Production of nasal droplets at the factory. Preparation of alcohol solutions

Making eye drops by dissolving medicinal and excipients. As an example, consider the manufacture of eye drops of pylocarpine hydrochloride.

Example 20.

RP. Solutions Pilocarpini Hydrochloridi 1% - 10 ML D.

S. 2 drops in the right eye 2 times a day.

pharmaceutical examination of recipe recipe. In the annex to the instructions for controlling the quality of drugs manufactured in pharmacies, the composition of the 1% solution of pylocarpine hydrochloride, quality requirements, sterilization mode, conditions and storage time is shown.

The composition of the drug:

Pilocarpine hydrochloride .............................................. 0, one

Sodium chloride................................................ .................... 0.068

Purified water................................................ ................ up to 10 ml

Putness components are compatible. In the propisi, the substance of the list of A. Doses is not checked, since the eye drops are a dosage form of external use. The issuance rate of the substance is not regulated.

Properties of medicinal and auxiliary substances recipe recipe.

Pilocarpinum Hydrochloridum. In a private article by the GF "Pilocarpini Hydrochloridum" it is indicated that this substance represents colorless crystals or white crystalline powder without smell, hygroscopic, very easily soluble in water.

Sodium chloride (Natrium Chloridum). White cubic crystals or white crystalline powder, odorless, salted taste, soluble in 3 parts of water. The pharmacy may be in the form of a 10% concentrated solution.

Water purified (Aqua Purificata). In accordance with the order of the Ministry of Health of Russia "On control of the quality of drugs manufactured in pharmacies", the water purified for the manufacture of sterile solutions, in addition to the previously indicated tests, during daily control should be tested for the absence of reducing substances, ammonium salts and dioxide carbon.

For the manufacture of eye drops In addition to water for injection, the use of freshly purified water is allowed.

Preparatory activities. All ophthalmic solutions are manufactured in aseptic conditions, i.e. in the aseptic block. On drugs with medicinal substances intended for the manufacture of sterile dosage forms, there must be a warning inscription "for sterile dosage forms".

To ensure the technological process should be prepared: Sterile vials in neutral glass bixes of 5, 10, 20 ml and more, vials of the brand AB-1 with a capacity of 150, 250 ml, sterile glass funnels, glass filters, J-10 dispenser, type syringe "Record", Filter-nozzle for low-pressure microfiltration (sterilization by filtration) Fa-25, Pipettes Pharmacy, UK-2, Caps and gaskets Aluminum, Tubes rubber, Fixture for crimping caps Pok-1, Sterile Auxiliary Material (Medical Wool, Filters Paper folded, gauze napkins), a set of nuclear membranes (CMA), a set of concentrated solutions and auxiliary substances, water purified or for injection. Freshly or sterile, steam sterilizer.

Calculations. In this case, the propisi has sodium chloride to bring the solution to a concentration, isotonic tear fluid, but for training purposes, appropriate calculations should be carried out.

On the back of the PPK, the isotonic equivalent of pylocarpine hydrochloride on sodium chloride (0.22), which is found in the corresponding Table of GF, is recorded. The recipe discharged 0.1 g of Pilocarpine hydrochloride. This amount will be equivalent to 0.022 g sodium chloride. Therefore, to obtain a solution of isotonic concentration, it is necessary to add sodium chloride in the amount of 0.068 (-0.07), i.e. 0.09 - 0.1 ■ 0.22 \u003d 0.068 or 0.09 - 0.022 \u003d 0.068 (0.07). Sodium chloride can be added in the form of a 10% solution (0.7 ml, -14 drops).

Drug technology. In order to implement the requirements of sterility in aseptic conditions in a sterile stand in 5 ml of water purified dissolve 0.1 g of hydrochloride pilocarpine, which is obtained by a decorated recipe. Add 0.07 g of sodium chloride (it is possible to use a 10% concentrated sodium solution chloride). An example of using concentrated solutions will be disassembled below.

Ophthalmological solutions are filtered through a sterile folded paper filter with a sterile wool padron. The filter is pre-washed with sterile water purified.

After filtering the solution through the same filter, the remaining volume of the solvent is passed. Filters can be used with a pore size of 10-16 microns. When filtering through glass and other fine filtering materials (for example, nuclear membranes) it is necessary to create an overpressure or vacuum.

In the presence of mechanical inclusions in the solution, the filtering is repeated.

After the manufacture of eye drops are filled with the front side of the PPK:

Date_____ . PPK 20. "A".

A solution of up to 100 ml is sterilized for 8 minutes at 120 + 2 ° C. Re-checking the absence of mechanical inclusions, with their absence, the solution is made to leave. In pharmacies, it is often made not by individual prescripts, but in the form of an in-laptop billet and release upon presentation of the recipe.

Concentrated solutions. Some medicinal substances in eye drops are contained in low concentrations (0.01; 0.02; 0.1%, etc.). In combination with a small volume of the solution, written in the recipe, it causes difficulties in weighing them and dissolve (especially moderately, small and very low-soluble medicinal substances).

In such cases, it is advisable to use sterile or aseptically made concentrated solutions of medicinal substances (single-component and combined).

The nomenclature of solved to use ophthalmic concentrated solutions is approved by the Ministry of Health of Russia and is presented in the methodological instructions for the manufacture of sterile solutions in pharmacies. This list includes propuses containing compatible drugs that carry out thermal sterilization methods that have analyzing methods for chemical control and setness of shelf life (Table 13.3).

The technology of manufacturing an ophthalmic concentrated solution will be analyzed on the following example:

Example 21.

Solutions Acidi Nicotinici 0.1% CUM RIBOFLAVINO 0.02% - 50 ML

In the private station. The GF is indicated that "riboflavinum" (Vitaminum B2) is a yellow-orange crystalline powder with a weak specific smell, bitter taste, unstable in light, very little soluble in water (1: 5000).

Acidum Nicotinicum is a white crystalline powder without smell, a weakness taste, moderately soluble in water, soluble in hot water.

Concentrated solutions of drug substances used in the manufacture of ophthalmic solutions Solution FROM, % Mode sterilization * Conditions storage ° S. time, time "FROM Water manufactured peeled: Potassium Yodida 20 (1:5) 120 8 30 25 Acid ascorbinova 2(1:50) ] 5(1:20) 100 30 30; 5 3-5; 10 (1:10)) 25 Born Acids 4(1:25) 120 8 30 25 Sodium thiosulfat 1 (1:100) 100 30 30 25 Sodium chloride 10 (1:10) 120 8 30 25 Riboflavina 00,2 (1:5000) 120 8 90 25 30 3-5 Zinc sulfate 1 (1:100) 120 8 30 25 Citral 2(1:50) 30 0,02 (1:5000) Prepare 30 2 3-4 aseptic chesky Received by 0.02% solution of riboflavin: Acid ascorbinova 2(1:50) 100 30 5; 30 25; 3-5 Born Acids 4(1:25) 120 8 30 25 Nicotinic acids 0,1(1:1000) 100 30 30 25 Sodium chloride 10 (1:10) 120 8 90 25 30 3-5

PR. Open bottles with sterile ophthalmic concentrates should be used during the day. Sterile concentrated solutions are used for the manufacture of ophthalmic solutions that are not subject to sterilization. The shelf life of the eye drops from sterile concentrates on non-standard registers - 2 days. During the day, concentrated solutions made in aseptic conditions, not subjected to sterilization, should be used. Concentrated solutions made in aseptic conditions (non-sterile) (in order to avoid re-sterilization, which can lead to decomposition of medicinal substances), are used for the manufacture of eye drops according to standard parameters with a set sterilization mode.

* Sterilized volume - up to 100 ml.

Riboflavina mass (50 ml) 0.01

0.02 - 100 ml x - 50 ml

Nicotinic acid mass (50 ml) 0.05 g

Calculations are entered into the book of accounting of laboratory and filling works.

Manufacturing technology. In aseptic conditions, 0.01 g riboflavin is dissolved during heating. After a total dissolution of riboflavin in 50 ml of a hot riboflavin solution dissolve 0.05 g of Nicotinic acid. The solution is filtered through a paper folded, glass or other filter, washed with 0.02% riboflavin solution. Check for mechanical inclusions.

Concentrated solutions are subjected to qualitative and quantitative control. The control results are logged in to the registration of the results of organoleptic, physical and chemical control.

The bottle with a solution will collapse with a rubber plug, a metal cap "under running", sterilize 30 min at 100 ° C.

Making eye drops using concentrated solutions. The preparation of concentrated solutions in the pharmacy allows you to accelerate the manufacture of eye drops.

The use of concentrated solutions made on water purified.

Example 22.

RP.: Solutions Riboflavini 0.01% - 10 ML Acidi Ascorbinici 0.05

Misce. DA. SIGNA. 2 drops 3 times a day in both eyes.

All stages of professional activity correspond to the stages described earlier. Let us dwell on the calculations. Mass sodium chloride for isotonic solution Calculate by the formula:

Mnaci \u003d 0.009-10-0.05-0.18 \u003d 0.09-0.009 \u003d 0.081.

The concentration of medicinal substances written in the recipe recipe is such that practically does not affect the value of osmotic pressure, so the solution should be made on an isotonic (0.9%) solution of sodium chloride.

The method of calculating the volume of concentrated solutions and water purified is similar to the calculations performed in the manufacture of mixtures using a burent system.

Volumes of concentrated solutions and water purified:

Riboflavina ................................... (0.001 5000) 5 ml

Acid ascorbic ................ (0.05 -20) 1.0 ml

Sodium chloride ..................... (0.081 -10) 0.8 ml

Water purified ................... (10 - 5 - 1 - 0.8) 3.2 ml

After making a memory fill the front side of the PPK:

Date ____ . PPK 22.

Aquae Purificatae ...................... 3.2 ML

Solutions Riboflavini 0.02% ...... 5 ML

Solutions Acidi Ascorbinici 5% .. 1 ml

Solutions Natrii Chloridi 10% ..... 0.8 ml

V \u003d 10 ML Signatures:

The sterilization mode of the eye drops, made according to this proper, is not specified in the regulatory documents, therefore, sterile concentrated solutions are used, which in aseptic conditions are measured by pharmaceutical pipettes into a sterile vacation bottle.

The use of concentrated solutions made by 0.02% riboflavin solution.

Example 23.

Rp.: Solutionis Riboflavini 0.02% - 10 ML ACIDI Ascorbinici 0.03 Acidi Borici 0.2

Misce. D. S. 2 drops 4 times a day in both eyes.

We pass in the annex to the instructions for controlling the quality of drugs manufactured in pharmacies. Sterilization mode: 120 ° C, 8 min. In the manufacture of concentrated aseptic solutions should be used.

Calculations. The isotonic acid equivalent boring sodium chloride is 0.53; 0.53-0.2 \u003d 0.106 (1.06%), i.e. The solution is slightly hypertonic, so sodium chloride in this case is not added. Given the limits of isotonic concentrations (0.9+ 0.2)%, the solution can be considered as isotonic. When using concentrated solutions made on the water purified, the volume of eye drops and the concentration of drug substances will be obtained, which do not correspond to the recipe recipe, which is unacceptable.

Riboflavina solution 0.02% - 10 ml (\u003d 0.002 5000)

Askorbinic acid solution 5% - 0.6 ml (\u003d 0.03 ■ 20)

Boric acid solution 4% - 5 ml (\u003d 0.2 - 25)

The calculated volume is 15.6 ml - much more

specified in the recipe recipe.

memory mortar fill the front side of the PPK:

Date _____ . PPK 23.

Solutions Riboflavini 0.02% .............................................. ......... 3.5 ml

Solutions Acidi Ascorbinici 2% CUM RIBOFLAVINO 0.02% .... 1.5 ML Solutions Acidi Borici 4% CUM RIBOFLAVINO 0.02% .................... .................................................. .................................... 5 ML

The concentrated solutions are measured into a vacation bottle, collapse, check the absence of mechanical inclusions, are designed for sterilization, sterilize and draw up to vacation.

Eyegalls, solutions for irrigation of the mucous membrane of the eye, solutions for washing and storing contact lenses and other ophthalmic solutions are manufactured in the same way as eye drops, in compliance with the requirements of sterility, stability, the absence of suspended particles visible to the unarmed eye, isotonicity and, if necessary, prolonged action . Most often, solutions are used: solutions: boring acids, sodium hydrocarbonate, furaticiline, lactate ethanidine, in extreme cases (for example, with lesions of eye drop-like poisoning substances), a 2% solution of gramicidine can be assigned.

Packaging, capping. The bottle will collapse with a rubber plug and rolled through an aluminum cap. If required (in accordance with ND), is issued for sterilization, strengthening a special tag or taking a wet parchment indicating the name, concentration of solution, surnames and the date of manufacture.

Sterilization. The solutions are released from the pharmacy aseptically manufactured or sterilized by the method specified in the regulatory documents. After sterilization, the solutions are again checked for mechanical inclusions.

Registration for vacation from the pharmacy. The bottle with the solution is sealed (if the substance of the list A) is present in the propishes, without removing the parchment strapping used to design the bottle to sterilization. If the solution was not sterilized, the bottle cover (aluminum cap) is tied with a wet parchment, the thread on top is fixed with the wax seal.

The bottle is supplied with the main pink label "Eye Caps", which indicates the number of the pharmacy, the date of manufacture, the surname and initials of the patient, the method of application, the number of analyzing the lifetime, and the warning label "contact

caution". The recipe containing a substance in a substance, located in the pharmacy, except when the recipe has a special abandon "for long-term use", for example, a recipe containing pilocarpine hydrochloride (for the treatment of glaucoma).

_International Scientific Journal "Symbol of Science" No. 10-3 / 2016 ISSN 2410-700x_

Pharmaceutical sciences

UDC 615.451.3

Vasileva Anastasia Vladimirovna

Student 4 Course of the Pharmaceutical Faculty of FBOU in KGMU IFC, RF, Kursk E-mail: [Email Protected] Boyko Inna Anatolevna FBOU in KGMU IFC, RF, Kursk E- Mail: [Email Protected]

Production technology and assortment of drops for external use of pharmacy and factory production

annotation

The article presents a study of the technological process of manufacturing drops for outdoor use in pharmacy and factory conditions, as well as the study of their range.

Keywords

Manufacturing technology, drops for outdoor use, pharmacy and factory production, liquid dosage forms.

Introduction: Liquid dosage forms occupy the main place (45-50%) in the recipe of modern pharmacies. Many diverse prescription of liquid drugs is manufactured in the factory. The focus of the individual formulation on a specific patient, the pricing accessibility and high confidence in the population of pharmacy manufacturer testifies to the importance of preserving and improving pharmacy production. Currently, drugs for the treatment of various kinds of diseases in the form of drops are widely used in medical practice. Drops (guttae) is a liquid dosage form designed for internal or external use, which is different in a single group characteristic, drip dosage. Therefore, the study of the manufacturing technology of drops for the external use of pharmacy and factory production is very relevant.

Research objectives: study the technological features of manufacturing and the range of drops for the external use of pharmacy and factory production.

Research Objectives: Analyze bibliographic sources on the topic, study the technology of manufacturing drops for outdoor use, consider general technological methods of making drops in a pharmacy, analyze the production technology of drops for nose, ear and dental, learn the range of droplets for outdoor use.

Research results: Having studied the production technology of pharmaceutical and factory production drops, it was found that drops are prepared by dissolving solid medicinal substances in the corresponding solvents, or by mixing liquids. Measuring of tinctures are made in ascending order of their amounts. Tincture, possessing a strong smell, add last. When mixing alcohol fluids with different content of alcohol, the liquids close in the fortress contained in them alcohol are first mixed. Drops are released in bottular droppers.

According to the results of the studies, it was found that drugs produced in the form of liquid dosage forms - 62.8% and 93 drugs (LP) predominate in the assortment of drugs for treatment of rhinitis - 62.8% and 93 drugs (LP), as the treatment of rhinitis is more convenient and more efficient to spend drops, which are filled with liquid medicinal phase. The main liquid

International Scientific Journal "Symbol of Science" No. 10-3 / 2016 ISSN 2410-700x

drugs are drops - 28.3% (42 lp). During the comparative analysis of the Russian market and the local range of drugs for the treatment of rhinitis by type of dosage forms, it was found that in the Russian Federation, 29.1% were recorded in the Russian Federation (LP - 43), in second place drops 28.3% (LP - 42), on the third - sprays Nasal 24.3% (LP - 36). Drops predominate on the Kursk market - 32.5% (LP - 38), in second place - tablets 27.3% (LP - 32), on the third - Nasal sprays 25.6% (LP - 30).

Conclusion: The preparation of the drops is made up of the following stages: dispensing of solvent and medicinal substances; dissolution of medicinal substances; Filling, packaging and decoration for vacation, grade quality drops. Methods of manufacturing drops depend on the composition. They are prepared by dissolving solid medicinal substances in the corresponding solvents or by mixing liquids. The range of droplets for external use is extensive. In recent years, new drugs in the form of droplets have appeared on the pharmaceutical market of Russia. A huge amount of preparations are used to treat rhinitis. Drops occupy a leading position among them. List of references:

1. Grossman V.A. Pharmaceutical technology. - M.: Gootar Media, 2014. - 512 p.

2. State Pharmacopoeia of the Russian Federation XII: Collection of basic standards used in pharmacopoeial analysis, production and treatment of medicines. - M.: Publisher "Scientific Center Examination of Medical Applications", 2008. - 704 p.

3. Unified regulations for the design of drugs prepared in pharmacy institutions (enterprises) of various forms of ownership. Methodical guidelines, (utensils. Ministry of Health of the Russian Federation 07/24/1997) [Electronic resource]. - Access Mode: http://www.consultant.ru/Gost National Pharmacope of the Russian Federation XII: Collection

4. Drug Registry [Electronic Resource]. - Access mode: http://www.rlsnet.ru/

© Vasileva A. V., Boyko I. A., 2016

UDC 615.454.1

Zheltieuchine Alina Yurevna FGBOU in kgmu of the Ministry of Health of the Russian Federation Student 4 Course of the Pharmaceutical Faculty

E-mail: [Email Protected] Scientific Director: Boyko Inna Anatolyevna FGBOU in KGMU MH RF Medical and Pharmaceutical College

kursk, RF E-Mail: [Email Protected]

Production technology and assortment of pharmacy and factory production

annotation

The article discusses the features of the manufacture of pastes of pharmacy and factory production, their range.

Keywords

Paste, pharmacy and factory manufacture, assortment, technology.

Paste - a soft dosage form designed to apply on the skin, wounds or mucous membranes. The penetability of the skin for different medicinal substances is sharply rising during the hydration of the skin with warming compresses, warm baths. Pastes consist of medicinal substances and bases. the main

Drops for outdoor and internal use Pharmaceutical Technology Lecture No. 14 Chereshneva Natalia Dmitrievna Candidate of Pharmaceutical Sciences

Drops (guttae) - a liquid dosage form intended for internal or external use of drops have all the advantages inherent in liquid dosage forms. They are more bioavailable than powders, tablets, pills, are convenient for use, relatively easy to manufacture. Drops are beneficial to the mixtures of their compactness, portability.

Drops must meet the requirements: compliance with the anatomy-physiological features of the route of administration and the physicochemical properties of medicinal substances; safe level of microbial contamination; compatibility of medicinal and excipients; the accuracy of the concentration of medicinal substances and volume (mass) of drops; Chemical and physical stability (for suspensions and emulsions); Lack of mechanical inclusions

Drops for internal use (Guttae Pro usu Interno) R.: SOL. Papaverini Hydrochloridi 2% 10 MLR DS 10 2 Drops times a day 1 ml - 20 cap 10 ml - 200 CAP 0, 2 - 200 CAP X-10 CAP X \u003d 0, 01 \u003d RD VD GF \u003d 0, 2 VDC GF \u003d 0, 2 0, 6 dissolve 0, 2 g of hydrochloride papaverine in 5 ml of water purified. The solution is filled through a cotton swab, pre-washed with water purified. The rest of the water is filled through the same tampon

R.: Aethylmorphini Hydrochloride 0, 2 P Tincturae BellAdonnae Tincturae Menthae Ana 5 ML Tincturae Valerianae Tincturae Convallariae Ana 10 ML M. D. S. 20 2 Drops times a day 1 ml - 50 cap 30 ml - 1500 CAP. On the table drops of GF: 0, 2 - 1500 Cap x - 20 Cap x \u003d 0, 0027 \u003d RD VD GF \u003d 0, 03 IRS GF \u003d 0, 1 250 - 1500 CAP X - 20 CAP X \u003d 3 CAP \u003d RD VD GF \u003d 23 CAP ISR GF \u003d 70 cap

Drops for the nose (gutttae rhinologicae. Rhinoguttae) The mucous membrane of the upper and lower airways is covered with a fiscal epithelium. The main structural element of the epithelium is semicircular cylindrical cells.

The movement of the fiscal epithelium in the nasal cavity is directed to the nasopharynx, and from the bottom departments of the respiratory tract - up. Thus, the respiratory tract is cleaned, necrotic cells, microorganisms, dust, mucus, etc. are removed from them.

Some medicinal substances slow down the fishing movement. It is not recommended to heat the solutions of silver nitrate, hydrochloride cocaine, boric acids above 1% concentration, sodium bicarbonate above 3%, ephedrine of hydrochloride - above 1-2%

On the transport function of the creation epithelium affects the values \u200b\u200bof osmotic pressure and p. H aqueous solutions of medicinal substances. The most favorable isotonic solutions and solutions with the value of p. H from 6, 4 to 9, 0. Acceptable solutions with osmotic pressure corresponding to sodium solutions of chloride at a concentration of 0, 3 to 4% dose of poisonous and potent substances in the nose drops are usually not verified, as they are prescribed for local action and In small quantities

R.: Furacilini 0, 002 r Dimedroli 0, 05 Ephedrini Hydrochloridi novocaini 0, 1 AA SOL. Natrii Chloridi 0, 9% 10 ml. D. S. 2 3 m drops in the nosed day once a day. Usually 0, 02% solution of furaticiline in 0, 9% sodium solution chloride is in the form of an inappeature workpiece. In 5 ml of this solution, DIMEDROL is dissolved, ephedrine hydrochloride and novocaine. The solution is filled with a cotton swab, pre-washed with a fuclinium solution. Through the same tampon, the remaining 5 ml of Furatcilina solution is filled

Aquatic, non-aqueous and combined solutions R.: SOL are used in the form of ear droplets. Dimexidi 20 p% 20 ml D. S. On the moistened Turunda, it is dissolved in the auditory 2- 3 passing times a day 4 g of domexide in 10 ml of water, the volume of the solution is adjusted with water to 20 ml of dumps (Guttae Otologicae. Otoguttae)

R.: Natrii HydroCarbonatis 0, 5 r Glycerini 5, 0 Aquae Purificatae 5 ml. D. S. M to bury in the auditory passage of 7-10 3 drops times a day, the solution is prepared when heated in a water bath at a temperature of 60-70 ° C

RP. : Resorcini Ephedrini Hydrochloride Ana 0, 04 Novocaini 0, 3 Dimexidi 4, 0 Glycerini 3, 0 Spiritus Aethylici 95% 3 ML. D. S. 8-10 m to droplets in the outer hearing 2- 3 pass times per day of resorcin, ephedrine hydrochloride and novocaine is dissolved in ethanol or in its mixture with glycerin and dimexide

The disadvantage of drops for nose - aqueous solutions of medicinal substances - is the short-term therapeutic action. To prolong the action of medicinal substances used at rhinitis, it is recommended to introduce the synthetic polymers into the drops - 1% methylcellulose or 1% oxypropylmethylcellulose or 4% polyvinyl alcohol

Methodological development can be used to carry out practical classes on the topic at the discipline of MDC 02.01 "Technology manufacturing techniques" of the specialty 33.02.01. "Pharmacy". The purpose of creating a methodological development: to form professional competencies on the manufacture of aquatic and alcohol droplets according to recipes with a concentration of dry drugs less than 3% or more (PC 2.1).

Download:

Preview:

Gapowa Co.

"Kaluga Basic Medical College"

Specialty: 33.02.01 "Pharmacy"

Section PM. 02. Production of dosage forms

MDK 02.01. "Technology manufacturing lec. forms "

Practical lesson number 27-28

Topic 3.3. "Production of drops containing one or more medicinal substances.

Prepared: Chekmareva N.A.

2016

Methodical development for the teacher.

Section MDK 02.01.3. Making liquid dosage forms

Production of alcohol droplets "

Objectives:

1. Training:

1. To form professional competences for the manufacture of water and alcohol droplets according to recipes with a concentration of dry lek. Funds less than 3%, 3% or more (PC 2.1).
2. Teach students:

• check doses in aquatic, alcohol, water-alcohol drops;

• choose and justify the optimal method of manufacturing drops;
• filter fluids in small quantities;
• packaging, draw up drops for vacation, evaluate the quality of the droplets made;
• documents of primary accounting (PC 2.5).

1. Continue the formation of professional competencies on the skill of working with weights, multiple, measuring devices, work with ND, regulating the quality of the manufacture of droplets.
2. Improve professional competence on the organization of the workplace and compliance with the rules of sanitary and hygienic regime, safety and fire safety (PC 2.4).

2. Educational:

1. To bring up students with a sense of professional responsibility and conscious attitude to the study of this topic.
2. Educating the ability to work with additional special literature, choose the main thing, substantial in the studied material (OK 4).
3. Orient students to the acquired profession, bring up a sense of love for the profession (OK 1).

3. Developing:

1. Continue the formation of professional competence on vacation drugs by the population, including in preferential recipes and according to the requirements of health institutions (PC 1.2).
2. Develop logical and analytical thinking from students.
3. Develop the ability to allocate the main thing in the material studied.
4. Make decisions in standard and non-standard situations and be responsible for them (OK 3).

1. Work in a team and in a team, to communicate effectively with colleagues, management, consumers (OK 6).

Type of classes: Laboratory and practical.

Training method: Independent practical work of students under the guidance of the teacher.

LOCATION: Laboratory No. 208, 209.

Duration: 180 min.

Equipment lessons:

GF-X. BP-1.0, BP-5. Cylinders, eye pipettes, napkins, wool, mix of alcohol with ether, scissors, glue, threads, coupon rings, surgum, alcohol, signature. Lek. SR-VA: Ephedrine hydrochloride, morphine hydrochloride, codeine phosphate, sodium bromide, adormizid, antipirine, adrenaline hydrochloride, solution of atropine sulfate 1%. Labels: "Outdoor", "Internal", "Store in a dark place", "Caution!"

DVS: "Dosing by mass. Libra. Differences "," Volumetric Dosing Methods "," State Qualification of Quality Lek. funds "," Tara. Packing material. Storage, work, vacation Lek. Tools list a and b ". "Solutions", "Production of solutions using concentrates".

MDS:

Lat. Yaz. "Chem. nomenclature. Name salts »

Pharmacognosia "LANs acting on the central nervous system"

Pharmacology "Narcotic analgesics"

MDC 02.02. "KK LS, a contract. Aminospirts "(adrenaline, hydrochloride, ephedrine hydrochloride)," QC LS, a contract. isoquinoline "(morphine hydrochloride, codeine phosphate)," CC LS, a contract. Tropane "(Atropine sulfate)

After self-studying material

students need to know:

• Check doses in aquatic, alcohol, water-alcohol drops.

Formed competencies:

1. General competencies:

The level of assimilation: 3

Structure of classes and time mode:

1. Organizing time. Mobilization of the audience 2 min.
2. Statement of classes, its motivation 2 min.
3. Input control 25 min.

a) Place the recipes at the board of 15 minutes.

b) Objective testing of 10 minutes.

1. Methodical instructions for practical work 2 min.
2. Performance of practical work 113 min.

Check by the teacher of intermediate results, the correction of students. Control over practical skills and skills, diary design.

1. Output control. Delivery of diaries 14 min.
2. Summing up, task for a house 2 min.

Structure occupation

1. Organizational moment. Mobilization of the audience.

The teacher welcomes students, draws attention to the appearance of students, adopts a report on the readiness of the Cabinet and students to occupy, notes missing.

2. Statement of occupation, its motivation.

The teacher notes that drops occupy a pharmacy recipe for about 15%, have their own characteristics both in testing doses and in manufacturing technique, in contrast to solutions, so pharmacists need to know these features to make high-quality lec. The form indicates the goals of classes.

3. Input control.

I. Planning recipes at the board:

Q: Morphine hydrochloride 0.03

Water purified 10 ml

About. 10 cap. 2 times a day, with pain.

Q: Ethylmorphine hydrochloride 0.15

Tandy beauties

Motherboard tincture of 15 ml

About. 15 cap. 3 times a day.

Q: Validol 4.0

Nitroglycerin solution 1% -1 ml

Mother's tincture

Valerian tinctures 20 ml

About. 10 cap. On sugar under the tongue with pain in the heart.

II. Knowledge control by objective testing.

For this, students are offered 2 options for 10 tasks. Tests of various types and level of complexity. Time is regulated by the teacher. For solutionstest tasks The doses table are needed, the tables of the GF-X drops. Options are attached (Appendix No. 2).

4. Methodical instructions for practical work.

The teacher notes that at today's occupation it is necessary to make lek. Forms - drops, indicates which dishes to take attention to the features of filtration of liquids in small quantities, shows how to wash the filter with water that is not included in the volume, manufacturing technique, based on the concentration of solid lec. Funds, purity checking and feature of registration for vacation, shows how to bite the penicillin bottle on vacation, how to seal.

5. Performing practical work.

Students receiveindividual registers(Appendix No. 3). Organize a workplace and prepare lek. Forms, in the course of the task, students enjoy GF-X,manufacturing algorithms (Appendix No. 4).The teacher adjusts the work of individual students, controls the work on students of professional competencies on this topic, students draw up lek. Preparations for vacation, draw up the opposite side of the recipes, PPKs, draw up diaries, as they perform work, approach the teacher to pass. drugs.

When taking Lek. The teacher conducts organoleptic control, checks the PPK, diary and sets students the following questions, at the discretion of the teacher:

1. What is drops?
2. How are they classified?
3. What does the droplet manufacturing technique depend on?
4. What is the technique of making drops with a concentration of dry lek. Funds less than 3%?
5. What is the technique of making drops with a concentration of dry lek. 3% and more?
6. How to check doses in water drops?
7. How to check doses in alcohol drops? If the fortress of alcohol is approximately the same, differ sharply?
8. What is the technique of making alcohol droplets?
9. How are the drops for vacation?

1. General competencies:

• OK 1. Understand the essence and social significance of your future profession, to show sustainable interest.
• OK 2. Organize your own activity, choose typical methods and methods for performing professional tasks, evaluate their effectiveness and quality.
• OK 3. To make decisions in standard and non-standard situations and be responsible for them.
• OK 4. Survey and use the information necessary to effectively perform professional tasks, professional personal development.
• OK 5. Use information and communication technologies in professional activities.
• OK 6. Work in the team and teamwork, effectively communicate with colleagues, management, consumers.
• OK 7. To take responsibility for the work of the team members (subordinates), for the result of the tasks.
• OK 8. Independently identify the tasks of professional and personal development, to engage in self-education, consciously plan to increase their skills.
• OK 9. Focus in conditions of frequent change of technology in professional activities.

2. Professional competencies:

• PC 2.1. Produce dosage forms on recipes and requirements of health care facilities.
• PC 2.2. Manufacture the intrapension workpiece and pack drugs for subsequent implementation.
• PC 2.4. Comply with the rules of sanitary and hygienic regime, safety and fire safety.
• PC 2.5. Documents of primary accounting.
• PC 1.2. Let us release drugs to the population, including, on preferential recipes and according to the requirements of health institutions.

6. Output control.

It is recommended to spend in the formwritten survey on checking doses in aquatic and alcohol drops of 10 options(DRF folder, 1 p., or KNF folder). Each student receives an individual task. The task consists of 5 recipes, when performing a task, students use the table of droplets of GF-X, dose tables. Time is regulated.

At the discretion of the teacher, the output control can be carried out aswritten survey byindividual optionswhere 2 recipes are given:

A) checking doses in water drops,

B) checking doses in alcohol drops (Appendix No. 5).

7. Summing up.

The teacher issues an assessment for the practice of each student, taking into account theoretical preparation for practical work, the estimates are commented. The teacher puts his signature and draws students attention to individual professional competencies. The execution of which was not at a high level. Notes students who competently, aesthetic lectured. Preparations for vacation. Lecturer asks students "Is the goal has been achieved"?

Main literature:

• Working with uch. lit-swarm.

Additional literature:

Appendix No. 1. Methodical recommendations to students for self-preparation to the practical lesson.

Appendix number 2. Options for test tasks.

Appendix number 3. Reception for execution in a practical lesson.

Appendix number 4. The algorithm for the manufacture of water droplets with dry leek concentration. Tools up to 3%, 3% or more.

Appendix number 5. Written survey options.

Appendix No. 1.

Specialty 060301

Professional Module PM.02: Making Lek. forms and carrying out mandatory types of internal control.

Section PM 1. Production of dosage forms.

MDK 02.01. "The technology of making medicinal forms."

Section MDK 02.01.3. Production of liquid dosage forms.

Topic 3.3.: "Production of drops containing one or several lec. Substances.

Production of alcohol droplets "

Objectives:

1. Check knowledge, students' skills on this topic.
2. Shape skills:

• Check doses in aquatic, alcohol, water-alcohol drops.
• Select and justify the optimal method of manufacturing drops.

1. To work out the ability to prepare drops with a concentration of dry lek. Funds less than 3%, 3% or more.
2. Skill:

• Filter liquids in small quantities.
• Packaging, draw up drops for vacation, evaluate the quality of the damned drops.

1. Secure skills to work with weights, multiple, measuring devices.
2. Secure the ability to work with ND, regulating the quality of the manufacture of droplets.
3. Improve the skill of the workplace organization.

Study time: 180 minutes.

LOCATION:Laboratory No. 208, 209

KNOW:

• Verification of doses in aquatic, alcohol and water-alcohol drops.
• Rules for making drops on aquatic and non-aqueous solvents.
• Storage. Vacation

At the lesson, students should:

1. Answer input control questions.
2. Make drops on aqueous and non-aqueous solvents with dry leek concentration. Tools up to 3%, 3% or more on the proposed recipes, arrange a diary.
3. Answer output control questions.

Approximate recipe:

Q: Morphine hydrochloride 0.1

Water purified 10 ml

D. about. 10 cap. 2 times a day.

Q: Lily of Lily

Tincture s handwriting in 10 ml

Sodium bromide 2.0.

Water purified 20 ml

In the course of practical work Students

the following competencies acquire:

1. General competencies:

• OK 1. Understand the essence and social significance of your future profession, to show sustainable interest.
• OK 2. Organize your own activity, choose typical methods and methods for performing professional tasks, evaluate their effectiveness and quality.
• OK 3. To make decisions in standard and non-standard situations and be responsible for them.
• OK 4. Survey and use the information necessary to effectively perform professional tasks, professional personal development.
• OK 5. Use information and communication technologies in professional activities.
• OK 6. Work in the team and teamwork, effectively communicate with colleagues, management, consumers.
• OK 7. To take responsibility for the work of the team members (subordinates), for the result of the tasks.
• OK 8. Independently identify the tasks of professional and personal development, to engage in self-education, consciously plan to increase their skills.
• OK 9. Focus in conditions of frequent change of technology in professional activities.

2. Professional competencies:

• PC 2.1. Produce dosage forms on recipes and requirements of health care facilities.
• PC 2.2. Manufacture the intrapension workpiece and pack drugs for subsequent implementation.
• PC 2.4. Comply with the rules of sanitary and hygienic regime, safety and fire safety.
• PC 2.5. Documents of primary accounting.
• PC 1.2. Let us release drugs to the population, including, on preferential recipes and according to the requirements of health institutions.

Independent work (homework):

Main literature:

• Uch. IN AND. Pogorelov "FT" R-Na-D, Phoenix, 2002, p. 183-184
• Working with uch. lit-swarm.
• Execution of calculations and description of tehnol. Human droplets.
• Decision of professional tasks for the manufacture, design and vacation of liquid dosage forms.

Additional literature:

• Uch. I.I. Krasyuk, K.V. Mikhailova, L.I. Muravyov "FT", I. ed. Group "Geobar-Media", 2011 p. 221-223

Appendix No. 2.

Answers to a test survey

	OPTION 1			OPTION 1
				B, G.
				1 - B.
				2 - A.
				3 - B.
				4 - B.
				5 - A.
	B, G.
	1 - B.
	2 - A.
	3 - B.
	4 - B.
	5 - A.

Evaluation Criteria:

15 - 14 Replies - "5"

13 - 12 replies - "4"

11 - 10 replies - "3"

9 responses and less - "2"

Appendix No. 3.

Reception for execution

In a practical lesson.

Q: Morphine hydrochloride 0.1

Water purified 10 ml

D. about. 10 cap. 3 times a day.

Q: Phosphate Codeina 0.2

Sodium bromide 2.0.

Adonizes 5 ml

Water purified 20 ml

D. about. 2 cap. 3 times a day.

Q: Lily of Lily

Valerian tincture of 10 ml

Sodium Bromide 1.0

Water purified 10 ml

D. about. 10 cap. 4 times a day.

Q: Sulfate atropine solution 0.1% -10 ml

D. about. 8 cap. For pain.

Q: Ephedrine Hydrochloride solution 3% -10 ml

D. about. 2 drops 3 times a day in the nose.

Q: Nisulfazole solution 2% -10 ml

D. about. 2 drops in the nose.

Q: Acids Born 0.3

Alcohol 10 ml

D. about. Drops in the ear.

Recipes can be changed at the discretion of the teacher based on the defect, taking into account the regional component.

Appendix No. 4.

Algorithm for the manufacture of water drops.

Concentration of solid lek. Funds less than 3%.	Concentration of solid lek. 3% and higher means.
Measure the exact amount of water. Devide into two parts. In one dissolve dry leek. funds. It is filtered on a vacation bottle through cotton, washed with water that is not included in the solution. Check for cleanliness. Add water from the second stand through the same filter.	Pour half water into the stand. Dissolve dry lek. funds. It is notified to filter into a cylinder through cotton, washed with water not included in the solution. Check for cleanliness. Bring the volume to the desired filter. Pour the vacation bottle.
Clear. Embed to vacation. Write down the PPK.

Appendix No. 5.

Option number 1.

Check doses:

Q: RR Promedol 1% - 10 ml

D. about: 5 cap. 2 r. per day with pain.

Q: H-ki Beauty 3 ml

N-ka dyeing 7 ml

H-ka hawthorn 10 ml

D. Oh.: 15 CAP. 3 r. in a day.

Option 2.

Check doses:

Q: R-ra ethylmorphine g / hl 0.2 - 15 ml

D. Oh: at 10 cap. 2 r. in a day.

Q: Adonizes 5 ml

N-ki mint 3 ml

N-ka dyeing 7 ml

N-ki valerian 10 ml

Option 3.

Check doses:

Q: Sulfate atropine 0.05

Water purified 10 ml

See D. about. 2 cap. 2 r. in a day.

In: n-ki strangement 2 ml

N-ki valerian

H-k wormwood in 5 ml

Option 4.

Check doses:

Q: P-ra Atropine sulfate 0.3% - 20 ml

D. about. 4 cap. 2 r. in a day.

In: n-ki strange 4 ml

N-ki valerian 16 ml

See D. about: 15 cap. 2 r. in a day.

Option number 5.

Check doses:

Q: Morphine hydrochloride 0.01

Water purified 10 ml

See D. about: 20 cap. 2 r. in a day.

In: n-ki beauties

N-ki valerian

N-ka lily of 10 ml

Option 6.

Check doses:

Q: iodine 0.05

Potassium Iodide 0.1

Water purified 50 ml

See D. about: 10 cap. 2 r. in a day.

Q: Adonizes 5 ml

N-ki valerian

N-ka lily of 10 ml

See D. about: 25 cap. 3 r. in a day.

Option number 7.

Check doses:

Q: RR Donin 1% - 10 ml

In: n-ki beauties 6 ml

N-ki dye

N-ki valerian 5 ml

H-ka Lily of 7 ml

See D. about: 30 cap. 2 r. in a day.

Option number 8.

Check doses:

Q: P-ra apomorphine hydrochloride 0.2% - 10 ml

Q: Menthla 0.2

N-ki beauties

N-ki valerian

N-ka lily of 10 ml

See D. about: 15 cap. 3 r. in a day.

Option number 9.

Check doses:

Q: P-RR Atropine sulfate 0.02 - 15 ml

D. Oh: at 10 cap. 3 r. in a day.

In: n-ki chilibuhi 6 ml

N-ki wormwoods

N-ki valerian on 7 ml

See D. about: 10 cap. 3 r. in a day.

Option number 10

Check doses:

Q: P-RG of Skopolamine Hydrobromide 0.1% - 10 ml

D. Oh: on the cap. 2 r. in a day.

Q: R-ra nitroglycerin 1% - 5 ml

N-ki valerian

N-ka lily of 10 ml

See D. about: 5 cap. appointment.

Option number 11.

rD 2 cap.

s.D. 0.005

s.D. 6 cap.

rD 0.0066.

rD 3 cap.

s.D. 0.0132.

s.D. 9 cap.

rD 0.005

rD 5 cap.

s.D. 0.001.

s.D. 10 cap.

rD 0.0006.

rD 3 cap.

s.D. 0.0012.

s.D. 6 cap.

rD 0.001.

rD 5 cap.

s.D. 0.001.

s.D. 15 cap.

rD 0.0005

rD 5 cap.

s.D. 0.001.

s.D. 15 cap.

rD 0.005

rD 8 cap.

s.D. 0.015

s.D. 16 cap.

rD 0.001.

rD 5 cap.

s.D. 0.003.

s.D. 15 cap.

rD 0.0006.

rD 3 cap.

s.D. 0.0018.

s.D. 9 cap.

rD 0.0005

rD 3 cap.

s.D. 0.001.

s.D. 9 cap.

rD 0.00125

rD 2.5 cap. (2.4)

s.D. 0.0025.

s.D. 10 cap. (9,6)

1. Purpose: Learning to prepare drops - aqueous solutions of medicinal substances and evaluate their quality on the basis of theoretical provisions of the theme, properties of drugs and in accordance with the requirements of ND.

2. Questions to prepare for the topic:

Characteristics of droplets as a dosage form.

Classification of drops by the method of destination and the nature of the solvent

Features of checking doses of poisonous and potent substances in drops for internal use.

Technology droplets - aqueous solutions of medicinal substances.

Evaluation of the quality of the droplets and the design of them for vacation.

The main ways of improving the quality and technology of drops.

3. Training material

Drops - a liquid dosage form intended for internal or external use dosing by drops. Drops have all the advantages inherent in liquid dosage forms (high bioavailability, compared with solid dosage forms, ease of use, simplicity in manufacture). But due to the higher concentration of medicinal substances, chemical incompatibilities are relatively more common compared to medicines in drops. In the EXTEMPORAL recipe, pharmacies drops occupy about 15%.

Drops qualify for use - for indoor and outdoor use (drops for nose, ear, dental, etc.). As dispersed systems can be true solutions, colloidal solutions, emulsions, suspensions. By the nature of the solvent - water and non-aqueous drops.

Cooking drops from the following stages:

I. Preparatory Stage:

Analysis of compatacity composition composition.

Checking doses of poisonous and potent substances (in drops for internal use) and vacation rates for narcotic and infusion drugs.

Preparation of packaging and closure material.

Conducting the necessary calculations.

II. Dissolution (dry medicinal substances in the calculated amount of water purified or the use of concentrated solutions of medicinal substances).

III. Filtering (using "Small Filtering").

IV. Packaging and decoration for vacation (in the vials of colorless or orange glass with tight plugs and gaskets, the label "outdoor" or "internal", additional labels - according to the properties of the ingredients of the droplets in accordance with the active ND).

V. Evaluation of the quality of the droplets (verification of documentation, the correctness of the packaging and design, organoleptic control, the absence of mechanical inclusions, deviations in the volume, selective and chemical and question control).

A feature of the technology of droplets - aqueous solutions of medicinal substances is due to the small volume of their prescription in the recipe (usually 5-15 ml). In order to maintain the volume and concentration, the drugs dissolve about half the amount of water purified. The resulting solution is filtered through a cotton tampon, pre-washed with water purified. The remaining amount of water is filtered through the same tampon.