Release form
Composition
For 1 suppository: The active substance is bisacodyl - 10 mg. ; Excipient - fatty acid glycerides (solid fat, witepsol H15)
Pharmacological effect
Combined antimicrobial drug. The effectiveness of the drug is due to the presence in its composition of such active ingredients as metronidazole and chlorhexidine. ; Metronidazole is a nitroimidazole derivative that has antiprotozoal and antibacterial action against anaerobic protozoa and anaerobic bacteria that cause periodontitis: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiformis, Eolinentilla spp. spp. ; Inactive against aerobic bacteria. ; The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. ; Chlorhexidine - disinfectant, active against a wide range of vegetative forms of gram-negative and gram-positive microorganisms, yeast, dermatophytes and lipophilic viruses. It acts on bacterial spores only at elevated temperatures. The bactericidal effect is due to the binding of cations (the result of the dissociation of chlorhexidine salt in a physiological environment) with negatively charged walls of bacterial cells and extramicrobial complexes. In low concentrations, disrupting the osmotic balance of bacterial cells and the release of potassium and phosphorus ions from them, has a bacteriostatic effect; at high concentrations, the cytoplasmic content of the bacterial cell is deposited, which ultimately leads to the death of bacteria.
Indications
acute gingivitis; ; acute necrotizing ulcerative gingivitis Vincent; chronic edematous gingivitis; chronic hyperplastic gingivitis; ; chronic atrophic (desquamative) gingivitis; ; chronic periodontitis; periodontal abscess; recurrent aphthous (ulcerative) stomatitis; ; gangrenous pulpitis; ; post-extraction alveolitis; ; juvenile periodontitis; ; toothache of infectious origin.
Contraindications
hypersensitivity (including to metronidazole, chlorhexidine and nitroimidazole derivatives). ; With caution: pregnancy, lactation.
Application during pregnancy and lactation
Method of administration and dosage
The product is intended for dental use only! ; Locally, after thoroughly brushing the teeth, rinse the mouth with a soda solution and wipe the gums with a dry cotton ball. Squeeze a small amount of the gel onto the toothbrush and apply the gel with the toothbrush to the gums and interdental spaces. After applying the gel, you can not rinse your mouth and eat for 30 minutes. Apply to the gum area 2 times / day. The duration of treatment is on average 7-10 days. ; To prevent disease, a small amount of gel (about the size of a pea) is added to the toothpaste. Prophylactic courses of treatment are carried out within 2-4 weeks. 1-2 times a year.
The last updated description by the manufacturer 14.08.2008
Filtered list
Active substance:
ATX
Pharmacological groups
Nosological classification (ICD-10)
Composition and form of release
in an aluminum tube 10 or 25 g; in a pack of cardboard 1 tube.
Description of the dosage form
Homogeneous gel, from white to white with a yellowish sheen.
pharmachologic effect
pharmachologic effect- antiseptic, antibacterial.Pharmacodynamics
The effectiveness of the drug is due to the presence of two antibacterial components in its composition:
Metronidazole has antibacterial action against anaerobic bacteria that cause periodontal disease: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp.;
Chlorhexidine is a broad spectrum antiseptic that has a bactericidal effect against vegetative forms of gram-negative and gram-positive microorganisms, as well as yeast, dermatophytes and lipophilic viruses.
Pharmacokinetics
When applied topically, Dentamet ™ gel is practically not absorbed.
Indications of the drug Dentamet
Infectious and inflammatory diseases of the periodontal and oral mucosa:
acute and chronic gingivitis;
acute necrotizing ulcerative gingivitis of Vincent;
acute and chronic periodontitis;
juvenile periodontitis;
periodontal disease complicated by gingivitis;
aphthous stomatitis;
inflammation of the oral mucosa when wearing prostheses;
postextraction alveolitis (inflammation of the socket after tooth extraction);
periodontitis, periodontal abscess (as part of combination therapy).
Contraindications
individual intolerance to metronidazole and other derivatives of nitroimidazole, chlorhexidine;
intolerance to any components that make up the drug;
children under 6 years of age.
Application during pregnancy and lactation
Side effects
With topical application of Dentamet ™ gel, the risk of developing systemic side effects is small, but sometimes headache, allergic reactions (skin rash, itching, urticaria) may occur.
Interaction
Method of administration and dosage
Locally, for dental use only.
Adults and children over 6 years of age with gum disease (gingivitis) Dentamet ™ is applied to the gum area 2 times a day, it is not recommended to wash off the gel. The duration of the course of treatment is on average 7-10 days. After applying the gel, you should refrain from drinking and eating for 30 minutes.
In case of periodontitis after removal of dental plaque, periodontal pockets are treated with Dentamet ™ gel and the gel is applied to the gum area. Exposure time - 30 min. The number of procedures depends on the severity of the disease. In the future, the patient can apply the gel independently: Dentamet ™ is applied to the gum area 2 times a day for 7-10 days.
In case of aphthous stomatitis, Dentamet ™ is applied to the affected area of the oral mucosa 2 times a day for 7-10 days.
To prevent exacerbations of chronic gingivitis and periodontitis, Dentamet ™ gel is applied to the gum area 2 times a day for 7-10 days. Preventive treatment courses are carried out 2-3 times a year.
To prevent post-extraction alveolitis after tooth extraction, the hole is treated with Dentamet ™ gel, then the gel is applied on an outpatient basis 2-3 times a day for 7-10 days.
Overdose
Cases of drug overdose with topical application were not observed.
special instructions
The use of Dentamet ™ gel does not replace hygienic teeth cleaning, therefore, during the course of treatment with the drug, teeth cleaning should be continued.
Storage conditions of the drug Dentamet
At a temperature not exceeding 25 ° C.Keep out of the reach of children.
Shelf life of the drug Dentamet
2 years.Do not use after the expiration date printed on the package.
Synonyms for nosological groups
| ICD-10 heading | Synonyms of diseases according to ICD-10 |
|---|---|
| A69.1 Other Vincent infections | Angina Vincent |
| Angina Plout-Vincent | |
| Angina Simanovsky-Plaut-Vincent | |
| Sore throat ulcerative membranous | |
| K05.0 Acute gingivitis | Gingivitis |
| Acute gingivitis | |
| Vincent's acute necrotizing gingivitis | |
| Acute ulcerative gingivitis | |
| K05.1 Chronic gingivitis | Chronic gingivitis |
| K05.2 Acute periodontitis | Periodontal disease |
| Periodontitis | |
| Acute periodontitis | |
| Periodontal disease complicated by gingivitis | |
| Pericoronitis | |
| K05.3 Chronic periodontitis | Periodontal infections |
| Chronic periodontitis | |
| Periodontitis | |
| K05.4 Periodontal disease | Alveolar pyorrhea |
| Amphodontosis | |
| Pyorrhea | |
| Superficial and deep periodontal disease | |
| Chronic periodontal disease | |
| K10.3 Alveolitis of jaws | Alveolitis |
| Post-extraction alveolitis | |
| K12.0 Recurrent oral aphthae | Aphthous stomatitis |
| Aphthous stomatitis | |
| Aphthae | |
| Aphthae of the oral mucosa | |
| Bednar Afta | |
| Oral ulceration | |
| Ulceration of the oral mucosa | |
| Ulceration of the oral mucosa | |
| Recurrent aphthous stomatitis | |
| Aphthous stomatitis | |
| K12.1 Other forms of stomatitis | Angular stomatitis |
| Ulcerative necrotizing stomatitis | |
| Ulcerative stomatitis | |
| K13.0 Diseases of lips | Actinic cheilosis |
| Inflammation of the mucous membrane of the lips | |
| Rash on the lips | |
| Glacial erythema of the lips | |
| Glandular cheilitis | |
| Zayed | |
| Mycotic jam | |
| Chapped lips | |
| Cracks in the corners of the mouth | |
| Heilit | |
| Exfoliative cheilitis | |
| Erosive cheilitis | |
| Z97.2 Presence of a dental prosthetic device (complete) (partial) | Sore gums when wearing dentures |
| Dentures | |
| Ulceration from dentures | |
| Damage to the mucous membrane when wearing dentures | |
| Bedsores from removable dentures | |
| Irritation from dentures | |
| Irritation of the oral mucosa with dentures and braces | |
| Wounds when wearing dentures | |
| Denture ulcers |
Dentamet- an effective antimicrobial complex that affects the main pathogenic microflora of the oral cavity, which is the main cause of the development of the inflammatory process
Due to the adhesive properties of its gel base, Dentamet is securely fixed in the lesion focus, which provides a long-term therapeutic effect.
The effectiveness of the drug is due to the presence of two antibacterial components in its composition:
Metronidazole has an antibacterial effect against anaerobic bacteria that cause periodontal disease: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp.
Chlorhexidine is a broad spectrum antiseptic that has a bactericidal effect against vegetative forms of gram-negative and gram-positive microorganisms, as well as yeast, dermatophytes and lipophilic viruses.
Indications for use:
Dentamet is intended for the treatment of infectious and inflammatory diseases of the periodontal and oral mucosa:
- acute and chronic gingivitis;
- Acute necrotizing ulcerative gingivitis of Vincent;
- acute and chronic periodontitis;
- juvenile periodontitis;
- periodontal disease complicated by gingivitis;
- aphthous stomatitis;
- cheilitis;
- inflammation of the oral mucosa when wearing prostheses;
- postextraction alveolitis (inflammation of the hole after tooth extraction);
- periodontitis, periodontal abscess (as part of combination therapy).
Mode of application:
Dentamet applied topically, for dental use only.
Adults and children over 6 years of age with gum disease (gingivitis) Dentamet is applied to the gum area 2 times a day, it is not recommended to wash off the gel. The duration of the course of treatment is on average 7-10 days. After applying the gel, you should refrain from drinking and eating for 30 minutes.
In case of periodontitis after removing dental plaque, periodontal pockets are treated with Dentamet gel and the gel is applied to the gum area. Exposure time - 30 min. The number of procedures depends on the severity of the disease.
In the future, the patient can apply the gel independently: Dentamet is applied to the gum area 2 times a day for 7-10 days.
With aphthous stomatitis, Dentamet is applied to the affected area of the oral mucosa 2 times a day for 7-10 days.
To prevent exacerbations of chronic gingivitis and periodontitis, Dentamet gel is applied to the gum area 2 times a day for 7-10 days. Preventive treatment courses are carried out 2-3 times a year.
To prevent post-extraction alveolitis after tooth extraction, the hole is treated with Dentamet gel, then the gel is applied on an outpatient basis 2-3 times a day for 7-10 days.
Side effects:
When applied topically gel Dentamet the risk of developing systemic side effects is small, but sometimes headache, allergic reactions (skin rash, itching, urticaria) may occur.
Contraindications:
Contraindications to the use of the gel Dentamet are: individual intolerance to metronidazole and other derivatives of nitroimidazole, chlorhexidine; intolerance to any components that make up the drug; children under 6 years of age.
Interaction with other medicinal products:
When applied topically in the recommended doses of systemic interaction of the gel Dentamet with other drugs has not been identified.
Overdose:
Cases of drug overdose Dentamet when applied topically, it was not observed.
Storage conditions:
In a dry, dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Release form:
Dentamet - dental gel.
In an aluminum tube 10 or 25 g.
Composition:
100 g of the drug Dentamet contains active substances: metronidazole 1 g, chlorhexidine gluconate 20% solution 0.5 g.
Excipients (adhesive gel base): menthol 0.25 g, glycerin (glycerol) 5g, propylene glycol 5g, thermostable triethanolamine 0.47g, Arespol 1.25 g, soluble saccharin 0.25 g, purified water 86.28 g.
Composition and release form of the drug
10 g - tubes (1) - cardboard packs.
25 g - tubes (1) - cardboard packs.
pharmachologic effect
Combined drug for topical use.
Metronidazole- a derivative of nitroimidazole, which has antiprotozoal and antibacterial action against anaerobic protozoa and anaerobic bacteria, causing: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiformis, Wolinella recta, Treponema spp., Epp.
Inactive against aerobic bacteria.
The mechanism of action consists in the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
- disinfectant, active against a wide range of vegetative forms of gram-negative and gram-positive microorganisms, yeast, dermatophytes and lipophilic viruses. It acts on bacterial spores only at elevated temperatures. The bactericidal effect is due to the binding of cations (the result of the dissociation of chlorhexidine salt in a physiological environment) with negatively charged walls of bacterial cells and extramicrobial complexes. At low concentrations, disrupting the osmotic balance of bacterial cells and the release of potassium and phosphorus ions from them, has a bacteriostatic effect; at high concentrations, the cytoplasmic content of the bacterial cell is deposited, which ultimately leads to the death of bacteria.
Indications
Acute gingivitis; acute necrotizing ulcerative gingivitis of Vincent; chronic edematous gingivitis; chronic hyperplastic gingivitis; chronic atrophic (desquamative) gingivitis; chronic periodontitis; periodontal abscess; recurrent aphthous (ulcerative) stomatitis; gangrenous pulpitis; post-extraction alveolitis; juvenile periodontitis; toothache of infectious origin.
Contraindications
Hypersensitivity (including to metronidazole, chlorhexidine and nitroimidazole derivatives); children under 6 years of age.
With care: pregnancy, lactation.
Dosage
For dental use only.
Locally, after thorough brushing of the teeth, apply to the gums and interdental spaces. Apply 2 times / day.
For the purpose of prevention, a small amount is added to the toothpaste.
Side effects
Local reactions:"metallic" taste in the mouth.
Systemic reactions:, allergic reactions (skin rash, itching, urticaria).
Drug interactions
Enhances the anticoagulant effect warfarin(an increase in the time of prothrombin formation).
Simultaneous use with disulfiram increases toxicity, which can lead to the development of neurological symptoms.
The antimicrobial activity of metronidazole decreases with simultaneous use with and phenytoin due to the accelerated metabolism of metronidazole.
Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in the concentration of metronidazole in the blood serum.
special instructions
The use of the drug does not replace hygienic cleaning of the teeth, therefore, during the course of treatment with the drug, tooth cleaning should be continued. However, you should not combine the application of the gel at the same time with the toothpaste.
Avoid contact with eyes.
Pregnancy and lactation
During lactation, if it is necessary to prescribe the drug, it is necessary to decide on the termination of breastfeeding.
Childhood use
Contraindication- children under 6 years of age.
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