Amg hormone lowered is it possible to get pregnant. The likelihood of spontaneous pregnancy with low amg

The article tells about the Antimüller hormone (AMH), what it is and how important it is in a woman's body.

Antimüller hormone: hormonal norm for the female body and the likelihood of pregnancy

In the human body, there are a great many, which are individually responsible for the correct operation of various functions.

Negative fluctuations in the hormonal level are the cause of many diseases. Let's figure out the characteristics of the Antimüller hormone, its functional features, hormonal norms and the rules for taking a blood test.

What is Anti-Müller Hormone (AMH)?

AMH is a special hormone associated with reproductive functions. In the female body, thanks to it, the processes of growth of the structural components of the ovaries - the follicle - and an increase in the number of eggs that have reached the final point of maturation occur. This substance plays an important role in the biological processes of women from birth.

Until the onset of adolescence, the value of the hormone remains at a minimum level. AMH is normalized at the onset of reproductive processes, and is kept within specific limits during the menstrual cycle.

Indications for taking the analysis

The content of the inhibitor in the blood cells of women indicates the number of follicles at rest. This indicator is called PCM, and it characterizes the likelihood of conception and how quickly menopause can occur.

Inhibitory analysis is prescribed for:

1. Serious ovarian disorders;
2. Slowing down the processes of puberty;
3. Premature onset;
4. Weak or no IVF effectiveness.

Passing this analysis reveals the causes of infertility or malignant tumor.

What is the normal outcome?

These values \u200b\u200bare characteristic of a healthy female, who is capable of conceiving and bearing a fetus.

For the Mueller inhibitor, the norm is 1-2.5 or 0.5-12.6 ng / ml (values \u200b\u200bmay vary depending on the examination methods). The laboratory must write the values \u200b\u200bthat are taken as the norm for them.

Increased rate

If the level of the hormone exceeds the norm, this may be due to the following manifestations:

1. Slowly flowing puberty;
2. The appearance of tumor formations in the ovarian region;
3. The onset of signs of polycystic disease.

These are the most common causes of an increase in the content of a substance in the blood.

Low level: causes

Low hormonal levels may indicate the following pathological manifestations:

1. Changes before menopause;
2. Obesity;
3. Decreased PCM due to age-related characteristics.

Is it possible to get pregnant with a low level?

The onset of pregnancy due to low levels of the inhibitor is possible, however, only in very rare circumstances. The egg cell in such a situation is not always able to mature to a full-fledged state.

To determine the possibility of a successful conception, you should pass the proper tests and undergo an ultrasound procedure.

The final results are more influenced by the age of the patient and the level of follitropin.

Pregnancy with a high AMH rate

A high hormonal concentration is always indicated by a value exceeding the established norm of 1-2.5. With minimal deviations in the value, when the girl prepares for the undergoing artificial insemination procedure, exceeding the indicators will in no way prevent a positive pregnancy. A high percentage of AMH signals the presence of tumor-like formations and other disorders that can interfere with an adequate bioprocess.

Anti-Müllerian hormone: the norm for conception in women

In order for conception to occur, a healthy hormonal background is needed. Despite the fact that this hormone does not directly affect the conception of a child, it shows how the female reproductive system works.

Indicators may vary slightly from person to person - this is normal.

Table

The hormone indicators are estimated according to the table below.

Decoding indicators

You can conceive and endure at any hormone level, except for a very low one. When diagnosing a very low level, egg maturation will be required, and it may also be necessary at a low level.

High values \u200b\u200bof the hormone may indicate diseases of the reproductive system, for example, polycystic disease, or be the result of stimulation.

Treatment

If analyzes show a low presence of an inhibitor substance, it is necessary to artificially stimulate the functioning of the ovaries so that they begin to produce eggs. There are also drugs on the market (for example, DHEA) that can increase the percentage of the component for a while, but this will not be enough to solve the problem with infertility, since pathology must be prevented for a positive result.

Diagnosis of infertility includes many studies, but one of the main ones is the analysis of hormones in a woman. Levels of endocrine hormones, which regulate the functioning of the reproductive system, are routinely determined. If such a study does not give results, an anti-Müllerian hormone test is additionally prescribed.

Anti-Müllerian hormone (AMH) is present in the body of both sexes. The hormone is produced by the gonads from birth, but only during puberty does it reach its maximum.

In men, AMH levels are high during periods of growth and puberty, since the hormone is involved in the development of the genitals. With a critical decrease in AMH levels, a man may be unable to conceive a child. After puberty, the level decreases, but the hormone continues to be produced until the end of life.

The importance of the hormone for women is different. The concentration of AMH remains in the blood from birth to menopause. In the female body, anti-Müllerian hormone is produced by the granulosa tissue of the ovaries. Accordingly, the more cells are involved in the process, the higher the hormone will be. With the onset of menopause.

How the number of eggs is determined

Experts call the anti-Müllerian hormone an “oocyte counter” because its level reflects the number of capable oocytes. The number of germ cells capable of fertilization is laid in the girl's body even at the stage of intrauterine development.

In puberty, there are up to 300 thousand of them, if the girl does not have serious pathologies. This number of cells is called the ovarian reserve. Each menstrual cycle in a healthy woman is marked by the maturation of the germ cells, from which the most capable and high-quality ones stand out.

The process of maturation of sex cells in the body of a sexually mature woman does not stop during pregnancy and the use of contraceptives. By itself, the anti-Müllerian hormone does not play an important role in the fertilization process, but its diagnostic potential is enormous.

The extended Efort test can be used to determine the concentration of AMH in a woman's blood and to assess her ovarian reserve. When the Efort test is prescribed:

• absence of pregnancy during normal sexual life without the use of contraception;
• infertility for unclear reasons;
• unsuccessful IVF in history;
• late puberty;
• determination of the results of antiandrogenic treatment;
• polycystic ovary syndrome;
• suspected ovarian tumor;
• increased levels of follicle-stimulating hormone.

Modern medicine makes it possible to predict the premature depletion of oocyte reserves and plan a pregnancy in order to be on time. For the study, it is necessary to collect anamnesis and determine the indicators of FSH, LH and AMH.

The number of follicles is counted using ultrasound. Additionally, candidate genes for premature ovarian failure are being investigated. Young girls who are at risk of early ovarian exhaustion should implement their reproductive plans and family planning on time.

There is an additional preventive measure: social and biological preservation of fertility, that is, cryopreservation of oocytes. This method is recommended for those women who postpone the birth of children due to temporary medical contraindications.

However, in women with increased FSH, decreased AMH, ovarian volume up to 3 ml and the number of antral follicles up to one, it is not always possible to obtain oocytes for storage. Such patients are advised to use donor material.

Preparation for analysis

In order for the test results to be informative and accurate, it is necessary to follow all the instructions for preparing for the study. To determine the level of AMH, venous blood is needed. The Efort test is carried out strictly on the third or fifth day of the cycle.

A few days before the test, it is necessary to minimize physical and psycho-emotional stress. One hour before the analysis, one must not eat or smoke. Donation of blood is postponed if, shortly before that, a woman has suffered an acute infection or other serious illness.

Anti-Müllerian hormone rate

Only a doctor can correctly interpret the results of any analysis, since many different factors can affect the data obtained. The hormone index is almost independent of external factors such as diet and lifestyle. Age also does not matter. Some women over 40 have significantly higher AMH levels than girls of reproductive age.

AMG standards:

• for a woman: 1-2.5 ng / ml;
• for a man: 0.49-5.98 ng / ml.

When the level deviates from the norm in a woman of reproductive age, it is important to first check the reproductive system for pathologies and disorders. The anti-Müllerian hormone reflects the functionality of the ovaries, therefore, the state of other organs and the concentration of other hormones, as a rule, do not affect the results of the study. When detecting deviations from the norm, violations must be looked for precisely in the ovaries and the processes that regulate their work.

Lowered anti-Müllerian hormone

A reduced indicator is considered to be less than 1 ng / ml in women of reproductive age. Before puberty and after menopause, low AMH levels are considered normal because primary follicular activity is absent at this age.

A low concentration of AMH in a woman of reproductive age indicates a small number of primary follicles ready for fertilization, as well as ovarian depletion. Both of these reasons lead to the same result - difficulty in conceiving naturally and minimal response to drug stimulation.

Atimüllerian hormone affects the growth and differentiation of tissues. Differentiation is the formation of a cell genotype. In a woman with a normal hormonal background, differentiation, maturation and release of one egg fall out for one cycle. In the presence of violations, anovulatory, irregular and other disruptions in the menstrual cycle appear.

The AMH indicator is only an indicator of the number of capable oocytes, but the reasons for their reduction are completely different. With a decrease in AMH levels, it is necessary to find and treat the cause, not the effect. This is the only way to correct consequences such as infertility and early climate change.

Reasons for the decrease in AMH:

• menopause;
• dysgenesis of the gonads (incomplete development of the glands);
• early puberty;
• obesity and other metabolic disorders;
• hypogonadotropic hypogonadism.

A decrease in AMH levels after age 30 may be a signal of early menopause. The decrease is due to various factors, so a woman will need to consult not only a gynecologist, but also an endocrinologist and reproductologist. Usually, changes in the concentration of AMH are detected precisely during preparation for fertilization or when clarifying the reasons why conception fails.

Natural conception with low AMH

The issue of natural conception with low AMH remains controversial. Critical is considered to be less than 0.2 ng / ml, low - up to 1 ng / ml. With very low AMH levels, the chances of conceiving spontaneously are minimal.

With a low concentration of the hormone, it is necessary to additionally pass an FSH test. If the level of follicle-stimulating hormone is within the normal range, the chances of natural conception remain.

A serious problem is the combination of low AMH and high FSH. A decrease in the level of AMH in women from 40 years old indicates that the reserve of eggs is running out, and there is no way to force the body to produce additional ones.

If the reason for the decrease in AMH was menopause, but the woman still wants to become pregnant, hormone replacement therapy may be required. This will help delay menopause and increase the chances of natural conception.

The ability to conceive depends on the number of oocytes, the number of genetic and chromosomal mutations, the degree of sensitivity of the endometrium of the uterus, the presence of gynecological and other pathologies.

In vitro fertilization with low AMH

Low AMH determines the chances of a natural pregnancy. If this indicator is not combined with other alarming signals, IVF allows you to achieve egg maturation and successful conception even with minimal stimulation. Therefore, a low AMH index does not become a contraindication to in vitro fertilization.

In contrast, IVF will be the most likely method of conception when anti-Müllerian hormone levels are low. The Japanese IVF protocol is recommended when combining low AMH and high FSH (from 15 IU / L). The minimum stimulation is divided at breaks to obtain 1–2 viable eggs in each cycle. The resulting cells are frozen and transferred to the uterus at a favorable time.

The IVF duct in the natural cycle is used in cases where a woman's ovarian reserve is depleted for one reason or another. Stimulation of ovulation is carried out minimally or not at all. Over the course of several cycles, doctors try to get at least one egg, which is fertilized and transferred into the uterine cavity.

The short IVF protocol with ovarian stimulation is indicated with a slight decrease in AMH, which does not accurately indicate an egg deficiency. It is necessary to take into account the level of FSH, the age of the patient, the results of previous protocols and stimulations. If all these indicators are normal, the chances of conception are high, therefore, a short protocol is carried out.

Preparation for IVF with low AMH levels may include the use of transdermal testosterone, androgens, estrogens, DHEP, hCG, LH, L-arginine, corticosteroids, aromatosis. Herbal medicine and hirudotherapy are recommended.

When to use donor eggs

A third of women of older reproductive age cannot get pregnant even through IVF. The use of donor eggs is required. Artificial ovarian stimulation is most often ineffective with low AMH in combination with other disorders. On the contrary, additional stimulation can deplete egg reserves more.

Indications for oocyte donation:

• increased FSH;
• lowered anti-Müllerian hormone;
• insufficient ovarian volume (less than 3 ml);
• the absence of antral follicles or the presence of only one.

If a woman does not want to use donor material, the most promising IVF protocol is used, although stimulation in such patients is most often ineffective. In this case, the best option would be to listen to the recommendations of your reproductologist.

Increased AMH levels

A woman's AMH level is considered elevated when it exceeds 2.5 ng / ml. It should be borne in mind that in preparation for IVF, this figure should be slightly exceeded. The increase will tell you that the stimulation is working and the chances of successful fertilization are high. Reasons for an increase in AMH levels:

• tumor;
• polycystic ovary disease;
• delayed sexual development;
• defects in luteinizing hormone receptors.

All the reasons for the increase in AMH levels can be divided into two groups. The first includes conditions in which the follicles mature normally, but the eggs do not go beyond the glands. This can be observed with polycystic ovary, when the follicle grows and develops, but is unable to overcome the cystic surface.

The second group includes an increase in the concentration of AMG against the background of the growth of granulosa tissue of the ovaries. The most obvious reason is the tumor transformation of the sex glands. When an elevated AMH is detected, an ultrasound of the ovaries is first prescribed. After detecting tumors or polycystic disease, it is necessary to undergo long-term treatment and re-take the analysis. The results are likely to improve significantly.

Therapy with elevated AMH

Treatment of the causes of an increase in AMH is carried out taking into account the age of the woman and the goals that need to be achieved in this way. Therapy for polycystic ovary syndrome includes the normalization of body weight, nutritional correction, adequate physical activity, rest and work regimen.

A woman should normalize hormones and carbohydrate metabolism. After this, it is possible to stimulate ovulation or to surgically ensure the release of the egg outside the ovaries. The tactics of treatment for hyperplastic processes in the ovaries are agreed with the oncologist. In case of detection of malignant neoplasms, the issue of conception is postponed until complete recovery.

How to increase AMG

An increase in AMH values \u200b\u200bdoes not lead to an increase in the chances of natural conception. Stimulation of hormone production with drugs does not change the number of capable eggs, and, therefore, does not solve the problem of infertility. In this case, the treatment consists in identifying and eliminating the causes of the decrease in the hormone.

Often, artificial stimulation is ineffective, since a decrease in AMH indicates a premature menopause. Such patients are advised to pay attention to assisted reproductive technologies. Even if the results of the analysis for AMG deviate from the norm, one should not panic ahead of time.

Decreased or elevated anti-Müllerian hormone is not an indicator of absolute infertility and the inability to conceive a child on your own. It is necessary to take into account many other factors and only after that make a decision on artificial stimulation and in vitro fertilization.

Every woman dreams of becoming a mother. Especially responsible couples are examined before conceiving a child. The most important thing to do is check your hormones. To do this, you should pass an analysis for hormones. These include anti-Müllerian hormone (AMH). But what to do when low AMH is noted in the analysis results? Is it possible to get pregnant in such a situation? The presented article will help you find answers to these questions.

Norma AMG

An AMG test helps to determine how many eggs are capable of turning into a baby. It shows how many follicles have matured in a woman's ovaries.

Before drawing conclusions about whether you have low AMH or normal, you need to familiarize yourself with the indicators of the norm. This hormone begins to increase from the moment puberty begins. Therefore, in women of reproductive age, this indicator reaches its maximum level and ranges from 1 to 2.5 ng / ml.

For a more accurate assessment of the hormone content, the analysis must be taken on the 5th day of the menstrual cycle. Deviations from the norm can be caused by various diseases. If you eliminate them, then at may be possible.

In the case when it comes to IVF, a slight increase in the hormone will only play into the hands of a woman. After all, this increases the likelihood of successful resolution of the procedure.

Reasons for the decrease in AMH

An increase in AMH levels can provoke one of the following conditions:

• normogonadotropic anovulatory infertility;
• abnormalities in the functioning of luteinizing hormone (LH) receptors;
• tumor processes in the ovaries;
• the presence of polycystic formations in the ovaries.

Low AMH is observed when:

• decrease (usually associated with aging of the body);
• menopause (not a pathology, since sooner or later it occurs in the life of every woman);
• overweight (obesity at childbearing age, that is, at 20-30 years old);
• ovarian dysfunction.

Possibility of pregnancy with reduced AMH

The presence of a reduced concentration of the hormone in a woman's body almost always indicates the presence of any pathology. Disorders in the reproductive system can be of a different nature: from the usual overweight and ending with tumor formations.

Despite the reasons that caused a decrease in the level of the hormone in the body, pregnancy with a low AMH becomes problematic. Since the content of this hormone cannot be artificially increased. The cause of the abnormality can be corrected, but an increase in the number of eggs is unlikely. It is possible to influence their quality and maturity.

Statistics indicate that for women with low AMH, only the procedure of artificial insemination can be consolation. In addition, it often requires donor biological materials.

But there are also cases when the AMH decrease is corrected independently. This suggests that during the delivery of the analysis, some negative factor influenced its content, which distorted the research result.

Therefore, in each specific case, it is necessary to contact a specialist and develop a specific action plan.

AMG index for IVF

In the modern world, for couples who want to conceive a child, but for some reason cannot do it naturally, there is an artificial insemination procedure. In medicine, it is called in vitro fertilization (IVF). This process is rather complicated and laborious.

Initially, you need to be examined. The most indicative in this case will be the analysis for AMG. The anti-Müllerian hormone will show the reproductologist how many of a woman's eggs are suitable for fertilization. That is why there is a framework, that is, a certain indicator of this hormone is needed.

For the procedure of artificial insemination, the AMH index in a woman must be at least 0.8 ng / ml. Otherwise, the procedure will simply be impossible, because there is not the required number of eggs for fertilization. Even low AMH stimulation will be difficult.

However, too high an indicator can be troublesome. In preparation for IVF, hormonal stimulation of follicle maturation is carried out. Due to the increased content of AMG in a woman's body, there is a risk of ovarian hyperstimulation.

Low AMH levels: is IVF possible?

Statistics indicate that IVF with low AMH is possible. But this is very difficult to accomplish. The hormone index does not affect whether the embryo will take root in a woman's body. But the very fact of fertilization can. Indeed, with a low AMH index, the number of eggs is very low, and their quality can be even worse. In addition, in this case, time is not on the side of future parents.

In principle, the procedure of artificial insemination with a low AMH is no different from the IVF procedure with a normal hormone level. But here the woman is forced to take more serious hormonal drugs. In addition, a longer period is required for the maturation of the eggs.

Typically, patients are prescribed hormonal drugs in a double dose. This, of course, sounds intimidating, but there is no reason to worry. A low hormone level will not lead to ovarian hyperstimulation or any other disease of the reproductive system.

Further actions of specialists depend on how the preparatory stage went. If everything went well and the number of eggs that can be fertilized has increased, then doctors take a follicle puncture, fertilize the egg and transfer the embryo into the mother's body. If the hormone indicator remains at a low level, then drug therapy should be reviewed.

IVF protocols

The AMG index is crucial for the IVF procedure. Knowing this indicator, the fertility specialist chooses a more appropriate action plan and protocol.

IVF protocols for low AMH can be of two types: long and short.

Long-term protocols are enforced one week before the onset of menstruation. Over the next three weeks, ovarian stimulation is performed to increase the number of eggs available for fertilization. Then a large number of eggs (up to 20) are punctured and fertilized. Artificially conceived three or five day old embryos are implanted in a woman. There is a possible complication in this protocol - the risk of ovarian hyperstimulation.

A short protocol begins to be performed on the 2-3rd day of menstruation. Ovum stimulation is performed. For this, a puncture of the dominant follicles is done. However, in this case, complications are possible - the lack of high-quality eggs. In addition, the procedure is only suitable for women with good ovaries.

IVF without hormonal stimulation

With a low AMH, fertilization is possible without exposing the woman to shock doses of hormonal drugs. In this case, doctors monitor the woman's natural ovulation using an ultrasound scan. In this way, no more than 2 mature eggs are obtained in one cycle, which significantly reduces the chance of pregnancy.

This method, however, is also very difficult and has its pros and cons. On the positive side, in this case, you will not get twins or triplets, and you will not suffer from the side effects of hormone therapy. In addition, the cost of such fertilization is much lower.

The disadvantages include the fact that there is a high probability of missing the moment of egg maturation. Moreover, its quality will not be exactly what is necessary for a successful procedure.

Statistics

Low FSH, low AMH and other abnormalities are obstacles to fertilization. As statistics show, with IVF only 20-60% end successfully. The likelihood of success depends on the woman's age, the quality of her egg and her hormonal status.

However, medicine does not stand still, and every year diagnostics and fertilization procedures are being improved. Thus, it becomes easier to give birth to a child from year to year.

High FSH and low AMH

Quite often, along with a low level of AMH, a high level of FSH is observed. FSH is a follicle-stimulating hormone that is responsible for the production of follicles in the ovaries. This situation is a rather serious obstacle to the IVF procedure.

Undoubtedly, statistics say that almost all IVF attempts end in pregnancy. But high FSH levels can prevent this from happening. In this case, it is recommended to complete the fertilization procedure using donor material.

And yet there is a chance to use your egg for this, but it is very small. This is only possible if the FSH level is slightly increased. But with a very high FSH, you should not waste precious time. A woman may never ovulate, which indicates the advisability of using a donor egg.

One of the serious stimulants of the proper functioning of the gonads in women and men is Anti-Müllerian hormone (AMH). It is an indicator of whether a woman can get pregnant. In men, the substance promotes the development of the genitals. If the couple cannot conceive a child in any way, it is worth checking the blood for AMH levels. When the indicator is lowered, women ask how to increase AMH? Many are interested in the question of whether it is possible to become pregnant if the anti-Müllerian hormone is lowered? This article will address this issue.

The hormone begins to be produced in an infant from the day of his birth. Upon reaching puberty and ready to conceive, the amount of substance in the blood rises and reaches a maximum. With a gradual decrease in reproductive function, the volume of the hormone decreases and reaches a minimum in women during menopause, in men at the end of life.

Generation and function of the hormone

Mueller's inhibitory substance is produced by the sex glands. in women, it stimulates the production of follicles, in which they are able to mature and prepare for the fertilization of the egg. If viable follicles are not produced, the woman's reproductive function will be impaired. In the absence of a dominant follicle and a mature egg, fertilization will not occur. Moreover, IVF fertilization using your own egg will be impossible.

The production of AMH in a woman's body depends on the specific day of the cycle. In humans, gonadotropins affect the generation of the hormone. What distinguishes the described inhibitory substance from other hormones, its secretion is not influenced by nutrition, the patient's lifestyle and other external circumstances.

In men, AMH contributes to the proper development of the genitals. If its volume is below normal, a male patient is likely to have a functional impossibility to conceive a baby.

Decreased value of the indicator

If the anti-Müllerian hormone is lowered, this means the development of pathology. The amount of anti-Müllerian substance is reduced in the following situations:

• Insufficient development of the ovaries in women and testes in men;
• Too early puberty;
• Insufficient functioning of the gonads and insufficient production of sex hormones by them;
• Violation of the menstrual cycle in women (with this frequent pathology, it is necessary to investigate the content of hormones in the blood);
• Decreased supply of healthy eggs in women;
• Decrease in the number of primary follicles suitable for reproduction;
• The onset of menopause, including early menopause;
• Ovarian dysfunction;
• Endometriosis (proliferation of the lining of the uterus);
• Tumor diseases of the ovaries.

Low levels of anti-Müllerian hormone in young men may be associated with early sexual development and "hormonal burnout." Developmental disorders are also possible - the absence of testicles, not lowering them into the scrotum, functional pathology. Rarely does a hereditary disease called false hermaphroditism, in which a man's external genitals are fully developed, but an ultrasound can reveal the presence of a small uterus.

The main thing with a low AMG value is to identify pathology in time. If the disease that caused the hormone to decrease is treated early, the ability to reproduce will return. When the hormone is lowered over time, infertility is much more difficult to cure. Surgery may be required for treatment.

Increased hormone levels

• Lack of ovulation in a woman caused by dysfunction of the endocrine and gonads.
• Decreased sensitivity of receptors to luteinizing hormone. It is the surge in LH that stimulates ovulation. Without its assistance or in the absence of sensitivity to LH, the body reacts with an increased amount of AMH.
• Tumor diseases of the ovaries. An increase in the volume of AMH with it is associated with the secretion of a substance by tumor cells that are not intended for this.

An increased value of the hormone can also indicate a slow sexual development of a girl or boy. It is necessary to lower the indicator, eliminating the reason for its increase, using medical methods. Hormone-reducing pills have not yet been invented.

Mueller Inhibiting Substance Rate

The hormone rate does not depend on the age of the patients. The anti-Müllerian hormone in a woman in her 40s may be higher, and she may have a larger supply of eggs than a 20-year-old girl, and the ability to become pregnant is sometimes inherent in quite old women. But in the same woman, the amount of the substance changes with age.

The normal AMH score depends on gender. In women, the norm ranges from 1 to 2.5 ng / ml. In men, it ranges from 0.49 to 5.88 ng / ml.

The violation of the indicator of the normal volume of a substance is sometimes random. It can be low or high. First of all, the doctor will send the patient for a second analysis after some time.

If the substances in the woman's body are more than normal, this indicates a disease. When the underlying disease is cured, this indicator will also decrease.

When a study shows a normal amount of AMH in a woman's blood, it is necessary to check the content of the substance in her partner.

Is it possible to increase the hormone?

What to do when Mueller's hormone is below normal? How to boost anti-Müllerian hormone? There is little consolation in the case of a reduced indicator. A woman most likely has a problem with reproductive function associated with the pathology of the female genital organs, obesity, early menopause, tumor diseases, etc. I have to go to the doctor.

It should be noted that a value less than 1 ng / ml is considered low. If the patient has a substance volume less than 0.2 ng / ml, it's time to sound the alarm. It is impossible to increase the anti-Müllerian indicator. Yes, it's not about him, but about the disease to which he points.

Of course, now there are many ways of artificial insemination. But they need a mature egg, which the patient does not have. In such cases, the doctor will recommend an IVF procedure or another method using a donor egg.

Pregnancy with low AMH

Is pregnancy possible with low AMH? If you see a doctor in time and identify the cause of the deviation of the hormone volume from the norm, there is a chance of recovery. Can anti-Müllerian hormone be increased? Yes, if the reasons that caused the decrease in its content are eliminated.

It is possible to increase the hormone if its decrease was caused by severe stress or heavy physical exertion. Then the elimination of a non-standard situation, rest, calmness will raise the indicator. When it comes to early menopause, it is difficult to deal with it. And there is early menopause, as the cause of reproductive disorders, more often.

Also, a low anti-Müllerian hormone can be observed when taking hormonal drugs. It is necessary to inform the doctor about their use.

It is usually not possible to increase the anti-Müllerian hormone with folk remedies. With the described pathology, the doctor at the family planning center must decide whether it makes sense to stimulate the ovaries to produce a viable egg or raise the question of IVF fertilization with a donor egg. The task of increasing the indicator is usually not set.

Treatment of a low AMH content is carried out by a doctor. It is dangerous to prescribe pills and procedures on your own. In addition, while the patient uses traditional methods of treatment to increase the volume of the substance, she may miss out on precious time of reproductive age.

Low levels of Müller hormone are usually combined with high levels of FSH (follicle-stimulating hormone). If this is not the case, the doctor will look deeper into the cause of the AMH decrease.

Hormone test

The analysis for AMG is taken by expectant mothers who have decided to undergo an IVF procedure. In the family planning center, every woman will be advised to take an analysis for gonadotropic and sex hormones when planning a pregnancy.

Typically, blood is drawn from a vein. Women should be tested on the 5th day of the cycle. Three days before the study, it is necessary to cancel heavy physical activity and take care of yourself from stress. You cannot take alcoholic beverages on the eve of the day when you donate blood. It is forbidden to drink hormonal drugs that increase the content of other hormones. You can eat the last time before the study in the evening a few hours before bedtime. In the morning, on the day of the analysis, you can neither drink nor eat. Also, in the morning before the analysis, you should stop smoking.

If the patient has suffered an acute illness of any kind shortly before the study, the doctor must be notified. It is not necessary to get upset if the norm of the amount of the hormone in the blood is violated. Perhaps, in your case, it is caused by temporary reasons, and in the next menstrual cycle you will get a good result.

Anti-Müllerian hormone (Müller's inhibitory substance, AMH) is secreted by the ovaries from the moment the girl is born until the menopausal period.

What is evidenced by the lowered anti-Müllerian hormone, is it possible to get pregnant with low levels of its content? Its production is not influenced by other hormones, organs and systems.

The amount of AMH is directly related to the ability of the ovaries to produce mature follicles and makes it possible to determine the number of eggs that can fertilize. With age, the amount of AMG decreases and disappears in the postmenopausal period.

With adequate hormonal control, one menstrual cycle corresponds to the maturation and release of one egg. If the control is violated, the cycle breaks: ovulation does not occur and the corpus luteum does not form. Menses without ovulation.

A small amount of AMH signals the poor performance of the ovaries, their inability to form healthy eggs capable of fertilization.

There is no way to increase this indicator: even if you artificially try to raise the level of the hormone with the help of drugs, an increase in the number of eggs will not occur.

The AMH level also characterizes the state of the ovarian resource.

A healthy, sexually mature woman has approximately 300,000 eggs, and their number decreases every year.

The ovarian ovarian resource indicates the number of follicles present in them and makes it possible to predict the result of ovarian stimulation during IVF. With a good RR index, patients even with critically low AMH levels have a hope of getting pregnant through artificial insemination.

The norm of AMG is from 2.2 to 6.8 ng / ml. The content of less than 2.2 ng / ml is considered to be reduced. Very low - less than 0.3 ng / ml. Smaller values \u200b\u200bare extremely unfavorable and prevent pregnancy.

What if the anti-Müllerian hormone is lowered?

A low level of AMH when planning a pregnancy requires additional examination and consultation with a doctor - an endocrinologist and reproductologist.

The level of follicle-stimulating hormone (FSH) should be determined: it affects the process of maturation of follicles, inside which there are eggs ripe for fertilization.

Its amount is directly determined by the phase of the ovular cycle and averages 2.8 - 21.0 IU / ml.

A small amount of AMH is an important reason for the increase in FSH levels and the emergence of difficulties with artificial insemination due to the poor quality of the eggs.

Luteinizing hormone (LH) is actively involved in the work of the reproductive sphere. You also need to know its content: the possibility of conception is influenced by the ratio of LH and FSH. Physiological indicators of the ratio LH / FSH should be respectively 1.3 - 2.5 / 1.0. This ratio of hormones indicates that pregnancy is possible.

Do not panic if the test result for AMG is unsatisfactory: the indicators can be influenced by excess body weight, smoking, taking certain medications, storage and transportation of test tubes with blood.

In addition, a specialist should deal with the interpretation of the result, bare numbers are not able to make a diagnosis.

Is it possible to get pregnant?

Lowered anti-Müllerian hormone - is it possible to get pregnant? This question interests women.

The possibility of conception depends on the causes of the decrease in anti-Müllerian hormone.

If it is reduced due to physical or emotional overload, then after the necessary rest, provided there are no other pathologies, the probability of conception increases.

However, the most common causes of low AMH are early menopause or obesity. The possibility of conception in this case should be calculated in conjunction with an endocrinologist, elimination of the causes will lead to a positive result.

To determine the likelihood of pregnancy, ovarian stimulation should be considered to produce fertile eggs. If the efforts have not led to the long-awaited pregnancy, alternative options can be considered.

Nothing can be done with a low follicular reserve, there is no way to increase it. You need to come to terms with this fact and contact a reproductologist to select the optimal IVF protocol.

Spontaneous conception with low AMH

With an uncritically lowered AMH index, an analysis is required for the amount of FSH.

If the indicators are not overestimated, there is a likelihood of self-conception.

If a low AMH level is caused by an approaching menopause, then the possibility of pregnancy should be assessed in conjunction with an endocrinologist.

Against the background of hormone replacement therapy, spontaneous conception is very likely.

More information about the anti-Müllerian hormone and its importance in the body of a woman is presented.

IVF procedure with a low AMH index

For the successful implementation of IVF, it is necessary that the hormone indicator is at least 0.8 ng / ml.

With lower hormone indices, the likelihood of pregnancy is low even with IVF due to the scanty amount of mature eggs.

However, a low AMG index does not affect whether the implanted embryo will take root or not. A critically low level of the hormone indicates significant difficulties, nevertheless, IVF has a chance of success.

In the case of an insufficient amount of AMG, the IVF procedure is carried out in the same way as with its normal content. The AMG index determines the choice of the most optimal IVF protocol. The stages of its implementation are the same for any AMG indicators. With a small AMH, several options are possible:

1. Long protocol used with a weak response of the ovaries: 3 - 7 follicles have matured. A powerful long-term (up to 45 days) hormonal therapy is pre-assigned, which stimulates the intensive production of eggs and accelerates the maturation of follicles. However, with a very low AMH, there is a high risk of disruption of ovulatory stimulation. A significant drawback of a long protocol is the danger of ovarian hyperstimulation, the severe form of which is dangerous to the health and life of a woman. A mild degree occurs in most cases and responds well to treatment.
2. Standard protocol used with a moderate response of the ovaries - 10 or more follicles have matured. If the stimulation stage is successful, the reproductive specialist carries out the subsequent manipulations provided for by the IVF protocol: ovarian puncture and fertilization of the egg. Within three to five days, their division is monitored and then planted into the uterine cavity.

A woman is registered with a reproductive specialist, and in case of pregnancy, an obstetrician - gynecologist in a antenatal clinic takes control of her.

The use of ovarian stimulation at a critically low level of AMH has no effect and can lead to a rapid depletion of the ovarian reserve. Difficulties arise in the stimulation phase due to the small number of eggs and in the fertilization phase due to their poor quality: cell division and embryo formation do not occur.

If the response of the ovaries is poor - no more than three follicles - the subsequent procedures are recommended to be carried out according to the cryoprotocol.

Eggs or embryos are frozen so that in case of IVF failure, they can be used without going through the ovular stimulation phase again.

IVF options with low AMG numbers can be the use of ICSI technology (ICSI) - sperm are injected directly into the egg.

IVF is possible using the donor's egg.

Along with low AMH, the patient's age influences negative IVF results.

With a small AMH, obtaining a finished embryo does not guarantee a successful IVF result: aged patients (over 40 years old) cannot always endure pregnancy, the fetus has chromosomal pathologies.

Low AMH levels do not in all cases lead to the inability to become pregnant and bear a child. Difficulties in conceiving are the result of various factors that must be detected and eliminated. It is worthwhile to repeatedly undergo a comprehensive examination and re-delivery of tests. In case of failure, donor eggs or surrogacy can be used.

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