Egilok 25 which course to use. Egilok S - an effective remedy for the normalization of blood pressure and heart rate

Instructions for use:

Egilok is a remedy for the treatment of pathology of the cardiovascular system.

pharmachologic effect

According to the instructions, Egilok refers to beta1-adrenergic blocking agents. The main active ingredient is metoprolol. It has antianginal, antiarrhythmic, blood pressure lowering effect. By blocking beta1-adrenergic receptors, Egilok reduces the stimulating effect of the sympathetic nervous system on the heart muscle, rapidly reduces heart rate and blood pressure. The antihypertensive effect of the drug is long-term, since the peripheral vascular resistance decreases gradually.

Against the background of long-term use of Egilok with high blood pressure, the mass of the left ventricle significantly decreases, it relaxes better in the diastolic phase. According to reviews, Egilok is able to reduce mortality from cardiovascular pathology in males with a moderate increase in blood pressure.

Like its counterparts, Egilok reduces the heart's need for oxygen due to a decrease in pressure and heart rate. Thanks to this, diastole is lengthened - the time during which the heart rests, which improves its blood supply and the absorption of oxygen from the blood. This action reduces the incidence of angina attacks, and against the background of asymptomatic episodes of ischemia, the patient's physical condition and quality of life are significantly improved.

The use of Egilok reduces the frequency of ventricular heartbeats during atrial fibrillation, ventricular premature beats and supraventricular tachycardia.

Compared to the non-selective beta-blockers of the Egilok analogs, it has less pronounced vasoconstrictor and bronchial properties, and it also has less effect on carbohydrate metabolism.

Against the background of taking the drug for several years, blood cholesterol is significantly reduced.

Egilok release form

Egilok is available in tablets of 25, 50 and 100 mg.

Indications

The drug is used to treat angina pectoris, myocardial infarction, arterial hypertension, including in elderly patients, rhythm disturbances, in the complex treatment of migraine.

Contraindications

According to the instructions, Egilok cannot be used in case of atrioventricular block of 2 and 3 degrees, weakness of the sinus node, lowering blood pressure below 90-100 mm Hg. Art., with sinus bradycardia with a heart rate below 50-60 beats per minute.

Hypersensitivity to the components of the drug is also a contraindication.

Egilok instructions for use

The drug in tablets is taken regardless of food, the selection of the dose is strictly individual and should be carried out gradually. Egilok cannot be taken more than 200 mg / day. To achieve the effect, regular intake of the drug is important.

To lower blood pressure, start with a dose of 25-50 mg 2 times a day (morning, evening), increasing the dose if necessary.

For the treatment of angina pectoris, take 25-50 mg 2-3 times a day, if the effect is insufficient, the dose is increased to 200 mg / day, or another drug is added to the treatment regimen. It is advisable to maintain a heart rate of 55-60 beats / min while taking the medication at rest and no more than 110 beats / min during exercise.

As a maintenance therapy after myocardial infarction, 100-200 mg / day is prescribed in 2 divided doses.

In case of cardiac arrhythmias, the initial dose is 25-50 mg 2-3 times a day, in case of insufficient effectiveness, it is increased to 200 mg / day or another antiarrhythmic agent is added to the treatment regimen.

If there are indications for Egilok in the treatment of migraine attacks, its dose in this case is 100 mg / day in 2 divided doses.

With concomitant pathology of the kidneys and liver, as well as in elderly patients, changes in the dose of Egilok are not required.

When a patient uses contact lenses, the patient should be aware of the possible appearance of discomfort due to a decrease in the production of tear fluid during treatment with this agent.

If a surgical operation is planned while taking Egilok, the anesthesiologist should be warned about this so that he can choose adequate means for anesthesia with minimal inotropic effect. It is not required to cancel the drug.

It is necessary to complete treatment with the drug gradually, once every 2 weeks, reducing the dose. Abrupt withdrawal of the drug may worsen the patient's condition.

Side effects

According to Egilok's reviews, it can sometimes cause headache, fatigue, depression, insomnia, dizziness, decreased concentration, decreased heart rate, shortness of breath, bronchospasm, rhinitis, nausea, diarrhea, vomiting, abdominal pain, increased sweating, allergic reactions.

Photo of the drug

Latin name: Egilok

ATX code: C07AB02

Active substance: Metoprolol (Metoprolol)

Producer: EGIS Pharmaceuticals PLC (Hungary)

Description up to date on: 10.11.17

Egilok is a drug that has been developed to treat diseases of the cardiovascular system. The use of Egilok helps to reduce the frequency of ventricular heart contractions in supraventricular tachycardia, ventricular premature beats and atrial fibrillation.

Active substance

Metoprolol (Metoprolol).

Release form and composition

It is produced in the form of white round, biconvex tablets. They are sold in dark glass jars of 30 and 60 tablets, in cardboard packages.

Indications for use

• myocardial infarction;
• angina pectoris;
• arterial hypertension;
• heart rhythm disturbances;
• migraine (in combination therapy);
• hyperthyroidism (as part of complex treatment).

Contraindications

• heart failure in the phase of decompensation;
• SSSU;
• sinoatrial blockade;
• cardiogenic shock;
• severe arterial hypotension;
• angiospastic angina pectoris;
• AV blockade of the second and third degree;
• severe bradycardia;
• persons under the age of 18;
• hypersensitivity to metoprolol and other components of the drug;
• breastfeeding.

With extreme caution, it is prescribed for the following pathologies: metabolic acidosis, diabetes mellitus, bronchial asthma, obliterating peripheral vascular disease, chronic obstructive pulmonary disease, chronic renal failure, myasthenia gravis, psoriasis, depression, chronic liver failure and thyrotoxicosis.

Instructions for use of Egilok (method and dosage)

The tablets are taken orally, regardless of the meal. The tablet can be split in half for ease of swallowing.

The dosage is selected individually in each case. The maximum daily dosage should not exceed 200 mg.

For the treatment of moderate or mild arterial hypertension, therapy should be started with 25-50 mg twice a day (in the morning and afternoon). The dosage can be gradually increased to 100-200 mg per day or combined with other antihypertensive drugs.

• For angina pectoris, treatment begins with 25-50 mg 2-3 times a day. The dosage can be gradually increased to 200 mg per day.
• After myocardial infarction, 100-200 mg is prescribed for maintenance therapy. Which are divided into two equal receptions.
• If the heart rhythm is disturbed, treatment should be started with 25-50 mg 2-3 times a day. The dosage can be gradually increased to 200 mg.
• For the treatment of hyperthyroidism, 150-200 mg is prescribed in 3-4 doses.
• For functional disorders of the heart, 50 mg is prescribed twice a day, if necessary, the dose can be increased to 200 mg.
• For the prevention of migraine, it is necessary to take 100 mg in two doses, with the possibility of increasing to 200 mg.

Side effects

The use of tablets can cause the following side effects:

• on the part of the cardiovascular system: palpitations, sinus bradycardia, orthostatic hypotension, decreased myocardial contractility, impaired myocardial conduction, cardialgia, arrhythmia, temporary worsening of symptoms of chronic heart failure;
• from the nervous system: weakness, fatigue, headache, inhibition of motor and mental reactions, depression, paresthesia in the limbs, insomnia or drowsiness, confusion, asthenic syndrome, nightmares, short-term memory impairment;
• from the gastrointestinal tract: abdominal pain, dry mouth, constipation, nausea, vomiting, taste changes, hyperbilirubinemia;
• from the hematopoietic system: leukopenia, agranulocytosis, thrombocytopenia;
• from the respiratory system: difficulty in exhaling, nasal congestion, shortness of breath;
• dermatological reactions: pruritus, urticaria, rash, exacerbation of psoriasis, increased sweating, photodermatosis, exanthema, skin hyperemia, reversible alopecia;
• others: decreased libido and potency, weight gain, back pain, hypoglycemia, decreased vision, tinnitus, conjunctiva.

Overdose

An overdose of the drug is manifested by the following symptoms: sinus bradycardia, heart failure, decreased blood pressure, vomiting, nausea, cyanosis, coma, loss of consciousness. The first signs appear half an hour or 2 hours after an overdose.

Treatment is carried out in an intensive care setting. Gastric lavage, activated charcoal intake are recommended, and symptomatic therapy is also used. In addition, the introduction of norepinephrine or dobutamine is recommended; for convulsions - diazepam; with bronchospasm, beta2-adrenomimetics are prescribed.

Analogs

Analogues according to the ATX code: Betalok, Vasokardin, Metroprolol, Serdok, Emzok.

Drugs with a similar mechanism of action (ATC level 4 match): Atenolol Belupo.

Do not make the decision to change the drug yourself, consult your doctor.

pharmachologic effect

Egilok is an effective drug that belongs to beta1-blockers. The main active component of the medication is metoprolol. This substance has hypotensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenoreceptols, metoprolol lowers the excitatory effect of the sympathetic nervous system on the heart, and also instantly lowers blood pressure and heart rate. As for the antihypertensive effect of the drug, it is quite long-term, since the resistance of peripheral vessels decreases gradually.

• Prolonged use at high blood pressure can lead to a decrease in left ventricular mass. The drug reduces mortality from cardiovascular disease in males with a moderate increase in blood pressure.
• Due to a decrease in heart rate and blood pressure, it reduces the oxygen demand of the heart muscle, due to which diastole is lengthened. This effect reduces the incidence of angina attacks and significantly improves the patient's quality of life and physical condition.
• Indications for Egilok are atrial fibrillation, supraventricular tachycardia and ventricular premature beats. With these pathologies, the medicine helps to reduce the ventricular heart rate. Regular use of the medication for several years leads to a decrease in blood cholesterol.

special instructions

• Before starting therapy and during treatment, blood pressure and heart rate should be monitored. If your heart rate drops below 50 beats per minute, medical attention is required.
• Patients with diabetes mellitus should regularly monitor their glucose levels and, if necessary, adjust the dosage of insulin.
• Should be withdrawn gradually, reducing the dosage over two weeks to avoid withdrawal symptoms, coronary disorders and angina pectoris.
• In patients using contact lenses, there may be a decrease in the secretion of tear fluid.
• It is recommended to be careful when driving and when engaging in potentially hazardous activities that require increased concentration.

During pregnancy and breastfeeding

Contraindicated during pregnancy and breastfeeding.

In childhood

Contraindicated in children and adolescents under 18 years of age.

In old age

Dose adjustments are not required in the elderly.

With impaired renal function

No dosage adjustment is required in patients with impaired renal function.

For violations of liver function

With extreme caution, it is prescribed for liver failure.

24.11.2018

Egilok is a drug of the group of beta1-blockers, produces an antianginal (myocardial oxygenation), hypotensive effect.

It reduces the heart's need for oxygen, increases endurance in coronary artery disease, reduces the risk of angina attacks, the risk of heart attack. The drug is used in the complex therapy of ischemic disease, arrhythmias, angina pectoris, heart failure, in the treatment of migraine and hyperthyroidism.

Appoint take Egilokin conditions caused by an increase in blood pressure and hypoxia (oxygen starvation) of cardiac tissues, which is due to its complex positive effect on the heart and hypotensive effects. Recommended for arrhythmias, migraines, high blood pressure, if there are no contraindications.

Release form and composition

Available in the form of white tablets for oral administration:

• Egilok usual action: round, biconvex tablets with a dosage of 25 mg - with a cross-shaped line on one side and the number "E 435" on the other;
• Egilok usual action: with a dosage of 50,100 mg of risk - on the one hand and "E 434" and "E 432" - on the other;
• Egilok Retard all dosages: white coated oblong biconvex tablets have a risk on both sides.
• Egilok S for all dosages: white oval biconvex tablets with a notch on both sides.

The active substance is metoprolol tartrate. In one capsule Egilok and Egilok Retard - 25, 50, 100 mg of active ingredient (metoprolol tartrate). In Engilok C, the active ingredient is metoprolol succinate (25-200 mg). Excipients: microcrystalline cellulose, povidone, sodium carboxymethyl, starch, magnesium stearate, colloidal silicon dioxide (titanium), etc.

Store at room temperature for 5 years. Use with a prescription from a cardiologist.

Egilok has a normal effect, and Egilok C and Egilok Retard - prolonged (prolonged), which reduces the likelihood of side effects. All varieties of the drug are produced by the pharmaceutical concern "EGIS Pharmaceuticals PLC" (Hungary). There is one more variety - a cheap analogue of Egilok S - Egilok SR, produced under license by the pharmaceutical plant Intas Pharmaceuticals Ltd (India).

All forms of the drug are considered the same, in them the active substance is different salts of metoprolol (tartrate and succinate), which disintegrate in the body and release metoprolol. The difference is only in the speed of absorption and the onset of the effect, as well as in the composition of excipients.

The cost of the drug: in Russia 125 rubles, in Kiev - 57-90 UAH.

Pharmacological properties

The active substance of the drug blocks beta 1 - adrenergic receptors of the heart, which reduces the frequency of heart contractions, the strength of myocardial contractions and the volume of blood pushed into the aorta.

Egilok reduces blood pressure. With prolonged use of Engilok, the risk of sudden death from stroke, heart attack, hypertensive crises, cardiac pathologies decreases. Providing an improvement in the delivery of oxygen to the heart, the drug increases a person's activity, reduces the risk of angina attacks.

Egilok and Egilok Retard are used if the patient has hyperthyroidism or hyperkinetic cardiac syndrome for the complex therapy of the disease.

Egilok and Egilok S are prescribed to avoid supraventricular arrhythmia. These drugs are indicated for heart failure.

Egilok Retard is used in conjunction with diuretics (diuretic) drugs, cardiac glycosides and ACE inhibitors.

In case of disruption of the left cardiac ventricle (systolic phase) and heart failure, Egilok C is more effective. This form of the drug reduces the likelihood of death in the late stages of a heart attack, eliminates tachycardia, and disruption of the myocardium.

Egilok prevents repeated attacks of angina pectoris, repeated attacks after a heart attack. The medicine does not cure these heart diseases, but increases the patient's endurance during physical, emotional stress, maintaining the normal functioning of the heart.

By eliminating the symptoms of heart disease, it allows a person to lead a normal life.

The active ingredient of Egilok metaprolol reduces the excitatory effect on the heart of the sympathetic nervous system, reduces heart rate and blood pressure. Gradually reduces peripheral vascular resistance and produces a hypotensive effect. Due to a decrease in blood pressure and heart rate, myocardial oxygen demand decreases. Thanks to this, the patient's condition improves, angina attacks become less frequent.

Instructions for use

Explore Egilok instructions for use: at what pressureit is prescribed, doses, features and contraindications of the drug.

Egilok tablets are taken regardless of the time of the meal, preferably at the same time of the day. The dose is selected individually, taking into account the patient's indications, increasing gradually, but not more than 200 mg / day.

The medicine is prescribed for such pathologies:

1. With increased pressure.
2. Angina pectoris (chest pain - "angina pectoris").
3. Migraine (throbbing headache in any area of ​​the head - occipital, temporal, frontal).
4. Tachycardia (increase in heart rate - 90 and>).
5. (slowing down the heart rate).
6. Functional disorders in the work of the heart.
7. Febrile atrial.

To protect yourself from the risk of harming your health, using the drug from pressure, you must carefully read the instructions, familiarize yourself with the features of the drug (contraindications, side effects, compatibility with other drugs) and follow the doctor's recommendations. Do not exceed the permissible dose, monitor for changes in condition.

To lower blood pressure, the initial dose is 25-50 mg in 2 doses (morning and evening). In the absence of the desired effect, the dose may be increased by the attending physician.

Treatment of angina pectoris involves 25-50 mg / day with a possible increase to 200 mg and the addition of a 2nd drug to obtain the desired result. It is necessary to ensure that the heart rate at rest and during exercise does not go beyond: 55-60 - 110 beats / min.

After myocardial infarction, 100-200 mg / day is prescribed for maintenance therapy, with arrhythmias 25-50 mg 2-3 r. / Day. In case of insufficient effectiveness, the dose is increased to 200 mg or a second drug against arrhythmia is additionally connected.

For migraine attacks, Egilok is prescribed 100 mg per day in 2 divided doses. In elderly patients and patients with liver or kidney disease, the dose of the drug is not increased.

The maximum therapeutic effect occurs 1.5 hours after ingestion. About 95% of the drug biotransforms (processes) the liver, 5% is excreted from the body by the kidneys.

When treating with Egilok, it reduces the release of tear fluid and may cause discomfort in patients using contact lenses. If surgery is to be performed during the appointment, the anesthesiologist should be warned about this so that he can choose an adequate anesthesia.

The treatment should be completed smoothly, reducing the dose (every 2 weeks). If abruptly canceled, the patient's condition may worsen.

Egilok contraindications

With a wide range of indications, the drug has a number of contraindications. You can use it only after making sure that there are no contraindications.

It is dangerous for patients with a slow heartbeat (50-60 beats / min. Or less), sick sinus syndrome.

It is undesirable to use in cases of sinoatrial blockade and in cases of peripheral circulation disorders. Do not take hypotensive patients (low blood pressure< 90-100 мм рт.ст.). Не рекомендуется пить при беременности, чтобы избежать вредного воздействия на плод. Препарат может вызвать аллергию при гиперчувствительности к его составляющим.

If the patient has contraindications, it is necessary to reduce the dose of the drug, monitor the body's reaction to taking Egilok in small doses, or select another drug.

The drug should not be taken when:

• heart failure during the period of decompensation;
• cardiogenic shock;
• during breastfeeding;
• hypersensitivity to the components of the drug;
• sinoatrial and atrioventricular blockade (2-3rd degree);
• (lowering blood pressure);
• angiospastic angina pectoris.

Side effects

Studies, observations of doctors and reviews of patients made it possible to compile a list of side effects from different organs and systems of a person.

Side effects during treatment with Egilok:

The cardiovascular system:

• pain in the region of the heart;
• palpitations, arrhythmias;
• swelling of the extremities (Egilok Retard, Egilok C);
• increased signs of heart failure;
• in patients after a heart attack;
• bradycardia;
• orthostatic hypotension (a sharp drop in blood pressure when standing up);
• fainting;
• coldness in the lower extremities.

Nervous system:

• dizziness and headache;
• anxiety;
• fatigue;
• depression;
• decreased concentration of attention;
• excitability;
• convulsions;
• Paresthesia (violation of sensitivity, "running of goose bumps").

Gastrointestinal tract:

• nausea, vomiting;
• abdominal pain;
• dry mouth;
• or diarrhea;
• liver pathologies (stagnation of bile, yellowing of the skin, whites of the eyes, dark urine);
• increased bilirubin in the blood;
• hepatitis (Egilok C).

Respiratory system :

• shortness of breath on exertion;
• rhinitis;
• bronchospasm;

Skin integuments:

• excessive sweating;
• hives (blisters and itching);
• rash, itchy skin;
• photosensitivity (increased sensitivity of the skin to sunlight);
• exanthema (skin rash);
• redness of the skin.

Senses:

• visual impairment;
• violation of taste;
• dry, irritated eyes;
• tinnitus;
• conjunctivitis (inflammation of the mucous membrane of the eyes).
  

In the initial stages of taking the medicine, there is a feeling of fatigue.

These effects are temporary and mild. If any of the effects manifests itself brightly and for a long time, you must stop taking the drug and consult a doctor.

Overdose

If the dose of the drug is exceeded, dizziness and bradycardia, sometimes nausea and vomiting, may occur. Blood pressure may drop. Sometimes the patient, when the dose of Egilok is exceeded, has arrhythmia, ventricular extrasystole and may faint.

In severe cases, with cardiogenic shock, the patient may lose consciousness and fall into a coma, cardiac arrest may occur. With a large dose of the drug, such symptoms appear in the period from 20 minutes to 2 hours after ingestion.

If this happened, the patient needs:

• flush the stomach;
• give adsorbents;
• put horizontally, raising your legs above your head (if pressure has dropped);
• intravenous beta-adrenostimulants are administered (if bradycardia, heart failure has developed);
• use Dopamine, Dobutamine, Norepinephrine, if the measures taken have not helped.

Doctors use different types of therapy based on the patient's symptoms and condition. If this happened at home, you must immediately call an ambulance, explaining the essence of the problem.

Egilok's analogs

There are many analogues of the drug, but before using them, it is necessary to consult a cardiologist, but they cannot fully replace the original. Analogs: Vasokardin, Betalok, Corvitol, Lidalok, Metocard, Metozok, Metolol, Emzok, Metoprolol.

It is forbidden to use Egilok with drugs:

• the hypotensive effect of metoprolol can be reduced with the combined use of Angilok and beta-blockers (theophylline, indomethacin, estrogens);
• when taken with Verapamil may lead to cardiac arrest.
• will increase the negative effect on the central nervous system, simultaneous reception with Ethanol;
• the likelihood of hypoglycemia will increase when mixing Egilok with insulin and hypoglycemic agents.

Egilok, a drug made in Hungary, is becoming more and more popular among hypertensive patients. Having a pressure-lowering effect, at the same time Egilok relieves the condition of the heart affected by complications of hypertension and atherosclerosis. The drug also helps with diseases that are not directly related to high blood pressure. Many patients prefer Egilok, ignoring analogues, of which there are many. What prompts them to make a particular choice?

Instructions for use

The name “egilok” is a trade mark given to the medicine by the manufacturer (Hungary). There is also an Indian egilok.

INN egiloka is metoprolol. This is the main active ingredient, supplemented by auxiliary ones: anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch and povidone. Dosage form of release: tablets.

Auxiliary components are used to preserve the base (active ingredient - metoprolol tartrate) before use. They serve as enterosorbents, emulsifiers, fillers, stabilizers. The components are arranged in such a way that they ensure the stability of the composition and the safety of the drug. Once in the body, they help the main component to fully manifest the desired effect.

In Latin, egilok is Egilok, and according to the current beginning it is designated: Metoprolol tartat, if it is a fast-acting form. Long-acting egilok retard contains another metoprolol compound - succinate. Accordingly: Metoprolol succinate.

The tablets are dosed in milligrams of the active substance, three types of dosage: 25, 50, 100 mg. All of them are white or close to white, biconvex. On tablets of a lower dosage (25 mg), the surface is marked with a cruciform notch. This makes it easier to split (break) the tablet when even smaller doses are needed. Usually - at the beginning of taking the drug, when the optimal dosage is being selected, this is necessary.

Large dosage pills have risks that help break neatly. The tablet preparation has no smell.

Pharmacological group, mechanism of action

Pharmacotherapeutic group of Egilok: beta1-blockers. Egilok refers to cardioselective - selective drugs, focused on the myocardium and the coronary vessels feeding it.

Selective beta1-blockers at a reasonable dosage work only with β1-adrenergic receptors, block only them. Another type, which is responsible for breathing, bearing the fetus, peripheral vessels - β2-adrenergic receptors - calmly continues to work, the egilok is not directed at them. The medicine deliberately moves towards its intended goal, finds the receptors for which it was created. By contacting them, egilok does not allow catecholamines to produce a strong shake-up of the body in case of provoking factors:

1. Emotional stress;
2. Increased physical exertion;
3. A sharp change in the weather (almost 100% of "vascular" patients react to this with a worsening of the condition).

The sympathetic system under the influence of egilok reduces activity against the myocardium. Egilok, blocking β1-adrenergic receptors, slows down the pulse, lowers four important values ​​at once: heart rate, cardiac output, contractility and blood pressure numbers.

Such support for the heart and its blood vessels improves the quality of life and significantly prolongs it.

When beta1-adrenergic receptors are blocked, the heart works calmly. Its blood filling is carried out more fully and without overload, at the time of relaxation (diastole phase) of the ventricles. The drugs of the group are a good find for pharmacists. Egilok () is a typical representative of a number of beta-blockers.

The problem of patients with high blood pressure is left ventricular dysfunction, an increase in the ventricle from excessive load (blood pressure) on it. Regular long-term intake of egilok allows you to reverse this pathology. The ventricle, without experiencing overload, changes size: it returns closer to normal.

Normalization of the size and function of the left ventricle, restoration of the time required for rest (diastole) has a direct impact on patient survival. Mortality from vascular accidents, especially in men, is significantly reduced. From which Egilok tablets are taken: to prevent such accidents as heart attacks, strokes, cases of sudden death. If the hypertension is moderate, "mild", then the therapeutic effect is more pronounced.

The need of the heart muscle for oxygen supply with blood decreases, blood supply increases. The preload on the heart decreases, he does not need to make so much effort to pump blood as before taking the medicine. Oxygen is absorbed better than it was at high heart rate and pressure.

The selectivity of egilok is an advantage over non-selective drugs of the same group. He almost does not manifest (with adequate doses) a spasmodic effect on the respiratory muscles (bronchi), as well as on the smooth muscles of the walls of peripheral vessels. It also does not affect the tissues of the muscles not included in the myocardial zone. It works only cardiologically, with a positive effect.

Egilok is good for diabetics: without affecting metabolic processes, it does not provoke hypoglycemia. Insulin secretion does not depend on the presence of metoprolol (egilok) in the blood. Cholesterol levels with prolonged therapy with egilok are significantly reduced.

Pharmacokinetics

The absorption of the active substance after passing through the metabolic barrier of the liver occurs quickly. The process improves with an increase in the percentage of bioavailability, if Egilok tablets, according to the instructions for its use, are consumed with food. The liver controls everything entering the gastrointestinal tract, therefore, it is easier for egiloku to "slip through" it unchanged with food. It becomes more available to the body by 40% than taken on an empty stomach. Metabolites lose the therapeutic activity of egilok.

The percentage of metoprolol binding to blood proteins fluctuates. It is small with a healthy liver, but reaches 10% - with its pathology.

The withdrawal of the drug is carried out by the kidneys. It can slow down in kidney failure, but it does not cause significant harm.

Indications for use

For egilok, the indications for its use are similar to the use of other beta-blockers. From what these pills are prescribed, you can understand by examining the mechanism of action of egilok. The drug is used for:

• Hypertension of all stages (arterial hypertension) - monotherapy or, as a component in a complex of drugs;
• Tachyarrhythmias (tachycardias) of inorganic genesis - functional reversible malfunctions of the myocardium;
• Arrhythmias with organic causes: supraventricular tachycardia, paroxysmal, atrial extrasystole, ventricular, supraventricular;
• Angina pectoris, stable course;
• Prevention of exacerbation of migraine, prevention of pain attacks;
• Hyperthyroidism (relief of symptoms, addition of specific therapeutic methods);
• Angina pectoris complicated by heart attack - egilok in the complex of basic therapeutic measures. Treatment of a post-infarction state, simultaneous prevention of recurrence, prevention of a new heart attack.

The instructions for use indicate at what pressure Egilok is effective. He is prescribed for any of the stages of this disease. With a slight excess of the norm of blood pressure indicators, the drug can help alone (monotherapy). Then the instructions for use provide a minimum - 25 mg of egilok may already be enough for the reception.

Ischemia - constriction, infringement. In fact, there is no infringement, there is a strong narrowing of the feeding arteries. In acute cases and - blocking them, closing the lumen in atherosclerosis (plaques come off), thrombosis (blockage of the vessel with a thrombus). When the lumen of the vessels is narrowed, the nutrition of the myocardium is inevitably disrupted. Egilok relaxes the vessels, facilitates the passage of blood through them to the myocardium. Ischemic heart disease is a form of angina pectoris "with experience", its dangerous phase. By improving blood supply, nutrition of the heart, egilok helps it to hold out.

Used after heart attacks, protects against recurrence, increases survival

These occur with neuroses, those suffering from dystonia, other disorders of the nervous system or cardiovascular. Among the whole complex of symptoms, tachycardia often comes out ahead of the rest. It worries more, generates fear, intensifies itself and intensifies the rest of the symptoms. Better than beta-blockers, there is no remedy here. Egilok will calm the fast pulse and, having some anxiolytic, anti-anxiety effect, will calm the person down. At the same time, other unpleasant symptoms will go away: fear, sweating, tremors. Even a heart that does not have organic changes is not good for such anxiety. The drug will help bring everything back to normal.

Arrythymia of organic genesis

Complex, difficult rhythm disturbances. Caused by various reasons: atherosclerosis, impaired conduction of myocardial impulses, pathology of the sinus node. Beta-blockers regulate the rhythm during tachycardia (decrease heart rate). Some types of ecstasystole lend themselves to egilok, the rhythm is evened out. Or extrasystoles at least become less frequent, acquire a sinus rhythm instead of a disorderly one. Egilok medicine is sometimes used even with implicit bradycardia - for health reasons. Special care is needed here, but it is necessary to save the patient's life. Even egilok 25 may turn out to be an excess, it is divided, dosed at first with a quarter of such a tablet. And this small dose will still have the desired effect. Almost without slowing down the pulse contractions.

Instructions for the use of bradycardia refers to the contraindications of egilok, but the reviews of practicing cardiologists indicate: sometimes, in the smallest doses, it is necessary. Grinding (again contrary to the instructions), right under the tongue - for speed of action. This will save lives in an acute situation, and the selection of other drugs - only later.

If the heart rate allows (not too low), beta-blockers help out with this diagnosis. Attacks of angina pectoris, it is not for nothing that it is named with the addition of the word "stress", occur with physical or mental overstrain. Egilok, taken constantly, relieves stress. The attacks are rare and mild.

Migraine, prevention of attacks

The disease is common, but little understood. The culprit of pain today is considered to be dilatation (expansion) of cerebral vessels from their overflow with blood and high blood pressure.

Reducing blood pressure, egilok warns, blocks dilatation.

In addition, an anti-anxiety effect works: it has been noticed that migraine attacks are frequent in anxious persons. No alarm - no migraine.

Beta-blocker disease cannot be cured. But with an auxiliary purpose they are used. Egilok will help to calm the frequent pulse characteristic of the disease. Along the way, the intensity of sweating, tremor, and blood pressure decrease. Symptoms of hyperthyroidism are smoothed out, this is important for the patient's well-being.

Prevention of repeated heart attacks

The drug in combination with others helps to protect a person from the risk of a recurrence of a heart attack. A weakened heart may not be able to withstand a second heart attack. Here, the role of drugs and the doctor's ability to navigate in their selection, building treatment tactics are vitally important.

Now you know what egilok helps from. It's time to find out when it's not shown. Contraindications to taking egilok are:

Use with caution

• Pheochromocytoma - a combination with alpha-blockers is necessary, without them egilok is not used.
• Diabetes mellitus is a dose-dependent effect; at high doses, hypoglycemia may be stimulated.
• Metabolic acidosis - there may be interference in the failure of the metabolic processes of the beta-blocker with an unpredictable result.
• Bronchial asthma - a small effect on the receptors of the second type that control the respiratory system - β2-adrenergic receptors are occasionally found in sensitive patients with asthma, patients.
• Obliterating endarteritis, peripheral vascular pathology.
• Insufficiency - renal, hepatic: possible clearance problems, delayed withdrawal, an increase in the concentration of the drug above the recommended one in the body.
• Depression is a stage of exacerbation or remission.
• Propensity to allergies - if it is necessary to administer anti-shock drugs (adrenaline), the body may not respond to them under the influence of egilok.
• Hyperthyroidism (thyrotoxicosis) - the increased hormonal activity of the affected thyroid gland requires careful selection of drugs and doses, even for symptomatic treatment.
• COPD - Severe lung disease makes the respiratory system sensitive even to nearly neutral selective beta-blockers. Egilok's cardioselectivity does not exclude microeffect on other systems. If they are disturbed by the disease, special control is required.

Pregnancy, lactation

If both are at risk: the mother - from the abolition of egilok, the fetus - from its use, the doctors correlate the risks. If possible, a child-friendly drug is selected for a pregnant woman. If such a possibility is excluded, and it is the egilok that is needed (for health reasons), they try to save both. The effect of the drug on the developing organism is carefully monitored.

The newborn is immediately examined, checked for possible pathological deviations of systems and organs.

If there are any, intensive therapy is carried out, they try to correct the negative effect of the drug received in utero.

A child can be under supervision for a long time.

Method of application, dosage

They take the drug without strictly linking the time of admission - with food. You don't have to wait minutes before or after eating. You can - right with food, it will be even better absorbed. The daily dose of egilok is divided according to the recommendations of the instructions into two doses - morning and evening. The minimum is set based on the state of concomitant diseases. They start with small doses. By gradual selection, they reach the optimal one. At each such increasing "step" they are delayed up to two weeks - they check the effectiveness.

Daily maximum: 200 mg, no more should be, the risk of side effects will increase. If the recommended daily dose is exceeded, the selectivity of egilok is partially lost. The active substance can begin to block both types of adrenergic receptors, which should not be allowed. The doctor's prescriptions should be met scrupulously: he knows how much to prescribe and takes into account all the features of the drug.

The dosage of egilok by type of disease can and should differ. There may be the same doses for some diagnoses.

The dosage of egilok varies from the initial - 25 mg to the maximum - 200 mg. The selection is individual, stepwise. Reception according to the scheme: morning + evening, the dose is divided in half. Stop at the most comfortable dose that provides the expected effect. Arterial hypertension, detected in time, at the onset stage, can be corrected with Egilok monotherapy. With a persistent course of the disease, high blood pressure indicators, well-combined drugs from other groups that lower blood pressure are added.

Start with 25 or 50 mg, according to the patient's condition and overall drug tolerance. This dosage for ischemic heart disease is taken twice or three times a day. The daily dose can be increased to 200 mg. If such an amount is poorly tolerated, and less does not give the desired effect, leave in a normally tolerated amount. The treatment is corrected by adding another medicine that supplements egilok, which alleviates the patient's condition.

Functional tachyarrhythmia

Appointment: morning and evening - 50 mg. If the effect is insufficient - 100 mg. Monotherapy usually works well.

Extrasystole, tachycardia

Start with 25 or 50 mg. Frequency rate of admission: three times a day. With good tolerance, but low efficiency, the dose is increased. Do not exceed the maximum bar - 200 mg. Combined treatment of arrhythmias can be practiced. Better to start - permanently.

Stable exertional angina

The treatment regimen is similar to the treatment of coronary artery disease, since ischemic heart disease is formed with the progression of angina pectoris and is one of its stages.

Prevention of migraine attacks

Dose selection is individual. Usually it is 100 mg, divided into two doses. Or - the maximum daily dose of two milligrams. It is also divided in half, taken twice (morning + evening).

If migraine attacks are rare, continuous use is not practiced. The approach of an attack is characterized by precursors (decreased vision, flickering of bright spots in front of the eyes). When there are such precursors, they immediately take egilok in a pre-selected dose. They continue for several days.

With often annoying migraine, Egilok is indicated for use - constantly

Up to four meals a day. The maximum daily dose or - close to it (150 - 100 mg).
Prevention of repeated heart attacks. The maximum or half daily dose of the drug (200 or 100 mg). Divided in two, reception: morning and evening.

Side effects

Egilok has side effects, which is understandable: the drug, even with its selectivity, is in the systemic circulation. Organisms are different, so is reactivity. What is useful for the majority is not suitable for everyone. Undesirable effects from taking egilok:

• Headache, dizziness;
• Suppression or activation of nervous processes: from excessive excitability to severe fatigue;
• Sexual dysfunction - decreased libido / potency;
• Amnesticoconfabulatory syndrome (memory problems);
• Increased unmotivated anxiety;
• Feeling of cold feet;

• Drying of the mucous membranes of the mouth;
• Insomnia or drowsiness;
• Symptomatic exacerbation of heart failure;
• Orthostatic hypotension;
• Hallucinations;
• Excruciating heartbeat;
• Cardiogenic shock;
• Liver failure;
• Abdominal pain,
• Violation of cardiac conduction;
• Constipation;

• Gangrene (due to the aggravation of peripheral circulatory disorders);
• Vomit;
• Tinnitus;
• Conjunctivitis;
• Distortion of taste perception;
• Decreased vision;
• Rhinitis;
• Alopecia;
• Bronchospasm;
• Irritation of the mucous membrane of the eyes;
• Photosensitivity;
• Shortness of breath on exertion;
• Hives;
• Arthralgia;
• Heavy sweating;
• Increased weight gain.

Myocardial blockade (atrioventricular);

Bronchospasm;

Hypoglycemia;

Cyanosis (cyanosis) of the skin;

Unconsciousness;

Falling into a coma.

An overdose of Egilok medication against the background of therapy with blood pressure lowering drugs, taking barbiurates, in the presence of ethanol in the body is more dangerous. The symptomatology increases, the prognosis worsens.

Urgent help is needed, hospitalization is required, a complex of rehabilitation measures.

Before the ambulance arrives, if consciousness is preserved, you can give enterosorbent, try to induce vomiting.

Drug interactions

Joint reception with antihypertensive drugs causes an additive effect. Combination therapy is prescribed, started and monitored - by a doctor. The cumulative effect is the goal of such treatment, but it should not be excessive. Excessive doses are dangerous with hypotension, which can cause a number of complications. Some of them are more dangerous than a rise in pressure.

It is risky to combine egilok and other beta-blockers with calcium channel blockers (slow). The intravenous use of verapamil is especially dangerous, there is a threat of asystole (cardiac arrest).

Oral antiarrhythmics (cordarone, quinine) can provoke an atrioventricular block. Severe bradycardia is not excluded.

Do not combine egilok with cardiac glycosides: the conductive function of the heart may suffer, severe bradycardia may develop.

Reserpine, some other antihypertensive drugs are not combined with egilok, a representative of beta-blockers. The situation is fraught with hypotension, bradycardia.

If clonidine is nevertheless taken with egiloc, long-term use of clonidine is not practiced now. It is impossible to cancel drugs at the same time. The sequence is as follows: first, stop taking metoprolol (egilok). Clonidine remains “on the drug menu” for several more days. Then it is canceled. If you do otherwise, remove clonidine first - the likelihood of two consequences is high. The development of a hypertensive crisis and the formation of drug dependence occur.

CNS depressants (antipsychotics, tranquilizers, ethanol and other substances of similar action) together with egilok can cause critical hypotension. Emergency recovery measures will be required. And if the recipient of the beta-blocker is given anesthesia, there is a risk of asystole.

Do not combine alpha and beta sympathomimetics with egilok (abruptly - hypotension, clinically significant bradycardia, there is a high risk of cardiac arrest).

Ergotamine has a vasoconstrictor effect, a beta-blocker cannot withstand it in such a combination.

Egilok has a lot of incompatibility with drugs. NSAIDs - anti-inflammatory drugs of this type reduce its effectiveness.

Sugar-lowering and insulin activity paired with egilok - increase (the risk of hypoglycemia).

Estrogens "interfere" with beta-blockers from lowering blood pressure

Inhibitors of various enzymes, neurotransmitters - the effect of the drug is enhanced, increasing its concentration in the body.

Barbiurates and other enzyme inducers inhibit metoprolol, the effect of egilok weakens.

If substances are used that block the nodes (ganglia) of the sympathetic NS (nervous system), and drugs of the same group with egilok (beta-blockers), even when these are eye drops, special control is needed. The body's reactions to these combinations are unpredictable.

special instructions

Analogs

Egilok, as the instructions for use reveal, is the same metoprolol (price and place of production differ).

The medicine is effective, widespread, necessary for many people. Egilok has many analogues in the country and around the world. Most are given a name that coincides with the active substance, some - by the companies that produce them. The price of Egilok is not the lowest, nor is it low: for thirty tablets of 100 mg, the patient will pay 130 - 150 rubles. You can buy a cheap analogue of egilok, instructions, composition, properties are the same: metoprolol (after agreeing on a replacement with a doctor) is German, the same packaging is 55 rubles.

The most famous analogs are:

• Metoprolol: Russia, Poland;
• Lidalok: Russia;
• Metoprolol Teva: Israel;
• Metolol: Russia;
• Metoprolol ratiopharm: Germany;
• Emsok: Germany;
• Metoprolol organics: Russia;
• Metoprolol Zentiva: Slovenia;
• Egilok Retard (prolonged): Switzerland, Hungary;
• Metoprolol-Obl: Russia;
• Metoprolol succinate: India;
• Metozok: Russia;
• Metokor adipharm: Bulgaria;
• Metoprolol tartrate: Ukraine;
• Corvitol 50: Germany;
• Betalok, Betalok ZOK (prolonged): Sweden, France;
• Metocard: Russia, Poland;
• Metoprolol-acri: Russia;
• Vasokardin: Slovenia;
• Betalok: Sweden;
• Egilok S (prolonged): Hungary;
• Serdol: Romania;
• Egilok: Hungary.

Leave - by prescription.

Egilok refers to complex drugs that regulate the heart rate and normalize blood pressure. Migraine, heart rhythm disturbances, high blood pressure - this is a short list of symptoms for which Egilok is prescribed.

It is an indispensable medicine for elderly people and all those who suffer from cardiovascular pathologies, both acute and chronic. When taken for many years, it reduces serum cholesterol levels.

The drug belongs to the group of cardioselective beta1-blockers. The drug has antihypertensive, antianginal, antiarrhythmic effects.

Influencing the beta1-adrenergic receptors of the heart muscle, it normalizes the formation of cAMP from ATP by catecholamines, reduces the intracellular flow of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (reduces heart rate, inhibits conductivity and excitability, reduces myocardial contractility).

The active substance of the Egilok preparation - metoprolol tartrate, reduces the effect of the excitability of the sympathetic system on the heart muscle, additionally causing a rapid decrease in the heart rate, cardiac output and blood pressure.

With hypertension, prolonged use of Egilok leads to a significant decrease in the mass of the left ventricle of the heart and an improvement in its diastolic function.

Metoprolol is almost completely excreted in the urine within 72 hours. About 5% of the dose is excreted unchanged. It lowers blood pressure well, especially when combined with tachycardia, tachysystole. The action is fast, especially when taken sublingually.

The medication is produced in tablet form:

1. Egilok tablets of usual duration of action of 25 mg, 50 mg and 100 mg of the active ingredient metoprolol tartrate.

2. Tablets Egilok Retard with prolonged action of 50 mg and 100 mg.

Indications for the use of Egilok

• exertional angina, unstable angina;
• myocardial infarction (acute phase, as well as secondary prevention);
• CHF (compensated) in combination with diuretics, ACE inhibitors and cardiac glycosides;
• arterial hypertension (increased blood pressure), including in patients over 60 years of age, hypertensive crisis;
• rhythm disturbances associated with an increase in heart rate (supraventricular arrhythmias, extrasystoles);
• preventive prevention of migraine attacks;
• Ischemic heart disease - ischemic heart disease;
• heart failure.

Indications for the use of tablets also apply to people over 60 years of age.

Egilok instructions for use, dosages

The dosage of the drug depends on the stage and symptoms of the manifestation of the disease and is selected by the attending physician in each case individually.

In case of arterial hypertension, it is prescribed in a daily dose of 50-100 mg / in 1 or 2 doses (morning and evening).

The maximum allowable daily dosage is 200 mg.

Heart failure with compensation: 25 mg per day.

When determining the dosage for angina pectoris, it is necessary to focus on the pulse, which at rest should be 55 - 60 beats per minute, and with a load - no more than 110 u / m.

Egilok tablets should be taken orally during or immediately after a meal. The tablets can be halved, but not chewed.

Application features

Care must be taken when driving and when engaging in potentially hazardous activities that require increased concentration of attention, since there is a likely risk of dizziness, weakness and fatigue.

When mixed with ethanol, the pumping effect on the central nervous system increases, therefore it is contraindicated to combine alcoholic beverages with tablets.

The interaction of Egilok with alcohol-containing substances leads to a sharp decrease in blood pressure, which in turn can cause brain hypoxia.

The list of prohibited drugs for simultaneous use with Egilok is wide and fully presented in the official instructions for use attached to the medication, which you should definitely familiarize yourself with before taking the drug. Therefore, special care should be taken to combine the drug with third-party medications and take it exclusively as directed by the attending physician.

In patients with diabetes mellitus, it is necessary to constantly monitor blood sugar levels.

Egilok side effects and contraindications

Possible side effects that may occur while taking Egilok:

• shortness of breath, bronchospasm;
• allergic rhinitis, secretion of mucus from the nasal passages;
• epigastric pain, nausea, vomiting, diarrhea and other dyspeptic disorders;
• insomnia;
• dizziness, headache, decreased concentration, deterioration of cognitive functions of the brain;
• decreased heart rate;
• increased sweating - hyperhidrosis;
• allergic reactions;
• excessive fatigue, lethargy, apathy, melancholy.

In relation to the sense organs (rarely), visual impairment may occur.

It should be noted that a sharp refusal to take Egilok is not recommended. This can cause an attack of angina pectoris. The medication should be withdrawn gradually, gradually reducing its dose over 10 days.

With an abrupt termination of treatment, a withdrawal syndrome may occur (increased angina attacks, increased blood pressure). During the period of drug withdrawal, patients with angina pectoris must be under close medical supervision.

In most cases, the medication is well tolerated.

Overdose

It is not recommended to increase the dose indicated in the annotation.

Symptoms of an oversaturation of the body with metoprolol: arterial hypotension, acute heart failure, bradycardia, cardiac arrest, AV blockade, cardiogenic shock, bronchospasm, impaired breathing and consciousness / coma, nausea, vomiting, generalized convulsions, cyanosis (appear 20 minutes - 2 hours after administration ).

From the digestive system: nausea, vomiting.

Treatment: gastric lavage, symptomatic therapy.

Contraindications:

• breastfeeding (lactation period);
• age under 18;
• heart failure in the phase of decompensation;
• cardiogenic shock;
• hypersensitivity to metoprolol and auxiliary ingredients of the medication;
• severe bradycardia;
• sinoatrial blockade, AV - blockade of 2 or 3 degrees;
• Prinzmetal's angina.

With care: diabetes mellitus; metabolic acidosis; bronchial asthma; COPD; renal / hepatic impairment; myasthenia gravis; pheochromocytoma (with simultaneous use with alpha-blockers); thyrotoxicosis; AV blockade of the I degree; depression (including history); psoriasis.

Egilok analogs, list of drugs

1. Betalok;
2. Vasokardin;
3. Lidalok;
4. Corvitol;
5. Metozok;
6. Metocardium;
7. Metokor Adipharm;
8. Metolol;
9. Metoprolol;
10. Metoprolol succinate;
11. Egilok Retard;
12. Emzok.

It is important to understand that the instructions for the use of Egilok, the price and reviews of the drug do not apply to analogues and cannot be used as a guide for use or prescription for other drugs, even similar ones. For any replacement of Gordox with an analogue or other changes, a specialist consultation is required.

It should be understood that analogs of a drug may not always fully replace the originally prescribed prescription. Therefore, when replacing a drug with a similar drug, be sure to consult with a cardiologist, therapist, neuropathologist and other specialized specialists.