Lowered anti-Müllerian hormone - is it possible to get pregnant? Is it possible to get pregnant if the anti-Müllerian hormone is increased or decreased? Amg norms in women for conception Amg 0.5 is pregnancy possible.

Diagnosis of infertility includes many studies, but one of the main ones is the analysis of hormones in a woman. Levels of endocrine hormones, which regulate the functioning of the reproductive system, are routinely determined. If such a study does not give results, an anti-Müllerian hormone test is additionally prescribed.

Anti-Müllerian hormone (AMH) is present in the body of both sexes. The hormone is produced by the gonads from birth, but only during puberty does it reach its maximum.

In men, AMH levels are high during periods of growth and puberty, since the hormone is involved in the development of the genitals. With a critical decrease in AMH levels, a man may be unable to conceive a child. After puberty, the level decreases, but the hormone continues to be produced until the end of life.

The importance of the hormone for women is different. The concentration of AMH remains in the blood from birth to menopause. In the female body, anti-Müllerian hormone is produced by the granulosa tissue of the ovaries. Accordingly, the more cells are involved in the process, the higher the hormone will be. With the onset of menopause.

How the number of eggs is determined

Experts call the anti-Müllerian hormone an “oocyte counter” because its level reflects the number of capable oocytes. The number of germ cells capable of fertilization is laid in the girl's body even at the stage of intrauterine development.

In puberty, there are up to 300 thousand of them, if the girl does not have serious pathologies. This number of cells is called the ovarian reserve. Each menstrual cycle in a healthy woman is marked by the maturation of the germ cells, from which the most capable and high-quality ones stand out.

The process of maturation of sex cells in the body of a sexually mature woman does not stop during pregnancy and the use of contraceptives. By itself, the anti-Müllerian hormone does not play an important role in the fertilization process, but its diagnostic potential is enormous.

The extended Efort test can be used to determine the concentration of AMH in a woman's blood and to assess her ovarian reserve. When the Efort test is prescribed:

• absence of pregnancy during normal sexual life without the use of contraception;
• infertility for unclear reasons;
• unsuccessful IVF in history;
• late puberty;
• determination of the results of antiandrogenic treatment;
• polycystic ovary syndrome;
• suspected ovarian tumor;
• increased levels of follicle-stimulating hormone.

Modern medicine makes it possible to predict the premature depletion of egg cells and plan a pregnancy so that it can be in time. For the study, it is necessary to collect anamnesis and determine the indicators of FSH, LH and AMH.

The number of follicles is counted using ultrasound. Additionally, candidate genes for premature ovarian failure are being investigated. Young girls who are at risk of early ovarian failure should implement their reproductive plans and family planning on time.

There is an additional preventive measure: social and biological preservation of fertility, that is, cryopreservation of oocytes. This method is recommended for those women who postpone the birth of children due to temporary medical contraindications.

However, in women with increased FSH, decreased AMH, ovarian volume up to 3 ml and the number of antral follicles up to one, it is not always possible to obtain oocytes for storage. Such patients are advised to use donor material.

Preparation for analysis

In order for the test results to be informative and accurate, it is necessary to follow all the instructions for preparing for the study. To determine the level of AMH, venous blood is needed. The Efort test is carried out strictly on the third or fifth day of the cycle.

A few days before the test, it is necessary to minimize physical and psycho-emotional stress. One hour before the analysis, one must not eat or smoke. Donation of blood is postponed if, shortly before that, a woman has suffered an acute infection or other serious illness.

Anti-Müllerian hormone rate

Only a doctor can correctly interpret the results of any analysis, since many different factors can affect the data obtained. The hormone index is almost independent of external factors such as diet and lifestyle. Age also does not matter. Some women over 40 have significantly higher AMH levels than girls of reproductive age.

AMG standards:

• for a woman: 1-2.5 ng / ml;
• for a man: 0.49-5.98 ng / ml.

When the level deviates from the norm in a woman of reproductive age, it is important to first check the reproductive system for pathologies and disorders. The anti-Müllerian hormone reflects the functionality of the ovaries, therefore, the state of other organs and the concentration of other hormones, as a rule, do not affect the results of the study. When deviations from the norm are detected, it is necessary to look for violations in the ovaries and the processes that regulate their work.

Lowered anti-Müllerian hormone

A reduced indicator is considered to be less than 1 ng / ml in women of reproductive age. Before puberty and after menopause, low AMH levels are considered normal because primary follicular activity is absent at this age.

A low concentration of AMH in a woman of reproductive age indicates a small number of primary follicles ready for fertilization, as well as ovarian depletion. Both of these reasons lead to the same result - difficulty in conceiving naturally and minimal response to drug stimulation.

Atimüllerian hormone affects the growth and differentiation of tissues. Differentiation is the formation of a cell genotype. In a woman with a normal hormonal background, differentiation, maturation and release of one egg fall out for one cycle. In the presence of violations, anovulatory, irregular and other disruptions in the menstrual cycle appear.

The AMH indicator is only an indicator of the number of capable eggs, but the reasons for their reduction are completely different. With a decrease in AMH levels, it is necessary to find and treat the cause, not the effect. This is the only way to correct consequences such as infertility and early climate change.

Reasons for the decrease in AMH:

• menopause;
• dysgenesis of the gonads (incomplete development of the glands);
• early puberty;
• obesity and other metabolic disorders;
• hypogonadotropic hypogonadism.

A decrease in AMH levels after age 30 may be a signal of early menopause. The decrease is due to various factors, so a woman will need to consult not only a gynecologist, but also an endocrinologist and reproductologist. Usually, changes in the concentration of AMH are detected precisely during preparation for fertilization or when clarifying the reasons why conception fails.

Natural conception with low AMH

The issue of natural conception with low AMH remains controversial. Critical is considered to be less than 0.2 ng / ml, low - up to 1 ng / ml. With very low AMH levels, the chances of conceiving spontaneously are minimal.

With a low concentration of the hormone, it is necessary to additionally pass an FSH test. If the level of follicle-stimulating hormone is within the normal range, the chances of natural conception remain.

A serious problem is the combination of low AMH and high FSH. A decrease in the level of AMH in women from 40 years old indicates that the reserve of eggs is running out, and there is no way to force the body to produce additional ones.

If the reason for the decrease in AMH was menopause, but the woman still wants to become pregnant, hormone replacement therapy may be required. This will help delay menopause and increase the chances of natural conception.

The ability to conceive depends on the number of oocytes, the number of genetic and chromosomal mutations, the degree of sensitivity of the endometrium of the uterus, the presence of gynecological and other pathologies.

In vitro fertilization with low AMH

Low AMH determines the chances of a natural pregnancy. If this indicator is not combined with other alarming signals, IVF allows you to achieve egg maturation and successful conception, even with minimal stimulation. Therefore, a low AMH index does not become a contraindication to in vitro fertilization.

In contrast, IVF will be the most likely method of conception when anti-Müllerian hormone levels are low. The Japanese IVF protocol is recommended when combining low AMH and high FSH (from 15 IU / L). The minimum stimulation is divided at breaks to obtain 1–2 viable eggs in each cycle. The resulting cells are frozen and transferred to the uterus at a favorable time.

The IVF duct in the natural cycle is used in cases where a woman's ovarian reserve is depleted for one reason or another. Stimulation of ovulation is carried out minimally or not at all. Over the course of several cycles, doctors try to get at least one egg, which is fertilized and transferred to the uterine cavity.

The short IVF protocol with ovarian stimulation is indicated with a slight decrease in AMH, which does not accurately indicate an oocyte deficiency. It is necessary to take into account the level of FSH, the age of the patient, the results of previous protocols and stimulations. If all these indicators are normal, the chances of conception are high, therefore, a short protocol is carried out.

Preparation for IVF with low AMH levels may include the use of transdermal testosterone, androgens, estrogens, DHEP, hCG, LH, L-arginine, corticosteroids, aromatosis. Herbal medicine and hirudotherapy are recommended.

When to use donor eggs

A third of women of older reproductive age cannot get pregnant even through IVF. The use of donor eggs is required. Artificial ovarian stimulation is most often ineffective with low AMH in combination with other disorders. On the contrary, additional stimulation can deplete egg reserves more.

Indications for oocyte donation:

• increased FSH;
• lowered anti-Müllerian hormone;
• insufficient ovarian volume (less than 3 ml);
• the absence of antral follicles or the presence of only one.

If a woman does not want to use donor material, the most promising IVF protocol is used, although stimulation in such patients is most often ineffective. In this case, the best option would be to listen to the recommendations of your reproductologist.

Increased AMH levels

A woman's AMH level is considered elevated when it exceeds 2.5 ng / ml. It should be borne in mind that in preparation for IVF, this figure should be slightly exceeded. The increase will tell you that the stimulation is working and the chances of successful fertilization are high. Reasons for an increase in AMH levels:

• tumor;
• polycystic ovary disease;
• delayed sexual development;
• defects in luteinizing hormone receptors.

All the reasons for the increase in AMH levels can be divided into two groups. The first includes conditions in which the follicles mature normally, but the eggs do not go beyond the glands. This can be observed in polycystic ovary disease, when the follicle grows and develops, but is unable to overcome the cystic surface.

The second group includes an increase in the concentration of AMG against the background of the growth of granulosa tissue of the ovaries. The most obvious reason is the tumor transformation of the sex glands. When an elevated AMH is detected, an ultrasound of the ovaries is prescribed first. After detecting tumors or polycystic disease, it is necessary to undergo long-term treatment and re-take the analysis. The results are likely to improve significantly.

Therapy with elevated AMH

Treatment of the causes of an increase in AMH is carried out taking into account the age of the woman and the goals that need to be achieved in this way. Therapy for polycystic ovary syndrome includes the normalization of body weight, nutritional correction, adequate physical activity, rest and work regimen.

A woman should normalize hormones and carbohydrate metabolism. After this, it is possible to stimulate ovulation or to surgically ensure the release of the egg outside the ovaries. The tactics of treatment for hyperplastic processes in the ovaries are agreed with the oncologist. In case of detection of malignant neoplasms, the issue of conception is postponed until complete recovery.

How to increase AMG

An increase in AMH values ​​does not lead to an increase in the chances of natural conception. Stimulation of hormone production with drugs does not change the number of capable eggs, and, therefore, does not solve the problem of infertility. In this case, the treatment consists in identifying and eliminating the causes of the decrease in the hormone.

Often, artificial stimulation is ineffective, since a decrease in AMH indicates a premature menopause. Such patients are advised to pay attention to assisted reproductive technologies. Even if the results of the analysis for AMG deviate from the norm, one should not panic ahead of time.

Decreased or elevated anti-Müllerian hormone is not an indicator of absolute infertility and the inability to conceive a child on your own. It is necessary to take into account many other factors and only after that make a decision on artificial stimulation and in vitro fertilization.

The anti-Müllerian hormone is lowered, is it possible to get pregnant and how to do it? When it comes to infertility and unsuccessful attempts to conceive, as a rule, hormones such as estrogen and progesterone are remembered, but the anti-Müllerian hormone plays the most important role in fertility.

Few know what the anti-Müllerian hormone is, to clarify the situation, it is required to clarify that this is a hormone responsible in the human body for reproductive function. It is present in people of both sexes. In the body of men in adolescence, it allows you to control adolescent puberty. It is produced before the end of this process, after which it begins to gradually dissolve. If the elements of the hormone still remain in the blood, then this can provoke forms of hermaphroditism and hernia in the groin area.

In the female body, this hormone gives an idea of ​​the state of the ovaries and the development of follicles in them. It is produced from birth to menopause. I would like to note that the female body of the above hormone is less than that of male adolescents. By the amount of the hormone, the doctor can accurately determine how well a woman is ready to bear a child.

How is the analysis done?

A woman takes an analysis for the amount of hormone, as a rule, on days 3 or 5 of the cycle. Men are allowed to do this at any time, the main thing is to completely stop smoking an hour before delivery and follow the instructions of medical personnel.

For analysis, blood is taken from a vein with a special sterile system. It is not recommended to drink a lot of fluids before the procedure, and not to be subjected to emotional stress and great physical exertion the day before the procedure. If you have found significant differences with the norm, do not rush to panic, remember that there is a human factor and in the laboratory something could be confused or overlooked. Perhaps you prepared incorrectly for the analysis and influenced the result with your feelings. The test can be taken again next month. To obtain a referral, you need to consult an endocrinologist. As a rule, these tests are prescribed to women for the following purpose:

• cancer control and detection;
• identification of developmental pathologies;
• sexual activity;
• failure of artificial insemination and possible reasons for this;
• diagnosis of infertility and causes.

To save yourself from unnecessary treatment, which is not uncommon in infertility, all women planning a child are advised to undergo this examination.

Doctors prescribe an analysis for anti-Müllerian hormone before surgery, the result of which may affect a woman's reproductive function in the future. To protect themselves and prevent possible consequences, women should freeze several full-fledged eggs, which can be used for artificial insemination.

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The doctor directs women planning a pregnancy for analysis in order to accurately diagnose. The test procedure for the level of anti-Müllerian hormone takes place in 3 stages:

• sampling for FSH and anti-Müllerian hormone;
• counting full-fledged eggs in a given cycle;
• determination of the exact volume of the ovaries.

The analysis is done within 5 days, the cost directly depends on the speed of obtaining the results. Modern medicine allows you to find out the answer in 1 day, but the price of the procedure will be several times higher. Based on the information received, the doctor prescribes a course of medical therapy.

Reasons for deviations from the norm

The norm of anti-Müllerian hormone in women is 1-2.5 ng / ml, if its amount is reduced, this indicates that there are violations of the ovaries. In the case of an increase in the amount of the hormone in the blood, there is a suspicion of tumors and polycystic ovaries. The anti-Müllerian hormone is elevated, usually in overweight and obese people.

Many women wonder if the anti-Müllerian hormone is lowered, whether it is possible to become pregnant naturally. The fact is that the Antimüller hormone significantly affects a woman's reproductive function, and an insufficient amount of it may indicate infertility. Even with long-term treatment, if the amount of the hormone does not work out, the woman will not be able to become pregnant, since her body is not able to produce a normal egg on its own.

If it is observed that the anti-Müllerian hormone, the norm in women of which should be 1-2.5 ng / ml, is present in a greater or lesser amount, then diseases of the reproductive system occur. Common illnesses include:

• infertility;
• inflammation of the appendages;
• cysts;
• malignant tumors;
• early menopause;
• diabetes;
• obesity;
• hormonal disruptions;
• developmental pathology.

Emotional shocks and stressful situations can provoke an increase in the hormone. Constant physical activity, chronic inflammatory diseases. I would like to mention that other hormones do not affect the production of anti-Müllerian hormone. When the rate differs from your indicators, then you need to look for tumors in the ovaries or polycystic.

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As for the case when the anti-Müllerian hormone decreases, this suggests the following:

• the onset of menopause;
• a reduced number of eggs;
• early puberty;
• ovarian dysfunction.

If the hormone index in women is below the mark in the table 0.2 ng / ml (Table 1), then this is a critical point, and in most cases the treatment will be long and, possibly, will not give results.

It is almost impossible to increase the amount of the hormone. Even if you raise it artificially and engage in active stimulation of the ovaries, then there will be few full-fledged eggs ready for fertilization and the likelihood of getting pregnant will remain very low. Women who are faced with the problem of a low hormone number are recommended to use a fertilized egg transplant from a female donor. A lowered anti-Müllerian hormone is by no means a cause for panic. Do not stop trying and striving to become a happy mom. A critical case is only when, in combination with a low amount of anti-Müllerian hormone, the index of follicle-stimulating hormone also decreases.

Modern science has advanced far in the treatment of infertility, which is associated precisely with an insufficient amount of hormone, but, as a rule, all methods involve artificial insemination.

It is impossible to increase the number of eggs ready for fertilization in a natural way. The reserve of the latter is laid during the period of intrauterine growth, when the genitals are formed. Each new menstrual cycle implies the release of one follicle with an egg ready for fertilization, the remaining ones die off by themselves, respectively, the number of eggs decreases every month.

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The dying off and maturation of new follicles, even when a woman is pregnant and breastfeeding, does not stop. While a newborn girl has 2 million eggs in her ovary, by the time of her puberty their number is 300 thousand. It is for this reason that it is much more difficult for women after 30 years to become pregnant. When the number of eggs is critical, menopause sets in and the woman will no longer be able to conceive a child. The highest amount of the hormone is observed in women of reproductive age from 20 to 30 years. During menopause, the amount of anti-Müllerian hormone is zero. So far, medicine does not know how to control its level. The only thing that can be advised for women is not to delay motherhood and get pregnant at the age of 20-25.

Summing up, I would like to note that every year more and more young women apply for artificial insemination, and all because the amount of anti-Müllerian hormone in the blood is reduced. As a rule, the most common reason for this is ovarian surgery and chronic inflammation. That is why doctors strongly recommend not to neglect your health and take care of it from a young age in order to bear a full-fledged child. Those who are faced with a similar problem can only wish not to give up and believe in the best. There are cases when the amount of anti-Müllerian hormone increased for no apparent reason. Such situations have not yet been studied in detail, but the leading institutions of family planning are actively working on this issue.

Anti-Müllerian hormone is a marker of a woman's ovarian reserve, in other words, the remaining number of eggs that can still be fertilized.

He himself does not affect the ability to conceive or bear a child. But its level in the body accurately predicts the chances of getting pregnant on their own and with the help of IVF. AMH is a kind of indicator of health and fertility.

Every woman is born with a fixed number of eggs. This indicator is laid as early as the 3rd month of intrauterine development. Before the beginning of the first menstruation, the girl's immature follicles are in a dormant state..

With the first menstruation, the first follicle matures, releasing an egg, ready for fertilization. Each cycle the number of such eggs will decrease, and what remains will be the woman's ovarian reserve.

This dynamics is shown by the anti-Müllerian hormone. To date AMG is the most accurate analysis by which you can determine a woman's ability to conceive. as well as predict the onset of menopause.

In IVF, the AMH test makes it possible to assess the likelihood of egg fertilization after ovarian stimulation.

We offer you to watch a video about what AMG is:

Influence of AMH on the ability to conceive

Anti-Müllerian hormone is produced by the sex glands... In the female body, it is responsible for the production of follicles, and, consequently, for the ability to mature eggs.

If the chain is broken at the very beginning and follicles are not produced, then fertilization is impossible and the woman is not able to conceive naturally, as well as with the help of IVF and using her own eggs.

We suggest watching a video about the importance of AMG for conception:

When do I need to get tested?

Analysis for AMG is prescribed in the following cases:

• infertility;
• increased levels of follicle-stimulating hormone;
• unsuccessful IVF attempts;
• control of antiandrogenic therapy.

And also a gynecologist can send a woman for analysis with a prolonged absence of pregnancy for no apparent reason.

AMG plays an important role at the stage of preparation for IVF. Based on its results, the fertility specialist can predict the response of the ovaries after stimulation.

The norm in women for conception

The norm of the anti-Muller hormone for the successful conception of a child depends on the age and individual characteristics of the woman. It often happens that a woman in her 40s has an AGM higher than that of a twenty-year-old girl.

Normally, a woman of reproductive age has an anti-Müllerian hormone in the range of 1 to 2.5 ng / ml. Analysis data may vary slightly in different laboratories..

The lower the level of anti-Müllerian hormone, the lower the chance of getting pregnant.

At what level of AMH is pregnancy possible?

Indicators above or below the norm indicate malfunctioning of the ovaries and require the attention of a doctor. In rare cases, deviations in the parameters indicate an incorrect sampling or delivery of an analysis, so a woman can be sent for a retake.

If lowered

Decreased hormone levels indicate ovarian depletion... A deviation can be detected using laboratory analysis. It is possible to speak of a low content of AMG at values ​​from 0.2 to 1 ng / ml. This may indicate the following diseases:

• obesity;
• infertility;
• early puberty;
• the onset of menopause;
• decreased ovarian reserve;
• violation of the menstrual cycle.

Consider whether pregnancy is possible with low levels of anti-Müllerian hormone. The lower the AMH content in a woman's body, the less chances of conception. A reading below 0.2 ng / ml is considered critical, at which a doctor can diagnose infertility.

The sooner it is possible to identify the disease that led to the decrease in the hormone, the more likely it is to return the ability to reproduce. If the anti-Müllerian hormone is low for a long time, then the question of how to get pregnant becomes relevant, and it will be more difficult to cure infertility.

If increased

Elevated AMH also indicates certain ovarian dysfunctions.... If it exceeds the norm by more than two times, it may be a symptom of the following diseases:

It should be noted that a high level of anti-Müllerian hormone can be a symptom of cancer.

Can the level be influenced?

Anti-Müllerian hormone is an indicator that indicates the remaining supply of eggs... An increase in its level will not lead to an early onset of conception, therefore, in the course of treatment, attention should be paid to the reasons that entailed a reduced concentration of AMH.

If, after the examination, infertility was diagnosed, doctors use various methods of influencing the ovaries. Their task is not to increase the level of anti-Müllerian hormone, but to achieve the formation of healthy cells for fertilization.

Studies have shown positive dynamics in patients after taking vitamin D3 and a dietary supplement DHEA.

An increase in the level of the hormone is observed in women in the summer due to the additional synthesis of vitamin D3.

Among adherents of traditional medicine, there is an opinion that royal jelly and propolis have a beneficial effect on the possibility of conception... These products have a positive effect on the body, however, a specialist should select the treatment and prescribe drugs.

An anti-Müllerian hormone level outside the normal range indicates an abnormal reproductive system. A woman who has received disappointing test results in her hands should not despair - modern IVF techniques help to get pregnant even with a low AMH level. Do not self-medicate. The sooner a qualified specialist makes the correct diagnosis and prescribes therapy, the more chances of giving birth to a healthy baby.

Every woman dreams of becoming a mother. Especially responsible couples are examined before conceiving a child. The most important thing to do is check your hormones. To do this, you should pass an analysis for hormones. These include anti-Müllerian hormone (AMH). But what to do when low AMH is noted in the analysis results? Is it possible to get pregnant in such a situation? The presented article will help you find answers to these questions.

Norma AMG

An AMG test helps to determine how many eggs are capable of turning into a baby. It shows how many follicles have matured in a woman's ovaries.

Before drawing conclusions about whether you have low AMH or normal, you need to familiarize yourself with the indicators of the norm. This hormone begins to increase from the moment puberty begins. Therefore, in women of reproductive age, this indicator reaches its maximum level and ranges from 1 to 2.5 ng / ml.

For a more accurate assessment of the hormone content, the analysis must be taken on the 5th day of the menstrual cycle. Deviations from the norm can be caused by various diseases. If you eliminate them, then at may be possible.

In the case when it comes to IVF, a slight increase in the hormone will only play into the hands of a woman. After all, this increases the likelihood of successful resolution of the procedure.

Reasons for the decrease in AMH

An increase in AMH levels can provoke one of the following conditions:

• normogonadotropic anovulatory infertility;
• abnormalities in the functioning of luteinizing hormone (LH) receptors;
• tumor processes in the ovaries;
• the presence of polycystic formations in the ovaries.

Low AMH is observed when:

• decrease (usually associated with aging of the body);
• menopause (not a pathology, since sooner or later it occurs in the life of every woman);
• overweight (obesity at childbearing age, that is, at 20-30 years old);
• ovarian dysfunction.

Possibility of pregnancy with reduced AMH

The presence of a reduced concentration of the hormone in a woman's body almost always indicates the presence of any pathology. Disorders in the reproductive system can be of a different nature: from the usual overweight and ending with tumor formations.

Despite the reasons that caused a decrease in the level of the hormone in the body, pregnancy with a low AMH becomes problematic. Since the content of this hormone cannot be artificially increased. The cause of the abnormality can be corrected, but an increase in the number of eggs is unlikely. It is possible to influence their quality and maturity.

Statistics indicate that for women with low AMH, only the procedure of artificial insemination can be consolation. In addition, it often requires donor biological materials.

But there are also cases when the AMH decrease is corrected independently. This suggests that during the delivery of the analysis, some negative factor influenced its content, which distorted the research result.

Therefore, in each specific case, it is necessary to contact a specialist and develop a specific action plan.

AMG index for IVF

In the modern world, for couples who want to conceive a child, but for some reason cannot do it naturally, there is an artificial insemination procedure. In medicine, it is called in vitro fertilization (IVF). This process is rather complicated and laborious.

Initially, you need to undergo an examination. The most indicative in this case will be the analysis for AMG. The anti-Müllerian hormone will show the reproductologist how many of a woman's eggs are suitable for fertilization. That is why there is a framework, that is, a certain indicator of this hormone is needed.

For the procedure of artificial insemination, the AMH index in a woman must be at least 0.8 ng / ml. Otherwise, the procedure will simply be impossible, because there is not the required number of eggs for fertilization. Even low AMH stimulation will be difficult.

However, too high an indicator can be troublesome. In preparation for IVF, hormonal stimulation of follicle maturation is carried out. Due to the increased content of AMG in a woman's body, there is a risk of ovarian hyperstimulation.

Low AMH: Is IVF Possible?

Statistics indicate that IVF with low AMH is possible. But this is very difficult to accomplish. The hormone index does not affect whether the embryo will take root in a woman's body. But the very fact of fertilization can. Indeed, with a low AMH index, the number of eggs is very low, and their quality can be even worse. In addition, in this case, time is not on the side of future parents.

In principle, the procedure of artificial insemination with a low AMH is no different from the IVF procedure with a normal hormone level. But here the woman is forced to take more serious hormonal drugs. In addition, a longer period is required for the maturation of the eggs.

Typically, patients are prescribed hormonal drugs in a double dose. This, of course, sounds intimidating, but there is no reason to worry. A low hormone level will not lead to ovarian hyperstimulation or any other disease of the reproductive system.

Further actions of specialists depend on how the preparatory stage went. If everything went well and the number of eggs that can be fertilized has increased, then doctors take a follicle puncture, fertilize the egg and transfer the embryo into the mother's body. If the hormone indicator remains at a low level, then drug therapy should be reviewed.

IVF protocols

The AMG index is crucial for the IVF procedure. Knowing this indicator, the fertility doctor chooses a more appropriate action plan and protocol.

IVF protocols for low AMH can be of two types: long and short.

Long-term protocols are enforced one week before the onset of menstruation. Over the next three weeks, ovarian stimulation is performed to increase the number of eggs available for fertilization. Then a large number of eggs (up to 20) are punctured and fertilized. The artificially conceived three or five day old embryos are implanted in a woman. There is a possible complication in this protocol - the risk of ovarian hyperstimulation.

A short protocol begins to be performed on the 2-3rd day of menstruation. Ovum stimulation is performed. For this, a puncture of the dominant follicles is done. However, in this case, complications are possible - the lack of high-quality eggs. In addition, the procedure is only suitable for women with good ovaries.

IVF without hormonal stimulation

With low AMH, fertilization is possible without exposing the woman to shock doses of hormonal drugs. In this case, doctors monitor the woman's natural ovulation using an ultrasound scan. In this way, no more than 2 mature eggs are obtained in one cycle, which significantly reduces the chance of pregnancy.

This method, however, is also very difficult and has its pros and cons. On the positive side, in this case, you will not get twins or triplets, and you will not suffer from the side effects of hormone therapy. In addition, the cost of such fertilization is much lower.

The disadvantages include the fact that there is a high probability of missing the moment of egg maturation. Moreover, its quality will not be exactly what is necessary for a successful procedure.

Statistics

Low FSH, low AMH and other abnormalities are obstacles to fertilization. As statistics show, with IVF only 20-60% end successfully. The likelihood of success depends on the woman's age, the quality of her egg and her hormonal status.

However, medicine does not stand still, and every year diagnostics and fertilization procedures are being improved. Thus, it becomes easier to give birth to a child from year to year.

High FSH and low AMH

Quite often, along with a low level of AMH, a high level of FSH is observed. FSH is a follicle-stimulating hormone that is responsible for the production of follicles in the ovaries. This situation is a rather serious obstacle to the IVF procedure.

Undoubtedly, statistics say that almost all IVF attempts end in pregnancy. But high FSH levels can prevent this from happening. In this case, it is recommended to complete the fertilization procedure using donor material.

And yet there is a chance to use your egg for this, but it is very small. This is only possible if the FSH level is slightly increased. But with a very high FSH, you should not waste precious time. Ovulation in a woman may never occur, which indicates the advisability of using a donor egg.

Antimüllerian hormone (AMH) is one of the serious stimulants of the proper functioning of the gonads in women and men. It is an indicator of whether a woman can get pregnant. In men, the substance promotes the development of the genitals. If a couple cannot conceive a child in any way, it is worth checking the blood for AMH levels. When the indicator is lowered, women ask how to increase AMH? Many are interested in the question of whether it is possible to become pregnant if the anti-Müllerian hormone is lowered? This article will address this issue.

The hormone begins to be produced in a baby from the day of his birth. Upon reaching puberty and ready to conceive, the amount of substance in the blood rises and reaches a maximum. With a gradual decrease in reproductive function, the volume of the hormone decreases and reaches a minimum in women during menopause, in men at the end of life.

Generation and function of the hormone

Mueller's inhibitory substance is produced by the gonads. in women, it stimulates the production of follicles in which they are able to mature and prepare for the fertilization of the egg. If viable follicles are not produced, the woman's reproductive function will be impaired. In the absence of a dominant follicle and a mature egg, fertilization will not occur. Moreover, IVF fertilization using your own egg will be impossible.

The production of AMH in a woman's body depends on the specific day of the cycle. In humans, gonadotropins affect the generation of the hormone. What distinguishes the described inhibitory substance from other hormones, its secretion is not influenced by nutrition, the patient's lifestyle and other external circumstances.

In men, AMG contributes to the correct development of the genitals. If its volume is below normal, a male patient is likely to have a functional impossibility to conceive a baby.

Decreased value of the indicator

If the anti-Müllerian hormone is lowered, this means the development of pathology. The amount of anti-Müllerian substance is reduced in the following situations:

• Insufficient development of the ovaries in women and testes in men;
• Too early puberty;
• Insufficient functioning of the gonads and insufficient production of sex hormones by them;
• Violation of the menstrual cycle in women (with this frequent pathology, it is necessary to investigate the content of hormones in the blood);
• Decreased supply of healthy eggs in women;
• Decrease in the number of primary follicles suitable for reproduction;
• The onset of menopause, including early menopause;
• Ovarian dysfunction;
• Endometriosis (proliferation of the lining of the uterus);
• Tumor diseases of the ovaries.

Low levels of anti-Müllerian hormone in young men may be associated with early sexual development and "hormonal burnout." Developmental disorders are also possible - the absence of testicles, not lowering them into the scrotum, functional pathology. Rarely does a hereditary disease called false hermaphroditism, in which a man's external genitals are fully developed, but an ultrasound can reveal the presence of a small uterus.

The main thing with a low AMG value is to identify pathology in time. If the disease that caused the hormone to decrease is treated early, the ability to reproduce will return. When the hormone is lowered over time, infertility is much more difficult to cure. Surgery may be required for treatment.

Increased hormone levels

• Lack of ovulation in a woman caused by dysfunction of the endocrine and gonads.
• Decreased sensitivity of receptors to luteinizing hormone. It is the surge in LH that stimulates ovulation. Without its assistance or in the absence of sensitivity to LH, the body reacts with an increased amount of AMH.
• Tumor diseases of the ovaries. An increase in the volume of AMH with it is associated with the secretion of a substance by tumor cells that are not intended for this.

An increased value of the hormone can also indicate a slow sexual development of a girl or boy. It is necessary to lower the indicator, eliminating the cause of its increase, using medical methods. Pills that reduce the volume of the hormone have not yet been invented.

Mueller Inhibiting Substance Rate

The hormone rate does not depend on the age of the patients. The anti-Müllerian hormone in a woman in her 40s may be higher, and she may have a larger supply of eggs than a 20-year-old girl, and the ability to become pregnant is sometimes inherent in quite old women. But in the same woman, the amount of the substance changes with age.

The normal AMH score depends on gender. In women, the norm ranges from 1 to 2.5 ng / ml. In men, it ranges from 0.49 to 5.88 ng / ml.

Violation of the indicator of the normal volume of a substance is sometimes random. It can be low or high. First of all, the doctor will send the patient for a second analysis after some time.

If the substances in the woman's body are more than normal, this indicates a disease. When the underlying disease is cured, this indicator will also decrease.

When a study has shown a normal amount of AMH in a woman's blood, it is necessary to check the content of the substance in her partner.

Is it possible to increase the hormone?

What to do when Mueller's hormone is below normal? How to boost anti-Müllerian hormone? There is little consolation in the case of a reduced indicator. A woman most likely has a problem with reproductive function associated with the pathology of the female genital organs, obesity, early menopause, tumor diseases, etc. I have to go to the doctor.

It should be noted that a value less than 1 ng / ml is considered low. If the patient has a substance volume less than 0.2 ng / ml, it's time to sound the alarm. It is impossible to increase the anti-Müllerian indicator. Yes, it's not about him, but about the disease to which he points.

Of course, now there are many ways of artificial insemination. But they need a mature egg, which the patient does not have. In such cases, the doctor will recommend an IVF procedure or another method using a donor egg.

Pregnancy with low AMH

Is pregnancy possible with low AMH? If you see a doctor in time and identify the cause of the deviation of the hormone volume from the norm, there is a chance of recovery. Can anti-Müllerian hormone be increased? Yes, if you eliminate the reasons that caused the decrease in its content.

It is possible to increase the hormone if its decrease was caused by severe stress or heavy physical exertion. Then the elimination of a non-standard situation, rest, calmness will raise the indicator. When it comes to early menopause, it is difficult to deal with it. And there is early menopause, as the cause of reproductive disorders, more often.

Also, a low anti-Müllerian hormone can be observed when taking hormonal drugs. It is necessary to inform the doctor about their use.

It is usually not possible to increase the anti-Müllerian hormone with folk remedies. With the described pathology, the doctor at the family planning center must decide whether it makes sense to stimulate the ovaries to produce a viable egg or raise the question of IVF fertilization with a donor egg. The task of increasing the indicator is usually not set.

Treatment of a low AMH content is carried out by a doctor. It is dangerous to prescribe pills and procedures on your own. In addition, while the patient uses traditional methods of treatment to increase the volume of the substance, she may miss out on precious time of reproductive age.

Low levels of Müller hormone are usually combined with high levels of FSH (follicle-stimulating hormone). If this is not the case, the doctor will look deeper into the cause of the AMH decrease.

Hormone test

The analysis for AMG is taken by expectant mothers who have decided to undergo the IVF procedure. In the family planning center, every woman will be advised to take an analysis for gonadotropic and sex hormones when planning a pregnancy.

Typically, blood is drawn from a vein. Women should be tested on the 5th day of the cycle. Three days before the study, it is necessary to cancel heavy physical activity and take care of yourself from stress. You cannot take alcoholic beverages on the eve of the day when you donate blood. It is forbidden to drink hormonal drugs that increase the content of other hormones. You can eat for the last time before the study in the evening a few hours before bedtime. In the morning, on the day of the analysis, you can neither drink nor eat. Also, in the morning before the analysis, you should stop smoking.

If the patient has suffered an acute illness of any kind shortly before the study, the doctor must be notified. It is not necessary to get upset if the norm of the amount of the hormone in the blood is violated. Perhaps, in your case, it is caused by temporary reasons, and in the next menstrual cycle you will get a good result.