During a cold, it is very important to find a good medicine. And among these undoubtedly include effervescent tablets Efferalgan. They relieve the main symptoms of the disease and put a person on his feet in a very short time.
All the information below about the drug Efferalgan is presented solely for familiarization with the main points, contraindications and side effects. The instruction should not be taken as a reason to start self-treatment, since a cold can lead to more serious and dangerous diseases. And only a medical practitioner can help professionally deal with such a delicate problem.
Therefore, be vigilant and do not harm yourself by ill-considered actions on the advice of friends, relatives and other third parties. Remember that the medicine that suits someone will not necessarily help you specifically.
Form, composition, packaging
The usual type of tablet is round, flattened. They have a white color without inclusions and a pronounced smell. When dissolved in water, they release a lot of bubbles and hiss slightly.
The main component of Efferalgan tablets is paracetamol, which is actively fighting the disease.
They are sold in cardboard packaging in almost every pharmacy at an affordable price, most often without surcharges.
Terms and conditions of storage
Efferalgan medicines do not like very high temperatures and are stored at a maximum of 30 degrees warmly. In the shade, away from direct sunlight and high humidity.
They retain their useful properties for three years, with a focus on the date that is written on the packages or directly on the plastic blisters.
Efferalgan indications for use
Efferalgan is used for severe pain in the head, lower back, or after accidental injuries. They help to cope effectively with toothache and even migraines.
With colds, it helps to get rid of weakness and fatigue, and also lowers body temperature in a fairly short period of time when used correctly.
- pain syndrome of mild or moderate intensity: headache, toothache, migraine, neuralgia, muscle pain, back pain, pain from injuries and burns, sore throat, algomenorrhea;
- elevated body temperature with colds and other infectious and inflammatory diseases.
Contraindications
Despite its positive qualities and properties, Efferalgan has a fairly large number of contraindications that must be considered. These primarily include:
- alcoholism (both male and female);
- alcoholic liver damage;
- insufficient amount of glucose in the human body;
- an allergic reaction to the main components of the drug.
Only under the supervision of doctors, the above-mentioned drug may be prescribed to people of advanced age, with renal or hepatic insufficiency, viral hepatitis or congenital hyperbilirubin.
Efferalgan effervescent tablets instructions for use
The dosage of Efferalgan largely depends on the condition of the patient himself. But the initial dose should not exceed one tablet per 200 ml of water. All you need to do is to drop the tablet into water, wait until it dissolves, mix well and drink immediately.
On the day of such repetitions, no more than three repetitions are carried out with an interval of at least four hours. Sometimes two tablets are prescribed at a time, but this one is at the discretion of the doctor.
Patients who suffer from renal insufficiency need to reduce the dose of Efferalgan tablets by half, the interval between doses is up to eight hours and closely monitor their condition. In case of any complaints or lack of result, the treatment course is terminated and an alternative treatment is sought.
It is strictly forbidden to use the above drug for more than five days without the permission of a doctor.
The tablet should be dissolved in a glass of water (200 ml) and drunk.
Assign inside 0.5-1 g (1-2 tab.) 2-3 times / day at intervals of at least 4 hours.
The maximum single dose is 1 g (2 tablets), daily - 4 g (8 tablets).
In patients with impaired liver or kidney function and elderly patients, the daily dose should be reduced, the interval between doses of the drug should be at least 8 hours.
The duration of treatment (without consulting a doctor) is no more than 5 days when used as an analgesic and 3 days as an antipyretic.
Efferalgan during pregnancy
During pregnancy and during breastfeeding, taking Efferalgan tablets is strictly prohibited, for the sake of the safety of the child.
In some cases, when there are no alternative methods of treatment, you can drink these tablets in the second trimester of pregnancy. But only by order of the doctor and under his strict control.
Efferalgan tablets for children
In childhood, Efferalgan tablets should not be drunk if the patient at the time of the disease was not fifteen years old. There is also a ban on treatment in this way if a person's body weight is less than fifty kilograms.
Side effects
If you follow all the rules and prescribed dosages, then there should be no negative consequences. But in rare cases, an allergic reaction manifests itself in the form of a skin rash and itching, anemia may occur, or a violation of the functions of the liver and kidneys. But this is on condition that the proposed dosage was greatly exaggerated.
Overdose
In case of an overdose, the skin begins to turn pale very quickly, weight decreases (up to anorexia), a feeling of nausea appears, and sometimes the patient begins to vomit. The remaining symptoms appear depending on the excess dosage of the drug Efferalgan.
The necessary treatment is gastric lavage later than six hours later and an ambulance call, since further actions can only be performed by people with special equipment and medical education.
Most likely, a patient with an overdose will have to lie down in the hospital for several days and be observed by specialized doctors in order to prevent complications in the form of liver or kidney failure.
Drug Interactions
Regarding the simultaneous use of Efferalgan medications with drugs of similar action, you should consult your doctor. He will be able to accurately answer the question of what is possible and what is not, based on the composition of a particular drug.
It is forbidden to self-administer any additional remedy.
Additional instructions
You should not take Efferalgan tablets if you are lactose or fructose intolerant. Patients who adhere to a special diet or suffer from alcohol dependence should be careful. In this case, it is better to find an alternative treatment for your disease.
If there is practically no result for three days, then a doctor's consultation is necessary regarding the further method of treatment, especially if the high temperature has not subsided during this time.
Analogues of effervescent tablets Efferalgan
Drugs of similar action undoubtedly include:
- Paracetamol MS;
- Panadol;
- Strimol.
All of them are available in the form of tablets and have an affordable price. They are easy to find in any pharmacy, but you should not replace Efferalgan with analogues on your own without the permission of a doctor.
Efferalgan tablet price
The price of Efferalgan effervescent tablets can reach 150 - 200 rubles in Moscow and nearby areas. In online stores, their price has been reduced to 140 rubles per pack.
Efferalgan reviews
The effectiveness of Efferalgan tablets can be assessed by the reviews left by patients with certain experience in its use.
Anatoly: Efferalgan tablets helped me very well with a severe cold. There was a high temperature and it was impossible to bring it down. I would like to say that not a single drug helped me much before, I had to apply cold cabbage to my forehead and wait until everything goes away on its own, or inject very strong and not safe antibiotics, from which I have to move away for another month.
Therefore, when the doctor prescribed Efferalgan to me, I was full of skepticism, but they gave the result the very next day. No, I did not completely recover, but the temperature reached 37 degrees and that made me happy.
I did not notice any side effects, and I liked the price of the tablets - I thought it would be much more expensive. So I'm happy with everything and recommend taking these pills if you have a doctor's permission for colds and high fever.
Konstantin: I started drinking Efferalgan tablets as prescribed by the doctor. I must say right away that they knock down a hundred temperatures well, relieve headaches, uncomfortable sensations in the vessels and lower back. But only my stomach was not happy with such medicinal help. He was constantly in pain, aching, heartburn and a slight pulling sensation appeared. All this appeared on the second day and on the third day I already refused to take them, although all the symptoms of a cold began to disappear.
After I told the doctor about this situation, he prescribed additional medicines to protect the stomach and keep it working. But still, I didn’t dare to drink Efferalgan anymore and I can’t advise others.
I must say right away that I had no contraindications to the use of this drug and my stomach was completely healthy. Therefore, focus on your feelings and well-being.
By the way, during the next cold, with the permission of the doctor, I replaced Efferalgan with its analogue called Panadol. It costs several times cheaper and I did not feel any negative impact on the stomach and other organs.
Similar instructions:
Antipyretic drugs are always in the medicine cabinet. An important point in taking any of them is not to resort to medical assistance until the temperature index passes the mark of 38 degrees. The body itself must learn to resist the virus and produce antibodies.
Efferalgan is one of the remedies that effectively and quickly fight high temperatures, are allowed for children and are not addictive. It is sold without a prescription, so when using it, follow the instructions.
Antipyretic syrup EfferalganComposition and properties of Efferalgan syrup for children
Efferalgan UPSA is a modern antipyretic that allows you to quickly bring down a high temperature. It comes in three forms:
- Effervescent tablets. They are white flat round pills. There is a stripe on one side. Sold in blister packs of 4. Upon contact with water, they begin to dissolve, while actively releasing gas bubbles.
- Syrup. It is released in vials designed for 90 ml of solution. Usually a special measuring spoon is included in the kit. The syrup itself is a viscous yellow-brown solution that smells of caramel and vanilla.
- Rectal suppositories. White, glossy and smooth. Released in blisters of 10 pieces.
For children, Efferalgan is recommended in the form of a syrup. Its main active ingredient is paracetamol - 3 grams per 100 ml of the product. The excipients included in the composition are as follows (their quantitative content in grams per 100 ml is indicated in brackets):
- sugar solution consisting of sucrose and water (50);
- macrogol 6000 (20);
- citric acid (0.107);
- sodium saccharinate (0.150);
- potassium sorbate (0.400);
- vanilla-caramel flavor (0.200);
- purified water.
In addition to syrup, Efferalgan is available in the form of effervescent tablets and rectal suppositories. The pharmacological action of the drug can be described by three main properties:
- antipyretic;
- painkiller;
- anti-inflammatory.
Paracetamol acts on the centers of pain and thermoregulation by blocking cyclooxygenase in the central nervous system (we recommend reading:). In tissues where the inflammatory process is taking place, its action is neutralized by cellular peroxidases, which explains their minimal anti-inflammatory effect.
After administration, the drug is rapidly absorbed from the gastrointestinal tract. The highest concentration of the substance in the blood plasma is observed after 10 - 60 minutes. In tissues and fluids, the distribution of the active component is well carried out. The drug is excreted through the kidneys with a half-life of 1 to 2 hours.
Indications for use
Efferalgan syrup is prescribed for children from the age of one month to 12 years old with a body weight ranging from 4 to 32 kilograms. The main purpose of the drug is to anesthetize and bring down the temperature.
Efferalgan is prescribed for children from the age of one month for pain relief and fever relief.
As an anesthetic, the drug is prescribed for such types of pain of mild and moderate intensity, such as:
- muscular;
- head;
- dental;
- having a neuralgic character;
- traumatic;
- resulting from burns.
In the second quality, the solution is used for acute respiratory infections and infections that are provoked by the following pathogens:
- staphylococci and streptococci;
- rhinovirus, influenza A and B, parainfluenza;
- golden staphylococcus aureus;
- coli;
- Pneumococcus;
- herpes 1 and 2 types.
Efferalgan is used as an adjuvant after vaccination When is the drug contraindicated?
The drug is contraindicated in case of high sensitivity to the components and children who have not yet turned 1 month old. In addition to the age limit and individual intolerance, Efferalgan is forbidden to use if the child has:
- malfunctions in the liver, which turned into a severe form;
- lack of the enzyme glucose-6-phosphate dehydrogenase in the body;
- pathology of the circulatory system;
- chronic diseases of internal organs;
- impaired renal function in a severe stage.
In addition to strict restrictions, there are situations when only the attending physician should prescribe the drug and control its intake, since the scheme will differ from the instructions included in the package. This approach is applicable for Gilbert's syndrome and kidney and liver problems with mild or moderate severity.
Instructions for use
Children who are not yet able to drink from a spoon are prescribed rectal suppositories with doses according to the age of the child. In most cases, they resort to the help of the second, more popular form - syrup. The table below lists the dosages of Efferalgan recommended for children of different ages and with different body weights:
| Age, years | Body weight, kg | Dose, ml (mg) |
| 3-5 months | 6-8 | 3 (90) |
| 5-12 months | 8-10 | 4 (120) |
| 1-2 | 10-12 | 5 (150) |
| 2-3 | 12-14 | 6 (180) |
| 3-4 | 14-16 | 7 (210) |
| 4-6 | 16-20 | 8 (240) |
| 6-7 | 20-22 | 10 (300) |
| 7-8 | 22-24 | 11 (330) |
| 8-9 | 24-26 | 12 (360) |
| 9-10 | 26-28 | 13 (390) |
| 10-11 | 28-30 | 14 (420) |
| 11-12 | 30-32 | 15 (450) |
When calculating the dosage, it is necessary to focus on body weight. Also, in order to avoid an overdose, it is undesirable to use Efferalgan in conjunction with other drugs that contain paracetamol. The course of treatment should not exceed 5-7 days. If a child takes Efferalgan, he should be given plenty of fluids during this period, especially after taking the syrup.
Efferalgan comes with a convenient measuring false, on which divisions are applied (15 mg per 1 kg of body weight) The drug should be stored in a dark place at temperatures up to 30 degrees and keep out of the reach of children. The shelf life is 3 years. From the moment the vial is opened, the solution is usable for six months. It is forbidden to give the child a remedy if it has expired.
Possible side effects
The antipyretic and analgesic drug has established itself as an effective remedy that is well accepted by the child's body. However, this does not exclude the appearance of a negative reaction in children whose body does not tolerate paracetamol or other components.
Among the side effects that may appear when taking Efferalgan, it should be noted:
- abdominal pain;
- bouts of nausea;
- vomit;
- diarrhea;
- irritation of the rectum;
- malfunctions of the digestive system;
- an allergic reaction that may appear in the form of hives, Quincke's edema, skin rashes and itching.
An overdose of Efferalgan may contribute to the development of urticaria In rare cases, anemia, leukopenia, agranulocytosis, thrombocytopenia can be observed. With prolonged use, abdominal pain may become regular, and blood pressure may become elevated. There is a risk of anaphylactic shock.
The threat is uncontrolled long-term use without observing the dosage. This causes changes in the composition of the blood, methemoglobinemia and pancytopenia, produces a hepatotoxic and nephrotoxic effect and leads to subsequent problems with the psychological health of the baby.
Consequences of an overdose
With regard to overdose in children, acute paracetamol poisoning can be identified by the appearance of symptoms, including:
- blanching of the skin;
- decrease in body temperature;
- anorexia;
- pain in the stomach;
- sweating.
If, when the above signs occur, you do not seek help from specialists, irreversible processes begin to occur in the cells, which are fraught with the development of acidosis, liver failure, hepatonecrosis, encephalopathy and coma.
After the drug has been discontinued and the child has been hospitalized, treatment is reduced to a number of activities, including:
- gastric lavage;
- intake of enterosorbents (Polifepan or activated carbon);
- intravenous administration of the antidote N-acetylcysteine;
- course of methionine;
- symptomatic therapy.
The cost of the drug and analogues
One of the advantages of the antipyretic drug Efferalgan UPSA is an affordable price. Despite the low cost, the tool is characterized by high efficiency and safety with proper use. On the territory of the Russian Federation, a bottle of Efferalgan 90 mg can be bought for 100 rubles. This price can vary in a range that depends on the city and pharmacy where the medicine is purchased.
Efferalgan is widely used in pediatric medicine due to its speed, safety for babies, minimum side effects and lack of addiction.
Despite all these advantages and availability, alternative drugs of a similar effect should be kept in mind. The pharmacological market provides a huge selection of all kinds of medications with similar properties and characteristics, the main active ingredient of which is paracetamol. Such drugs differ in the country where they were made, and auxiliary elements in the composition.
Among the main analogues of Efferalgan it is worth noting.
Efferalgan is an effective and affordable drug. It has an antipyretic and analgesic effect, already 20 minutes after application. Allowed for children, from the first month of life, pregnant and lactating mothers.
Shelf life 3 years. The main storage conditions for the tablet form require compliance with the temperature regime up to 30 ° C, syrup - up to 25 ° C, rectal suppositories up to 15 ° C.
Release form
Efferalgan is manufactured by the Bristol-Myers Squibb Company in France. The tool is available in the following forms:
- Tablets are flat, round, white. Packaged in 4 pieces per box. In one package there can be 4 or 25 konvalyu. One tablet contains 500 mg of paracetamol.
- Efferalgan Upsa tablets with vitamin C are round in shape. The box contains one tube containing 10 tablets. When in contact with water, they quickly dissolve, releasing gas bubbles.
- The syrup is intended for children's use. It is sold in a cardboard box, inside a 90 ml glass bottle and a measuring spoon. 1 ml of syrup contains 30 mg of paracetamol. The syrup has a caramel smell, viscous, yellow-brown color.
- Rectal suppositories, white with a glossy surface. One candle contains 80, 150 or 300 mg of paracetamol. Packed in contour cells, 5 pieces, only 10 candles per pack.
Pharmacological properties
Efferalgan has an antipyretic and analgesic effect. Its active ingredient is paracetamol. It belongs to non-selective anti-inflammatory and non-steroidal drugs. It inhibits the activity of the enzyme cyclooxygenase, resulting in a decrease in the synthesis of prostaglandins from arachidonic acid. Due to a decrease in the number of prostaglandins in the central nervous system, the conduction of a pain impulse decreases. The antipyretic effect is due to the direct effect on the center of thermoregulation.
After application, the drug is absorbed in the gastrointestinal tract after 20 minutes, the maximum concentration is noted from half an hour to an hour. It is excreted by the genitourinary system, the half-life is 2 hours, after a day, it is excreted by 90%.
Indications for use
It is necessary to take Efferalgan as an anesthetic for toothache, migraine, pain after injuries and burns, muscle and joint pain, sore throat, during menstruation.
It is used as an antipyretic for children with colds and flu, in the post-immunization period, with infectious and viral diseases accompanied by fever.
Efferalgan syrup for children is used orally, if necessary, diluted with water, milk or juice. Rectal suppositories are inserted into the anus. The effect of the drug will be achieved faster after a natural bowel movement or enema. Effervescent tablets are dissolved in 200 ml of water. The interval between doses is from 4 to 6 hours. As an antipyretic drug, do not use for more than 3 days, as an anesthetic for more than 5 days.
Efferalgan basic instructions for use.
- Syrup. The dosage is determined based on the weight of the child. For 1 kg, 10-15 mg of paracetamol will be required, three or four times a day. The maximum allowable dose should not exceed 60 mg per 1 kg. You need to measure the suspension with a special measuring spoon.
- Candles. For 1 kg of weight - 10-15 mg 3 or 4 times a day. The maximum allowable dose is 60 mg per 1 kg. Children weighing 6 to 8 kg - 1 suppository (80 mg), from 10 to 14 kg - 1 suppository (150 mg), from 20 to 30 kg - 1 suppository with a dosage of 300 mg.
- Pills. Adults and children over 15 years of age, weighing over 50 kg, use 1 or 2 tablets of 500 mg for a single dose. The maximum dosage per day is 4-8 tablets.
People with functional disorders of the liver and kidneys, Gilbert's syndrome, the elderly, should adhere to the interval between taking the drug at 8 hours.
Contraindications, overdose and side effects
The use of Efferalgan is contraindicated in:
- blood diseases;
- renal and hepatic insufficiency;
- inflammation and bleeding from the rectum;
- babies of the first month of life;
- alcoholism;
- individual intolerance to one of the components of the remedy.
Use with caution in the elderly, in the presence of viral hepatitis, liver damage due to alcoholism, pregnancy and lactation.
In rare cases, the following adverse reactions have been recorded:
- allergic manifestations (rash, urticaria, angioedema);
- nausea and vomiting;
- anemia;
- thrombocytopenia;
- neutropenia.
Overdose is accompanied by nausea, vomiting, increased sweating, pallor of the skin, hepatonecrosis.
During pregnancy and lactation
In medical practice, doctors use Efferalgan in a therapeutic dosage for the treatment of pregnant and lactating women. The drug crosses the placental barrier and is excreted in small amounts in breast milk. At the moment, it is not known whether Efferalgan has a negative effect on the developing fetus. The drug should be used after consulting a doctor.
Analogues
Efferalgan has a lot of analogues, one of the cheapest and most affordable is Panadol tablets. A substitute for effervescent tablets will be Rapidol, which must also be dissolved in water. The syrup, which will replace Milistan, is approved for use by infants from the first month of life. An analogue of rectal suppositories is Cefecon.
Efficiency and reviews
Efferalgan is a popular drug used in medical practice to normalize body temperature, relieve pain not only for adults and children, but also for infants. The reviews of millions of customers speak about its effectiveness.
Veronika, Moscow: “I always spend my summer holidays actively, traveling around the world. After the flights, acclimatization begins, which is accompanied by a temperature and a slight cold. It’s enough for me to take Efferalgan once, and after 30 minutes I’m already going to get acquainted with a new city, and the temperature remains in the past.”
This annotation to the drug is a simplified and fact-finding version of the official instructions for the use of Efferalgan.
Name: Efferalgan (Efferalgan) effervescent tablets
Release form, composition and pack
Effervescent tablets, white, round, flat, with bevelled edges and a notch on one side; when dissolved in water, an intensive release of gas bubbles is observed.
1 tab. - paracetamol 500 mg.
Excipients: anhydrous citric acid, anhydrous sodium carbonate, sodium bicarbonate, sorbitol, soluble saccharin, sodium docusate, povidone, sodium benzoate.
Clinical and pharmacological group
Analgesic-antipyretic.
pharmachologic effect
Analgesic-antipyretic. It has an analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of its anti-inflammatory effect.
It does not adversely affect the water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa due to the lack of influence on the synthesis of prostaglandins in peripheral tissues. The possibility of the formation of methemoglobin is unlikely.
Pharmacokinetics
Data on the pharmacokinetics of the product Efferalgan in the form of effervescent tablets are not provided.
Indications for use of the product
pain syndrome of mild or moderate intensity: headache, toothache, migraine, neuralgia, muscle pain, back pain, pain from injuries and burns, sore throat, algomenorrhea;
high body temperature with colds and other infectious and inflammatory diseases.
Dosing regimen
The tablet should be dissolved in a glass of water (200 ml) and drunk.
Assign inside 0.5-1 g (1-2 tablets) 2-3 at intervals of at least 4 hours.
The maximum single dose is 1 g (2 tablets), daily - 4 g (8 tablets).
In patients with impaired liver or kidney function and elderly patients, the daily dose should be reduced, the interval between doses of the product should be at least 8 hours.
The duration of treatment (without consulting a doctor) is no more than 5 days when used as an analgesic and 3 days as an antipyretic.
Side effect
Allergic reactions: sometimes - skin rash, itching, angioedema.
On the part of the hematopoietic system: infrequently - anemia, thrombocytopenia, methemoglobinemia.
Others: with long-term use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases (peripheral blood picture monitoring is necessary).
Contraindications to the use of the product
chronic alcoholism;
deficiency of glucose-6-phosphate dehydrogenase;
I and III trimesters of pregnancy;
lactation period (breastfeeding);
children's age up to 15 years (body weight less than 50 kg);
high susceptibility to product components.
The product should be used with caution in renal and / or liver failure, congenital hyperbilirubinemia (Gilbert, Dubinin-Johnson and Rotor syndromes), viral hepatitis, alcoholic liver damage, in elderly patients.
Pregnancy and lactation
The use of the product in the I and III trimesters of pregnancy and lactation (breastfeeding) is contraindicated.
special instructions
With ongoing febrile syndrome against the background of the use of paracetamol for more than 3 days, and pain syndrome for more than 5 days, a doctor's consultation is required.
Distorts the indicators of laboratory studies in the quantitative determination of the content of uric acid in plasma.
In order to avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, and should also be taken by persons prone to chronic alcohol consumption.
The risk of developing liver damage increases in patients with alcoholic hepatosis.
With prolonged use of the product, it is necessary to control the pattern of peripheral blood and the functional state of the liver.
Efferalgan contains 412.4 mg of sodium per 1 tablet, which should be taken into account by patients on a strict low-salt diet. The tablets contain sorbitol, so the product should not be used in case of fructose intolerance, low absorption of glucose and galactose, isomaltase deficiency.
Overdose
Symptoms: pallor of the skin, anorexia, nausea, vomiting; hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effects in adults are possible after taking paracetamol at a dose of more than 10-15 g: an increase in the activity of hepatic transaminases, an increase in prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage appears after 1-6 days. Rarely - fulminant development of liver failure, which may be complicated by renal failure (tubular necrosis).
Treatment: in the first 6 hours after an overdose - gastric lavage, the introduction of donators of SH groups and precursors of the synthesis of glutathione - methionine after 8-9 hours after an overdose and N-acetylcysteine after 12 hours. The need for additional therapeutic measures (further administration of methionine , intravenous administration of N-acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
drug interaction
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxication with a slight overdose of the product.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.
Paracetamol reduces the effectiveness of uricosuric products.
When used simultaneously with paracetamol, ethanol contributes to the development of acute pancreatitis.
Terms of dispensing from pharmacies
The drug is approved for use as a means of OTC.
Storage conditions and periods
The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 30°C. The shelf life is 3 years.
Attention!Before using the medication "Efferalgan (Efferalgan) effervescent tablets" you need to consult a doctor.
The instructions are provided solely for familiarization with " Efferalgan (Efferalgan) effervescent tablets».
Tradename
Efferalgan
International non-proprietary name
Paracetamol
Dosage form
Effervescent tablets 500 mg
Compound
One tablet contains
active substance: paracetamol - 500 mg,
Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, sorbitol E 420, sodium docusate, povidone, sodium saccharin E 954, sodium benzoate.
Description
Tablets of white color with beveled edges and risk, soluble in water. When dissolved in water, the release of gas bubbles is observed.
Pharmacotherapeutic group
Analgesics and antipyretics. Anilides. Paracetamol.
ATX code N02BE01
Pharmacological properties
Pharmacokinetics
With oral administration of paracetamol, absorption occurs quickly and completely. Peak plasma concentrations are reached 30-60 minutes after ingestion. Paracetamol is quickly and evenly distributed to all tissues. Plasma protein binding is weak. Paracetamol is metabolized primarily in the liver. The drug is excreted mainly in the urine. 90% of the dose taken is excreted by the kidneys within 24 hours, mainly in the form of glucuronic conjugates (60-80%) and sulfate conjugates (20-30%). Less than 5% is excreted unchanged. The half-life is about 2 hours.
Renal insufficiency: in case of severe renal insufficiency (creatinine clearance less than 10 ml / min.), the excretion of paracetamol and its metabolites slows down.
In the elderly, the ability to conjugate does not change.
Pharmacodynamics
The analgesic effect of effervescent tablets occurs faster than when taking conventional tablets containing paracetamol. Efferalgan (paracetamol), has an analgesic and antipyretic effect, which is associated with its effect on the thermoregulatory center in the hypothalamus and the ability to inhibit the synthesis of prostaglandins, eliminates headaches and other types of pain, reduces fever.
Indications for use
Pain syndrome of mild or moderate intensity, including: headache and toothache, pain with sciatica, muscle and rheumatic pain, neuralgia, algomenorrhea, pain in injuries and burns, sore throat with "cold" diseases.
"Colds" (acute respiratory diseases, influenza), and other infectious diseases, accompanied by fever.
Dosage and administration
Dissolve the tablet completely in a glass of water and drink.
This form of release is intended for adults and children weighing more than 50 kg (15 years and older).
The maximum single dose is 2 tablets of 500 mg. Maximum daily - 8 tablets. Always observe an interval of 4 hours between doses.
In case of severe renal insufficiency, the interval between doses should be at least 8 hours and the daily dose should not exceed 3 g of paracetamol per day.
The duration of treatment without medical supervision should not exceed 3 days, when prescribed as an antipyretic and 5 days as an analgesic.
Side effects
Nausea, vomiting, abdominal pain,
Skin rash, urticaria, angioedema, angioedema, Lyell's syndrome, Stevenson-Johnson syndrome.
With prolonged use:
Anemia, agranulocytosis, thrombocytopenia, leukopenia, hemolytic and aplastic anemia.
With prolonged use in high doses:
Methemoglobinemia,
Pancytopenia.
Anaphylactic shock,
Impaired liver function
Interstitial nephritis, impaired renal function, oliguria, anuria.
Contraindications
Hypersensitivity to paracetamol and other components of the drug,
hepatocellular insufficiency,
Blood disorders, including anemia
Deficiency of the enzyme glucose-6-phosphate dehydrogenase,
Pregnancy, lactation,
chronic alcoholism,
Children's age up to 15 years.
Drug Interactions
Reduces the effectiveness of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant agents (decrease in the synthesis of procoagulant factors in the liver). Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Ethanol contributes to the development of acute pancreatitis. Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity. Long-term combined use of paracetamol and other non-steroidal anti-inflammatory drugs increases the risk of developing analgesic nephropathy and renal capillary necrosis, the onset of end-stage renal failure. Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.
special instructions
With ongoing febrile syndrome against the background of the use of paracetamol for more than 3 days, and pain syndrome for more than 5 days, a doctor's consultation is required.
The risk of developing liver damage increases in patients with alcoholic hepatosis. Distorts the indicators of laboratory studies in the quantitative determination of glucose and uric acid in plasma.
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.
This medicinal product contains 412.4 mg of sodium per tablet, which should be taken into account by people on a strict low-salt diet. Since the drug contains sorbitol, it should not be used in case of fructose intolerance, poor absorption of glucose and galactose, isomaltose deficiency.
Be wary appoint patients with Gilbert's syndrome, with benign hyperbilirubinemia, as well as elderly patients. Paracetamol is a methemoglobin former. If side effects occur, you should stop taking the drugs.
Features of the influence of the drug on the ability to drive vehicles and dangerous mechanisms
Given the side effects of the drug, care should be taken when driving vehicles or potentially dangerous mechanisms.
Overdose
Symptoms: nausea, vomiting, anorexia, pallor, abdominal pain usually appear within the first 24 hours.
An overdose of more than 10 g of paracetamol at a time in adults and 150 mg / kg of body weight at a time in children can cause cytolysis of hepatocytes, which can lead to complete and irreversible necrosis, followed by the development of liver failure, metabolic acidosis, encephalopathy, which can lead to coma or death.
At the same time, there is an increase in the level of hepatic transaminases, lactate dehydrogenase, bilirubin and a reduced level of prothrombin within 12-48 hours after an overdose.
Treatment: gastric lavage, activated charcoal, induction of vomiting, the introduction of donators of SH-groups and precursors of the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine - 12 hours later.
Release form and packaging
4 tablets are placed in a contour non-cell packaging (strip) made of aluminum foil with a polyethylene coating.
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