia increases, with furosemide and other loop diuretics - the excretion of calcium by the kidneys increases.
Calcemin® should not be used together with BCC.
Regulators of calcium-phosphorus metabolism.
Composition of Kalcemin
Active Ingredients:
- Calcium 250 mg (calcium citrate and calcium carbonate,
- Vitamin D3 (cholecalciferol) 50 M,
- copper (copper oxide) 0.5 m,
- zinc (zinc oxide) 2 m,
- manganese (manganese sulfate) 0.5 m,
- boron (sodium borate) 50 mcg.
Inactive Ingredients:
- maltodextry,
- microcrystalline cellulose,
- croscamelose sodium,
- acacia,
- stearic acid,
- soy polysugars,
- magnesium stearate.
Manufacturers
Sagmel Inc (United States of America)
pharmachologic effect
A combined preparation containing vitamin D3, micro- and macroelements.
Regulates phosphorus-calcium metabolism, replenishes the relative deficiency of microelements and vitamin D3, prevents diseases of the musculoskeletal system, helps strengthen the skeletal system and joints.
Side effects of Calcemin
In rare cases:
- nausea, nausea
- vomiting
- flatulence,
- hypercalcemia and hypercalciuri,
- allergic reactions.
Indications for use
I. Prevention and complex treatment of osteoporosis of various origins; 2. To replenish the deficiency of calcium and microelements in adolescents, women during pregnancy and breastfeeding.
Contraindications Calcemin
Increased individual sensitivity to any of the components of the drug, urolithiasis, hypercalcemia and hypercalciuria.
Directions for use and dosage
Adults and children over 12 years of age, one tablet 2 times a day with meals.
During pregnancy and breastfeeding, from the 20th week of pregnancy and the entire period of breastfeeding, up to 1 tablet 2 times a day.
For children from 5 to 12 years old, take 1 tablet 1 time per day with meals.
Overdose
In case of overdose, constipation, nausea, and vomiting are possible.
Manifestations of overdose also include hypercalcemia and hypercalciuria, leading to the accumulation of calcium in soft tissues and irreversible changes in the kidneys and cardiovascular system.
Interaction
No data.
special instructions
The dose should not exceed that indicated in the instructions, since increased calcium intake can inhibit the absorption of iron, zinc and other essential minerals in the intestines.
During pregnancy and breastfeeding, take the drug in consultation with your doctor.
In nursing women, it should be taken into account that cholecalciferol and its metabolites pass into breast milk.
Or Calcium-D3 Nycomed. They find out what is best to take for the treatment of osteoporosis by studying the composition and properties of the drugs, because each of them has its own characteristics and indications for use.
Calcemin Advance
The drug is used to treat osteopenia in women over 45 years of age. It contains the following ingredients:
- calcium citrate or carbonate;
- vitamin D (Calciferol);
- magnesium;
- copper;
- manganese;
- zinc.
Copper ensures the process of collagen synthesis and takes part in the formation of red blood cells and skin pigments. With osteoporosis, the body needs to get enough zinc to produce hormones:
- insulin;
- somatotropin;
- corticotropin.
Lack of copper and manganese leads to deterioration of bone tissue. Vitamin D is essential for strengthening the immune system, reducing the risk of hip fracture, and preventing cancer and heart disease.
To whom and when is the medicine prescribed?
- postmenopausal;
- senile;
- juvenile.
A diet rich in foods containing large amounts of phosphorus leads to the development of osteoporosis in old age. Therefore, it is so important to consult a doctor in time and undergo an examination.
Prescribed for the treatment of patients with atrophic gastritis, regardless of the acidity of gastric juice. The medicine is recommended for patients suffering from hypocalcemia, Graves' disease or thyrotoxicosis.
Contraindications for use
The diagnosis has been made definitively, but the patient cannot take Calcemin Advance for certain reasons.
Treatment with the drug is not carried out in case of the development of the following pathological conditions:
- hypercalcemia;
- femoral neck fracture with immobilization;
- allergic reaction;
- renal failure;
- circulatory disorders.
The patient should not self-medicate so as not to harm his health. In the early stages of the disease, it is necessary to adjust therapy by replacing drugs that are hazardous to health with similar drugs.
Directions for use and side effects
For proper absorption of calcium, the medicine is taken according to the doctor’s recommendation. Adults take the tablet with meals once a day. It is not recommended to exceed a single dose, since a large amount of the active substance affects the absorption of iron and zinc in the intestines.
While taking the drug, you must stop smoking. Take the tablet with plenty of water or milk. During treatment, follow a diet and eat foods rich in phytoestrogens.
Calcium-D3 Nycomed or Calcemin Advance is well tolerated by elderly patients if the instructions are strictly followed during treatment and do not exceed the recommended dose.
In some cases, the patient develops side effects:
- allergic reaction;
- headache;
- heartburn;
- constipation;
- fever.
If dizziness occurs during treatment, medications that prevent vertigo are prescribed to reduce the likelihood of falling.
Sometimes after taking Calcemin, the patient experiences swelling, redness and itching of the skin. In this case, you must stop treatment and seek medical help.
- Alpha D3-Teva.
Calcium-D3 Nycomed
Patients often ask what medicine is effective in the fight against osteoporosis. In the early stages of the disease, the process of bone tissue restoration is ensured by the drug Calcium-D3 Nycomed. In patients over 65 years of age, after a course of treatment, bone mineral density increases and the likelihood of fractures decreases.
Indications for use
The medicine prevents osteopenia if the patient quits smoking and corrects body weight. The treatment prevents deformation of the lumbar spine. The medicine is well tolerated by patients and does not cause the development of hypercalcemia with long-term use.
In more complex cases, Calcium-D3 Nycomed is prescribed for the prevention of osteoporosis during hormone therapy. During long-term treatment, calcium levels in the urine are monitored.
If the disease is too advanced, phosphorus-calcium metabolism changes. The drug is recommended for the treatment of patients with impaired bone density. The medicine reduces the level of alkaline phosphatase within six months after the start of treatment.
The drug reduces pain in the spine and prevents sudden fracture of the femoral neck in elderly women. Calcium-D3 Nycomed is recommended for the treatment of juvenile osteoporosis and pain in the lower extremities.
Restrictions
The medicine is prescribed with caution to people with renal failure. The drug is not recommended for patients suffering from phenylketonuria or urolithiasis.
Some patients have an individual course of the disease, however, in case of hypersensitivity to the components of the drug, its use is not recommended. In patients with an active form of tuberculosis, during treatment with Calcium-D3 Nycomed, side effects develop that worsen the course of the underlying disease.
The patient needs to study the rules for taking the drug and pay attention to the fact that the tablet should be kept in the mouth until completely dissolved.
The dose of the drug depends on the patient’s age, individual sensitivity to the active substance, hereditary factors that determine unusual reactions to taking the drug Calcium-D3 Nycomed.
Side effect
In addition to the positive therapeutic effect, the drug causes unwanted symptoms:
- anorexia;
- arrhythmias;
- thirst;
- decreased muscle tone;
- nausea;
- vomiting;
- constipation;
- weaknesses;
- mental disorder.
Adverse reactions develop after a single dose of the entire daily dose of the drug. The patient develops dry mouth, constipation, and heart rhythm disturbances.
The drug, taken in large doses, has a toxic effect on the nervous system.
Comparative characteristics of drugs
When comparing two medications, the patient learns that Calcemin tablets are coated with a film coating, which contains the following substances:
- glycerol triacetate;
- mineral oil;
- dye “Red No. 40”;
- aluminum varnish.
1 tablet of Calcium-D3 Nycomed contains less excipients:
- sorbitol-390 mg;
- povidone-36.4 mg.
The chewable tablets come in mint, orange and strawberry-watermelon flavors. As can be seen from the table, the drug Calcemin Advance contains minerals, but they are completely absent in Calcium-D3 Nycomed tablets.
The price of the drugs differs slightly; both drugs are sold in pharmacies without a prescription. Calcemin Advance is manufactured by SAGMEL, Inc. (USA), in a package of 50, 60 or 120 tablets. The drug Calcium-D3 Nycomed is produced by Nycomed Pharma AS (Norway).
Criterias of choice
When considering the question of which drug is better, it should be noted that it is not difficult to restore youth to the skeletal system, and the Calcemin Advance and Calcium-D3 Nycomed tablets have fully proven this fact. All consumers like the original, convenient packaging design. 90% of patients note that after several courses of therapy, the symptoms of osteoporosis disappeared, joints and ligaments became stronger.
Another important point to remember: both drugs are not completely harmless. For Calcemin Advance or Calcium-D3 Nycomed to be effective, you must take them under the supervision of a doctor, without increasing the dose of the medicine yourself.
Before starting therapy, the patient needs to undergo a complete examination to identify concomitant pathologies. A visit to the doctor is necessary if an elderly person is taking the medicine, because... self-medication can harm his health.
In this article you can read the instructions for use of the drug Kalcemin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of vitamin Calcemin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Calcemin analogues in the presence of existing structural analogues. Use for the treatment of hypovitaminosis and osteoporosis in adults, children, as well as during pregnancy and lactation. Composition of vitamins and duration of treatment with the drug.
Kalcemin- a combined preparation of vitamins and microelements. Regulates phosphorus-calcium metabolism. Replenishes the deficiency of microelements, calcium and vitamin D3, helps strengthen bones and joints, and prevents diseases of the musculoskeletal system.
Compound
Calcium (calcium citrate and calcium carbonate) + Colecalciferol (vit. D3) + Zinc (in the form of oxide) + Copper (in the form of oxide) + Manganese (in the form of sulfate) + Boron (in the form of sodium borate) + excipients.
Calcium (calcium citrate and calcium carbonate) + Colecalciferol (vit. D3) + Magnesium (in the form of oxide) + Zinc (in the form of oxide) + Copper (in the form of oxide) + Manganese (in the form of sulfate) + Boron (in the form of sodium borate ) + excipients (Calcemin Advance).
Indications
- prevention and treatment of osteoporosis of various origins;
- replenishment of calcium and microelements deficiency in adolescents;
- replenishment of calcium and microelements deficiency in women during pregnancy and breastfeeding.
Release forms
Film-coated tablets (including Calcemin Advance).
Instructions for use and course of treatment
Adults and children over 12 years of age are prescribed 1 tablet 2 times a day with meals. The duration of the course of preventive treatment is 1 month.
Children aged 5 to 12 years are prescribed 1 tablet 1 time per day with meals.
From the 20th week of pregnancy and throughout the entire period of breastfeeding, 1 tablet is prescribed 2 times a day.
For calcium and microelements deficiency, 1 tablet per day is prescribed.
Advance
Adults and children (over 12 years old) - 1 tablet 2 times a day. The drug is prescribed orally during meals.
For calcium and mineral salt deficiency, the recommended dose is 1 tablet per day.
Side effect
- nausea, vomiting;
- flatulence;
- hypercalcemia;
- hypercalciuria;
- allergic reactions.
Contraindications
- urolithiasis disease;
- hypercalcemia;
- hypercalciuria;
- children under 5 years of age;
- children under 12 years of age (Advance);
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
It is possible to prescribe the drug Kalcemin during pregnancy and lactation according to indications.
When used during breastfeeding, it should be taken into account that colecalciferol and its metabolites are excreted in breast milk.
Use in children
The drug is prescribed to children over 5 years of age.
special instructions
When using the drug, you should not exceed the recommended dose, because Increased calcium intake may inhibit intestinal absorption of iron, zinc and other essential minerals.
Drug interactions
Drug interactions with Kalcemin have not been described.
Analogues of the drug Kalcemin
The drug Kalcemin has no structural analogues of the active substance. However, there are a large number of similar preparations based on various combinations of vitamins and microelements:
- Aktiferrin;
- Van-E-Day;
- Vi-Fer;
- Vitaspectrum;
- Vitrum;
- Glutamevit;
- Jungle with minerals;
- Dr. Theiss Multivitamol;
- Duovit;
- Calcium Sandoz Forte;
- Calcium Sandoz;
- Kaltsinova;
- Complivit;
- Lavita;
- Magwit;
- Magne B6;
- Magne B6 forte;
- Magnelis B6;
- Magnesium plus B6;
- Maxamine forte;
- Materna;
- Mega Vite;
- Megadin Pronatal;
- Menopace;
- Multi-Sanostol;
- Multi-tabs;
- Multimax;
- Multiproduct for children;
- Multiproduct for women;
- Oligovit;
- Osteocea;
- Pedivit forte;
- Pikovit;
- Polivit;
- Pregnavite;
- Pregnakea;
- Sorbifer Durules;
- Supradin;
- Teravit;
- Totema;
- Tri-V-Plus;
- Pharmaton Vital;
- Fenyuls;
- Ferretab;
- Ferro-Folgamma;
- Ferroplex;
- Centrum;
- Unicap.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Calcemin is a well-known vitamin and mineral complex used for the prevention and treatment of diseases of the musculoskeletal system. Calcemin is necessary during pregnancy and lactation, as well as during intensive growth of children.
Pharmacological action of Calcemin
Calcemin contains: calcium, zinc, boron, manganese, copper, vitamin D. Calcium is part of bone tissue. With its help, the body ensures normal vascular permeability, heart automaticity, interneuronal and neuromuscular conduction. Calcium plays an important role in the contraction of skeletal and smooth muscles, as well as in the process of blood clotting.
In Kalcemin, calcium is represented by carbonate and citrate salts. Calcium carbonate contains elemental calcium. Under the influence of calcium citrate, the drug is absorbed regardless of the state of the gastrointestinal tract and the stage of digestion; with long-term use, the risk of stone formation in the urinary tract is reduced, in addition, the activity of parathyroid hormone is reduced.
Calcium is absorbed in the gastrointestinal tract and excreted through feces, sweat and urine. The speed of calcium excretion depends on the presence of calbindin in intestinal cells. The more it is, the faster calcium is removed from the body.
Reviews of Calcemin indicate that vitamin D included in the complex normalizes the absorption of calcium and promotes its participation in the construction and, if necessary, regeneration of bone tissue. Vitamin D absorption occurs in the small intestine. Then it enters the plasma of lymph and blood, and from there to the liver, adrenal glands, bones, myocardium, muscles and adipose tissue. Vitamin D is excreted through bile into the intestines, where it is again partially absorbed and then converted into inactive metabolites.
Zinc is one of the components that make up more than two hundred enzymes that take part in the synthesis of nucleic acids responsible for gene expression. In addition, these enzymes are involved in protein synthesis, cell growth and repair, and contribute to the normal activity of alkaline phosphatase (ALP). Absorption of zinc occurs in the intestines, and excretion occurs in the urine (from two to ten percent) and in feces (ninety percent).
Copper in Calcemin is necessary for participation in the synthesis of elastin and collagen; it reduces bone demineralization. Partial absorption occurs in the small intestine. The main part in the form of insoluble compounds is removed from the body with feces. Eighty percent of absorbed copper is excreted through bile, sixteen percent through the walls of the gastrointestinal tract, and about four percent through urine. The remaining small amount comes from sweat.
Manganese helps normalize the synthesis of glycosaminoglycans, thus helping to produce components of bone and cartilage tissue. Duplicates the calcium-sparing effect of vitamin D. Ninety-five percent is excreted in bile.
Boron in Kalcemin affects the activity of parathyroid hormone produced by the thyroid gland, which, in turn, is involved in the metabolism of calcium, phosphorus, magnesium, colecalciferol, vitamin D. It is very quickly absorbed by the gastrointestinal tract, ninety percent is excreted in the urine.
Release form
Calcemin is available in the form of tablets containing 250 milligrams of elemental calcium or 500 milligrams of Calcemin Advance.
Indications for use of Calcemin
According to the instructions, Kalcemin is prescribed for the prevention of diseases of the musculoskeletal system, including osteoporosis, as well as for preventive purposes in case of weakened periodontium and teeth. If you do not receive enough necessary vitamins and minerals from food, the drug is used to replenish them.
According to reviews, Kalcemin is useful for children during intensive growth. In addition, Calcemin is prescribed during pregnancy and breastfeeding to maintain the required level of vitamins and minerals. The drug is often taken by women during menopause.
The drug is also indicated for patients taking medications belonging to the groups of immunosuppressants and glucocorticosteroids.
Many patients who took the enhanced formulation of the drug give good reviews about Calcemin Advance. With its help, the healing of fractures improves, and the deficiency of microelements and calcium in adolescents is compensated. The drug is used both for the treatment and prevention of osteoporosis.
Directions for use and dosage
According to the instructions, Kalcemin is allowed to be taken by children aged five years and older. The drug is taken either before meals or during meals. The dose of the drug for children from five to twelve years old is one tablet once a day. Children over twelve years of age and adults are prescribed Calcemin one tablet twice a day. The duration of treatment is determined individually for each patient; the duration of taking the drug is not limited.
Calcemin Advance is approved for use in children aged twelve years and older. The dose of the drug for adults and children is one tablet twice a day with meals. It is also possible to prescribe the drug after the twentieth week of pregnancy. The dose is the same as usual - one tablet twice a day.
Sometimes a drug with a higher content of components is taken to increase the content of calcium and mineral salts in the body. In this case, it is recommended to take one tablet of Calcemin Advance per day.
Side effects
According to the instructions for Kalcemin, side effects may occur due to an overdose or hypersensitivity to the components of the drug. Nausea, vomiting, flatulence, hypercalcemia, hypercalciuria, and sometimes allergic reactions may occur.
Contraindications for use
Calcemin is prohibited for kidney stones, hypercalcemia, hypersensitivity, hypercalciuria. If, according to indications, the drug is needed for children under five years of age, it is prescribed under strict medical supervision.
Conditions and shelf life
Calcemin is stored in a dry, dark place, out of reach of children, at room temperature. The shelf life, subject to the above conditions, is three years.
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